Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DCX_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
43 Leu Ser Lissencephaly,X-linked1(LISX1) -
47 Ser Arg Lissencephaly,X-linked1(LISX1) -
47 Ser Arg SubcorticalbandheterotopiaX-linked(SBHX) -
59 Arg Leu Lissencephaly,X-linked1(LISX1) -
59 Arg Leu SubcorticalbandheterotopiaX-linked(SBHX) -
59 Arg His SubcorticalbandheterotopiaX-linked(SBHX) -
62 Asp Asn Lissencephaly,X-linked1(LISX1) -
62 Asp Asn SubcorticalbandheterotopiaX-linked(SBHX) -
78 Arg Leu SubcorticalbandheterotopiaX-linked(SBHX) -
86 Asp His SubcorticalbandheterotopiaX-linked(SBHX) -
100 Gly Ala Lissencephaly,X-linked1(LISX1) -
100 Gly Ala SubcorticalbandheterotopiaX-linked(SBHX) -
102 Arg Ser Lissencephaly,X-linked1(LISX1) -
125 Tyr His Lissencephaly,X-linked1(LISX1) -
125 Tyr His SubcorticalbandheterotopiaX-linked(SBHX) -
125 Tyr Asp SubcorticalbandheterotopiaX-linked(SBHX) -
178 Arg Leu SubcorticalbandheterotopiaX-linked(SBHX) -
186 Arg Cys SubcorticalbandheterotopiaX-linked(SBHX) -
191 Pro Arg SubcorticalbandheterotopiaX-linked(SBHX) -
192 Arg Trp Lissencephaly,X-linked1(LISX1) -
192 Arg Trp SubcorticalbandheterotopiaX-linked(SBHX) -
200 Asn Lys SubcorticalbandheterotopiaX-linked(SBHX) -
203 Thr Arg Lissencephaly,X-linked1(LISX1) -
203 Thr Arg SubcorticalbandheterotopiaX-linked(SBHX) -
214 Ile Thr SubcorticalbandheterotopiaX-linked(SBHX) -
222 Thr Ile SubcorticalbandheterotopiaX-linked(SBHX) -
223 Gly Glu SubcorticalbandheterotopiaX-linked(SBHX) -
236 Val Ile SubcorticalbandheterotopiaX-linked(SBHX) -
250 Ile Asn SubcorticalbandheterotopiaX-linked(SBHX) -
250 Ile Thr SubcorticalbandheterotopiaX-linked(SBHX) -
253 Gly Asp SubcorticalbandheterotopiaX-linked(SBHX) -
89 Arg Gly SubcorticalbandheterotopiaX-linked(SBHX) -
42 Thr Ile Lissencephaly,X-linked1(LISX1) -
50 Lys Asn SubcorticalbandheterotopiaX-linked(SBHX) -
60 Asn Asp Lissencephaly,X-linked1(LISX1) -
67 Gly Glu SubcorticalbandheterotopiaX-linked(SBHX) -
71 Ala Ser Lissencephaly,X-linked1(LISX1) -
97 Leu Arg SubcorticalbandheterotopiaX-linked(SBHX) -
104 Ile Thr SubcorticalbandheterotopiaX-linked(SBHX) -
178 Arg Cys SubcorticalbandheterotopiaX-linked(SBHX) -
191 Pro Leu SubcorticalbandheterotopiaX-linked(SBHX) -
196 Arg His Lissencephaly,X-linked1(LISX1) -
200 Asn Ile SubcorticalbandheterotopiaX-linked(SBHX) -
203 Thr Ala SubcorticalbandheterotopiaX-linked(SBHX) -
223 Gly Val SubcorticalbandheterotopiaX-linked(SBHX) -
243 Phe Leu Lissencephaly,X-linked1(LISX1) -
251 Ala Ser SubcorticalbandheterotopiaX-linked(SBHX) -
251 Ala Val SubcorticalbandheterotopiaX-linked(SBHX) -
262 Asp Gly Lissencephaly,X-linked1(LISX1) -
262 Asp Gly SubcorticalbandheterotopiaX-linked(SBHX) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DCX_HUMAN
GO:0019900 kinase binding 28.0000 4 yes
GO:0043169 cation binding 24.0000 4 no
GO:0046872 metal ion binding 24.0000 5 no
GO:0008017 microtubule binding 20.0000 5 yes
GO:0015631 tubulin binding 20.0000 4 yes
GO:0019901 protein kinase binding 20.0000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DCX_HUMAN
GO:0048522 positive regulation of cellular process 52.0000 4 no
GO:0048523 negative regulation of cellular process 52.0000 4 no
GO:0022607 cellular component assembly 48.0000 4 yes
GO:0031323 regulation of cellular metabolic process 48.0000 4 no
GO:0051246 regulation of protein metabolic process 48.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 48.0000 4 no
GO:0080090 regulation of primary metabolic process 48.0000 4 no
GO:0051128 regulation of cellular component organization 48.0000 4 no
GO:0008104 protein localization 44.0000 4 no
GO:0030030 cell projection organization 44.0000 4 no
GO:0006996 organelle organization 40.0000 4 yes
GO:0031399 regulation of protein modification process 40.0000 6 no
GO:0009966 regulation of signal transduction 40.0000 4 no
GO:0010646 regulation of cell communication 40.0000 4 no
GO:0001764 neuron migration 32.0000 4 yes
GO:0007010 cytoskeleton organization 32.0000 5 yes
GO:0009893 positive regulation of metabolic process 32.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 32.0000 5 no
GO:0036211 protein modification process 32.0000 4 no
GO:0043412 macromolecule modification 32.0000 4 no
GO:0048584 positive regulation of response to stimulus 32.0000 4 no
GO:0048812 neuron projection morphogenesis 32.0000 5 no
GO:0120036 plasma membrane bounded cell projection organization 32.0000 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 32.0000 4 no
GO:0009889 regulation of biosynthetic process 28.0000 4 no
GO:0009892 negative regulation of metabolic process 28.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 28.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 28.0000 5 no
GO:0051247 positive regulation of protein metabolic process 28.0000 6 no
GO:0009967 positive regulation of signal transduction 28.0000 5 no
GO:0010647 positive regulation of cell communication 28.0000 5 no
GO:0019220 regulation of phosphate metabolic process 28.0000 6 no
GO:0023056 positive regulation of signaling 28.0000 4 no
GO:0031344 regulation of cell projection organization 28.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 28.0000 5 no
GO:1902531 regulation of intracellular signal transduction 28.0000 5 no
GO:0031175 neuron projection development 28.0000 6 no
GO:0044087 regulation of cellular component biogenesis 28.0000 4 no
GO:0051130 positive regulation of cellular component organization 28.0000 5 no
GO:0009894 regulation of catabolic process 24.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 24.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 24.0000 5 no
GO:0031401 positive regulation of protein modification process 24.0000 7 no
GO:0043933 protein-containing complex organization 24.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 24.0000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 24.0000 6 no
GO:0141124 intracellular signaling cassette 24.0000 4 no
GO:0010468 regulation of gene expression 24.0000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 24.0000 5 no
GO:0050890 cognition 24.0000 4 no
GO:0033043 regulation of organelle organization 24.0000 5 no
GO:0051726 regulation of cell cycle 24.0000 4 no
GO:0007399 nervous system development 16.0000 4 yes
GO:0007417 central nervous system development 16.0000 4 yes
GO:0001578 microtubule bundle formation 8.0000 4 yes
GO:0035082 axoneme assembly 8.0000 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KLH15_HUMAN [view interactions] Low throughput no yes
DCLK1_HUMAN [view entry] [view interactions] Low throughput yes yes
USP9X_HUMAN [view entry] [view interactions] Low throughput yes yes
LIS1_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
NEB2_HUMAN [view entry] [view interactions] Low throughput yes yes
DCX_HUMAN [view entry] [view interactions] Low throughput yes yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
IKZF1_HUMAN [view interactions] High throughput no no
TINF2_HUMAN [view interactions] High throughput no no
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CK5P2_HUMAN [view interactions] High throughput no yes
CEP63_HUMAN [view interactions] High throughput no yes
CE192_HUMAN [view interactions] High throughput no yes
CP110_HUMAN [view interactions] High throughput no yes
POC5_HUMAN [view interactions] High throughput no yes
ZBTB5_HUMAN [view interactions] High throughput no yes
TRI23_HUMAN [view interactions] High throughput no yes
TRI27_HUMAN [view interactions] High throughput no yes
MEOX1_HUMAN [view interactions] High throughput no no
KR108_HUMAN [view interactions] High throughput no no
CACO2_HUMAN [view interactions] High throughput no yes
K1C40_HUMAN [view interactions] High throughput no no
RINT1_HUMAN [view interactions] High throughput no yes
SPAG5_HUMAN [view interactions] High throughput no yes
KIFC3_HUMAN [view interactions] High throughput no no
TERF1_HUMAN [view interactions] High throughput no no
ACD_HUMAN [view interactions] High throughput no no
POTE1_HUMAN [view interactions] High throughput no no
OSTP_HUMAN [view interactions] High throughput no yes
TRIM1_HUMAN [view interactions] High throughput no no
RBM5_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
MK09_HUMAN [view interactions] High throughput no yes
HOOK2_HUMAN [view interactions] High throughput no yes
MEOX2_HUMAN [view interactions] High throughput no no
MTUS2_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
FSD2_HUMAN [view interactions] High throughput no no
ZBT10_HUMAN [view interactions] High throughput no yes
VPS52_HUMAN [view entry] [view interactions] High throughput yes no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
HAX1_HUMAN [view interactions] High throughput no no
NUFP1_HUMAN [view interactions] High throughput no yes
NMNA3_HUMAN [view interactions] High throughput no yes
RRP44_HUMAN [view interactions] High throughput no yes
CUL1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
NDUAA_HUMAN [view entry] [view interactions] High throughput yes yes
LEG9C_HUMAN [view interactions] High throughput no no
RGDSR_HUMAN [view interactions] High throughput no no
DPF3_HUMAN [view interactions] High throughput no yes
AGTR1_HUMAN [view interactions] High throughput no no
KTU_HUMAN [view interactions] High throughput no yes
RNF13_HUMAN [view interactions] High throughput no yes
MTEF2_HUMAN [view interactions] High throughput no yes
GDAH_HUMAN [view interactions] High throughput no no
ARMC1_HUMAN [view interactions] High throughput no yes
SRTD4_HUMAN [view interactions] High throughput no yes
IDH3B_HUMAN [view entry] [view interactions] High throughput yes yes
BABA2_HUMAN [view interactions] High throughput no yes
CYTIP_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
POPD1_HUMAN [view interactions] High throughput no yes
UBL7_HUMAN [view interactions] High throughput no yes
KLHL8_HUMAN [view interactions] High throughput no no
LIPL_HUMAN [view interactions] High throughput no no
OR2A4_HUMAN [view interactions] High throughput no no
DCAF5_HUMAN [view interactions] High throughput no yes
BACD3_HUMAN [view interactions] High throughput no yes
BT1A1_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
FBX25_HUMAN [view interactions] High throughput no no
CPXM1_HUMAN [view interactions] High throughput no no
SPAS1_HUMAN [view interactions] High throughput no no
LIMC1_HUMAN [view entry] [view interactions] High throughput yes no
MAP4_HUMAN [view entry] [view interactions] High throughput yes no
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA5_HUMAN [view entry] [view interactions] High throughput yes yes
CDC27_HUMAN [view interactions] High throughput no yes
APC5_HUMAN [view interactions] High throughput no yes
CDC16_HUMAN [view interactions] High throughput no yes
CDC20_HUMAN [view interactions] High throughput no no
CCNA2_HUMAN [view interactions] High throughput no no
CCNB1_HUMAN [view interactions] High throughput no no
CDN1A_HUMAN [view interactions] High throughput no no
PTTG1_HUMAN [view interactions] High throughput no no