Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DCX_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
43 Leu Ser Lissencephaly,X-linked1(LISX1) -
47 Ser Arg Lissencephaly,X-linked1(LISX1) -
47 Ser Arg SubcorticalbandheterotopiaX-linked(SBHX) -
59 Arg Leu Lissencephaly,X-linked1(LISX1) -
59 Arg Leu SubcorticalbandheterotopiaX-linked(SBHX) -
59 Arg His SubcorticalbandheterotopiaX-linked(SBHX) -
62 Asp Asn Lissencephaly,X-linked1(LISX1) -
62 Asp Asn SubcorticalbandheterotopiaX-linked(SBHX) -
78 Arg Leu SubcorticalbandheterotopiaX-linked(SBHX) -
86 Asp His SubcorticalbandheterotopiaX-linked(SBHX) -
100 Gly Ala Lissencephaly,X-linked1(LISX1) -
100 Gly Ala SubcorticalbandheterotopiaX-linked(SBHX) -
102 Arg Ser Lissencephaly,X-linked1(LISX1) -
125 Tyr His Lissencephaly,X-linked1(LISX1) -
125 Tyr His SubcorticalbandheterotopiaX-linked(SBHX) -
125 Tyr Asp SubcorticalbandheterotopiaX-linked(SBHX) -
178 Arg Leu SubcorticalbandheterotopiaX-linked(SBHX) -
186 Arg Cys SubcorticalbandheterotopiaX-linked(SBHX) -
191 Pro Arg SubcorticalbandheterotopiaX-linked(SBHX) -
192 Arg Trp Lissencephaly,X-linked1(LISX1) -
192 Arg Trp SubcorticalbandheterotopiaX-linked(SBHX) -
200 Asn Lys SubcorticalbandheterotopiaX-linked(SBHX) -
203 Thr Arg Lissencephaly,X-linked1(LISX1) -
203 Thr Arg SubcorticalbandheterotopiaX-linked(SBHX) -
214 Ile Thr SubcorticalbandheterotopiaX-linked(SBHX) -
222 Thr Ile SubcorticalbandheterotopiaX-linked(SBHX) -
223 Gly Glu SubcorticalbandheterotopiaX-linked(SBHX) -
236 Val Ile SubcorticalbandheterotopiaX-linked(SBHX) -
250 Ile Asn SubcorticalbandheterotopiaX-linked(SBHX) -
250 Ile Thr SubcorticalbandheterotopiaX-linked(SBHX) -
253 Gly Asp SubcorticalbandheterotopiaX-linked(SBHX) -
89 Arg Gly SubcorticalbandheterotopiaX-linked(SBHX) -
42 Thr Ile Lissencephaly,X-linked1(LISX1) -
50 Lys Asn SubcorticalbandheterotopiaX-linked(SBHX) -
60 Asn Asp Lissencephaly,X-linked1(LISX1) -
67 Gly Glu SubcorticalbandheterotopiaX-linked(SBHX) -
71 Ala Ser Lissencephaly,X-linked1(LISX1) -
97 Leu Arg SubcorticalbandheterotopiaX-linked(SBHX) -
104 Ile Thr SubcorticalbandheterotopiaX-linked(SBHX) -
178 Arg Cys SubcorticalbandheterotopiaX-linked(SBHX) -
191 Pro Leu SubcorticalbandheterotopiaX-linked(SBHX) -
196 Arg His Lissencephaly,X-linked1(LISX1) -
200 Asn Ile SubcorticalbandheterotopiaX-linked(SBHX) -
203 Thr Ala SubcorticalbandheterotopiaX-linked(SBHX) -
223 Gly Val SubcorticalbandheterotopiaX-linked(SBHX) -
243 Phe Leu Lissencephaly,X-linked1(LISX1) -
251 Ala Ser SubcorticalbandheterotopiaX-linked(SBHX) -
251 Ala Val SubcorticalbandheterotopiaX-linked(SBHX) -
262 Asp Gly Lissencephaly,X-linked1(LISX1) -
262 Asp Gly SubcorticalbandheterotopiaX-linked(SBHX) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DCX_HUMAN
GO:0019900 kinase binding 28.5714 4 yes
GO:0019901 protein kinase binding 23.8095 5 yes
GO:0046872 metal ion binding 23.8095 4 no
GO:0019902 phosphatase binding 23.8095 4 no
GO:0019903 protein phosphatase binding 23.8095 5 no
GO:0008017 microtubule binding 19.0476 5 yes
GO:0015631 tubulin binding 19.0476 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DCX_HUMAN
GO:0048522 positive regulation of cellular process 61.9048 4 no
GO:0051171 regulation of nitrogen compound metabolic process 57.1429 4 no
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0051246 regulation of protein metabolic process 52.3810 5 no
GO:0031323 regulation of cellular metabolic process 52.3810 4 no
GO:0048523 negative regulation of cellular process 52.3810 4 no
GO:0022607 cellular component assembly 52.3810 4 yes
GO:0031399 regulation of protein modification process 47.6190 6 no
GO:0051128 regulation of cellular component organization 47.6190 4 no
GO:0008104 protein localization 42.8571 4 no
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0010646 regulation of cell communication 42.8571 4 no
GO:0009893 positive regulation of metabolic process 42.8571 4 no
GO:0030030 cell projection organization 42.8571 4 no
GO:0036211 protein modification process 38.0952 4 no
GO:0043412 macromolecule modification 38.0952 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 38.0952 5 no
GO:0031325 positive regulation of cellular metabolic process 38.0952 5 no
GO:0001764 neuron migration 38.0952 4 yes
GO:0009892 negative regulation of metabolic process 38.0952 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.0952 5 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0032990 cell part morphogenesis 33.3333 4 no
GO:0048812 neuron projection morphogenesis 33.3333 7 no
GO:0048858 cell projection morphogenesis 33.3333 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 33.3333 6 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0006996 organelle organization 33.3333 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0051726 regulation of cell cycle 28.5714 4 no
GO:0007010 cytoskeleton organization 28.5714 5 yes
GO:0010468 regulation of gene expression 28.5714 5 no
GO:0031175 neuron projection development 23.8095 6 no
GO:0051248 negative regulation of protein metabolic process 23.8095 6 no
GO:0071702 organic substance transport 23.8095 4 no
GO:0071705 nitrogen compound transport 23.8095 4 no
GO:2000112 regulation of cellular macromolecule biosynthetic process 23.8095 6 no
GO:0006796 phosphate-containing compound metabolic process 23.8095 4 no
GO:0050890 cognition 23.8095 4 no
GO:0007346 regulation of mitotic cell cycle 23.8095 5 no
GO:0080134 regulation of response to stress 23.8095 4 no
GO:0080135 regulation of cellular response to stress 23.8095 4 no
GO:1902531 regulation of intracellular signal transduction 23.8095 5 no
GO:0009894 regulation of catabolic process 23.8095 4 no
GO:0007399 nervous system development 19.0476 4 yes
GO:0007417 central nervous system development 14.2857 4 yes
GO:0048666 neuron development 14.2857 4 yes
GO:0001578 microtubule bundle formation 9.5238 4 yes
GO:0035082 axoneme assembly 9.5238 5 yes
GO:0042461 photoreceptor cell development 9.5238 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in DCX_HUMAN
DOID:0050453 lissencephaly 9.5238 3 yes
DOID:0112239 X-linked lissencephaly 1 9.5238 4 yes

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KLH15_HUMAN [view interactions] Low throughput no yes
DCLK1_HUMAN [view entry] [view interactions] Low throughput yes yes
USP9X_HUMAN [view entry] [view interactions] Low throughput yes yes
LIS1_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
NEB2_HUMAN [view entry] [view interactions] Low throughput yes yes
DCX_HUMAN [view entry] [view interactions] Low throughput yes yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
IKZF1_HUMAN [view interactions] High throughput no no
TINF2_HUMAN [view interactions] High throughput no no
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
ZBTB5_HUMAN [view interactions] High throughput no yes
TRI23_HUMAN [view interactions] High throughput no yes
TRI27_HUMAN [view interactions] High throughput no yes
KR108_HUMAN [view interactions] High throughput no no
MEOX1_HUMAN [view interactions] High throughput no no
K1C40_HUMAN [view interactions] High throughput no no
CACO2_HUMAN [view interactions] High throughput no yes
SPAG5_HUMAN [view interactions] High throughput no yes
RINT1_HUMAN [view interactions] High throughput no yes
KIFC3_HUMAN [view interactions] High throughput no no
TERF1_HUMAN [view interactions] High throughput no no
ACD_HUMAN [view interactions] High throughput no no
POTE1_HUMAN [view interactions] High throughput no no
OSTP_HUMAN [view interactions] High throughput no yes
TRIM1_HUMAN [view interactions] High throughput no no
RBM5_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
MK09_HUMAN [view interactions] High throughput no yes
HOOK2_HUMAN [view interactions] High throughput no yes
MEOX2_HUMAN [view interactions] High throughput no no
MTUS2_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
FSD2_HUMAN [view interactions] High throughput no no
ZBT10_HUMAN [view interactions] High throughput no yes
VPS52_HUMAN [view entry] [view interactions] High throughput yes no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
HAX1_HUMAN [view interactions] High throughput no no
NUFP1_HUMAN [view interactions] High throughput no yes
NMNA3_HUMAN [view interactions] High throughput no yes
RRP44_HUMAN [view interactions] High throughput no yes
CUL1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
NDUAA_HUMAN [view entry] [view interactions] High throughput yes yes
LEG9C_HUMAN [view interactions] High throughput no no
RGDSR_HUMAN [view interactions] High throughput no no
DPF3_HUMAN [view interactions] High throughput no yes
AGTR1_HUMAN [view interactions] High throughput no no
KTU_HUMAN [view interactions] High throughput no yes
RNF13_HUMAN [view interactions] High throughput no yes
MTEF2_HUMAN [view interactions] High throughput no yes
SPEB_HUMAN [view interactions] High throughput no no
ARMC1_HUMAN [view interactions] High throughput no yes
SRTD4_HUMAN [view interactions] High throughput no yes
IDH3B_HUMAN [view entry] [view interactions] High throughput yes yes
BABA2_HUMAN [view interactions] High throughput no yes
CYTIP_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
POPD1_HUMAN [view interactions] High throughput no yes
UBL7_HUMAN [view interactions] High throughput no yes
KLHL8_HUMAN [view interactions] High throughput no no
LIPL_HUMAN [view interactions] High throughput no no
OR2A4_HUMAN [view interactions] High throughput no no
DCAF5_HUMAN [view interactions] High throughput no yes
BACD3_HUMAN [view interactions] High throughput no yes
BT1A1_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
FBX25_HUMAN [view interactions] High throughput no no
CPXM1_HUMAN [view interactions] High throughput no no
SPAS1_HUMAN [view interactions] High throughput no no
LIMC1_HUMAN [view entry] [view interactions] High throughput yes no