LIS1_HUMAN
Evidence for PS localization
Functions
Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates to the PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner . Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors . Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (PubMed). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LIS1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 38.8889 | 4 | no |
| GO:0043168 | anion binding | 29.3651 | 4 | no |
| GO:0000166 | nucleotide binding | 27.7778 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.7778 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 27.7778 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 23.8095 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.8095 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.8095 | 4 | no |
| GO:0019900 | kinase binding | 20.6349 | 4 | no |
| GO:0015631 | tubulin binding | 15.8730 | 4 | yes |
| GO:0008017 | microtubule binding | 13.4921 | 5 | yes |
| GO:0046982 | protein heterodimerization activity | 6.3492 | 4 | yes |
| GO:0051010 | microtubule plus-end binding | 6.3492 | 6 | yes |
| GO:0043274 | phospholipase binding | 2.3810 | 4 | yes |
| GO:0034452 | dynactin binding | 1.5873 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LIS1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 46.8254 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 39.6825 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 37.3016 | 4 | yes |
| GO:0022607 | cellular component assembly | 36.5079 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 34.9206 | 4 | no |
| GO:0010646 | regulation of cell communication | 34.9206 | 4 | yes |
| GO:0006996 | organelle organization | 34.1270 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 32.5397 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 32.5397 | 4 | no |
| GO:0009966 | regulation of signal transduction | 31.7460 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 30.9524 | 4 | yes |
| GO:0008104 | protein localization | 30.9524 | 4 | yes |
| GO:0009059 | macromolecule biosynthetic process | 26.1905 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.1905 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 26.1905 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 25.3968 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.3968 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.3968 | 5 | no |
| GO:0033043 | regulation of organelle organization | 25.3968 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 24.6032 | 4 | no |
| GO:0007010 | cytoskeleton organization | 24.6032 | 5 | yes |
| GO:0010468 | regulation of gene expression | 23.8095 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.0159 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.0159 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 23.0159 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 23.0159 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 22.2222 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 21.4286 | 5 | yes |
| GO:0002181 | cytoplasmic translation | 21.4286 | 5 | no |
| GO:0006412 | translation | 21.4286 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.4286 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.4286 | 4 | no |
| GO:0071310 | cellular response to organic substance | 20.6349 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 19.8413 | 6 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 17.4603 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 15.8730 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 15.8730 | 4 | yes |
| GO:0030030 | cell projection organization | 15.8730 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 15.0794 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 15.0794 | 4 | yes |
| GO:0071702 | organic substance transport | 15.0794 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 14.2857 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 13.4921 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 13.4921 | 4 | yes |
| GO:0032886 | regulation of microtubule-based process | 13.4921 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 12.6984 | 4 | yes |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 12.6984 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 12.6984 | 6 | yes |
| GO:0009968 | negative regulation of signal transduction | 12.6984 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 12.6984 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 12.6984 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 12.6984 | 5 | yes |
| GO:0070925 | organelle assembly | 11.9048 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 11.9048 | 4 | yes |
| GO:0015031 | protein transport | 11.1111 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 11.1111 | 4 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 11.1111 | 4 | yes |
| GO:0099111 | microtubule-based transport | 10.3175 | 4 | yes |
| GO:0001558 | regulation of cell growth | 10.3175 | 4 | yes |
| GO:0010970 | transport along microtubule | 10.3175 | 4 | yes |
| GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 9.5238 | 4 | yes |
| GO:0043408 | regulation of MAPK cascade | 8.7302 | 6 | yes |
| GO:0050807 | regulation of synapse organization | 8.7302 | 5 | yes |
| GO:0060284 | regulation of cell development | 8.7302 | 5 | yes |
| GO:0010975 | regulation of neuron projection development | 8.7302 | 7 | yes |
| GO:0031346 | positive regulation of cell projection organization | 8.7302 | 6 | yes |
| GO:0045597 | positive regulation of cell differentiation | 7.9365 | 5 | yes |
| GO:0048812 | neuron projection morphogenesis | 7.9365 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 7.9365 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 7.9365 | 4 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 7.9365 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 7.9365 | 4 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 7.9365 | 6 | yes |
| GO:0001764 | neuron migration | 7.9365 | 4 | yes |
| GO:0007346 | regulation of mitotic cell cycle | 7.9365 | 5 | yes |
| GO:0022411 | cellular component disassembly | 7.9365 | 4 | yes |
| GO:0045927 | positive regulation of growth | 7.1429 | 4 | yes |
| GO:0061024 | membrane organization | 7.1429 | 4 | yes |
| GO:0030307 | positive regulation of cell growth | 7.1429 | 5 | yes |
| GO:0051293 | establishment of spindle localization | 6.3492 | 4 | yes |
| GO:0051650 | establishment of vesicle localization | 6.3492 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 6.3492 | 5 | yes |
| GO:0072384 | organelle transport along microtubule | 6.3492 | 4 | yes |
| GO:0045787 | positive regulation of cell cycle | 5.5556 | 5 | yes |
| GO:0050767 | regulation of neurogenesis | 5.5556 | 6 | yes |
| GO:0050890 | cognition | 5.5556 | 4 | yes |
| GO:0051962 | positive regulation of nervous system development | 5.5556 | 5 | yes |
| GO:0099175 | regulation of postsynapse organization | 5.5556 | 6 | yes |
| GO:0008088 | axo-dendritic transport | 5.5556 | 5 | yes |
| GO:0010720 | positive regulation of cell development | 5.5556 | 6 | yes |
| GO:0040001 | establishment of mitotic spindle localization | 5.5556 | 5 | yes |
| GO:0048638 | regulation of developmental growth | 4.7619 | 4 | yes |
| GO:0050769 | positive regulation of neurogenesis | 4.7619 | 6 | yes |
| GO:0051294 | establishment of spindle orientation | 4.7619 | 5 | yes |
| GO:0098930 | axonal transport | 4.7619 | 6 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 4.7619 | 5 | yes |
| GO:0007409 | axonogenesis | 4.7619 | 6 | yes |
| GO:0022604 | regulation of cell morphogenesis | 4.7619 | 5 | yes |
| GO:0031345 | negative regulation of cell projection organization | 4.7619 | 6 | yes |
| GO:0046328 | regulation of JNK cascade | 3.9683 | 7 | yes |
| GO:0047496 | vesicle transport along microtubule | 3.9683 | 5 | yes |
| GO:0048639 | positive regulation of developmental growth | 3.9683 | 5 | yes |
| GO:0048814 | regulation of dendrite morphogenesis | 3.9683 | 5 | yes |
| GO:0050770 | regulation of axonogenesis | 3.9683 | 5 | yes |
| GO:0050773 | regulation of dendrite development | 3.9683 | 4 | yes |
| GO:0050905 | neuromuscular process | 3.9683 | 4 | yes |
| GO:0060759 | regulation of response to cytokine stimulus | 3.9683 | 4 | yes |
| GO:0060760 | positive regulation of response to cytokine stimulus | 3.9683 | 5 | yes |
| GO:0060998 | regulation of dendritic spine development | 3.9683 | 4 | yes |
| GO:0061387 | regulation of extent of cell growth | 3.9683 | 5 | yes |
| GO:0000132 | establishment of mitotic spindle orientation | 3.9683 | 6 | yes |
| GO:0000165 | MAPK cascade | 3.9683 | 5 | yes |
| GO:0001959 | regulation of cytokine-mediated signaling pathway | 3.9683 | 5 | yes |
| GO:0001961 | positive regulation of cytokine-mediated signaling pathway | 3.9683 | 6 | yes |
| GO:0007097 | nuclear migration | 3.9683 | 4 | yes |
| GO:0010976 | positive regulation of neuron projection development | 3.9683 | 7 | yes |
| GO:0016042 | lipid catabolic process | 3.9683 | 4 | yes |
| GO:0030516 | regulation of axon extension | 3.9683 | 5 | yes |
| GO:0031122 | cytoplasmic microtubule organization | 3.9683 | 4 | yes |
| GO:0043409 | negative regulation of MAPK cascade | 3.1746 | 7 | yes |
| GO:0045773 | positive regulation of axon extension | 3.1746 | 6 | yes |
| GO:0045995 | regulation of embryonic development | 3.1746 | 5 | yes |
| GO:0050772 | positive regulation of axonogenesis | 3.1746 | 6 | yes |
| GO:0060999 | positive regulation of dendritic spine development | 3.1746 | 5 | yes |
| GO:0071763 | nuclear membrane organization | 3.1746 | 5 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 3.1746 | 6 | yes |
| GO:0099536 | synaptic signaling | 3.1746 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 3.1746 | 5 | yes |
| GO:0140650 | radial glia-guided pyramidal neuron migration | 3.1746 | 5 | yes |
| GO:0001667 | ameboidal-type cell migration | 3.1746 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 3.1746 | 7 | yes |
| GO:0008090 | retrograde axonal transport | 3.1746 | 7 | yes |
| GO:0008344 | adult locomotory behavior | 3.1746 | 4 | yes |
| GO:0010977 | negative regulation of neuron projection development | 3.1746 | 7 | yes |
| GO:0016050 | vesicle organization | 3.1746 | 5 | yes |
| GO:0030097 | hemopoiesis | 3.1746 | 4 | yes |
| GO:0030182 | neuron differentiation | 3.1746 | 4 | yes |
| GO:0046329 | negative regulation of JNK cascade | 2.3810 | 8 | yes |
| GO:0046486 | glycerolipid metabolic process | 2.3810 | 4 | yes |
| GO:0046903 | secretion | 2.3810 | 4 | yes |
| GO:0048666 | neuron development | 2.3810 | 4 | yes |
| GO:0050775 | positive regulation of dendrite morphogenesis | 2.3810 | 6 | yes |
| GO:0051081 | nuclear membrane disassembly | 2.3810 | 6 | yes |
| GO:0061001 | regulation of dendritic spine morphogenesis | 2.3810 | 5 | yes |
| GO:0061003 | positive regulation of dendritic spine morphogenesis | 2.3810 | 6 | yes |
| GO:0061515 | myeloid cell development | 2.3810 | 5 | yes |
| GO:0071692 | protein localization to extracellular region | 2.3810 | 5 | yes |
| GO:1904936 | interneuron migration | 2.3810 | 5 | yes |
| GO:0006644 | phospholipid metabolic process | 2.3810 | 4 | yes |
| GO:0006650 | glycerophospholipid metabolic process | 2.3810 | 5 | yes |
| GO:0009306 | protein secretion | 2.3810 | 4 | yes |
| GO:0010770 | positive regulation of cell morphogenesis | 2.3810 | 6 | yes |
| GO:0021955 | central nervous system neuron axonogenesis | 2.3810 | 7 | yes |
| GO:0030397 | membrane disassembly | 2.3810 | 5 | yes |
| GO:0033363 | secretory granule organization | 2.3810 | 6 | yes |
| GO:0035592 | establishment of protein localization to extracellular region | 2.3810 | 4 | yes |
| GO:0038026 | reelin-mediated signaling pathway | 2.3810 | 4 | yes |
| GO:0040019 | positive regulation of embryonic development | 1.5873 | 5 | yes |
| GO:0042249 | establishment of planar polarity of embryonic epithelium | 1.5873 | 5 | yes |
| GO:0043622 | cortical microtubule organization | 1.5873 | 5 | yes |
| GO:0045931 | positive regulation of mitotic cell cycle | 1.5873 | 6 | yes |
| GO:0046469 | platelet activating factor metabolic process | 1.5873 | 4 | yes |
| GO:0046485 | ether lipid metabolic process | 1.5873 | 4 | yes |
| GO:0048854 | brain morphogenesis | 1.5873 | 4 | yes |
| GO:0050885 | neuromuscular process controlling balance | 1.5873 | 5 | yes |
| GO:0051012 | microtubule sliding | 1.5873 | 4 | yes |
| GO:0051660 | establishment of centrosome localization | 1.5873 | 4 | yes |
| GO:0051661 | maintenance of centrosome location | 1.5873 | 4 | yes |
| GO:0060117 | auditory receptor cell development | 1.5873 | 6 | yes |
| GO:0060119 | inner ear receptor cell development | 1.5873 | 5 | yes |
| GO:0090176 | microtubule cytoskeleton organization involved in establishment of planar polarity | 1.5873 | 4 | yes |
| GO:0098751 | bone cell development | 1.5873 | 4 | yes |
| GO:0001736 | establishment of planar polarity | 1.5873 | 4 | yes |
| GO:0006662 | glycerol ether metabolic process | 1.5873 | 4 | yes |
| GO:0007254 | JNK cascade | 1.5873 | 6 | yes |
| GO:0007405 | neuroblast proliferation | 1.5873 | 4 | yes |
| GO:0019226 | transmission of nerve impulse | 1.5873 | 4 | yes |
| GO:0021540 | corpus callosum morphogenesis | 1.5873 | 9 | yes |
| GO:0021895 | cerebral cortex neuron differentiation | 1.5873 | 6 | yes |
| GO:0021952 | central nervous system projection neuron axonogenesis | 1.5873 | 8 | yes |
| GO:0021953 | central nervous system neuron differentiation | 1.5873 | 5 | yes |
| GO:0030865 | cortical cytoskeleton organization | 1.5873 | 6 | yes |
| GO:0036035 | osteoclast development | 1.5873 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NUDC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LIS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KTNB1_HUMAN | [view interactions] | Low throughput | no | yes |
| DCX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MAP1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KTNA1_HUMAN | [view interactions] | Low throughput | no | yes |
| PDE4B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDE4D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RHG01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LNX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GDIR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHOC_HUMAN | [view interactions] | Low throughput | no | no |
| RELN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DAB1_HUMAN | [view interactions] | Low throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSK21_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDEL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PA1B3_HUMAN | [view interactions] | Low throughput | no | no |
| NUDC_HUMAN | [view interactions] | Low throughput | no | yes |
| NDE1_HUMAN | [view interactions] | Low throughput | no | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PA1B2_HUMAN | [view interactions] | Low throughput | no | yes |
| CENPF_HUMAN | [view interactions] | Low throughput | no | no |
| NUDC3_HUMAN | [view interactions] | Low throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| TLK2_HUMAN | [view interactions] | High throughput | no | no |
| SYK_HUMAN | [view interactions] | High throughput | no | yes |
| PPR18_HUMAN | [view interactions] | High throughput | no | no |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EDIL3_HUMAN | [view interactions] | High throughput | no | yes |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| GID8_HUMAN | [view interactions] | High throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYLT3_HUMAN | [view interactions] | High throughput | no | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| MARE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AHI1_HUMAN | [view interactions] | High throughput | no | yes |
| DYT2B_HUMAN | [view interactions] | High throughput | no | no |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| TEST_HUMAN | [view interactions] | High throughput | no | no |
| NELFD_HUMAN | [view interactions] | High throughput | no | yes |
| ARI4B_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| CIA2B_HUMAN | [view interactions] | High throughput | no | yes |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| CCND1_HUMAN | [view interactions] | High throughput | no | yes |
| SOSD1_HUMAN | [view interactions] | High throughput | no | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |
| ARP10_HUMAN | [view interactions] | High throughput | no | no |
| APC13_HUMAN | [view interactions] | High throughput | no | no |
| ARL2_HUMAN | [view interactions] | High throughput | no | yes |
| CENPK_HUMAN | [view interactions] | High throughput | no | no |
| CENPM_HUMAN | [view interactions] | High throughput | no | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNL3L_HUMAN | [view interactions] | High throughput | no | yes |
| BACD3_HUMAN | [view interactions] | High throughput | no | yes |
| CE295_HUMAN | [view interactions] | High throughput | no | yes |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| MPH6_HUMAN | [view interactions] | High throughput | no | yes |
| MZT1_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSD12_HUMAN | [view interactions] | High throughput | no | yes |
| RL28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL36A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C560_HUMAN | [view interactions] | High throughput | no | no |
| SGO1_HUMAN | [view interactions] | High throughput | no | no |
| SKA3_HUMAN | [view interactions] | High throughput | no | no |
| RUXG_HUMAN | [view interactions] | High throughput | no | yes |
| TCOF_HUMAN | [view interactions] | High throughput | no | yes |
| SAE2_HUMAN | [view interactions] | High throughput | no | yes |
| VPS72_HUMAN | [view interactions] | High throughput | no | no |
| ZN574_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| CRYAA_HUMAN | [view interactions] | High throughput | no | no |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| HMGB3_HUMAN | [view interactions] | High throughput | no | no |
| PUR9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| IF5_HUMAN | [view interactions] | High throughput | no | yes |
| ISOC1_HUMAN | [view interactions] | High throughput | no | no |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAPS1_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| SMD2_HUMAN | [view interactions] | High throughput | no | yes |
| TATD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RUXF_HUMAN | [view interactions] | High throughput | no | no |
| AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHID1_HUMAN | [view interactions] | High throughput | no | yes |
| CHM2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSTF1_HUMAN | [view interactions] | High throughput | no | yes |
| SBDS_HUMAN | [view interactions] | High throughput | no | yes |
| SCLY_HUMAN | [view interactions] | High throughput | no | yes |
| CENPE_HUMAN | [view interactions] | High throughput | no | no |
| DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPR_HUMAN | [view interactions] | High throughput | no | yes |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF3B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUP85_HUMAN | [view interactions] | High throughput | no | yes |
| ZN276_HUMAN | [view interactions] | High throughput | no | yes |
| CCNT1_HUMAN | [view interactions] | High throughput | no | yes |
| FNTA_HUMAN | [view interactions] | High throughput | no | yes |
| FNTB_HUMAN | [view interactions] | High throughput | no | no |
| ZFAN6_HUMAN | [view interactions] | High throughput | no | yes |
| GRPE2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| AP4E1_HUMAN | [view interactions] | High throughput | no | no |
| CPSF3_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| ENTR1_HUMAN | [view interactions] | High throughput | no | no |
| TSR1_HUMAN | [view interactions] | High throughput | no | no |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCKGM_HUMAN | [view interactions] | High throughput | no | no |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| MRP7_HUMAN | [view interactions] | High throughput | no | yes |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| H1X_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| TOP2A_HUMAN | [view interactions] | High throughput | no | no |
| P5CS_HUMAN | [view interactions] | High throughput | no | yes |
| C1TM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P5CR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCCB_HUMAN | [view interactions] | High throughput | no | yes |
| RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUCB2_HUMAN | [view interactions] | High throughput | no | no |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| RS25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GANAB_HUMAN | [view interactions] | High throughput | no | yes |
| RL22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBRL_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAVN1_HUMAN | [view interactions] | High throughput | no | no |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2A2A_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| RL26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| MCCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRRM2_HUMAN | [view interactions] | High throughput | no | yes |
| H6ST2_HUMAN | [view interactions] | High throughput | no | no |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| ZN616_HUMAN | [view interactions] | High throughput | no | yes |
| RL36_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIXC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPO4_HUMAN | [view interactions] | High throughput | no | no |
| RL18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMPCT_HUMAN | [view interactions] | High throughput | no | yes |
| RS12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| RS9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2512_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACACB_HUMAN | [view interactions] | High throughput | no | no |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H31T_HUMAN | [view interactions] | High throughput | no | yes |
| DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| CCSE2_HUMAN | [view interactions] | High throughput | no | yes |
| SYIC_HUMAN | [view interactions] | High throughput | no | yes |
| KI20B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS30_HUMAN | [view interactions] | High throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |