DLRB2_HUMAN
Evidence for PS localization
Functions
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DLRB2_HUMAN |
|---|---|---|---|---|
| GO:0005524 | ATP binding | 26.6667 | 5 | no |
| GO:0017076 | purine nucleotide binding | 26.6667 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 26.6667 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 26.6667 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 26.6667 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.6667 | 4 | no |
| GO:0046872 | metal ion binding | 26.6667 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DLRB2_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 53.3333 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 46.6667 | 4 | no |
| GO:0051726 | regulation of cell cycle | 46.6667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.6667 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 40.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0010564 | regulation of cell cycle process | 40.0000 | 5 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0051050 | positive regulation of transport | 33.3333 | 4 | no |
| GO:0030030 | cell projection organization | 33.3333 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 33.3333 | 6 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 33.3333 | 7 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 33.3333 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 33.3333 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0051336 | regulation of hydrolase activity | 33.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0010970 | transport along microtubule | 33.3333 | 4 | no |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 33.3333 | 4 | no |
| GO:0099111 | microtubule-based transport | 33.3333 | 4 | no |
| GO:0007010 | cytoskeleton organization | 33.3333 | 5 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0045787 | positive regulation of cell cycle | 26.6667 | 5 | no |
| GO:0070925 | organelle assembly | 26.6667 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.6667 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 26.6667 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 26.6667 | 8 | no |
| GO:0010038 | response to metal ion | 26.6667 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 26.6667 | 6 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 26.6667 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.6667 | 5 | no |
| GO:0010799 | regulation of peptidyl-threonine phosphorylation | 26.6667 | 8 | no |
| GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 26.6667 | 9 | no |
| GO:0019722 | calcium-mediated signaling | 26.6667 | 5 | no |
| GO:0019932 | second-messenger-mediated signaling | 26.6667 | 4 | no |
| GO:0021762 | substantia nigra development | 26.6667 | 4 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 26.6667 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0031399 | regulation of protein modification process | 26.6667 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 26.6667 | 7 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 26.6667 | 5 | no |
| GO:0033674 | positive regulation of kinase activity | 26.6667 | 6 | no |
| GO:0034762 | regulation of transmembrane transport | 26.6667 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 26.6667 | 5 | no |
| GO:0042326 | negative regulation of phosphorylation | 26.6667 | 8 | no |
| GO:0042327 | positive regulation of phosphorylation | 26.6667 | 8 | no |
| GO:0043085 | positive regulation of catalytic activity | 26.6667 | 4 | no |
| GO:0043269 | regulation of ion transport | 26.6667 | 5 | no |
| GO:0043549 | regulation of kinase activity | 26.6667 | 5 | no |
| GO:0044057 | regulation of system process | 26.6667 | 4 | no |
| GO:0045859 | regulation of protein kinase activity | 26.6667 | 6 | no |
| GO:0045860 | positive regulation of protein kinase activity | 26.6667 | 7 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 26.6667 | 7 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 26.6667 | 7 | no |
| GO:0051099 | positive regulation of binding | 26.6667 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.6667 | 5 | no |
| GO:0051338 | regulation of transferase activity | 26.6667 | 4 | no |
| GO:0051345 | positive regulation of hydrolase activity | 26.6667 | 5 | no |
| GO:0051347 | positive regulation of transferase activity | 26.6667 | 5 | no |
| GO:0071900 | regulation of protein serine/threonine kinase activity | 26.6667 | 7 | no |
| GO:0071902 | positive regulation of protein serine/threonine kinase activity | 26.6667 | 8 | no |
| GO:1903522 | regulation of blood circulation | 26.6667 | 5 | no |
| GO:1904062 | regulation of cation transmembrane transport | 26.6667 | 6 | no |
| GO:2001257 | regulation of cation channel activity | 26.6667 | 6 | no |
| GO:0033043 | regulation of organelle organization | 26.6667 | 5 | no |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in DLRB2_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 13.3333 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 13.3333 | 5 | no |
| DOID:114 | heart disease | 13.3333 | 3 | no |
| DOID:2843 | long QT syndrome | 13.3333 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BCL2_HUMAN | [view interactions] | Low throughput | no | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| T2H2L_HUMAN | [view interactions] | High throughput | no | no |
| DC2I2_HUMAN | [view interactions] | High throughput | no | yes |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF7_HUMAN | [view interactions] | High throughput | no | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| DYT2B_HUMAN | [view interactions] | High throughput | no | no |
| DC2I1_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC2L1_HUMAN | [view interactions] | Computational | no | no |
| DYL2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NUDC3_HUMAN | [view interactions] | Computational | no | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DLRB1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DYLT5_HUMAN | [view interactions] | Computational | no | no |
| DYLT2_HUMAN | [view interactions] | Computational | no | no |
| DC1L2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DYLT3_HUMAN | [view interactions] | Computational | no | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | Computational | yes | no |