Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DC1I2_HUMAN

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 . Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes . [View more on UniProt]

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No data found.

ELM instance Name Type Start End Partner
ELMI001218 LIG_Dynein_DLC8_1 LIG 156 162 -
ELMI001218 LIG_Dynein_DLC8_1 LIG 156 162 -

Molecular function

Term Name % Distance from the top of the tree Annotated in DC1I2_HUMAN
GO:0043168 anion binding 35.3982 4 no
GO:0000166 nucleotide binding 33.6283 4 no
GO:0017076 purine nucleotide binding 33.6283 5 no
GO:0030554 adenyl nucleotide binding 31.8584 6 no
GO:0032555 purine ribonucleotide binding 31.8584 4 no
GO:0003723 RNA binding 31.8584 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.9735 4 no
GO:0032559 adenyl ribonucleotide binding 30.0885 5 no
GO:0005524 ATP binding 29.2035 5 no
GO:0016462 pyrophosphatase activity 21.2389 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.2389 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 20.3540 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in DC1I2_HUMAN
GO:0048522 positive regulation of cellular process 47.7876 4 no
GO:0060255 regulation of macromolecule metabolic process 46.0177 4 no
GO:0031323 regulation of cellular metabolic process 45.1327 4 no
GO:0048523 negative regulation of cellular process 45.1327 4 no
GO:0080090 regulation of primary metabolic process 44.2478 4 no
GO:0009889 regulation of biosynthetic process 38.9381 4 no
GO:0051128 regulation of cellular component organization 38.9381 4 no
GO:0031326 regulation of cellular biosynthetic process 37.1681 5 no
GO:0010556 regulation of macromolecule biosynthetic process 36.2832 5 no
GO:0033043 regulation of organelle organization 32.7434 5 no
GO:0006996 organelle organization 30.9735 4 no
GO:0009893 positive regulation of metabolic process 30.9735 4 no
GO:0010646 regulation of cell communication 29.2035 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.3186 5 no
GO:0009892 negative regulation of metabolic process 26.5487 4 no
GO:0051246 regulation of protein metabolic process 26.5487 5 no
GO:0010468 regulation of gene expression 26.5487 6 no
GO:0031325 positive regulation of cellular metabolic process 26.5487 5 no
GO:0022607 cellular component assembly 26.5487 4 no
GO:0008104 protein localization 24.7788 4 no
GO:0031324 negative regulation of cellular metabolic process 24.7788 5 no
GO:0009966 regulation of signal transduction 24.7788 4 no
GO:0044087 regulation of cellular component biogenesis 24.7788 4 no
GO:0051130 positive regulation of cellular component organization 24.7788 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.7788 5 no
GO:0060341 regulation of cellular localization 23.8938 4 no
GO:0009891 positive regulation of biosynthetic process 23.8938 5 no
GO:0010605 negative regulation of macromolecule metabolic process 23.0088 5 no
GO:0031328 positive regulation of cellular biosynthetic process 23.0088 6 no
GO:0032880 regulation of protein localization 22.1239 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.1239 6 no
GO:0043933 protein-containing complex organization 21.2389 4 no
GO:0007010 cytoskeleton organization 20.3540 5 no
GO:0030705 cytoskeleton-dependent intracellular transport 8.8496 4 yes
GO:0010970 transport along microtubule 7.9646 4 yes
GO:0099111 microtubule-based transport 7.9646 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DYL1_HUMAN [view entry] [view interactions] Low throughput yes no
DC1L2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLRB1_HUMAN [view entry] [view interactions] Low throughput yes no
DYHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
DYLT1_HUMAN [view interactions] Low throughput no no
DC1I2_HUMAN [view entry] [view interactions] Low throughput yes yes
SPHK2_HUMAN [view interactions] Low throughput no no
LRP2_HUMAN [view interactions] Low throughput no no
BICL1_HUMAN [view interactions] Low throughput no yes
PAXI_HUMAN [view interactions] Low throughput no yes
RGS12_HUMAN [view entry] [view interactions] High throughput yes no
RSU1_HUMAN [view interactions] High throughput no no
SH3G2_HUMAN [view entry] [view interactions] High throughput yes yes
SIMC1_HUMAN [view interactions] High throughput no yes
S39A9_HUMAN [view interactions] High throughput no yes
TBCD1_HUMAN [view interactions] High throughput no no
TFB2M_HUMAN [view interactions] High throughput no no
TGM3_HUMAN [view interactions] High throughput no no
TM209_HUMAN [view interactions] High throughput no no
TM41B_HUMAN [view interactions] High throughput no yes
TR112_HUMAN [view interactions] High throughput no yes
UBE3C_HUMAN [view entry] [view interactions] High throughput yes yes
VPS29_HUMAN [view entry] [view interactions] High throughput yes yes
ZN565_HUMAN [view interactions] High throughput no no
TBB4A_HUMAN [view interactions] High throughput no yes
PFD3_HUMAN [view interactions] High throughput no yes
PFD5_HUMAN [view interactions] High throughput no yes
RFOX2_HUMAN [view interactions] High throughput no yes
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
KBTB2_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
TCPE_HUMAN [view entry] [view interactions] High throughput yes yes
PFD6_HUMAN [view interactions] High throughput no yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
CENPE_HUMAN [view interactions] High throughput no no
BICD2_HUMAN [view interactions] High throughput no yes
PPID_HUMAN [view entry] [view interactions] High throughput yes yes
UN45A_HUMAN [view interactions] High throughput no yes
PFD2_HUMAN [view interactions] High throughput no yes
SCNAA_HUMAN [view interactions] High throughput no no
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
GLUT4_HUMAN [view interactions] High throughput no no
H32_HUMAN [view interactions] High throughput no yes
FTM_HUMAN [view interactions] High throughput no yes
ARAF_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
AKTIP_HUMAN [view interactions] High throughput no yes
MECOM_HUMAN [view interactions] High throughput no yes
AIP_HUMAN [view entry] [view interactions] High throughput yes yes
RIN3_HUMAN [view interactions] High throughput no yes
TBA1C_HUMAN [view interactions] High throughput no yes
MOT11_HUMAN [view interactions] High throughput no no
STXB2_HUMAN [view interactions] High throughput no no
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
APT_HUMAN [view interactions] High throughput no yes
SPAT7_HUMAN [view interactions] High throughput no no
PFD4_HUMAN [view interactions] High throughput no yes
TIM44_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
GGYF1_HUMAN [view interactions] High throughput no yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
ATE1_HUMAN [view interactions] High throughput no yes
HOOK1_HUMAN [view interactions] High throughput no no
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
FHI1A_HUMAN [view interactions] High throughput no yes
RB6I2_HUMAN [view entry] [view interactions] High throughput yes yes
DYLT3_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
K1C9_HUMAN [view interactions] High throughput no no
AL7A1_HUMAN [view entry] [view interactions] High throughput yes no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
NOB1_HUMAN [view interactions] High throughput no yes
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
DYH7_HUMAN [view interactions] High throughput no no
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
K1C19_HUMAN [view interactions] High throughput no no
DRC5_HUMAN [view interactions] High throughput no no
BT3L4_HUMAN [view interactions] High throughput no yes
NIN_HUMAN [view interactions] High throughput no no
RL28_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
CFAI_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
CCSE2_HUMAN [view interactions] High throughput no yes
NECA2_HUMAN [view entry] [view interactions] High throughput yes yes
DEP1B_HUMAN [view interactions] High throughput no yes
CC136_HUMAN [view interactions] High throughput no yes
FLII_HUMAN [view entry] [view interactions] High throughput yes yes
LIPA1_HUMAN [view entry] [view interactions] High throughput yes yes
NUDC_HUMAN [view interactions] High throughput no yes
NUDC3_HUMAN [view interactions] High throughput no yes
SRRM2_HUMAN [view interactions] High throughput no yes
SIR2_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2_HUMAN [view interactions] High throughput no no
BRX1_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
GCP3_HUMAN [view interactions] High throughput no yes
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
RING2_HUMAN [view interactions] High throughput no yes
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
LRC49_HUMAN [view interactions] High throughput no no
KAP3_HUMAN [view entry] [view interactions] High throughput yes yes
RL15_HUMAN [view entry] [view interactions] High throughput yes no
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
XRCC5_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
KDM1B_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
RSRP1_HUMAN [view interactions] High throughput no no
RFA2_HUMAN [view interactions] High throughput no yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
RFA3_HUMAN [view interactions] High throughput no yes
NBEA_HUMAN [view entry] [view interactions] High throughput yes yes
PAPS1_HUMAN [view interactions] High throughput no yes
ITK_HUMAN [view interactions] High throughput no no
GNL1_HUMAN [view entry] [view interactions] High throughput yes yes
DC1I1_HUMAN [view entry] [view interactions] High throughput yes yes
BRCA1_HUMAN [view interactions] High throughput no yes
TEDC2_HUMAN [view interactions] High throughput no no
EGLN3_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
HEXI1_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
WDR76_HUMAN [view interactions] High throughput no no
H4_HUMAN [view interactions] High throughput no yes
H2B1B_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1B_HUMAN [view interactions] High throughput no yes
ARI2_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
NINL_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
UBQL1_HUMAN [view interactions] High throughput no yes
DNJB3_HUMAN [view interactions] High throughput no no
ABCD1_HUMAN [view entry] [view interactions] High throughput yes no
HUMMR_HUMAN [view interactions] High throughput no yes
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
CLAP1_HUMAN [view entry] [view interactions] High throughput yes yes
CLAP2_HUMAN [view entry] [view interactions] High throughput yes no
CLIP1_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN3_HUMAN [view entry] [view interactions] High throughput yes yes
ACTY_HUMAN [view entry] [view interactions] High throughput yes no
DCTN4_HUMAN [view entry] [view interactions] High throughput yes yes
ARP10_HUMAN [view interactions] High throughput no no
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
ACTZ_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4B_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
TLS1_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
MSX2_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CDK7_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
RUFY1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
ASXL1_HUMAN [view interactions] High throughput no no
ASXL2_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
CFAH_HUMAN [view interactions] High throughput no no
MOB3C_HUMAN [view interactions] High throughput no no
RICTR_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
ITA2B_HUMAN [view interactions] High throughput no no
PEX14_HUMAN [view interactions] High throughput no yes
AKA12_HUMAN [view entry] [view interactions] High throughput yes no
DDX1_HUMAN [view entry] [view interactions] High throughput yes yes
ABCF1_HUMAN [view interactions] High throughput no yes
EIF3G_HUMAN [view interactions] High throughput no yes
ROA0_HUMAN [view interactions] High throughput no yes
MTAP2_HUMAN [view entry] [view interactions] High throughput yes yes
PRUN2_HUMAN [view entry] [view interactions] High throughput yes yes
PRS8_HUMAN [view interactions] High throughput no yes
PSMD8_HUMAN [view interactions] High throughput no yes
RS13_HUMAN [view entry] [view interactions] High throughput yes yes
RS26_HUMAN [view entry] [view interactions] High throughput yes yes
SERB1_HUMAN [view interactions] High throughput no yes
EIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3B_HUMAN [view interactions] High throughput no yes
EIFCL_HUMAN [view interactions] High throughput no yes
EIF3K_HUMAN [view interactions] High throughput no yes
RS5_HUMAN [view entry] [view interactions] High throughput yes yes
YBOX1_HUMAN [view interactions] High throughput no yes
ADDA_HUMAN [view entry] [view interactions] High throughput yes yes
ADDG_HUMAN [view entry] [view interactions] High throughput yes yes
AHNK2_HUMAN [view interactions] High throughput no yes
CCAR1_HUMAN [view interactions] High throughput no yes
DLRB2_HUMAN [view entry] [view interactions] High throughput yes no
PSA2_HUMAN [view interactions] High throughput no yes
PSA5_HUMAN [view interactions] High throughput no yes
CSN4_HUMAN [view interactions] High throughput no yes
CSN2_HUMAN [view interactions] High throughput no yes
CSN3_HUMAN [view entry] [view interactions] High throughput yes yes
CSN8_HUMAN [view interactions] High throughput no yes
TULP3_HUMAN [view interactions] High throughput no yes
EIF3C_HUMAN [view entry] [view interactions] High throughput yes yes
GOLP3_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
IPO5_HUMAN [view entry] [view interactions] High throughput yes yes
IMA4_HUMAN [view interactions] High throughput no yes
PSMD3_HUMAN [view interactions] High throughput no yes
PSD10_HUMAN [view entry] [view interactions] High throughput yes yes
LC7L3_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
PABP1_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA4_HUMAN [view interactions] High throughput no yes
ERF3A_HUMAN [view interactions] High throughput no yes
GNS_HUMAN [view interactions] High throughput no yes
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
U2AF2_HUMAN [view interactions] High throughput no yes
MAP4_HUMAN [view entry] [view interactions] High throughput yes no
PSB6_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA1_HUMAN [view entry] [view interactions] High throughput yes yes
KINH_HUMAN [view entry] [view interactions] High throughput yes no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
TAF6_HUMAN [view interactions] High throughput no no
HNRPF_HUMAN [view interactions] High throughput no yes
PSMD4_HUMAN [view interactions] High throughput no yes
WDR5_HUMAN [view interactions] High throughput no no
PRS4_HUMAN [view entry] [view interactions] High throughput yes yes
SMD2_HUMAN [view interactions] High throughput no yes
2ABA_HUMAN [view interactions] High throughput no yes
KLC1_HUMAN [view entry] [view interactions] High throughput yes no
RBBP4_HUMAN [view interactions] High throughput no yes
SRSF9_HUMAN [view interactions] High throughput no yes
PSMD6_HUMAN [view interactions] High throughput no yes
ADRM1_HUMAN [view interactions] High throughput no yes
DDB1_HUMAN [view interactions] High throughput no yes
RBBP7_HUMAN [view interactions] High throughput no yes
CPSF6_HUMAN [view interactions] High throughput no yes
PARG_HUMAN [view interactions] High throughput no yes
CARM1_HUMAN [view interactions] High throughput no yes
GEMI5_HUMAN [view interactions] High throughput no yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
PSB7_HUMAN [view interactions] High throughput no yes
CNN2_HUMAN [view interactions] High throughput no no
PSMD1_HUMAN [view entry] [view interactions] High throughput yes yes
TSNAX_HUMAN [view interactions] High throughput no yes
PI51A_HUMAN [view interactions] High throughput no yes
ASH2L_HUMAN [view interactions] High throughput no yes
RUVB2_HUMAN [view interactions] High throughput no yes
RUVB1_HUMAN [view interactions] High throughput no yes
LC7L2_HUMAN [view interactions] High throughput no yes
STRAP_HUMAN [view entry] [view interactions] High throughput yes yes
TRI14_HUMAN [view interactions] High throughput no yes
PLCE_HUMAN [view entry] [view interactions] High throughput yes yes
BCKD_HUMAN [view entry] [view interactions] High throughput yes yes
BICD1_HUMAN [view interactions] High throughput no yes
RMC1_HUMAN [view interactions] High throughput no no
CAN7_HUMAN [view interactions] High throughput no no
TCPW_HUMAN [view entry] [view interactions] High throughput yes yes
COMD2_HUMAN [view interactions] High throughput no yes
DCTD_HUMAN [view interactions] High throughput no yes
DCTN6_HUMAN [view interactions] High throughput no no
DECR_HUMAN [view entry] [view interactions] High throughput yes yes
DJC12_HUMAN [view interactions] High throughput no yes
ELMO2_HUMAN [view entry] [view interactions] High throughput yes no
ERLN1_HUMAN [view entry] [view interactions] High throughput yes yes
F110B_HUMAN [view interactions] High throughput no yes
GLMN_HUMAN [view interactions] High throughput no no
GOSR1_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH3_HUMAN [view interactions] High throughput no no
MGST1_HUMAN [view interactions] High throughput no no
MIPO1_HUMAN [view interactions] High throughput no yes
MLF1_HUMAN [view entry] [view interactions] High throughput yes yes
AF1Q_HUMAN [view interactions] High throughput no yes
RM14_HUMAN [view interactions] High throughput no yes
RT06_HUMAN [view interactions] High throughput no yes
MYL6B_HUMAN [view entry] [view interactions] High throughput yes no
NDC80_HUMAN [view interactions] High throughput no no
NDRG1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS6_HUMAN [view entry] [view interactions] High throughput yes yes
NECP2_HUMAN [view interactions] High throughput no yes
PHLP_HUMAN [view interactions] High throughput no yes
ODPX_HUMAN [view entry] [view interactions] High throughput yes yes
PFD1_HUMAN [view interactions] High throughput no yes
KPBB_HUMAN [view interactions] High throughput no no
RASEF_HUMAN [view interactions] High throughput no yes