Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DC1I2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 . Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI001218 LIG_Dynein_DLC8_1 LIG 156 162 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DC1I2_HUMAN
GO:0017076 purine nucleotide binding 31.6327 4 no
GO:0032555 purine ribonucleotide binding 31.6327 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.6122 4 no
GO:0030554 adenyl nucleotide binding 27.5510 5 no
GO:0032559 adenyl ribonucleotide binding 27.5510 5 no
GO:0003723 RNA binding 26.5306 4 no
GO:0005524 ATP binding 26.5306 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in DC1I2_HUMAN
GO:0048522 positive regulation of cellular process 44.8980 4 no
GO:0060255 regulation of macromolecule metabolic process 41.8367 4 no
GO:0080090 regulation of primary metabolic process 41.8367 4 no
GO:0031323 regulation of cellular metabolic process 40.8163 4 no
GO:0048523 negative regulation of cellular process 39.7959 4 no
GO:0051171 regulation of nitrogen compound metabolic process 39.7959 4 no
GO:0051128 regulation of cellular component organization 38.7755 4 no
GO:0033043 regulation of organelle organization 35.7143 5 no
GO:0006996 organelle organization 34.6939 4 no
GO:0022607 cellular component assembly 31.6327 4 no
GO:0009889 regulation of biosynthetic process 31.6327 4 no
GO:0009893 positive regulation of metabolic process 31.6327 4 no
GO:0031326 regulation of cellular biosynthetic process 30.6122 5 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0010604 positive regulation of macromolecule metabolic process 27.5510 5 no
GO:0044087 regulation of cellular component biogenesis 26.5306 4 no
GO:0008104 protein localization 26.5306 4 no
GO:0051130 positive regulation of cellular component organization 26.5306 5 no
GO:0010468 regulation of gene expression 24.4898 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.4898 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 24.4898 5 no
GO:0010646 regulation of cell communication 24.4898 4 no
GO:0031325 positive regulation of cellular metabolic process 23.4694 5 no
GO:0051246 regulation of protein metabolic process 22.4490 5 no
GO:0009966 regulation of signal transduction 21.4286 4 no
GO:0007010 cytoskeleton organization 21.4286 5 no
GO:0051493 regulation of cytoskeleton organization 20.4082 6 no
GO:0009892 negative regulation of metabolic process 20.4082 4 no
GO:0031324 negative regulation of cellular metabolic process 20.4082 5 no
GO:0071702 organic substance transport 20.4082 4 no
GO:0009891 positive regulation of biosynthetic process 20.4082 5 no
GO:0010638 positive regulation of organelle organization 20.4082 6 no
GO:0060341 regulation of cellular localization 20.4082 4 no
GO:0030705 cytoskeleton-dependent intracellular transport 6.1224 4 yes
GO:0010970 transport along microtubule 5.1020 4 yes
GO:0099111 microtubule-based transport 5.1020 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in DC1I2_HUMAN
DOID:331 central nervous system disease 2.0408 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DYL1_HUMAN [view entry] [view interactions] Low throughput yes no
DC1L2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLRB1_HUMAN [view entry] [view interactions] Low throughput yes no
DYHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
DYLT1_HUMAN [view interactions] Low throughput no no
DC1I2_HUMAN [view entry] [view interactions] Low throughput yes yes
SPHK2_HUMAN [view interactions] Low throughput no no
LRP2_HUMAN [view interactions] Low throughput no no
PAXI_HUMAN [view interactions] Low throughput no yes
BICL1_HUMAN [view interactions] Low throughput no yes
MECOM_HUMAN [view interactions] High throughput no yes
RIN3_HUMAN [view interactions] High throughput no yes
MOT11_HUMAN [view interactions] High throughput no no
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
SPAT7_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
DYLT3_HUMAN [view interactions] High throughput no yes
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
DRC5_HUMAN [view interactions] High throughput no no
NIN_HUMAN [view interactions] High throughput no no
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
NECA2_HUMAN [view interactions] High throughput no yes
CC136_HUMAN [view interactions] High throughput no yes
LIPA1_HUMAN [view entry] [view interactions] High throughput yes yes
SRRM2_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
GCP3_HUMAN [view interactions] High throughput no yes
RING2_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
KAP3_HUMAN [view entry] [view interactions] High throughput yes yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
XRCC5_HUMAN [view interactions] High throughput no yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
KDM1B_HUMAN [view interactions] High throughput no yes
RSRP1_HUMAN [view interactions] High throughput no no
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
PAPS1_HUMAN [view interactions] High throughput no yes
ITK_HUMAN [view interactions] High throughput no no
GNL1_HUMAN [view entry] [view interactions] High throughput yes yes
DC1I1_HUMAN [view entry] [view interactions] High throughput yes yes
BRCA1_HUMAN [view interactions] High throughput no yes
TEDC2_HUMAN [view interactions] High throughput no no
EGLN3_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
HEXI1_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
WDR76_HUMAN [view interactions] High throughput no no
H4_HUMAN [view interactions] High throughput no yes
H2B1B_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1B_HUMAN [view interactions] High throughput no yes
ARI2_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
NINL_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
UBQL1_HUMAN [view interactions] High throughput no yes
DNJB3_HUMAN [view interactions] High throughput no no
ABCD1_HUMAN [view entry] [view interactions] High throughput yes no
HUMMR_HUMAN [view interactions] High throughput no yes
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
CLAP1_HUMAN [view entry] [view interactions] High throughput yes yes
CLAP2_HUMAN [view entry] [view interactions] High throughput yes no
CLIP1_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN3_HUMAN [view entry] [view interactions] High throughput yes yes
ACTY_HUMAN [view entry] [view interactions] High throughput yes no
DCTN4_HUMAN [view entry] [view interactions] High throughput yes yes
ARP10_HUMAN [view interactions] High throughput no no
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
ACTZ_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4B_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
ITA2B_HUMAN [view interactions] High throughput no no
PEX14_HUMAN [view interactions] High throughput no yes
AKA12_HUMAN [view entry] [view interactions] High throughput yes no
DDX1_HUMAN [view entry] [view interactions] High throughput yes yes
ABCF1_HUMAN [view interactions] High throughput no yes
EIF3G_HUMAN [view interactions] High throughput no yes
ROA0_HUMAN [view interactions] High throughput no yes
MTAP2_HUMAN [view entry] [view interactions] High throughput yes yes
PRUN2_HUMAN [view entry] [view interactions] High throughput yes yes
PRS8_HUMAN [view interactions] High throughput no yes
PSMD8_HUMAN [view interactions] High throughput no yes
RS13_HUMAN [view entry] [view interactions] High throughput yes yes
RS26_HUMAN [view entry] [view interactions] High throughput yes yes
PAIRB_HUMAN [view interactions] High throughput no yes
EIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3B_HUMAN [view interactions] High throughput no yes
EIFCL_HUMAN [view interactions] High throughput no yes
EIF3K_HUMAN [view interactions] High throughput no yes
RS5_HUMAN [view entry] [view interactions] High throughput yes yes
YBOX1_HUMAN [view interactions] High throughput no yes
ADDA_HUMAN [view entry] [view interactions] High throughput yes yes
ADDG_HUMAN [view entry] [view interactions] High throughput yes yes
AHNK2_HUMAN [view interactions] High throughput no yes
CCAR1_HUMAN [view interactions] High throughput no yes
DLRB2_HUMAN [view entry] [view interactions] High throughput yes no
PSA2_HUMAN [view interactions] High throughput no yes
PSA5_HUMAN [view interactions] High throughput no yes
CSN4_HUMAN [view interactions] High throughput no yes
CSN2_HUMAN [view interactions] High throughput no yes
CSN3_HUMAN [view entry] [view interactions] High throughput yes yes
CSN8_HUMAN [view interactions] High throughput no yes
TULP3_HUMAN [view interactions] High throughput no yes
EIF3C_HUMAN [view entry] [view interactions] High throughput yes yes
GOLP3_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
TRI14_HUMAN [view interactions] High throughput no yes
PLCE_HUMAN [view entry] [view interactions] High throughput yes yes
BCKD_HUMAN [view entry] [view interactions] High throughput yes yes
BICD1_HUMAN [view interactions] High throughput no yes
RMC1_HUMAN [view interactions] High throughput no no
CAN7_HUMAN [view interactions] High throughput no no
TCPW_HUMAN [view entry] [view interactions] High throughput yes yes
COMD2_HUMAN [view interactions] High throughput no yes
DCTD_HUMAN [view interactions] High throughput no yes
DCTN6_HUMAN [view interactions] High throughput no no
DECR_HUMAN [view entry] [view interactions] High throughput yes yes
DJC12_HUMAN [view interactions] High throughput no yes
ELMO2_HUMAN [view entry] [view interactions] High throughput yes no
ERLN1_HUMAN [view entry] [view interactions] High throughput yes yes
F110B_HUMAN [view interactions] High throughput no yes
GLMN_HUMAN [view interactions] High throughput no no
GOSR1_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH3_HUMAN [view interactions] High throughput no no
MGST1_HUMAN [view interactions] High throughput no no
MIPO1_HUMAN [view interactions] High throughput no yes
MLF1_HUMAN [view entry] [view interactions] High throughput yes yes
AF1Q_HUMAN [view interactions] High throughput no yes
RM14_HUMAN [view interactions] High throughput no yes
RT06_HUMAN [view interactions] High throughput no yes
MYL6B_HUMAN [view entry] [view interactions] High throughput yes no
NDC80_HUMAN [view interactions] High throughput no no
NDRG1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS6_HUMAN [view entry] [view interactions] High throughput yes yes
NECP2_HUMAN [view interactions] High throughput no yes
PHLP_HUMAN [view interactions] High throughput no yes
ODPX_HUMAN [view entry] [view interactions] High throughput yes yes
PFD1_HUMAN [view interactions] High throughput no yes
KPBB_HUMAN [view interactions] High throughput no no
RASEF_HUMAN [view interactions] High throughput no yes
RGS12_HUMAN [view interactions] High throughput no no
RSU1_HUMAN [view interactions] High throughput no no
RUFY1_HUMAN [view interactions] High throughput no yes
SH3G2_HUMAN [view entry] [view interactions] High throughput yes yes
SIMC1_HUMAN [view interactions] High throughput no yes
S39A9_HUMAN [view interactions] High throughput no yes
TBCD1_HUMAN [view interactions] High throughput no no
TFB2M_HUMAN [view interactions] High throughput no no
TGM3_HUMAN [view interactions] High throughput no no
TM209_HUMAN [view interactions] High throughput no no
TM41B_HUMAN [view interactions] High throughput no yes
TR112_HUMAN [view interactions] High throughput no yes
UBE3C_HUMAN [view entry] [view interactions] High throughput yes yes
VPS29_HUMAN [view entry] [view interactions] High throughput yes yes
ZN565_HUMAN [view interactions] High throughput no no
TBB4A_HUMAN [view interactions] High throughput no yes
PFD3_HUMAN [view interactions] High throughput no yes
PFD5_HUMAN [view interactions] High throughput no yes
RFOX2_HUMAN [view interactions] High throughput no yes
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
KBTB2_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
TCPE_HUMAN [view entry] [view interactions] High throughput yes yes
PFD6_HUMAN [view interactions] High throughput no yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
CENPE_HUMAN [view interactions] High throughput no no
BICD2_HUMAN [view interactions] High throughput no yes
PPID_HUMAN [view entry] [view interactions] High throughput yes yes
UN45A_HUMAN [view interactions] High throughput no yes
PFD2_HUMAN [view interactions] High throughput no yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
H32_HUMAN [view interactions] High throughput no yes
ARAF_HUMAN [view interactions] High throughput no yes
AKTIP_HUMAN [view interactions] High throughput no yes
AIP_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1C_HUMAN [view interactions] High throughput no yes
STXB2_HUMAN [view interactions] High throughput no no
APT_HUMAN [view interactions] High throughput no yes
PFD4_HUMAN [view interactions] High throughput no yes
TIM44_HUMAN [view interactions] High throughput no yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA1_HUMAN [view entry] [view interactions] High throughput yes yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
ATE1_HUMAN [view interactions] High throughput no yes
HOOK1_HUMAN [view interactions] High throughput no no
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
RUVB1_HUMAN [view interactions] High throughput no yes
FHI1A_HUMAN [view interactions] High throughput no yes
RB6I2_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
K1C9_HUMAN [view interactions] High throughput no no
RUVB2_HUMAN [view interactions] High throughput no yes
AL7A1_HUMAN [view entry] [view interactions] High throughput yes no
NOB1_HUMAN [view interactions] High throughput no yes
DYH7_HUMAN [view interactions] High throughput no no
K1C19_HUMAN [view interactions] High throughput no no
BT3L4_HUMAN [view interactions] High throughput no yes
RL28_HUMAN [view entry] [view interactions] High throughput yes yes
CFAI_HUMAN [view interactions] High throughput no no
CCSE2_HUMAN [view interactions] High throughput no yes
DEP1B_HUMAN [view interactions] High throughput no yes
FLII_HUMAN [view entry] [view interactions] High throughput yes yes
NUDC_HUMAN [view interactions] High throughput no yes
NUDC3_HUMAN [view interactions] High throughput no yes
SIR2_HUMAN [view entry] [view interactions] High throughput yes yes
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
BRX1_HUMAN [view interactions] High throughput no no
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
LRC49_HUMAN [view interactions] High throughput no no
RL15_HUMAN [view entry] [view interactions] High throughput yes no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
NBEA_HUMAN [view entry] [view interactions] High throughput yes yes
SCNAA_HUMAN [view interactions] High throughput no no
GLUT4_HUMAN [view interactions] High throughput no no
FTM_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
PCNT_HUMAN [view interactions] Computational no yes
RAB18_HUMAN [view entry] [view interactions] Computational yes yes
RILP_HUMAN [view interactions] Computational no no
RBGPR_HUMAN [view entry] [view interactions] Computational yes yes
MCR_HUMAN [view entry] [view interactions] Computational yes yes
GCR_HUMAN [view entry] [view interactions] Computational yes yes
RAB7A_HUMAN [view entry] [view interactions] Computational yes yes
PRGR_HUMAN [view interactions] Computational no no
DCTN5_HUMAN [view interactions] Computational no yes
DC2L1_HUMAN [view interactions] Computational no no
CAZA1_HUMAN [view entry] [view interactions] Computational yes yes
HS90A_HUMAN [view entry] [view interactions] Computational yes yes
ANDR_HUMAN [view interactions] Computational no no
RB3GP_HUMAN [view entry] [view interactions] Computational yes yes
RAB7B_HUMAN [view interactions] Computational no no