Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GNL1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Possible regulatory or functional link with the histocompatibility cluster. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GNL1_HUMAN
GO:0003723 RNA binding 46.4286 4 no
GO:0017076 purine nucleotide binding 17.8571 4 yes
GO:0032555 purine ribonucleotide binding 17.8571 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 17.8571 4 yes
GO:0003924 GTPase activity 7.1429 7 yes
GO:0005525 GTP binding 7.1429 5 yes
GO:0016462 pyrophosphatase activity 7.1429 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 7.1429 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 7.1429 6 yes
GO:0019001 guanyl nucleotide binding 7.1429 5 yes
GO:0032561 guanyl ribonucleotide binding 7.1429 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GNL1_HUMAN
GO:0031323 regulation of cellular metabolic process 46.4286 4 no
GO:0051171 regulation of nitrogen compound metabolic process 46.4286 4 no
GO:0060255 regulation of macromolecule metabolic process 46.4286 4 no
GO:0080090 regulation of primary metabolic process 46.4286 4 no
GO:0048522 positive regulation of cellular process 42.8571 4 no
GO:0048523 negative regulation of cellular process 42.8571 4 no
GO:0051246 regulation of protein metabolic process 39.2857 5 no
GO:0009966 regulation of signal transduction 35.7143 4 no
GO:0010646 regulation of cell communication 35.7143 4 no
GO:0022607 cellular component assembly 32.1429 4 no
GO:0006412 translation 32.1429 4 no
GO:0006518 peptide metabolic process 32.1429 4 no
GO:0009059 macromolecule biosynthetic process 32.1429 4 no
GO:0034645 cellular macromolecule biosynthetic process 32.1429 4 no
GO:0043043 peptide biosynthetic process 32.1429 5 no
GO:0043603 cellular amide metabolic process 32.1429 4 no
GO:0043604 amide biosynthetic process 32.1429 5 no
GO:0044271 cellular nitrogen compound biosynthetic process 32.1429 4 no
GO:1901566 organonitrogen compound biosynthetic process 32.1429 4 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0010468 regulation of gene expression 28.5714 5 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 28.5714 5 no
GO:0009894 regulation of catabolic process 28.5714 4 no
GO:0031329 regulation of cellular catabolic process 28.5714 5 no
GO:0009893 positive regulation of metabolic process 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0002181 cytoplasmic translation 25.0000 5 no
GO:0010941 regulation of cell death 25.0000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0051049 regulation of transport 25.0000 4 no
GO:0051128 regulation of cellular component organization 25.0000 4 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0008104 protein localization 21.4286 4 no
GO:0031325 positive regulation of cellular metabolic process 21.4286 5 no
GO:0043933 protein-containing complex organization 21.4286 4 no
GO:0051241 negative regulation of multicellular organismal process 21.4286 4 no
GO:0065003 protein-containing complex assembly 21.4286 5 no
GO:0006396 RNA processing 21.4286 6 no
GO:0016070 RNA metabolic process 21.4286 5 no
GO:0090304 nucleic acid metabolic process 21.4286 4 no
GO:0009889 regulation of biosynthetic process 21.4286 4 no
GO:0009968 negative regulation of signal transduction 21.4286 5 no
GO:0010648 negative regulation of cell communication 21.4286 5 no
GO:0023057 negative regulation of signaling 21.4286 4 no
GO:0031326 regulation of cellular biosynthetic process 21.4286 5 no
GO:0042981 regulation of apoptotic process 21.4286 6 no
GO:0043067 regulation of programmed cell death 21.4286 5 no
GO:0051094 positive regulation of developmental process 21.4286 4 no
GO:0080134 regulation of response to stress 21.4286 4 no
GO:0071310 cellular response to organic substance 21.4286 4 no
GO:0030162 regulation of proteolysis 21.4286 6 no
GO:0051223 regulation of protein transport 21.4286 5 no
GO:0060548 negative regulation of cell death 21.4286 5 no
GO:0070201 regulation of establishment of protein localization 21.4286 6 no

Disease

Term Name % Distance from top the of the tree Annotated in GNL1_HUMAN
DOID:0050890 synucleinopathy 7.1429 5 no
DOID:0060892 late onset Parkinsons disease 7.1429 7 no
DOID:1289 neurodegenerative disease 7.1429 4 no
DOID:14330 Parkinsons disease 7.1429 6 no
DOID:331 central nervous system disease 7.1429 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TNKS1_HUMAN [view interactions] High throughput no yes
GDIA_HUMAN [view entry] [view interactions] High throughput yes yes
TP4A1_HUMAN [view interactions] High throughput no no
ZN212_HUMAN [view interactions] High throughput no no
GTR12_HUMAN [view interactions] High throughput no yes
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
KLH40_HUMAN [view interactions] High throughput no no
TULP3_HUMAN [view interactions] High throughput no yes
WDCP_HUMAN [view interactions] High throughput no yes
ABCF2_HUMAN [view interactions] High throughput no yes
PAPS1_HUMAN [view interactions] High throughput no yes
HINT1_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
RS30_HUMAN [view interactions] High throughput no yes
TRI63_HUMAN [view interactions] High throughput no no
HDAC4_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
MICA3_HUMAN [view interactions] High throughput no yes
RAD21_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
CC116_HUMAN [view interactions] High throughput no no
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
U5S1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
BCAR1_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
WDR5_HUMAN [view interactions] High throughput no no
SMAD4_HUMAN [view interactions] High throughput no yes
NTNG1_HUMAN [view interactions] High throughput no no
RM42_HUMAN [view interactions] High throughput no yes
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
EP300_HUMAN [view interactions] High throughput no yes
FBX32_HUMAN [view interactions] High throughput no no
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
PGK1_HUMAN [view entry] [view interactions] High throughput yes yes
RACK1_HUMAN [view interactions] High throughput no yes
RL19_HUMAN [view entry] [view interactions] High throughput yes yes
RL4_HUMAN [view entry] [view interactions] High throughput yes yes
SRP14_HUMAN [view interactions] High throughput no no
SHPS1_HUMAN [view entry] [view interactions] High throughput yes yes
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
RL5_HUMAN [view entry] [view interactions] High throughput yes yes
RS15A_HUMAN [view entry] [view interactions] High throughput yes yes
ALDOC_HUMAN [view entry] [view interactions] High throughput yes yes
THOC4_HUMAN [view interactions] High throughput no no
DDX18_HUMAN [view interactions] High throughput no yes
IF2P_HUMAN [view interactions] High throughput no yes
HNRPC_HUMAN [view interactions] High throughput no yes
HUWE1_HUMAN [view interactions] High throughput no yes
IMA4_HUMAN [view interactions] High throughput no yes
KRR1_HUMAN [view interactions] High throughput no yes
NOP58_HUMAN [view interactions] High throughput no yes
PABP4_HUMAN [view entry] [view interactions] High throughput yes yes
PESC_HUMAN [view entry] [view interactions] High throughput yes yes
RAGP1_HUMAN [view entry] [view interactions] High throughput yes yes
RL7_HUMAN [view entry] [view interactions] High throughput yes yes
RLA0_HUMAN [view entry] [view interactions] High throughput yes yes
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
DDX55_HUMAN [view interactions] Computational no yes
ZN622_HUMAN [view interactions] Computational no yes
GTPB4_HUMAN [view interactions] Computational no yes
NOC2L_HUMAN [view interactions] Computational no yes
GNL3L_HUMAN [view interactions] Computational no yes
GNL3_HUMAN [view interactions] Computational no yes
BOP1_HUMAN [view interactions] Computational no yes
WDR12_HUMAN [view interactions] Computational no yes
PA2G4_HUMAN [view interactions] Computational no yes
CEBPZ_HUMAN [view interactions] Computational no no
RPF2_HUMAN [view interactions] Computational no yes
NMD3_HUMAN [view interactions] Computational no no
PUM3_HUMAN [view interactions] Computational no yes
RL3_HUMAN [view entry] [view interactions] Computational yes yes
NAT10_HUMAN [view interactions] Computational no yes
DDX49_HUMAN [view interactions] Computational no no
SPB1_HUMAN [view interactions] Computational no yes
EF1A1_HUMAN [view entry] [view interactions] Computational yes yes
IF6_HUMAN [view interactions] Computational no yes
SDA1_HUMAN [view interactions] Computational no yes