SAHH2_HUMAN
Evidence for PS localization
Functions
Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous pseudoligand whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (PubMed). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid . Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation . Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SAHH2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 33.7662 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 33.7662 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.7662 | 4 | no |
| GO:0019900 | kinase binding | 23.3766 | 4 | no |
| GO:0003723 | RNA binding | 20.7792 | 4 | yes |
| GO:0019901 | protein kinase binding | 20.7792 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SAHH2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 55.8442 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 54.5455 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 51.9481 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 49.3506 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 48.0519 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 44.1558 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.2597 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.2597 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.9610 | 4 | no |
| GO:0010646 | regulation of cell communication | 38.9610 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 37.6623 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.3636 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 36.3636 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.7662 | 5 | no |
| GO:0010468 | regulation of gene expression | 33.7662 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 27.2727 | 4 | no |
| GO:0031399 | regulation of protein modification process | 27.2727 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.2727 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.2727 | 5 | no |
| GO:0006996 | organelle organization | 27.2727 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.9740 | 5 | yes |
| GO:0051049 | regulation of transport | 25.9740 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 25.9740 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 25.9740 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.9740 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.9740 | 5 | no |
| GO:0071702 | organic substance transport | 24.6753 | 4 | yes |
| GO:0036211 | protein modification process | 24.6753 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 24.6753 | 4 | no |
| GO:0043412 | macromolecule modification | 24.6753 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.6753 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.6753 | 4 | no |
| GO:0008104 | protein localization | 23.3766 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.3766 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.3766 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.3766 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 23.3766 | 4 | no |
| GO:0022607 | cellular component assembly | 23.3766 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.0779 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.0779 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 22.0779 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.0779 | 4 | no |
| GO:0030030 | cell projection organization | 22.0779 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.0779 | 5 | no |
| GO:0033043 | regulation of organelle organization | 22.0779 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 22.0779 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.7792 | 5 | yes |
| GO:0071705 | nitrogen compound transport | 20.7792 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 20.7792 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.7792 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 20.7792 | 7 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.7792 | 4 | no |
| GO:0071310 | cellular response to organic substance | 20.7792 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.7792 | 5 | no |
| GO:0009894 | regulation of catabolic process | 20.7792 | 4 | no |
| GO:0015031 | protein transport | 19.4805 | 4 | yes |
| GO:0090304 | nucleic acid metabolic process | 19.4805 | 4 | yes |
| GO:0016070 | RNA metabolic process | 14.2857 | 5 | yes |
| GO:0051050 | positive regulation of transport | 12.9870 | 4 | yes |
| GO:0006915 | apoptotic process | 11.6883 | 4 | yes |
| GO:0043269 | regulation of ion transport | 11.6883 | 5 | yes |
| GO:0006886 | intracellular protein transport | 10.3896 | 4 | yes |
| GO:0006396 | RNA processing | 9.0909 | 6 | yes |
| GO:0010038 | response to metal ion | 9.0909 | 4 | yes |
| GO:0010959 | regulation of metal ion transport | 6.4935 | 6 | yes |
| GO:0016071 | mRNA metabolic process | 6.4935 | 6 | yes |
| GO:0034762 | regulation of transmembrane transport | 6.4935 | 4 | yes |
| GO:0043270 | positive regulation of ion transport | 6.4935 | 5 | yes |
| GO:0051592 | response to calcium ion | 6.4935 | 5 | yes |
| GO:1903311 | regulation of mRNA metabolic process | 6.4935 | 6 | yes |
| GO:0006397 | mRNA processing | 5.1948 | 7 | yes |
| GO:0006913 | nucleocytoplasmic transport | 5.1948 | 5 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 5.1948 | 5 | yes |
| GO:0050684 | regulation of mRNA processing | 5.1948 | 7 | yes |
| GO:0051169 | nuclear transport | 5.1948 | 4 | yes |
| GO:0006611 | protein export from nucleus | 3.8961 | 5 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 3.8961 | 4 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 3.8961 | 5 | yes |
| GO:0033353 | S-adenosylmethionine cycle | 3.8961 | 4 | yes |
| GO:0042044 | fluid transport | 3.8961 | 4 | yes |
| GO:0042045 | epithelial fluid transport | 3.8961 | 5 | yes |
| GO:0044070 | regulation of anion transport | 3.8961 | 6 | yes |
| GO:0051168 | nuclear export | 3.8961 | 6 | yes |
| GO:0070633 | transepithelial transport | 3.8961 | 4 | yes |
| GO:0002028 | regulation of sodium ion transport | 2.5974 | 7 | yes |
| GO:0006378 | mRNA polyadenylation | 2.5974 | 7 | yes |
| GO:0010765 | positive regulation of sodium ion transport | 2.5974 | 6 | yes |
| GO:0031123 | RNA 3-end processing | 2.5974 | 7 | yes |
| GO:0031124 | mRNA 3-end processing | 2.5974 | 8 | yes |
| GO:0031440 | regulation of mRNA 3-end processing | 2.5974 | 8 | yes |
| GO:0038166 | angiotensin-activated signaling pathway | 2.5974 | 4 | yes |
| GO:0043631 | RNA polyadenylation | 2.5974 | 6 | yes |
| GO:1990456 | mitochondrion-endoplasmic reticulum membrane tethering | 2.5974 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SAHH2_HUMAN |
|---|---|---|---|---|
| DOID:0080000 | muscular disease | 2.5974 | 3 | no |
| DOID:3191 | nemaline myopathy | 2.5974 | 7 | no |
| DOID:422 | congenital structural myopathy | 2.5974 | 6 | no |
| DOID:423 | myopathy | 2.5974 | 5 | no |
| DOID:66 | muscle tissue disease | 2.5974 | 4 | no |
| DOID:0060038 | specific developmental disorder | 2.5974 | 3 | no |
| DOID:1059 | intellectual disability | 2.5974 | 4 | no |
| DOID:0050686 | organ system cancer | 2.5974 | 3 | no |
| DOID:10283 | prostate cancer | 2.5974 | 6 | no |
| DOID:193 | reproductive organ cancer | 2.5974 | 4 | no |
| DOID:3856 | male reproductive organ cancer | 2.5974 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| B2L10_HUMAN | [view interactions] | Low throughput | no | yes |
| ITPR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SAHH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SAHH3_HUMAN | [view interactions] | Low throughput | no | yes |
| CPSF1_HUMAN | [view interactions] | Low throughput | no | no |
| CPSF3_HUMAN | [view interactions] | Low throughput | no | yes |
| CPSF4_HUMAN | [view interactions] | Low throughput | no | yes |
| FIP1_HUMAN | [view interactions] | Low throughput | no | yes |
| PRP16_HUMAN | [view interactions] | Low throughput | no | yes |
| SRP14_HUMAN | [view interactions] | Low throughput | no | no |
| MB3L2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA2_HUMAN | [view interactions] | High throughput | no | no |
| DKK2_HUMAN | [view interactions] | High throughput | no | no |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| FOXK2_HUMAN | [view interactions] | High throughput | no | yes |
| BANP_HUMAN | [view interactions] | High throughput | no | yes |
| CLK1_HUMAN | [view interactions] | High throughput | no | yes |
| HME1_HUMAN | [view interactions] | High throughput | no | no |
| PLD1_HUMAN | [view interactions] | High throughput | no | no |
| TRAF5_HUMAN | [view interactions] | High throughput | no | yes |
| FOXF2_HUMAN | [view interactions] | High throughput | no | no |
| DUS11_HUMAN | [view interactions] | High throughput | no | no |
| CAN10_HUMAN | [view interactions] | High throughput | no | yes |
| HXA5_HUMAN | [view interactions] | High throughput | no | no |
| CA174_HUMAN | [view interactions] | High throughput | no | yes |
| RBM23_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB3_HUMAN | [view interactions] | High throughput | no | yes |
| IKBL1_HUMAN | [view interactions] | High throughput | no | no |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| HXB6_HUMAN | [view interactions] | High throughput | no | no |
| PRP6_HUMAN | [view interactions] | High throughput | no | yes |
| PKHJ1_HUMAN | [view interactions] | High throughput | no | yes |
| HXB9_HUMAN | [view interactions] | High throughput | no | no |
| TFPI2_HUMAN | [view interactions] | High throughput | no | no |
| ZN696_HUMAN | [view interactions] | High throughput | no | no |
| WDR33_HUMAN | [view interactions] | High throughput | no | yes |
| SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLK4_HUMAN | [view interactions] | High throughput | no | yes |
| FOXK1_HUMAN | [view interactions] | High throughput | no | yes |
| SPON1_HUMAN | [view interactions] | High throughput | no | no |
| CREB5_HUMAN | [view interactions] | High throughput | no | no |
| PI42B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGF12_HUMAN | [view interactions] | High throughput | no | no |
| ATF7_HUMAN | [view interactions] | High throughput | no | no |
| PLCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB40C_HUMAN | [view interactions] | High throughput | no | no |
| AK17A_HUMAN | [view interactions] | High throughput | no | no |
| PITX1_HUMAN | [view interactions] | High throughput | no | yes |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| BATF3_HUMAN | [view interactions] | High throughput | no | no |
| EF1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOST_HUMAN | [view interactions] | High throughput | no | no |
| SYT6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI41_HUMAN | [view interactions] | High throughput | no | yes |
| FOSL1_HUMAN | [view interactions] | High throughput | no | yes |
| AN36B_HUMAN | [view interactions] | High throughput | no | no |
| ZEB1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F241A_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| TBCA_HUMAN | [view interactions] | High throughput | no | yes |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2C_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| ZPR1_HUMAN | [view interactions] | High throughput | no | yes |
| STAM1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP_HUMAN | [view interactions] | High throughput | no | yes |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| TACC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| THADA_HUMAN | [view interactions] | High throughput | no | yes |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAB2_HUMAN | [view interactions] | High throughput | no | yes |
| TM1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAE2_HUMAN | [view interactions] | High throughput | no | yes |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ST1A1_HUMAN | [view interactions] | High throughput | no | no |
| TTL12_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D2_HUMAN | [view interactions] | High throughput | no | yes |
| UB2L3_HUMAN | [view interactions] | High throughput | no | yes |
| UBP34_HUMAN | [view interactions] | High throughput | no | yes |
| CD2B2_HUMAN | [view interactions] | High throughput | no | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| SHOT1_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| STMN1_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TLE3_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC1_HUMAN | [view interactions] | High throughput | no | yes |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBE2B_HUMAN | [view interactions] | High throughput | no | no |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLD5_HUMAN | [view interactions] | High throughput | no | yes |
| SPS1_HUMAN | [view interactions] | High throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUG_HUMAN | [view interactions] | High throughput | no | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBL7_HUMAN | [view interactions] | High throughput | no | yes |
| LAGE3_HUMAN | [view interactions] | High throughput | no | yes |
| PPIL3_HUMAN | [view interactions] | High throughput | no | yes |
| SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
| SP100_HUMAN | [view interactions] | High throughput | no | no |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| SRXN1_HUMAN | [view interactions] | High throughput | no | no |
| UBP42_HUMAN | [view interactions] | High throughput | no | no |
| TPD54_HUMAN | [view interactions] | High throughput | no | yes |
| WDR48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC9C_HUMAN | [view interactions] | High throughput | no | yes |
| TF2LY_HUMAN | [view interactions] | High throughput | no | no |
| UB2D1_HUMAN | [view interactions] | High throughput | no | yes |
| FOXD4_HUMAN | [view interactions] | High throughput | no | no |
| UBE4B_HUMAN | [view interactions] | High throughput | no | yes |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFC1_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3H3_HUMAN | [view interactions] | High throughput | no | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| ZN414_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| DOK4_HUMAN | [view interactions] | High throughput | no | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| JOS2_HUMAN | [view interactions] | High throughput | no | no |
| USP9X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN263_HUMAN | [view interactions] | High throughput | no | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HXC9_HUMAN | [view interactions] | High throughput | no | no |
| VPS4B_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SERC_HUMAN | [view interactions] | High throughput | no | yes |
| DHX8_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI2_HUMAN | [view interactions] | High throughput | no | yes |
| SKP1_HUMAN | [view interactions] | High throughput | no | yes |
| RSLAB_HUMAN | [view interactions] | High throughput | no | no |
| SNX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCF2_HUMAN | [view interactions] | High throughput | no | yes |
| STAT6_HUMAN | [view interactions] | High throughput | no | yes |
| CEP72_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| NUDC1_HUMAN | [view interactions] | High throughput | no | no |
| TBB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISD3_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1G_HUMAN | [view interactions] | High throughput | no | no |
| SERPH_HUMAN | [view interactions] | High throughput | no | no |
| FA13B_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L3_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| STMN2_HUMAN | [view interactions] | High throughput | no | no |
| EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TYSY_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| UFM1_HUMAN | [view interactions] | High throughput | no | yes |
| VP26A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MK04_HUMAN | [view interactions] | High throughput | no | no |
| ANCHR_HUMAN | [view interactions] | High throughput | no | yes |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIN3A_HUMAN | [view interactions] | High throughput | no | yes |
| CLK3_HUMAN | [view interactions] | High throughput | no | yes |
| PDC6I_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1G2_HUMAN | [view interactions] | High throughput | no | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBA6_HUMAN | [view interactions] | High throughput | no | no |
| NUAK2_HUMAN | [view interactions] | High throughput | no | yes |
| AN32A_HUMAN | [view interactions] | High throughput | no | yes |
| PAK6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN32B_HUMAN | [view interactions] | High throughput | no | yes |
| MAST1_HUMAN | [view interactions] | High throughput | no | yes |
| AN32E_HUMAN | [view interactions] | High throughput | no | yes |
| TLX1_HUMAN | [view interactions] | High throughput | no | no |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3M_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| MYL6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
| SOX30_HUMAN | [view interactions] | High throughput | no | no |
| PSME3_HUMAN | [view interactions] | High throughput | no | yes |
| PEPL_HUMAN | [view interactions] | High throughput | no | yes |
| PTPS_HUMAN | [view interactions] | High throughput | no | yes |
| CDN2C_HUMAN | [view interactions] | High throughput | no | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GEM_HUMAN | [view interactions] | High throughput | no | yes |
| PSD12_HUMAN | [view interactions] | High throughput | no | yes |
| BID_HUMAN | [view interactions] | High throughput | no | no |
| RL37A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S23A1_HUMAN | [view interactions] | High throughput | no | no |
| FBX3_HUMAN | [view interactions] | High throughput | no | no |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| UACA_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| PRDM6_HUMAN | [view interactions] | High throughput | no | no |
| CTIF_HUMAN | [view interactions] | High throughput | no | yes |
| ZN165_HUMAN | [view interactions] | High throughput | no | no |
| CAPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HBAT_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB7_HUMAN | [view interactions] | High throughput | no | no |
| M2OM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| PIAS4_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| PPE1_HUMAN | [view interactions] | High throughput | no | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAGA2_HUMAN | [view interactions] | High throughput | no | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFI_HUMAN | [view interactions] | High throughput | no | no |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| NXPE1_HUMAN | [view interactions] | High throughput | no | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T23O_HUMAN | [view interactions] | High throughput | no | no |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| CSAG1_HUMAN | [view interactions] | High throughput | no | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| TIFAB_HUMAN | [view interactions] | High throughput | no | no |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| MFHA1_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| POC1A_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STYK1_HUMAN | [view interactions] | High throughput | no | yes |
| DACH1_HUMAN | [view interactions] | High throughput | no | no |
| RNF6_HUMAN | [view interactions] | High throughput | no | no |
| PKHG5_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| FBXL7_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| MB213_HUMAN | [view interactions] | High throughput | no | no |
| PITX2_HUMAN | [view interactions] | High throughput | no | no |
| EDA_HUMAN | [view interactions] | High throughput | no | no |
| ZN444_HUMAN | [view interactions] | High throughput | no | no |
| FA13C_HUMAN | [view interactions] | High throughput | no | yes |
| PTN21_HUMAN | [view interactions] | High throughput | no | yes |
| TAFA3_HUMAN | [view interactions] | High throughput | no | no |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| YAF2_HUMAN | [view interactions] | High throughput | no | yes |
| TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGF11_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDM6B_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MPIP1_HUMAN | [view interactions] | High throughput | no | no |
| MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
| AUXI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS5_HUMAN | [view interactions] | High throughput | no | no |
| MTMR4_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TP4A2_HUMAN | [view interactions] | High throughput | no | yes |
| PTPC1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN14_HUMAN | [view interactions] | High throughput | no | yes |
| PTN2_HUMAN | [view interactions] | High throughput | no | yes |
| PTN3_HUMAN | [view interactions] | High throughput | no | yes |
| PTN7_HUMAN | [view interactions] | High throughput | no | no |
| TNS2_HUMAN | [view interactions] | High throughput | no | no |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| FA13A_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAFB_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| CR3L3_HUMAN | [view interactions] | High throughput | no | no |
| SBP1_HUMAN | [view interactions] | Computational | no | no |
| KAT3_HUMAN | [view interactions] | Computational | no | yes |
| S4A7_HUMAN | [view interactions] | Computational | no | no |
| DNM3A_HUMAN | [view interactions] | Computational | no | yes |
| DNM3B_HUMAN | [view interactions] | Computational | no | yes |
| SDHL_HUMAN | [view interactions] | Computational | no | yes |
| CGL_HUMAN | [view interactions] | Computational | no | yes |
| SDSL_HUMAN | [view interactions] | Computational | no | yes |
| METH_HUMAN | [view interactions] | Computational | no | yes |
| ITPR3_HUMAN | [view interactions] | Computational | no | yes |
| METK2_HUMAN | [view interactions] | Computational | no | no |
| DNMT1_HUMAN | [view interactions] | Computational | no | no |
| SL9A3_HUMAN | [view interactions] | Computational | no | yes |
| BHMT2_HUMAN | [view interactions] | Computational | no | no |
| BHMT1_HUMAN | [view interactions] | Computational | no | no |
| CBS_HUMAN | [view interactions] | Computational | no | yes |
| S4A4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| METK1_HUMAN | [view interactions] | Computational | no | no |