TF65_HUMAN
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI001961 | DOC_WW_Pin1_4 | DOC | 251 | 256 | - |
ELMI001188 | LIG_EH_1 | LIG | 138 | 142 | - |
ELMI002162 | TRG_NLS_MonoExtC_3 | TRG | 301 | 307 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in TF65_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 38.5246 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 37.7049 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 37.7049 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 33.6066 | 5 | no |
GO:0005524 | ATP binding | 32.7869 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 32.7869 | 5 | no |
GO:0046872 | metal ion binding | 27.0492 | 4 | no |
GO:0016301 | kinase activity | 22.1311 | 4 | no |
GO:0003723 | RNA binding | 22.1311 | 4 | no |
GO:0019900 | kinase binding | 21.3115 | 4 | yes |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 21.3115 | 4 | no |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 21.3115 | 4 | no |
GO:0019901 | protein kinase binding | 19.6721 | 5 | yes |
GO:0044389 | ubiquitin-like protein ligase binding | 18.8525 | 4 | yes |
GO:0031625 | ubiquitin protein ligase binding | 17.2131 | 5 | yes |
GO:0003677 | DNA binding | 16.3934 | 4 | yes |
GO:0140297 | DNA-binding transcription factor binding | 14.7541 | 4 | yes |
GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | 12.2951 | 5 | yes |
GO:0003690 | double-stranded DNA binding | 10.6557 | 5 | yes |
GO:0042803 | protein homodimerization activity | 10.6557 | 4 | yes |
GO:0000976 | transcription cis-regulatory region binding | 9.0164 | 5 | yes |
GO:0001067 | transcription regulatory region nucleic acid binding | 9.0164 | 4 | yes |
GO:0043565 | sequence-specific DNA binding | 9.0164 | 5 | yes |
GO:1990837 | sequence-specific double-stranded DNA binding | 9.0164 | 6 | yes |
GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | 7.3770 | 6 | yes |
GO:0000987 | cis-regulatory region sequence-specific DNA binding | 7.3770 | 6 | yes |
GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | 6.5574 | 7 | yes |
GO:0042826 | histone deacetylase binding | 5.7377 | 4 | yes |
GO:0051059 | NF-kappaB binding | 5.7377 | 6 | yes |
GO:0001046 | core promoter sequence-specific DNA binding | 4.0984 | 6 | yes |
GO:0001221 | transcription coregulator binding | 4.0984 | 4 | yes |
GO:0001223 | transcription coactivator binding | 3.2787 | 5 | yes |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | 3.2787 | 4 | yes |
GO:0140296 | general transcription initiation factor binding | 3.2787 | 4 | yes |
GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding | 2.4590 | 7 | yes |
GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | 2.4590 | 4 | yes |
GO:0042301 | phosphate ion binding | 1.6393 | 4 | yes |
GO:0042805 | actinin binding | 1.6393 | 4 | yes |
GO:0071532 | ankyrin repeat binding | 1.6393 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in TF65_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 67.2131 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 67.2131 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 65.5738 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 65.5738 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 60.6557 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 55.7377 | 4 | yes |
GO:0010646 | regulation of cell communication | 54.9180 | 4 | yes |
GO:0009966 | regulation of signal transduction | 51.6393 | 4 | yes |
GO:0010468 | regulation of gene expression | 51.6393 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 50.8197 | 4 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 48.3607 | 5 | yes |
GO:0051246 | regulation of protein metabolic process | 48.3607 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 46.7213 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 46.7213 | 5 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 46.7213 | 5 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 44.2623 | 5 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 44.2623 | 5 | yes |
GO:0051252 | regulation of RNA metabolic process | 43.4426 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 41.8033 | 5 | yes |
GO:0048584 | positive regulation of response to stimulus | 41.8033 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 41.8033 | 4 | no |
GO:0010941 | regulation of cell death | 40.9836 | 4 | yes |
GO:1902531 | regulation of intracellular signal transduction | 39.3443 | 5 | yes |
GO:1903506 | regulation of nucleic acid-templated transcription | 39.3443 | 7 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 39.3443 | 6 | yes |
GO:0006355 | regulation of DNA-templated transcription | 38.5246 | 6 | yes |
GO:0009892 | negative regulation of metabolic process | 38.5246 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 37.7049 | 5 | yes |
GO:0043067 | regulation of programmed cell death | 37.7049 | 5 | yes |
GO:0036211 | protein modification process | 37.7049 | 4 | no |
GO:0043412 | macromolecule modification | 37.7049 | 4 | no |
GO:0042981 | regulation of apoptotic process | 36.8852 | 6 | yes |
GO:0051247 | positive regulation of protein metabolic process | 36.8852 | 6 | yes |
GO:0010647 | positive regulation of cell communication | 36.0656 | 5 | yes |
GO:0023056 | positive regulation of signaling | 36.0656 | 4 | yes |
GO:0009967 | positive regulation of signal transduction | 35.2459 | 5 | yes |
GO:0031399 | regulation of protein modification process | 35.2459 | 6 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 33.6066 | 5 | yes |
GO:0071310 | cellular response to organic substance | 33.6066 | 4 | yes |
GO:0009894 | regulation of catabolic process | 31.9672 | 4 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 31.9672 | 5 | yes |
GO:0045595 | regulation of cell differentiation | 31.9672 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 31.1475 | 4 | no |
GO:0006996 | organelle organization | 31.1475 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 30.3279 | 4 | yes |
GO:0019220 | regulation of phosphate metabolic process | 29.5082 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 29.5082 | 5 | no |
GO:0008104 | protein localization | 29.5082 | 4 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 28.6885 | 6 | yes |
GO:0010628 | positive regulation of gene expression | 27.8689 | 6 | yes |
GO:0060548 | negative regulation of cell death | 27.8689 | 5 | yes |
GO:0030162 | regulation of proteolysis | 27.8689 | 6 | no |
GO:0010243 | response to organonitrogen compound | 27.0492 | 4 | yes |
GO:0048585 | negative regulation of response to stimulus | 27.0492 | 4 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 27.0492 | 4 | yes |
GO:0080134 | regulation of response to stress | 27.0492 | 4 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 27.0492 | 6 | yes |
GO:0042325 | regulation of phosphorylation | 27.0492 | 7 | no |
GO:0043066 | negative regulation of apoptotic process | 26.2295 | 7 | yes |
GO:0043069 | negative regulation of programmed cell death | 26.2295 | 6 | yes |
GO:0044087 | regulation of cellular component biogenesis | 26.2295 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 25.4098 | 5 | yes |
GO:0010648 | negative regulation of cell communication | 25.4098 | 5 | yes |
GO:0023057 | negative regulation of signaling | 25.4098 | 4 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 25.4098 | 6 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 25.4098 | 4 | yes |
GO:0022607 | cellular component assembly | 25.4098 | 4 | no |
GO:0051049 | regulation of transport | 25.4098 | 4 | no |
GO:0033043 | regulation of organelle organization | 25.4098 | 5 | no |
GO:0009968 | negative regulation of signal transduction | 24.5902 | 5 | yes |
GO:0051248 | negative regulation of protein metabolic process | 24.5902 | 6 | yes |
GO:0031401 | positive regulation of protein modification process | 24.5902 | 7 | no |
GO:0060341 | regulation of cellular localization | 24.5902 | 4 | no |
GO:0051094 | positive regulation of developmental process | 24.5902 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 24.5902 | 5 | no |
GO:0006357 | regulation of transcription by RNA polymerase II | 23.7705 | 7 | yes |
GO:0031329 | regulation of cellular catabolic process | 23.7705 | 5 | no |
GO:0016310 | phosphorylation | 23.7705 | 5 | no |
GO:0051254 | positive regulation of RNA metabolic process | 22.9508 | 6 | yes |
GO:0001932 | regulation of protein phosphorylation | 22.9508 | 7 | no |
GO:0043085 | positive regulation of catalytic activity | 22.9508 | 4 | no |
GO:0051726 | regulation of cell cycle | 22.9508 | 4 | no |
GO:0008284 | positive regulation of cell population proliferation | 22.1311 | 5 | yes |
GO:0006468 | protein phosphorylation | 22.1311 | 5 | no |
GO:0018193 | peptidyl-amino acid modification | 22.1311 | 5 | no |
GO:0032880 | regulation of protein localization | 22.1311 | 5 | no |
GO:0051336 | regulation of hydrolase activity | 22.1311 | 4 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.3115 | 6 | yes |
GO:0090304 | nucleic acid metabolic process | 21.3115 | 4 | yes |
GO:0045597 | positive regulation of cell differentiation | 21.3115 | 5 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 20.4918 | 6 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 20.4918 | 7 | no |
GO:0071702 | organic substance transport | 20.4918 | 4 | no |
GO:0014070 | response to organic cyclic compound | 20.4918 | 4 | no |
GO:0002684 | positive regulation of immune system process | 19.6721 | 4 | yes |
GO:0045893 | positive regulation of DNA-templated transcription | 19.6721 | 7 | yes |
GO:0050776 | regulation of immune response | 19.6721 | 4 | yes |
GO:1902680 | positive regulation of RNA biosynthetic process | 19.6721 | 7 | yes |
GO:1903508 | positive regulation of nucleic acid-templated transcription | 19.6721 | 8 | yes |
GO:0031400 | negative regulation of protein modification process | 18.8525 | 7 | yes |
GO:0042176 | regulation of protein catabolic process | 18.8525 | 5 | yes |
GO:1901699 | cellular response to nitrogen compound | 18.8525 | 4 | yes |
GO:0009890 | negative regulation of biosynthetic process | 18.0328 | 5 | yes |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 18.0328 | 6 | yes |
GO:0030155 | regulation of cell adhesion | 18.0328 | 4 | yes |
GO:0031327 | negative regulation of cellular biosynthetic process | 18.0328 | 6 | yes |
GO:0032101 | regulation of response to external stimulus | 18.0328 | 4 | yes |
GO:0045944 | positive regulation of transcription by RNA polymerase II | 18.0328 | 8 | yes |
GO:0071417 | cellular response to organonitrogen compound | 18.0328 | 4 | yes |
GO:0001817 | regulation of cytokine production | 17.2131 | 4 | yes |
GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 17.2131 | 6 | yes |
GO:2001233 | regulation of apoptotic signaling pathway | 17.2131 | 5 | yes |
GO:0033993 | response to lipid | 16.3934 | 4 | yes |
GO:0051253 | negative regulation of RNA metabolic process | 16.3934 | 6 | yes |
GO:1901652 | response to peptide | 16.3934 | 4 | yes |
GO:0001819 | positive regulation of cytokine production | 15.5738 | 5 | yes |
GO:0016070 | RNA metabolic process | 15.5738 | 5 | yes |
GO:0032870 | cellular response to hormone stimulus | 15.5738 | 4 | yes |
GO:0031347 | regulation of defense response | 14.7541 | 5 | yes |
GO:0045892 | negative regulation of DNA-templated transcription | 14.7541 | 7 | yes |
GO:0051091 | positive regulation of DNA-binding transcription factor activity | 14.7541 | 4 | yes |
GO:1902679 | negative regulation of RNA biosynthetic process | 14.7541 | 7 | yes |
GO:1903320 | regulation of protein modification by small protein conjugation or removal | 14.7541 | 7 | yes |
GO:1903507 | negative regulation of nucleic acid-templated transcription | 14.7541 | 8 | yes |
GO:0034097 | response to cytokine | 13.9344 | 4 | yes |
GO:1902532 | negative regulation of intracellular signal transduction | 13.9344 | 6 | yes |
GO:0043434 | response to peptide hormone | 13.1148 | 4 | yes |
GO:0045785 | positive regulation of cell adhesion | 13.1148 | 5 | yes |
GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 13.1148 | 5 | yes |
GO:0009895 | negative regulation of catabolic process | 12.2951 | 5 | yes |
GO:0044271 | cellular nitrogen compound biosynthetic process | 12.2951 | 4 | yes |
GO:0050778 | positive regulation of immune response | 12.2951 | 5 | yes |
GO:0071396 | cellular response to lipid | 12.2951 | 5 | yes |
GO:0000122 | negative regulation of transcription by RNA polymerase II | 11.4754 | 8 | yes |
GO:0048732 | gland development | 11.4754 | 4 | yes |
GO:0070848 | response to growth factor | 11.4754 | 4 | yes |
GO:1901653 | cellular response to peptide | 11.4754 | 5 | yes |
GO:2001234 | negative regulation of apoptotic signaling pathway | 11.4754 | 6 | yes |
GO:0009059 | macromolecule biosynthetic process | 10.6557 | 4 | yes |
GO:0022407 | regulation of cell-cell adhesion | 10.6557 | 5 | yes |
GO:0062197 | cellular response to chemical stress | 10.6557 | 4 | yes |
GO:0034248 | regulation of cellular amide metabolic process | 9.8361 | 5 | yes |
GO:0034599 | cellular response to oxidative stress | 9.8361 | 4 | yes |
GO:0043122 | regulation of I-kappaB kinase/NF-kappaB signaling | 9.8361 | 6 | yes |
GO:0019221 | cytokine-mediated signaling pathway | 9.0164 | 4 | yes |
GO:0022409 | positive regulation of cell-cell adhesion | 9.0164 | 6 | yes |
GO:1903037 | regulation of leukocyte cell-cell adhesion | 9.0164 | 6 | yes |
GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 9.0164 | 7 | yes |
GO:0000302 | response to reactive oxygen species | 8.1967 | 4 | yes |
GO:0006954 | inflammatory response | 8.1967 | 4 | yes |
GO:0018130 | heterocycle biosynthetic process | 8.1967 | 4 | yes |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 8.1967 | 7 | yes |
GO:0071345 | cellular response to cytokine stimulus | 8.1967 | 5 | yes |
GO:0071363 | cellular response to growth factor stimulus | 8.1967 | 5 | yes |
GO:0071375 | cellular response to peptide hormone stimulus | 8.1967 | 5 | yes |
GO:1901362 | organic cyclic compound biosynthetic process | 8.1967 | 4 | yes |
GO:1903321 | negative regulation of protein modification by small protein conjugation or removal | 8.1967 | 8 | yes |
GO:0001889 | liver development | 7.3770 | 5 | yes |
GO:0006325 | chromatin organization | 7.3770 | 4 | yes |
GO:0019438 | aromatic compound biosynthetic process | 7.3770 | 4 | yes |
GO:0034654 | nucleobase-containing compound biosynthetic process | 7.3770 | 4 | yes |
GO:0050727 | regulation of inflammatory response | 7.3770 | 5 | yes |
GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 7.3770 | 6 | yes |
GO:0009416 | response to light stimulus | 6.5574 | 4 | yes |
GO:0032774 | RNA biosynthetic process | 6.5574 | 5 | yes |
GO:0034614 | cellular response to reactive oxygen species | 6.5574 | 5 | yes |
GO:0042542 | response to hydrogen peroxide | 6.5574 | 4 | yes |
GO:0070555 | response to interleukin-1 | 6.5574 | 5 | yes |
GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 6.5574 | 7 | yes |
GO:0002237 | response to molecule of bacterial origin | 5.7377 | 4 | yes |
GO:0006351 | DNA-templated transcription | 5.7377 | 7 | yes |
GO:0032677 | regulation of interleukin-8 production | 5.7377 | 5 | yes |
GO:0034250 | positive regulation of cellular amide metabolic process | 5.7377 | 6 | yes |
GO:0042177 | negative regulation of protein catabolic process | 5.7377 | 6 | yes |
GO:0097659 | nucleic acid-templated transcription | 5.7377 | 6 | yes |
GO:1902991 | regulation of amyloid precursor protein catabolic process | 5.7377 | 6 | yes |
GO:0007249 | I-kappaB kinase/NF-kappaB signaling | 4.9180 | 4 | yes |
GO:0032496 | response to lipopolysaccharide | 4.9180 | 4 | yes |
GO:0032757 | positive regulation of interleukin-8 production | 4.9180 | 6 | yes |
GO:0034612 | response to tumor necrosis factor | 4.9180 | 5 | yes |
GO:0035994 | response to muscle stretch | 4.9180 | 4 | yes |
GO:0043620 | regulation of DNA-templated transcription in response to stress | 4.9180 | 4 | yes |
GO:0051607 | defense response to virus | 4.9180 | 4 | yes |
GO:0070301 | cellular response to hydrogen peroxide | 4.9180 | 5 | yes |
GO:0071219 | cellular response to molecule of bacterial origin | 4.9180 | 4 | yes |
GO:0140546 | defense response to symbiont | 4.9180 | 4 | yes |
GO:1901222 | regulation of NIK/NF-kappaB signaling | 4.9180 | 6 | yes |
GO:1901224 | positive regulation of NIK/NF-kappaB signaling | 4.9180 | 7 | yes |
GO:1990776 | response to angiotensin | 4.9180 | 5 | yes |
GO:0009411 | response to UV | 4.0984 | 5 | yes |
GO:0033209 | tumor necrosis factor-mediated signaling pathway | 4.0984 | 5 | yes |
GO:0070498 | interleukin-1-mediated signaling pathway | 4.0984 | 5 | yes |
GO:0071222 | cellular response to lipopolysaccharide | 4.0984 | 5 | yes |
GO:0071356 | cellular response to tumor necrosis factor | 4.0984 | 6 | yes |
GO:0099527 | postsynapse to nucleus signaling pathway | 4.0984 | 4 | yes |
GO:1902003 | regulation of amyloid-beta formation | 4.0984 | 6 | yes |
GO:1902893 | regulation of miRNA transcription | 4.0984 | 7 | yes |
GO:1902993 | positive regulation of amyloid precursor protein catabolic process | 4.0984 | 7 | yes |
GO:2000628 | regulation of miRNA metabolic process | 4.0984 | 6 | yes |
GO:0032655 | regulation of interleukin-12 production | 3.2787 | 5 | yes |
GO:0033233 | regulation of protein sumoylation | 3.2787 | 8 | yes |
GO:0050854 | regulation of antigen receptor-mediated signaling pathway | 3.2787 | 5 | yes |
GO:0050856 | regulation of T cell receptor signaling pathway | 3.2787 | 6 | yes |
GO:0050857 | positive regulation of antigen receptor-mediated signaling pathway | 3.2787 | 6 | yes |
GO:0050862 | positive regulation of T cell receptor signaling pathway | 3.2787 | 7 | yes |
GO:1902895 | positive regulation of miRNA transcription | 3.2787 | 8 | yes |
GO:1904385 | cellular response to angiotensin | 3.2787 | 6 | yes |
GO:2000630 | positive regulation of miRNA metabolic process | 3.2787 | 7 | yes |
GO:0002221 | pattern recognition receptor signaling pathway | 2.4590 | 4 | yes |
GO:0032494 | response to peptidoglycan | 2.4590 | 4 | yes |
GO:0032735 | positive regulation of interleukin-12 production | 2.4590 | 6 | yes |
GO:0033234 | negative regulation of protein sumoylation | 2.4590 | 9 | yes |
GO:0035728 | response to hepatocyte growth factor | 2.4590 | 5 | yes |
GO:0035729 | cellular response to hepatocyte growth factor stimulus | 2.4590 | 6 | yes |
GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 2.4590 | 6 | yes |
GO:1902004 | positive regulation of amyloid-beta formation | 2.4590 | 7 | yes |
GO:1902894 | negative regulation of miRNA transcription | 2.4590 | 8 | yes |
GO:2000629 | negative regulation of miRNA metabolic process | 2.4590 | 7 | yes |
GO:0002753 | cytoplasmic pattern recognition receptor signaling pathway | 1.6393 | 4 | yes |
GO:0006968 | cellular defense response | 1.6393 | 4 | yes |
GO:0007218 | neuropeptide signaling pathway | 1.6393 | 4 | yes |
GO:0010224 | response to UV-B | 1.6393 | 6 | yes |
GO:0032495 | response to muramyl dipeptide | 1.6393 | 5 | yes |
GO:0035872 | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | 1.6393 | 4 | yes |
GO:0038061 | NIK/NF-kappaB signaling | 1.6393 | 4 | yes |
GO:0070391 | response to lipoteichoic acid | 1.6393 | 4 | yes |
GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway | 1.6393 | 5 | yes |
GO:0070431 | nucleotide-binding oligomerization domain containing 2 signaling pathway | 1.6393 | 6 | yes |
GO:0070741 | response to interleukin-6 | 1.6393 | 5 | yes |
GO:0071223 | cellular response to lipoteichoic acid | 1.6393 | 5 | yes |
GO:0071224 | cellular response to peptidoglycan | 1.6393 | 5 | yes |
GO:0071316 | cellular response to nicotine | 1.6393 | 4 | yes |
GO:0071347 | cellular response to interleukin-1 | 1.6393 | 6 | yes |
GO:0071354 | cellular response to interleukin-6 | 1.6393 | 6 | yes |
GO:1901223 | negative regulation of NIK/NF-kappaB signaling | 1.6393 | 7 | yes |
GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus | 1.6393 | 9 | yes |
GO:1904994 | regulation of leukocyte adhesion to vascular endothelial cell | 1.6393 | 7 | yes |
GO:1904996 | positive regulation of leukocyte adhesion to vascular endothelial cell | 1.6393 | 8 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in TF65_HUMAN |
---|---|---|---|---|
DOID:612 | primary immunodeficiency disease | 4.0984 | 3 | no |
DOID:0111962 | combined immunodeficiency | 2.4590 | 4 | no |
DOID:1289 | neurodegenerative disease | 1.6393 | 4 | no |
DOID:231 | motor neuron disease | 1.6393 | 5 | no |
DOID:331 | central nervous system disease | 1.6393 | 3 | no |
DOID:332 | amyotrophic lateral sclerosis | 1.6393 | 6 | no |
DOID:0050686 | organ system cancer | 1.6393 | 3 | no |
DOID:2531 | hematologic cancer | 1.6393 | 4 | no |
DOID:627 | severe combined immunodeficiency | 1.6393 | 5 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
PRGC1_HUMAN | [view interactions] | Low throughput | no | no |
CENPJ_HUMAN | [view interactions] | Low throughput | no | no |
JUN_HUMAN | [view interactions] | Low throughput | no | yes |
PIAS3_HUMAN | [view interactions] | Low throughput | no | yes |
RNF25_HUMAN | [view interactions] | Low throughput | no | no |
IASPP_HUMAN | [view interactions] | Low throughput | no | yes |
ING4_HUMAN | [view interactions] | Low throughput | no | no |
NCOR2_HUMAN | [view interactions] | Low throughput | no | yes |
APBA2_HUMAN | [view interactions] | Low throughput | no | yes |
TLE5_HUMAN | [view interactions] | Low throughput | no | no |
KAT5_HUMAN | [view interactions] | Low throughput | no | yes |
ZBT7A_HUMAN | [view interactions] | Low throughput | no | yes |
PPARG_HUMAN | [view interactions] | Low throughput | no | yes |
AP2A_HUMAN | [view interactions] | Low throughput | no | no |
MEOX2_HUMAN | [view interactions] | Low throughput | no | no |
BANP_HUMAN | [view interactions] | Low throughput | no | yes |
1433S_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TNIP2_HUMAN | [view interactions] | Low throughput | no | yes |
TBK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BARD1_HUMAN | [view interactions] | Low throughput | no | yes |
BRCA1_HUMAN | [view interactions] | Low throughput | no | yes |
UN5CL_HUMAN | [view interactions] | Low throughput | no | no |
TRIB3_HUMAN | [view interactions] | Low throughput | no | yes |
HMGB1_HUMAN | [view interactions] | Low throughput | no | yes |
CSK22_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CDK9_HUMAN | [view interactions] | Low throughput | no | yes |
PML_HUMAN | [view interactions] | Low throughput | no | yes |
NOTC1_HUMAN | [view interactions] | Low throughput | no | yes |
ETHE1_HUMAN | [view interactions] | Low throughput | no | yes |
AHR_HUMAN | [view interactions] | Low throughput | no | yes |
CENPR_HUMAN | [view interactions] | Low throughput | no | yes |
TERT_HUMAN | [view interactions] | Low throughput | no | no |
RFC1_HUMAN | [view interactions] | Low throughput | no | yes |
FBW1A_HUMAN | [view interactions] | Low throughput | no | yes |
TLE1_HUMAN | [view interactions] | Low throughput | no | yes |
PARP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MTPN_HUMAN | [view interactions] | Low throughput | no | yes |
PO2F1_HUMAN | [view interactions] | Low throughput | no | yes |
MYC_HUMAN | [view interactions] | Low throughput | no | yes |
NKX21_HUMAN | [view interactions] | Low throughput | no | no |
FUS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TBP_HUMAN | [view interactions] | Low throughput | no | yes |
SIR5_HUMAN | [view interactions] | Low throughput | no | yes |
UBP31_HUMAN | [view interactions] | Low throughput | no | yes |
BRMS1_HUMAN | [view interactions] | Low throughput | no | yes |
AKIP1_HUMAN | [view interactions] | Low throughput | no | no |
ATF3_HUMAN | [view interactions] | Low throughput | no | yes |
HDAC6_HUMAN | [view interactions] | Low throughput | no | yes |
ANM1_HUMAN | [view interactions] | Low throughput | no | yes |
MAFK_HUMAN | [view interactions] | Low throughput | no | no |
PPARD_HUMAN | [view interactions] | Low throughput | no | yes |
PSD10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MTA1_HUMAN | [view interactions] | Low throughput | no | yes |
P63_HUMAN | [view interactions] | Low throughput | no | no |
ZBT7B_HUMAN | [view interactions] | Low throughput | no | no |
SP3_HUMAN | [view interactions] | Low throughput | no | no |
CEBPZ_HUMAN | [view interactions] | Low throughput | no | no |
HSP74_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CHIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EZH2_HUMAN | [view interactions] | Low throughput | no | no |
SUZ12_HUMAN | [view interactions] | Low throughput | no | no |
KLF4_HUMAN | [view interactions] | Low throughput | no | no |
PIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACTS_HUMAN | [view interactions] | Low throughput | no | no |
FAF1_HUMAN | [view interactions] | Low throughput | no | yes |
TBL1X_HUMAN | [view interactions] | Low throughput | no | yes |
CHFR_HUMAN | [view interactions] | Low throughput | no | no |
DNJA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SOCS3_HUMAN | [view interactions] | Low throughput | no | yes |
NANOG_HUMAN | [view interactions] | Low throughput | no | no |
NANP8_HUMAN | [view interactions] | Low throughput | no | no |
FEM1A_HUMAN | [view interactions] | Low throughput | no | no |
UBP7_HUMAN | [view interactions] | Low throughput | no | yes |
HIF1A_HUMAN | [view interactions] | Low throughput | no | no |
ANM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HS71B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HS71A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HSP7C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MBB1A_HUMAN | [view interactions] | Low throughput | no | yes |
KC1G1_HUMAN | [view interactions] | Low throughput | no | no |
ASPP2_HUMAN | [view interactions] | Low throughput | no | yes |
THIOM_HUMAN | [view interactions] | Low throughput | no | yes |
DHX9_HUMAN | [view interactions] | Low throughput | no | yes |
NCF1_HUMAN | [view interactions] | Low throughput | no | no |
IKBB_HUMAN | [view interactions] | Low throughput | no | no |
IKBA_HUMAN | [view interactions] | Low throughput | no | yes |
NFKB1_HUMAN | [view interactions] | Low throughput | no | yes |
UXT_HUMAN | [view interactions] | Low throughput | no | yes |
REL_HUMAN | [view interactions] | Low throughput | no | yes |
TF65_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IKBE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NPM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KEAP1_HUMAN | [view interactions] | Low throughput | no | yes |
TXNIP_HUMAN | [view interactions] | Low throughput | no | no |
MED17_HUMAN | [view interactions] | Low throughput | no | no |
CCNB1_HUMAN | [view interactions] | Low throughput | no | no |
SIX2_HUMAN | [view interactions] | Low throughput | no | no |
P53_HUMAN | [view interactions] | Low throughput | no | no |
KS6A5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ECSIT_HUMAN | [view interactions] | Low throughput | no | yes |
CSK21_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AATF_HUMAN | [view interactions] | Low throughput | no | yes |
PDLI2_HUMAN | [view interactions] | Low throughput | no | no |
RS3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CASK_HUMAN | [view interactions] | Low throughput | no | no |
SIR6_HUMAN | [view interactions] | Low throughput | no | yes |
CSN1_HUMAN | [view interactions] | Low throughput | no | no |
SETD7_HUMAN | [view interactions] | Low throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CUL2_HUMAN | [view interactions] | Low throughput | no | yes |
KAISO_HUMAN | [view interactions] | Low throughput | no | yes |
SOCS1_HUMAN | [view interactions] | Low throughput | no | yes |
COMD1_HUMAN | [view interactions] | Low throughput | no | yes |
PAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EHMT1_HUMAN | [view interactions] | Low throughput | no | yes |
DNM3L_HUMAN | [view interactions] | Low throughput | no | yes |
GFI1_HUMAN | [view interactions] | Low throughput | no | yes |
SIR1_HUMAN | [view interactions] | Low throughput | no | yes |
IKKA_HUMAN | [view interactions] | Low throughput | no | yes |
CDX2_HUMAN | [view interactions] | Low throughput | no | no |
LOX5_HUMAN | [view interactions] | Low throughput | no | no |
BRD4_HUMAN | [view interactions] | Low throughput | no | yes |
DAXX_HUMAN | [view interactions] | Low throughput | no | yes |
BECN1_HUMAN | [view interactions] | Low throughput | no | yes |
IEX1_HUMAN | [view interactions] | Low throughput | no | yes |
PDCD4_HUMAN | [view interactions] | Low throughput | no | yes |
CBP_HUMAN | [view interactions] | Low throughput | no | yes |
MKRN2_HUMAN | [view interactions] | Low throughput | no | yes |
SNAI1_HUMAN | [view interactions] | Low throughput | no | yes |
VDR_HUMAN | [view interactions] | Low throughput | no | no |
KLF6_HUMAN | [view interactions] | Low throughput | no | yes |
FBXW7_HUMAN | [view interactions] | Low throughput | no | yes |
IRF5_HUMAN | [view interactions] | Low throughput | no | no |
TEAD4_HUMAN | [view interactions] | Low throughput | no | no |
M3K8_HUMAN | [view interactions] | Low throughput | no | yes |
PIAS4_HUMAN | [view interactions] | Low throughput | no | yes |
MYCD_HUMAN | [view interactions] | Low throughput | no | yes |
NOS2_HUMAN | [view interactions] | Low throughput | no | yes |
NR4A1_HUMAN | [view interactions] | Low throughput | no | yes |
DPF3_HUMAN | [view interactions] | Low throughput | no | yes |
REQU_HUMAN | [view interactions] | Low throughput | no | yes |
IMA3_HUMAN | [view interactions] | Low throughput | no | yes |
FOS_HUMAN | [view interactions] | Low throughput | no | yes |
HDAC3_HUMAN | [view interactions] | Low throughput | no | yes |
PP2AA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RRP5_HUMAN | [view interactions] | Low throughput | no | yes |
KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TF2B_HUMAN | [view interactions] | Low throughput | no | yes |
HDAC1_HUMAN | [view interactions] | Low throughput | no | no |
COMDA_HUMAN | [view interactions] | Low throughput | no | yes |
COMD6_HUMAN | [view interactions] | Low throughput | no | no |
ZHX2_HUMAN | [view interactions] | Low throughput | no | yes |
CK5P3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NMI_HUMAN | [view interactions] | Low throughput | no | yes |
UBB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ZFP91_HUMAN | [view interactions] | Low throughput | no | yes |
RS27A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAD51_HUMAN | [view interactions] | Low throughput | no | yes |
RL40_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SAP18_HUMAN | [view interactions] | Low throughput | no | yes |
SETD6_HUMAN | [view interactions] | Low throughput | no | yes |
UBP48_HUMAN | [view interactions] | Low throughput | no | yes |
2AAA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ESR1_HUMAN | [view interactions] | Low throughput | no | no |
TWST1_HUMAN | [view interactions] | Low throughput | no | no |
MEN1_HUMAN | [view interactions] | Low throughput | no | yes |
TRIP6_HUMAN | [view interactions] | Low throughput | no | yes |
MED16_HUMAN | [view interactions] | Low throughput | no | yes |
F16P1_HUMAN | [view interactions] | Low throughput | no | no |
MACD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
TRIM7_HUMAN | [view interactions] | Low throughput | no | yes |
NCOA3_HUMAN | [view interactions] | Low throughput | no | yes |
SPSB1_HUMAN | [view interactions] | Low throughput | no | no |
EP300_HUMAN | [view interactions] | Low throughput | no | yes |
GCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TMUB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NFKB2_HUMAN | [view interactions] | Low throughput | no | yes |
RO52_HUMAN | [view interactions] | Low throughput | no | yes |
TGM2_HUMAN | [view interactions] | Low throughput | no | no |
KMT2D_HUMAN | [view interactions] | Low throughput | no | yes |
OGT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LYRIC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NR4A2_HUMAN | [view interactions] | Low throughput | no | yes |
STAT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SP1_HUMAN | [view interactions] | Low throughput | no | yes |
ANXA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
NR0B2_HUMAN | [view interactions] | Low throughput | no | no |
NR1H4_HUMAN | [view interactions] | Low throughput | no | no |
GSK3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NDK5_HUMAN | [view interactions] | Low throughput | no | yes |
RELB_HUMAN | [view interactions] | Low throughput | no | yes |
CDC20_HUMAN | [view interactions] | Low throughput | no | no |
CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
APC11_HUMAN | [view interactions] | Low throughput | no | yes |
KAT2A_HUMAN | [view interactions] | Low throughput | no | no |
FBXW2_HUMAN | [view interactions] | Low throughput | no | yes |
SIR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TYY1_HUMAN | [view interactions] | Low throughput | no | yes |
RUVB2_HUMAN | [view interactions] | Low throughput | no | yes |
FOXP3_HUMAN | [view interactions] | Low throughput | no | no |
NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
ELF3_HUMAN | [view interactions] | Low throughput | no | no |
KDM2A_HUMAN | [view interactions] | Low throughput | no | yes |
ANDR_HUMAN | [view interactions] | Low throughput | no | no |
NSD1_HUMAN | [view interactions] | Low throughput | no | yes |
CITE2_HUMAN | [view interactions] | Low throughput | no | yes |
ARRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CRIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CTNA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CARM1_HUMAN | [view interactions] | Low throughput | no | yes |
TADBP_HUMAN | [view interactions] | Low throughput | no | yes |
KPCZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IKKB_HUMAN | [view interactions] | Low throughput | no | yes |
HMGA2_HUMAN | [view interactions] | Low throughput | no | yes |
HEXI1_HUMAN | [view interactions] | Low throughput | no | yes |
PP2AB_HUMAN | [view interactions] | Low throughput | no | yes |
SRF_HUMAN | [view interactions] | Low throughput | no | yes |
PPARA_HUMAN | [view interactions] | Low throughput | no | yes |
IMA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PRGR_HUMAN | [view interactions] | Low throughput | no | no |
NKRF_HUMAN | [view interactions] | Low throughput | no | no |
PP4C_HUMAN | [view interactions] | Low throughput | no | yes |
MDM2_HUMAN | [view interactions] | Low throughput | no | yes |
TAF1_HUMAN | [view interactions] | Low throughput | no | yes |
TAF6_HUMAN | [view interactions] | Low throughput | no | no |
TAF11_HUMAN | [view interactions] | Low throughput | no | no |
TAF4B_HUMAN | [view interactions] | Low throughput | no | yes |
EGR1_HUMAN | [view interactions] | Low throughput | no | yes |
CEBPD_HUMAN | [view interactions] | Low throughput | no | no |
IRF8_HUMAN | [view interactions] | Low throughput | no | no |
TRIP4_HUMAN | [view interactions] | Low throughput | no | yes |
IRF2_HUMAN | [view interactions] | Low throughput | no | yes |
IRF9_HUMAN | [view interactions] | Low throughput | no | yes |
SNIP1_HUMAN | [view interactions] | Low throughput | no | no |
TAF9_HUMAN | [view interactions] | Low throughput | no | yes |
MED15_HUMAN | [view interactions] | Low throughput | no | yes |
MED23_HUMAN | [view interactions] | Low throughput | no | no |
MED7_HUMAN | [view interactions] | Low throughput | no | no |
PLK1_HUMAN | [view interactions] | Low throughput | no | yes |
PK3CA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IKKE_HUMAN | [view interactions] | Low throughput | no | yes |
UB2D1_HUMAN | [view interactions] | Low throughput | no | yes |
UB2E1_HUMAN | [view interactions] | Low throughput | no | yes |
UBE2H_HUMAN | [view interactions] | Low throughput | no | yes |
UB2R1_HUMAN | [view interactions] | Low throughput | no | yes |
UB2D2_HUMAN | [view interactions] | Low throughput | no | yes |
UB2D3_HUMAN | [view interactions] | Low throughput | no | yes |
UB2L3_HUMAN | [view interactions] | Low throughput | no | yes |
UBE2C_HUMAN | [view interactions] | Low throughput | no | yes |
CHK1_HUMAN | [view interactions] | Low throughput | no | no |
CEBPB_HUMAN | [view interactions] | Low throughput | no | no |
SMCA2_HUMAN | [view interactions] | Low throughput | no | yes |
HSF1_HUMAN | [view interactions] | Low throughput | no | yes |
HDAC2_HUMAN | [view interactions] | Low throughput | no | yes |
RPB1_HUMAN | [view interactions] | Low throughput | no | no |
RXRA_HUMAN | [view interactions] | Low throughput | no | yes |
ATM_HUMAN | [view interactions] | Low throughput | no | yes |
DNM3B_HUMAN | [view interactions] | Low throughput | no | yes |
ICAM1_HUMAN | [view interactions] | High throughput | no | no |
MKS1_HUMAN | [view interactions] | High throughput | no | no |
SMD3_HUMAN | [view interactions] | High throughput | no | yes |
HOOK1_HUMAN | [view interactions] | High throughput | no | no |
SSH3_HUMAN | [view interactions] | High throughput | no | yes |
HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITF2_HUMAN | [view interactions] | High throughput | no | yes |
MX1_HUMAN | [view interactions] | High throughput | no | yes |
ASB9_HUMAN | [view interactions] | High throughput | no | no |
PO6F2_HUMAN | [view interactions] | High throughput | no | no |
RT4I1_HUMAN | [view interactions] | High throughput | no | yes |
SUOX_HUMAN | [view interactions] | High throughput | no | no |
TRI55_HUMAN | [view interactions] | High throughput | no | no |
TRI63_HUMAN | [view interactions] | High throughput | no | no |
IQGA2_HUMAN | [view interactions] | High throughput | no | yes |
AKP8L_HUMAN | [view interactions] | High throughput | no | yes |
AFF1_HUMAN | [view interactions] | High throughput | no | no |
FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
DCD_HUMAN | [view interactions] | High throughput | no | no |
K2C5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
POTEJ_HUMAN | [view interactions] | High throughput | no | no |
IL1RA_HUMAN | [view interactions] | High throughput | no | no |
POTEE_HUMAN | [view interactions] | High throughput | no | no |
PLMN_HUMAN | [view interactions] | High throughput | no | no |
SRSF7_HUMAN | [view interactions] | High throughput | no | yes |
DHSO_HUMAN | [view interactions] | High throughput | no | no |
DI3L2_HUMAN | [view interactions] | High throughput | no | yes |
RBTN2_HUMAN | [view interactions] | High throughput | no | yes |
GAN_HUMAN | [view interactions] | High throughput | no | yes |
PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PIWL4_HUMAN | [view interactions] | High throughput | no | yes |
MK10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABCA1_HUMAN | [view interactions] | High throughput | no | yes |
SOCS6_HUMAN | [view interactions] | High throughput | no | yes |
S31A3_HUMAN | [view interactions] | High throughput | no | no |
PEX1_HUMAN | [view interactions] | High throughput | no | no |
CNNM3_HUMAN | [view interactions] | High throughput | no | yes |
REV1_HUMAN | [view interactions] | High throughput | no | yes |
MK14_HUMAN | [view interactions] | High throughput | no | yes |
CDK4_HUMAN | [view interactions] | High throughput | no | no |
RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCND1_HUMAN | [view interactions] | High throughput | no | yes |
PA24A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RING2_HUMAN | [view interactions] | High throughput | no | yes |
CCN3_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
WASP_HUMAN | [view interactions] | High throughput | no | yes |
HERC3_HUMAN | [view interactions] | High throughput | no | yes |
PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
PRS7_HUMAN | [view interactions] | High throughput | no | yes |
HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
HYPK_HUMAN | [view interactions] | High throughput | no | no |
NUFP2_HUMAN | [view interactions] | High throughput | no | no |
CD006_HUMAN | [view interactions] | High throughput | no | no |
TIM8A_HUMAN | [view interactions] | High throughput | no | yes |
TIM8B_HUMAN | [view interactions] | High throughput | no | yes |
TIM13_HUMAN | [view interactions] | High throughput | no | yes |
IMA4_HUMAN | [view interactions] | High throughput | no | yes |
AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
PHF10_HUMAN | [view interactions] | High throughput | no | yes |
GPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DPF1_HUMAN | [view interactions] | High throughput | no | yes |
IMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IMB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NF2L2_HUMAN | [view interactions] | High throughput | no | yes |
HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PTOV1_HUMAN | [view interactions] | High throughput | no | yes |
PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IMA7_HUMAN | [view interactions] | High throughput | no | yes |
GPC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WDR26_HUMAN | [view interactions] | High throughput | no | yes |
DECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COMD2_HUMAN | [view interactions] | High throughput | no | yes |
WDR61_HUMAN | [view interactions] | High throughput | no | yes |
DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COMD4_HUMAN | [view interactions] | High throughput | no | no |
GSLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COMD5_HUMAN | [view interactions] | High throughput | no | no |
SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COMD8_HUMAN | [view interactions] | High throughput | no | yes |
HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LRC66_HUMAN | [view interactions] | High throughput | no | no |
COMD7_HUMAN | [view interactions] | High throughput | no | no |
ATX3_HUMAN | [view interactions] | High throughput | no | yes |
ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTBP2_HUMAN | [view interactions] | High throughput | no | no |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
DDX58_HUMAN | [view interactions] | High throughput | no | yes |
PAXX_HUMAN | [view interactions] | High throughput | no | yes |
CB27A_HUMAN | [view interactions] | High throughput | no | no |
CB27B_HUMAN | [view interactions] | High throughput | no | no |
PXDC2_HUMAN | [view interactions] | High throughput | no | yes |
BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DAPP1_HUMAN | [view interactions] | High throughput | no | yes |
CLH2_HUMAN | [view interactions] | High throughput | no | no |
PIP_HUMAN | [view interactions] | High throughput | no | no |
EFMT3_HUMAN | [view interactions] | High throughput | no | no |
DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MPIP1_HUMAN | [view interactions] | High throughput | no | no |
PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
KITH_HUMAN | [view interactions] | High throughput | no | yes |
KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
PNMT_HUMAN | [view interactions] | High throughput | no | no |
ATG12_HUMAN | [view interactions] | High throughput | no | yes |
MSH2_HUMAN | [view interactions] | High throughput | no | yes |
FA20C_HUMAN | [view interactions] | High throughput | no | no |
NCOA6_HUMAN | [view interactions] | High throughput | no | yes |
C1QB_HUMAN | [view interactions] | High throughput | no | no |
CO2A1_HUMAN | [view interactions] | High throughput | no | no |
DDC_HUMAN | [view interactions] | High throughput | no | no |
EF1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ISL1_HUMAN | [view interactions] | High throughput | no | no |
SMAD3_HUMAN | [view interactions] | High throughput | no | yes |
SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
KPYM_HUMAN | [view interactions] | High throughput | no | yes |
RNAS1_HUMAN | [view interactions] | High throughput | no | yes |
SAT1_HUMAN | [view interactions] | High throughput | no | yes |
CCL5_HUMAN | [view interactions] | High throughput | no | no |
RU17_HUMAN | [view interactions] | High throughput | no | yes |
TELT_HUMAN | [view interactions] | High throughput | no | no |
RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGO1_HUMAN | [view interactions] | High throughput | no | no |
FKB11_HUMAN | [view interactions] | High throughput | no | no |
RIOK2_HUMAN | [view interactions] | High throughput | no | yes |
GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BATF2_HUMAN | [view interactions] | High throughput | no | yes |
CASP6_HUMAN | [view interactions] | High throughput | no | no |
CCKN_HUMAN | [view interactions] | High throughput | no | yes |
FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
DNMT1_HUMAN | [view interactions] | High throughput | no | no |
PANKY_HUMAN | [view interactions] | High throughput | no | no |
SRBP1_HUMAN | [view interactions] | High throughput | no | yes |
ZDH13_HUMAN | [view interactions] | High throughput | no | no |
ZMY11_HUMAN | [view interactions] | High throughput | no | no |
ANKR7_HUMAN | [view interactions] | High throughput | no | no |
CXXC1_HUMAN | [view interactions] | High throughput | no | yes |
EPHA2_HUMAN | [view interactions] | High throughput | no | no |
CERS2_HUMAN | [view interactions] | High throughput | no | no |
GLIS1_HUMAN | [view interactions] | High throughput | no | no |
BRPF1_HUMAN | [view interactions] | High throughput | no | yes |
NFIC_HUMAN | [view interactions] | High throughput | no | yes |
USF2_HUMAN | [view interactions] | High throughput | no | no |
RASF1_HUMAN | [view interactions] | High throughput | no | yes |
RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARNT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CCND2_HUMAN | [view interactions] | High throughput | no | yes |
MP2K6_HUMAN | [view interactions] | High throughput | no | yes |
IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LATS2_HUMAN | [view interactions] | High throughput | no | yes |
M3K7_HUMAN | [view interactions] | High throughput | no | yes |
STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARHG7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSME1_HUMAN | [view interactions] | Computational | no | yes |
UBC9_HUMAN | [view interactions] | Computational | no | yes |
KAT2B_HUMAN | [view interactions] | Computational | no | yes |
PSA7_HUMAN | [view interactions] | Computational | no | yes |
IL23R_HUMAN | [view interactions] | Computational | no | yes |
SMRD1_HUMAN | [view interactions] | Computational | no | yes |
B2LA1_HUMAN | [view interactions] | Computational | no | no |
CXCL3_HUMAN | [view interactions] | Computational | no | no |
PRS4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NGF_HUMAN | [view interactions] | Computational | no | no |
APOA2_HUMAN | [view interactions] | Computational | no | no |
PSMD5_HUMAN | [view interactions] | Computational | no | yes |
PSME4_HUMAN | [view interactions] | Computational | no | yes |
PSMD8_HUMAN | [view interactions] | Computational | no | yes |
TF2AA_HUMAN | [view interactions] | Computational | no | yes |
CPT1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KPCD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSMD7_HUMAN | [view interactions] | Computational | no | yes |
LPAR1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
FOXO3_HUMAN | [view interactions] | Computational | no | yes |
KLF2_HUMAN | [view interactions] | Computational | no | yes |
S10AC_HUMAN | [view interactions] | Computational | no | no |
COX2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSMD3_HUMAN | [view interactions] | Computational | no | yes |
GROA_HUMAN | [view interactions] | Computational | no | no |
PSB9_HUMAN | [view interactions] | Computational | no | no |
PSA5_HUMAN | [view interactions] | Computational | no | yes |
KPCT_HUMAN | [view interactions] | Computational | no | no |
PRS6B_HUMAN | [view interactions] | Computational | no | yes |
TLR2_HUMAN | [view interactions] | Computational | no | no |
PSMD9_HUMAN | [view interactions] | Computational | no | yes |
PSME2_HUMAN | [view interactions] | Computational | no | no |
SODM_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PSDE_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TFF2_HUMAN | [view interactions] | Computational | no | no |
PO2F2_HUMAN | [view interactions] | Computational | no | no |
ARI1A_HUMAN | [view interactions] | Computational | no | yes |
PRS8_HUMAN | [view interactions] | Computational | no | yes |
ACOX1_HUMAN | [view interactions] | Computational | no | yes |
SMCA4_HUMAN | [view interactions] | Computational | no | yes |
KSYK_HUMAN | [view interactions] | Computational | no | no |
IRF4_HUMAN | [view interactions] | Computational | no | no |
PSB7_HUMAN | [view interactions] | Computational | no | yes |
CXCL2_HUMAN | [view interactions] | Computational | no | no |
PSB11_HUMAN | [view interactions] | Computational | no | no |
IL23A_HUMAN | [view interactions] | Computational | no | no |
RAF1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
IRAK1_HUMAN | [view interactions] | Computational | no | yes |
PSMA8_HUMAN | [view interactions] | Computational | no | no |
IKBZ_HUMAN | [view interactions] | Computational | no | no |
MUC5A_HUMAN | [view interactions] | Computational | no | no |
JAK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
STAT4_HUMAN | [view interactions] | Computational | no | yes |
A4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IL8_HUMAN | [view interactions] | Computational | no | no |
LPAR3_HUMAN | [view interactions] | Computational | no | no |
PSB4_HUMAN | [view interactions] | Computational | no | yes |
MTOR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PRS10_HUMAN | [view interactions] | Computational | no | yes |
ECHP_HUMAN | [view interactions] | Computational | no | no |
BCL3_HUMAN | [view interactions] | Computational | no | yes |
C4BPA_HUMAN | [view interactions] | Computational | no | no |
ATF2_HUMAN | [view interactions] | Computational | no | yes |
PSA2_HUMAN | [view interactions] | Computational | no | yes |
MK03_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TYK2_HUMAN | [view interactions] | Computational | no | no |
T2FA_HUMAN | [view interactions] | Computational | no | yes |
IRF6_HUMAN | [view interactions] | Computational | no | yes |
KAPCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MK08_HUMAN | [view interactions] | Computational | no | yes |
PSD11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TYDP2_HUMAN | [view interactions] | Computational | no | no |
P85A_HUMAN | [view interactions] | Computational | no | yes |
DDX1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IL12B_HUMAN | [view interactions] | Computational | no | yes |
TIE2_HUMAN | [view interactions] | Computational | no | no |
TRAF6_HUMAN | [view interactions] | Computational | no | yes |
RAC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PAWR_HUMAN | [view interactions] | Computational | no | yes |
IL4_HUMAN | [view interactions] | Computational | no | no |
BIRC3_HUMAN | [view interactions] | Computational | no | no |
ROCK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NAA10_HUMAN | [view interactions] | Computational | no | yes |
CCL2_HUMAN | [view interactions] | Computational | no | no |
SMCE1_HUMAN | [view interactions] | Computational | no | yes |
PSB2_HUMAN | [view interactions] | Computational | no | yes |
TRADD_HUMAN | [view interactions] | Computational | no | yes |
ROCK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAGE_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RB6I2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KBRS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSA3_HUMAN | [view interactions] | Computational | no | no |
PSMD6_HUMAN | [view interactions] | Computational | no | yes |
TNFA_HUMAN | [view interactions] | Computational | no | no |
FABPL_HUMAN | [view interactions] | Computational | no | no |
IRF7_HUMAN | [view interactions] | Computational | no | yes |
IRF3_HUMAN | [view interactions] | Computational | no | yes |
M3K1_HUMAN | [view interactions] | Computational | no | yes |
I12R1_HUMAN | [view interactions] | Computational | no | no |
TGFB2_HUMAN | [view interactions] | Computational | no | no |
PSMF1_HUMAN | [view interactions] | Computational | no | yes |
PSB5_HUMAN | [view interactions] | Computational | no | yes |
SMRC1_HUMAN | [view interactions] | Computational | no | yes |
SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
S100B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IL1AP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
T2EA_HUMAN | [view interactions] | Computational | no | yes |
RIPK1_HUMAN | [view interactions] | Computational | no | yes |
PSB6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IL2_HUMAN | [view interactions] | Computational | no | no |
IL18R_HUMAN | [view interactions] | Computational | no | yes |
PSMD2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CAR11_HUMAN | [view interactions] | Computational | no | no |
RASK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
LPAR2_HUMAN | [view interactions] | Computational | no | yes |
KPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IRF1_HUMAN | [view interactions] | Computational | no | yes |
PSD12_HUMAN | [view interactions] | Computational | no | yes |
IFNB_HUMAN | [view interactions] | Computational | no | no |
PRS6A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSB10_HUMAN | [view interactions] | Computational | no | no |
SMRC2_HUMAN | [view interactions] | Computational | no | yes |
I18RA_HUMAN | [view interactions] | Computational | no | yes |
TRAF1_HUMAN | [view interactions] | Computational | no | no |
KAPCG_HUMAN | [view interactions] | Computational | no | no |
KPCI_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MYD88_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSD13_HUMAN | [view interactions] | Computational | no | yes |
PSME3_HUMAN | [view interactions] | Computational | no | yes |
TAB1_HUMAN | [view interactions] | Computational | no | yes |
TRAF2_HUMAN | [view interactions] | Computational | no | yes |
IL1R1_HUMAN | [view interactions] | Computational | no | no |
IL18_HUMAN | [view interactions] | Computational | no | yes |
TAB2_HUMAN | [view interactions] | Computational | no | yes |
PSB3_HUMAN | [view interactions] | Computational | no | yes |
NAL12_HUMAN | [view interactions] | Computational | no | yes |
PSA6_HUMAN | [view interactions] | Computational | no | yes |
KBRS2_HUMAN | [view interactions] | Computational | no | no |
PSB1_HUMAN | [view interactions] | Computational | no | yes |
PSA1_HUMAN | [view interactions] | Computational | no | yes |
IFNG_HUMAN | [view interactions] | Computational | no | no |
BIRC2_HUMAN | [view interactions] | Computational | no | yes |
TGFB3_HUMAN | [view interactions] | Computational | no | no |
TLR4_HUMAN | [view interactions] | Computational | no | yes |
APOA1_HUMAN | [view interactions] | Computational | no | no |
MAOX_HUMAN | [view interactions] | Computational | no | yes |
FAT1_HUMAN | [view interactions] | Computational | no | yes |
IL1B_HUMAN | [view interactions] | Computational | no | no |
IL6_HUMAN | [view interactions] | Computational | no | no |
TNR1A_HUMAN | [view interactions] | Computational | no | yes |
CD40L_HUMAN | [view interactions] | Computational | no | no |
SAA1_HUMAN | [view interactions] | Computational | no | no |