DNJB6_HUMAN
Evidence for PS localization
Functions
Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DNJB6_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 34.8624 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 32.1101 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.1927 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 30.2752 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 27.5229 | 5 | no |
| GO:0005524 | ATP binding | 26.6055 | 5 | no |
| GO:0003723 | RNA binding | 22.9358 | 4 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 21.1009 | 4 | no |
| GO:0003677 | DNA binding | 6.4220 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DNJB6_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 54.1284 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 54.1284 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.2936 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 52.2936 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 52.2936 | 4 | yes |
| GO:0010468 | regulation of gene expression | 44.9541 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 44.0367 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 42.2018 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 40.3670 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.3670 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 39.4495 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 39.4495 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 38.5321 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 37.6147 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.6147 | 5 | no |
| GO:0010646 | regulation of cell communication | 37.6147 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.6972 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 34.8624 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 34.8624 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.8624 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 33.9450 | 6 | yes |
| GO:0006996 | organelle organization | 33.9450 | 4 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 33.9450 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 33.9450 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 31.1927 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 30.2752 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.2752 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.3578 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 28.4404 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.5229 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 27.5229 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.5229 | 5 | no |
| GO:0022607 | cellular component assembly | 26.6055 | 4 | no |
| GO:0010941 | regulation of cell death | 25.6881 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 24.7706 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 24.7706 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 24.7706 | 4 | yes |
| GO:0036211 | protein modification process | 24.7706 | 4 | no |
| GO:0043412 | macromolecule modification | 24.7706 | 4 | no |
| GO:0051049 | regulation of transport | 24.7706 | 4 | no |
| GO:0008104 | protein localization | 23.8532 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 23.8532 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 23.8532 | 4 | no |
| GO:0071702 | organic substance transport | 23.8532 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 22.9358 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.9358 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.9358 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 22.9358 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.9358 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.0183 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.0183 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 22.0183 | 5 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.0183 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.0183 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.0183 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 22.0183 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.1009 | 6 | yes |
| GO:0080134 | regulation of response to stress | 21.1009 | 4 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.1009 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 21.1009 | 7 | no |
| GO:0031329 | regulation of cellular catabolic process | 21.1009 | 5 | no |
| GO:0060341 | regulation of cellular localization | 20.1835 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 20.1835 | 7 | no |
| GO:0015031 | protein transport | 20.1835 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.1835 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 20.1835 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.1835 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 20.1835 | 5 | no |
| GO:0030162 | regulation of proteolysis | 18.3486 | 6 | yes |
| GO:0051129 | negative regulation of cellular component organization | 18.3486 | 5 | yes |
| GO:0060548 | negative regulation of cell death | 17.4312 | 5 | yes |
| GO:0032880 | regulation of protein localization | 16.5138 | 5 | yes |
| GO:0043066 | negative regulation of apoptotic process | 16.5138 | 7 | yes |
| GO:0043069 | negative regulation of programmed cell death | 16.5138 | 6 | yes |
| GO:0007010 | cytoskeleton organization | 14.6789 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 14.6789 | 4 | yes |
| GO:0080135 | regulation of cellular response to stress | 14.6789 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 12.8440 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 12.8440 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 12.8440 | 6 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 11.9266 | 6 | yes |
| GO:0043086 | negative regulation of catalytic activity | 11.0092 | 4 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 11.0092 | 7 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 11.0092 | 6 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 11.0092 | 7 | yes |
| GO:1903507 | negative regulation of nucleic acid-templated transcription | 11.0092 | 8 | yes |
| GO:0033365 | protein localization to organelle | 9.1743 | 5 | yes |
| GO:0045861 | negative regulation of proteolysis | 9.1743 | 7 | yes |
| GO:0097435 | supramolecular fiber organization | 8.2569 | 4 | yes |
| GO:0052547 | regulation of peptidase activity | 6.4220 | 5 | yes |
| GO:0090083 | regulation of inclusion body assembly | 6.4220 | 5 | yes |
| GO:0051346 | negative regulation of hydrolase activity | 5.5046 | 5 | yes |
| GO:0052548 | regulation of endopeptidase activity | 5.5046 | 6 | yes |
| GO:0090084 | negative regulation of inclusion body assembly | 5.5046 | 6 | yes |
| GO:0010466 | negative regulation of peptidase activity | 4.5872 | 6 | yes |
| GO:0010951 | negative regulation of endopeptidase activity | 4.5872 | 7 | yes |
| GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 3.6697 | 8 | yes |
| GO:2000116 | regulation of cysteine-type endopeptidase activity | 3.6697 | 7 | yes |
| GO:0034504 | protein localization to nucleus | 2.7523 | 6 | yes |
| GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 2.7523 | 8 | yes |
| GO:2000117 | negative regulation of cysteine-type endopeptidase activity | 2.7523 | 8 | yes |
| GO:0030198 | extracellular matrix organization | 1.8349 | 5 | yes |
| GO:0043062 | extracellular structure organization | 1.8349 | 4 | yes |
| GO:0045229 | external encapsulating structure organization | 1.8349 | 4 | yes |
| GO:1900034 | regulation of cellular response to heat | 1.8349 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in DNJB6_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 3.6697 | 3 | no |
| DOID:0050686 | organ system cancer | 2.7523 | 3 | no |
| DOID:0050155 | sensory system disease | 1.8349 | 3 | no |
| DOID:0050563 | nonsyndromic deafness | 1.8349 | 5 | no |
| DOID:2742 | auditory system disease | 1.8349 | 4 | no |
| DOID:12377 | spinal muscular atrophy | 1.8349 | 6 | no |
| DOID:1289 | neurodegenerative disease | 1.8349 | 4 | no |
| DOID:231 | motor neuron disease | 1.8349 | 5 | no |
| DOID:936 | brain disease | 1.8349 | 4 | no |
| DOID:120 | female reproductive organ cancer | 1.8349 | 5 | no |
| DOID:193 | reproductive organ cancer | 1.8349 | 4 | no |
| DOID:6457 | Cowden syndrome | 1.8349 | 3 | no |
| DOID:0050700 | cardiomyopathy | 1.8349 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 1.8349 | 5 | no |
| DOID:114 | heart disease | 1.8349 | 3 | no |
| DOID:12930 | dilated cardiomyopathy | 1.8349 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BRMS1_HUMAN | [view interactions] | Low throughput | no | yes |
| K1C18_HUMAN | [view interactions] | Low throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ALKB1_HUMAN | [view interactions] | Low throughput | no | yes |
| BAG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CHIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| K2C8_HUMAN | [view interactions] | Low throughput | no | no |
| HSPB8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | Low throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HDAC7_HUMAN | [view interactions] | Low throughput | no | no |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRF4_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECEL1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRBA_HUMAN | [view interactions] | High throughput | no | yes |
| SYHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG18_HUMAN | [view interactions] | High throughput | no | yes |
| TM263_HUMAN | [view interactions] | High throughput | no | yes |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| PP1R8_HUMAN | [view interactions] | High throughput | no | yes |
| STAM1_HUMAN | [view interactions] | High throughput | no | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| DNJB8_HUMAN | [view interactions] | High throughput | no | no |
| ES8L2_HUMAN | [view interactions] | High throughput | no | yes |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TKFC_HUMAN | [view interactions] | High throughput | no | no |
| TTL12_HUMAN | [view interactions] | High throughput | no | yes |
| NACC2_HUMAN | [view interactions] | High throughput | no | yes |
| SYNC_HUMAN | [view interactions] | High throughput | no | yes |
| INT3_HUMAN | [view interactions] | High throughput | no | yes |
| NAA15_HUMAN | [view interactions] | High throughput | no | yes |
| KDM3B_HUMAN | [view interactions] | High throughput | no | yes |
| RGS10_HUMAN | [view interactions] | High throughput | no | yes |
| CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD2_HUMAN | [view interactions] | High throughput | no | yes |
| ENAH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| CCDC6_HUMAN | [view interactions] | High throughput | no | yes |
| 5NTC_HUMAN | [view interactions] | High throughput | no | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERF1_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASML_HUMAN | [view interactions] | High throughput | no | yes |
| NFS1_HUMAN | [view interactions] | High throughput | no | yes |
| PUR8_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| AASD1_HUMAN | [view interactions] | High throughput | no | yes |
| CIP4_HUMAN | [view interactions] | High throughput | no | no |
| KTHY_HUMAN | [view interactions] | High throughput | no | yes |
| GAMT_HUMAN | [view interactions] | High throughput | no | no |
| CK5P3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MANF_HUMAN | [view interactions] | High throughput | no | yes |
| TRM1_HUMAN | [view interactions] | High throughput | no | yes |
| SCAM1_HUMAN | [view interactions] | High throughput | no | no |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRP44_HUMAN | [view interactions] | High throughput | no | yes |
| LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7E_HUMAN | [view interactions] | High throughput | no | yes |
| OXSM_HUMAN | [view interactions] | High throughput | no | yes |
| SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARFP1_HUMAN | [view interactions] | High throughput | no | no |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EHD2_HUMAN | [view interactions] | High throughput | no | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| NAA10_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRE1A_HUMAN | [view interactions] | High throughput | no | yes |
| RPAC2_HUMAN | [view interactions] | High throughput | no | no |
| CYRIB_HUMAN | [view interactions] | High throughput | no | yes |
| GALE_HUMAN | [view interactions] | High throughput | no | no |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| PDS5A_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| PHP14_HUMAN | [view interactions] | High throughput | no | yes |
| HDA11_HUMAN | [view interactions] | High throughput | no | no |
| TTC1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| NAA50_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TOPK_HUMAN | [view interactions] | High throughput | no | no |
| SCRN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG4_HUMAN | [view interactions] | High throughput | no | yes |
| BIEA_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| JAM1_HUMAN | [view interactions] | High throughput | no | yes |
| MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYMPK_HUMAN | [view interactions] | High throughput | no | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCMBP_HUMAN | [view interactions] | High throughput | no | yes |
| TCEA1_HUMAN | [view interactions] | High throughput | no | no |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| PLSI_HUMAN | [view interactions] | High throughput | no | no |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| PRRC1_HUMAN | [view interactions] | High throughput | no | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EHD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ1_HUMAN | [view interactions] | High throughput | no | yes |
| CBX4_HUMAN | [view interactions] | High throughput | no | yes |
| MGST1_HUMAN | [view interactions] | High throughput | no | no |
| S10A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFT27_HUMAN | [view interactions] | High throughput | no | yes |
| FPRP_HUMAN | [view interactions] | High throughput | no | yes |
| MTA70_HUMAN | [view interactions] | High throughput | no | no |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| S29A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| NDRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| NTM1A_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2Z_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| FGD3_HUMAN | [view interactions] | High throughput | no | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| OBI1_HUMAN | [view interactions] | High throughput | no | yes |
| GPX8_HUMAN | [view interactions] | High throughput | no | no |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K21_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA8_HUMAN | [view interactions] | High throughput | no | yes |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P5CS_HUMAN | [view interactions] | High throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| KAPCG_HUMAN | [view interactions] | High throughput | no | no |
| AKP8L_HUMAN | [view interactions] | High throughput | no | yes |
| M3K9_HUMAN | [view interactions] | High throughput | no | yes |
| ARAP1_HUMAN | [view interactions] | High throughput | no | yes |
| NIM1_HUMAN | [view interactions] | High throughput | no | no |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEX14_HUMAN | [view interactions] | High throughput | no | no |
| PP6R3_HUMAN | [view interactions] | High throughput | no | yes |
| ANKK1_HUMAN | [view interactions] | High throughput | no | no |
| QSER1_HUMAN | [view interactions] | High throughput | no | yes |
| COQ8B_HUMAN | [view interactions] | High throughput | no | yes |
| IQEC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K14_HUMAN | [view interactions] | High throughput | no | yes |
| HEMH_HUMAN | [view interactions] | High throughput | no | yes |
| DYRK4_HUMAN | [view interactions] | High throughput | no | no |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKG3_HUMAN | [view interactions] | High throughput | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLA3_HUMAN | [view interactions] | High throughput | no | yes |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOMA_HUMAN | [view interactions] | High throughput | no | no |
| CF047_HUMAN | [view interactions] | High throughput | no | no |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPT22_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPP25_HUMAN | [view interactions] | High throughput | no | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| RED_HUMAN | [view interactions] | High throughput | no | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CBLB_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| ASCL4_HUMAN | [view interactions] | High throughput | no | no |
| RCL1_HUMAN | [view interactions] | High throughput | no | no |
| F117B_HUMAN | [view interactions] | High throughput | no | no |
| RPP30_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TBL3_HUMAN | [view interactions] | High throughput | no | yes |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| UT14A_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR3_HUMAN | [view interactions] | High throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHD1_HUMAN | [view interactions] | High throughput | no | yes |
| LMBL1_HUMAN | [view interactions] | High throughput | no | no |
| SPB1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN211_HUMAN | [view interactions] | High throughput | no | yes |
| WDR36_HUMAN | [view interactions] | High throughput | no | yes |
| NBEL2_HUMAN | [view interactions] | High throughput | no | no |
| DDX10_HUMAN | [view interactions] | High throughput | no | yes |
| REC8_HUMAN | [view interactions] | High throughput | no | yes |
| CENPV_HUMAN | [view interactions] | High throughput | no | yes |
| AKA10_HUMAN | [view interactions] | High throughput | no | no |
| RALY_HUMAN | [view interactions] | High throughput | no | yes |
| KATIP_HUMAN | [view interactions] | High throughput | no | yes |
| RRP5_HUMAN | [view interactions] | High throughput | no | yes |
| RTRAF_HUMAN | [view interactions] | High throughput | no | yes |
| RBM34_HUMAN | [view interactions] | High throughput | no | yes |
| RRP12_HUMAN | [view interactions] | High throughput | no | no |
| ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BOP1_HUMAN | [view interactions] | High throughput | no | yes |
| ANKR1_HUMAN | [view interactions] | High throughput | no | no |
| PESC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTPB4_HUMAN | [view interactions] | High throughput | no | yes |
| CAND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCA13_HUMAN | [view interactions] | High throughput | no | yes |
| MRT4_HUMAN | [view interactions] | High throughput | no | yes |
| ASPM_HUMAN | [view interactions] | High throughput | no | no |
| MYPC1_HUMAN | [view interactions] | High throughput | no | no |
| NOC2L_HUMAN | [view interactions] | High throughput | no | yes |
| MYOM1_HUMAN | [view interactions] | High throughput | no | no |
| NOG2_HUMAN | [view interactions] | High throughput | no | yes |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKAP2_HUMAN | [view interactions] | High throughput | no | no |
| NOP2_HUMAN | [view interactions] | High throughput | no | yes |
| SPT6H_HUMAN | [view interactions] | High throughput | no | yes |
| UTP18_HUMAN | [view interactions] | High throughput | no | yes |
| TITIN_HUMAN | [view interactions] | High throughput | no | no |
| NLE1_HUMAN | [view interactions] | High throughput | no | yes |
| GCP3_HUMAN | [view interactions] | High throughput | no | yes |
| WDR74_HUMAN | [view interactions] | High throughput | no | no |
| DYSF_HUMAN | [view interactions] | High throughput | no | no |
| PPM1G_HUMAN | [view interactions] | High throughput | no | no |
| SGCG_HUMAN | [view interactions] | High throughput | no | no |
| NOL8_HUMAN | [view interactions] | High throughput | no | yes |
| HACD3_HUMAN | [view interactions] | High throughput | no | yes |
| HEAT1_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX27_HUMAN | [view interactions] | High throughput | no | no |
| TSR1_HUMAN | [view interactions] | High throughput | no | no |
| M3K1_HUMAN | [view interactions] | High throughput | no | yes |
| BCCIP_HUMAN | [view interactions] | High throughput | no | no |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NOC3L_HUMAN | [view interactions] | High throughput | no | no |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KRI1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| DRC5_HUMAN | [view interactions] | High throughput | no | no |
| SURF6_HUMAN | [view interactions] | High throughput | no | yes |
| CE164_HUMAN | [view interactions] | High throughput | no | yes |
| TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| UBF1_HUMAN | [view interactions] | High throughput | no | yes |
| NOL9_HUMAN | [view interactions] | High throughput | no | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| AN32E_HUMAN | [view interactions] | High throughput | no | yes |
| SIR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN644_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| RPF2_HUMAN | [view interactions] | High throughput | no | yes |
| P63_HUMAN | [view interactions] | High throughput | no | no |
| LMNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P73_HUMAN | [view interactions] | High throughput | no | no |
| SLX9_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOLC1_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| CTR9_HUMAN | [view interactions] | High throughput | no | yes |
| BMS1_HUMAN | [view interactions] | High throughput | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TOIP1_HUMAN | [view interactions] | High throughput | no | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| K1C13_HUMAN | [view interactions] | High throughput | no | no |
| ERR2_HUMAN | [view interactions] | High throughput | no | no |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CIA2B_HUMAN | [view interactions] | High throughput | no | yes |
| DJC21_HUMAN | [view interactions] | High throughput | no | yes |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EBP2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SP16H_HUMAN | [view interactions] | High throughput | no | yes |
| NOPC1_HUMAN | [view interactions] | High throughput | no | yes |
| RRS1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| RL7L_HUMAN | [view interactions] | High throughput | no | no |
| UBR5_HUMAN | [view interactions] | High throughput | no | no |
| NIP7_HUMAN | [view interactions] | High throughput | no | yes |
| PODO_HUMAN | [view interactions] | High throughput | no | no |
| WDR12_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| SMRCD_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX31_HUMAN | [view interactions] | High throughput | no | no |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| MK67I_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TDIF2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| PWP2_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| UTP15_HUMAN | [view interactions] | High throughput | no | no |
| BRAF_HUMAN | [view interactions] | High throughput | no | yes |
| NPA1P_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| HIF1A_HUMAN | [view interactions] | High throughput | no | no |
| TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCND1_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| MFRN2_HUMAN | [view interactions] | High throughput | no | no |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| SP100_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| TBB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDGR2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PGAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DJB12_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC3_HUMAN | [view interactions] | High throughput | no | yes |
| SCO2_HUMAN | [view interactions] | High throughput | no | no |
| RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
| DNMT1_HUMAN | [view interactions] | High throughput | no | no |
| HS74L_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| HIKES_HUMAN | [view interactions] | Computational | no | yes |
| HSP13_HUMAN | [view interactions] | Computational | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HSP74_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HS12B_HUMAN | [view interactions] | Computational | no | yes |
| HS12A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |