AN32E_HUMAN
Evidence for PS localization
Functions
Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AN32E_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 50.0000 | 4 | no |
| GO:0045296 | cadherin binding | 20.8333 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AN32E_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 54.1667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 54.1667 | 4 | no |
| GO:0008104 | protein localization | 54.1667 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 45.8333 | 4 | no |
| GO:0071702 | organic substance transport | 45.8333 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 41.6667 | 4 | no |
| GO:0010468 | regulation of gene expression | 41.6667 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.6667 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 41.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 41.6667 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 41.6667 | 4 | no |
| GO:0071705 | nitrogen compound transport | 41.6667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 37.5000 | 4 | no |
| GO:0010646 | regulation of cell communication | 37.5000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 37.5000 | 4 | no |
| GO:0006886 | intracellular protein transport | 37.5000 | 4 | no |
| GO:0015031 | protein transport | 37.5000 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | no |
| GO:0032880 | regulation of protein localization | 33.3333 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0060341 | regulation of cellular localization | 33.3333 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 29.1667 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 29.1667 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 29.1667 | 7 | no |
| GO:0009893 | positive regulation of metabolic process | 29.1667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.1667 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 29.1667 | 5 | no |
| GO:0080134 | regulation of response to stress | 29.1667 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 29.1667 | 6 | no |
| GO:0051129 | negative regulation of cellular component organization | 29.1667 | 5 | no |
| GO:0033365 | protein localization to organelle | 29.1667 | 5 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 25.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.8333 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 20.8333 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.8333 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 20.8333 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.8333 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 20.8333 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.8333 | 6 | no |
| GO:0032101 | regulation of response to external stimulus | 20.8333 | 4 | no |
| GO:0032870 | cellular response to hormone stimulus | 20.8333 | 4 | no |
| GO:0036211 | protein modification process | 20.8333 | 4 | no |
| GO:0043412 | macromolecule modification | 20.8333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.8333 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.8333 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.8333 | 6 | no |
| GO:0009894 | regulation of catabolic process | 20.8333 | 4 | no |
| GO:0033043 | regulation of organelle organization | 20.8333 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 20.8333 | 5 | no |
| GO:0006913 | nucleocytoplasmic transport | 20.8333 | 5 | no |
| GO:0051169 | nuclear transport | 20.8333 | 4 | no |
| GO:0006325 | chromatin organization | 12.5000 | 6 | yes |
| GO:0071824 | protein-DNA complex organization | 12.5000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| H2B1C_HUMAN | [view interactions] | Low throughput | no | yes |
| MRGBP_HUMAN | [view interactions] | Low throughput | no | no |
| H2AZ_HUMAN | [view interactions] | Low throughput | no | yes |
| H2B1J_HUMAN | [view interactions] | Low throughput | no | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| RS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNH2B_HUMAN | [view interactions] | High throughput | no | yes |
| SYSC_HUMAN | [view interactions] | High throughput | no | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAHH3_HUMAN | [view interactions] | High throughput | no | yes |
| AN32A_HUMAN | [view interactions] | High throughput | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAPP1_HUMAN | [view interactions] | High throughput | no | no |
| EIF3G_HUMAN | [view interactions] | High throughput | no | yes |
| BRD8_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| NSD2_HUMAN | [view interactions] | High throughput | no | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| MK14_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC9_HUMAN | [view interactions] | High throughput | no | yes |
| CBX3_HUMAN | [view interactions] | High throughput | no | yes |
| RPA34_HUMAN | [view interactions] | High throughput | no | yes |
| DDX23_HUMAN | [view interactions] | High throughput | no | yes |
| MK67I_HUMAN | [view interactions] | High throughput | no | yes |
| NOP56_HUMAN | [view interactions] | High throughput | no | yes |
| RL31_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN330_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| DDA1_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| IMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1A_HUMAN | [view interactions] | High throughput | no | no |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| TRRAP_HUMAN | [view interactions] | High throughput | no | no |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| ACL6A_HUMAN | [view interactions] | High throughput | no | yes |
| MO4L2_HUMAN | [view interactions] | High throughput | no | yes |
| MO4L1_HUMAN | [view interactions] | High throughput | no | yes |
| EPC1_HUMAN | [view interactions] | High throughput | no | no |
| EPC2_HUMAN | [view interactions] | High throughput | no | yes |
| KAT5_HUMAN | [view interactions] | High throughput | no | yes |
| ING3_HUMAN | [view interactions] | High throughput | no | no |
| YETS4_HUMAN | [view interactions] | High throughput | no | no |
| DMAP1_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC5_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| MSH2_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP6_HUMAN | [view interactions] | High throughput | no | yes |
| IPO9_HUMAN | [view interactions] | High throughput | no | no |
| PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SP16H_HUMAN | [view interactions] | High throughput | no | yes |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| VPS72_HUMAN | [view interactions] | High throughput | no | no |
| ZNHI1_HUMAN | [view interactions] | High throughput | no | yes |
| H31_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| NP1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| NR4A2_HUMAN | [view interactions] | High throughput | no | yes |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| MGMT_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| UIF_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| PTN2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1B_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| IMA7_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1O_HUMAN | [view interactions] | High throughput | no | yes |
| H2B3B_HUMAN | [view interactions] | High throughput | no | yes |
| IMA6_HUMAN | [view interactions] | High throughput | no | yes |
| H2A2B_HUMAN | [view interactions] | High throughput | no | yes |
| PB1_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1_HUMAN | [view interactions] | High throughput | no | yes |
| TPGS1_HUMAN | [view interactions] | High throughput | no | no |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| RPAC2_HUMAN | [view interactions] | High throughput | no | no |
| RPA49_HUMAN | [view interactions] | High throughput | no | yes |
| SRP09_HUMAN | [view interactions] | High throughput | no | no |
| FOXC1_HUMAN | [view interactions] | High throughput | no | no |
| E2F4_HUMAN | [view interactions] | High throughput | no | no |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| CAVN3_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| TET5C_HUMAN | [view interactions] | High throughput | no | yes |
| UBP1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ1_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |