Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SNX2_HUMAN

GO
G2C
SynGO

Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SNX2_HUMAN
GO:0000166 nucleotide binding 28.9855 4 no
GO:0043168 anion binding 28.9855 4 no
GO:0017076 purine nucleotide binding 27.5362 5 no
GO:0032555 purine ribonucleotide binding 26.0870 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.0870 4 no
GO:0043169 cation binding 23.1884 4 no
GO:0046872 metal ion binding 23.1884 5 no
GO:0019900 kinase binding 21.7391 4 no
GO:0045296 cadherin binding 20.2899 4 yes
GO:0019901 protein kinase binding 20.2899 5 no
GO:0042803 protein homodimerization activity 17.3913 4 yes
GO:0035091 phosphatidylinositol binding 15.9420 4 yes
GO:0046982 protein heterodimerization activity 8.6957 4 yes
GO:0005158 insulin receptor binding 7.2464 4 yes
GO:0070851 growth factor receptor binding 5.7971 4 yes
GO:1990459 transferrin receptor binding 5.7971 4 yes
GO:1990460 leptin receptor binding 5.7971 4 yes
GO:0005154 epidermal growth factor receptor binding 5.7971 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SNX2_HUMAN
GO:0008104 protein localization 56.5217 4 yes
GO:0048522 positive regulation of cellular process 53.6232 4 no
GO:0010646 regulation of cell communication 50.7246 4 no
GO:0031323 regulation of cellular metabolic process 46.3768 4 no
GO:0048523 negative regulation of cellular process 46.3768 4 no
GO:0051128 regulation of cellular component organization 44.9275 4 no
GO:0071702 organic substance transport 43.4783 4 yes
GO:0060255 regulation of macromolecule metabolic process 43.4783 4 no
GO:0071705 nitrogen compound transport 42.0290 4 yes
GO:0009966 regulation of signal transduction 42.0290 4 no
GO:0080090 regulation of primary metabolic process 42.0290 4 no
GO:0006996 organelle organization 40.5797 4 no
GO:0015031 protein transport 39.1304 4 yes
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0044087 regulation of cellular component biogenesis 31.8841 4 no
GO:0051049 regulation of transport 31.8841 4 no
GO:1902531 regulation of intracellular signal transduction 31.8841 5 no
GO:0010468 regulation of gene expression 31.8841 6 no
GO:0010556 regulation of macromolecule biosynthetic process 31.8841 5 no
GO:0009893 positive regulation of metabolic process 30.4348 4 no
GO:0031325 positive regulation of cellular metabolic process 28.9855 5 no
GO:0006886 intracellular protein transport 28.9855 4 yes
GO:0030030 cell projection organization 27.5362 4 yes
GO:0033043 regulation of organelle organization 27.5362 5 no
GO:0022607 cellular component assembly 27.5362 4 no
GO:0010604 positive regulation of macromolecule metabolic process 27.5362 5 no
GO:0051246 regulation of protein metabolic process 27.5362 5 no
GO:0120036 plasma membrane bounded cell projection organization 26.0870 5 yes
GO:0048584 positive regulation of response to stimulus 26.0870 4 no
GO:0031344 regulation of cell projection organization 26.0870 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.0870 6 no
GO:0009894 regulation of catabolic process 24.6377 4 no
GO:0010647 positive regulation of cell communication 24.6377 5 no
GO:0023056 positive regulation of signaling 24.6377 4 no
GO:0051130 positive regulation of cellular component organization 24.6377 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.6377 5 no
GO:0009891 positive regulation of biosynthetic process 23.1884 5 no
GO:0009967 positive regulation of signal transduction 23.1884 5 no
GO:0031328 positive regulation of cellular biosynthetic process 23.1884 6 no
GO:0042981 regulation of apoptotic process 23.1884 5 no
GO:0043067 regulation of programmed cell death 23.1884 4 no
GO:0048585 negative regulation of response to stimulus 23.1884 4 no
GO:0006355 regulation of DNA-templated transcription 23.1884 7 no
GO:0051252 regulation of RNA metabolic process 23.1884 5 no
GO:2001141 regulation of RNA biosynthetic process 23.1884 6 no
GO:0032880 regulation of protein localization 23.1884 5 no
GO:0051093 negative regulation of developmental process 23.1884 4 no
GO:0051129 negative regulation of cellular component organization 23.1884 5 no
GO:0060341 regulation of cellular localization 23.1884 4 no
GO:0009968 negative regulation of signal transduction 21.7391 5 no
GO:0010648 negative regulation of cell communication 21.7391 5 no
GO:0023057 negative regulation of signaling 21.7391 4 no
GO:0009892 negative regulation of metabolic process 21.7391 4 no
GO:0010605 negative regulation of macromolecule metabolic process 21.7391 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.7391 6 no
GO:0016482 cytosolic transport 20.2899 4 yes
GO:0042147 retrograde transport, endosome to Golgi 20.2899 4 yes
GO:0051050 positive regulation of transport 20.2899 4 no
GO:0051240 positive regulation of multicellular organismal process 20.2899 4 no
GO:0071310 cellular response to organic substance 20.2899 4 no
GO:0022603 regulation of anatomical structure morphogenesis 20.2899 4 no
GO:0045595 regulation of cell differentiation 20.2899 4 no
GO:0033365 protein localization to organelle 20.2899 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 11.5942 4 yes
GO:0097581 lamellipodium organization 5.7971 6 yes
GO:0034498 early endosome to Golgi transport 4.3478 4 yes
GO:0072673 lamellipodium morphogenesis 4.3478 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FNBP1_HUMAN [view interactions] Low throughput no yes
SNX1_HUMAN [view entry] [view interactions] Low throughput yes yes
VP26A_HUMAN [view entry] [view interactions] Low throughput yes no
SNX2_HUMAN [view entry] [view interactions] Low throughput yes no
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
LAMC1_HUMAN [view interactions] High throughput no yes
NFYC_HUMAN [view interactions] High throughput no no
ZN202_HUMAN [view interactions] High throughput no no
SNX5_HUMAN [view entry] [view interactions] High throughput yes yes
SNX6_HUMAN [view entry] [view interactions] High throughput yes no
CA122_HUMAN [view interactions] High throughput no no
OTUB1_HUMAN [view interactions] High throughput no yes
POTB3_HUMAN [view interactions] High throughput no no
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
DYT2B_HUMAN [view interactions] High throughput no no
HENMT_HUMAN [view interactions] High throughput no yes
CP1A1_HUMAN [view interactions] High throughput no yes
TRML2_HUMAN [view interactions] High throughput no no
F221A_HUMAN [view interactions] High throughput no yes
TRI17_HUMAN [view interactions] High throughput no yes
SNX32_HUMAN [view interactions] High throughput no no
CK042_HUMAN [view interactions] High throughput no no
CAST3_HUMAN [view interactions] High throughput no no
WASC5_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
T22D1_HUMAN [view interactions] High throughput no no
CDC5L_HUMAN [view interactions] High throughput no yes
VPS29_HUMAN [view entry] [view interactions] High throughput yes yes
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
DUS10_HUMAN [view entry] [view interactions] High throughput yes yes
PAK6_HUMAN [view entry] [view interactions] High throughput yes yes
AR6P1_HUMAN [view interactions] High throughput no yes
YIF1A_HUMAN [view interactions] High throughput no yes
PLIN3_HUMAN [view interactions] High throughput no yes
IF3M_HUMAN [view interactions] High throughput no yes
CENPQ_HUMAN [view interactions] High throughput no yes
PNKP_HUMAN [view interactions] High throughput no yes
SMN_HUMAN [view interactions] High throughput no yes
GDAP1_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
FOXL1_HUMAN [view interactions] High throughput no no
TMM17_HUMAN [view interactions] High throughput no yes
EPHA5_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR4_HUMAN [view interactions] High throughput no no
VGFR3_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
FHI1A_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
TM239_HUMAN [view interactions] High throughput no no
AVR2B_HUMAN [view interactions] High throughput no no
ACV1B_HUMAN [view interactions] High throughput no no
PGFRA_HUMAN [view interactions] High throughput no no
PGFRB_HUMAN [view interactions] High throughput no yes
SNX4_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
INSR_HUMAN [view interactions] High throughput no yes
LEPR_HUMAN [view interactions] High throughput no no
CCDC8_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
UBP46_HUMAN [view entry] [view interactions] High throughput yes yes
SFXN2_HUMAN [view interactions] High throughput no no
DYN3_HUMAN [view entry] [view interactions] High throughput yes no
GNAT2_HUMAN [view interactions] High throughput no no
F90A1_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
CA087_HUMAN [view interactions] High throughput no no
CYB5_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
FXL13_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
NR2C2_HUMAN [view interactions] High throughput no yes
ZDH18_HUMAN [view interactions] High throughput no yes
ZDH23_HUMAN [view interactions] High throughput no no
ATX1_HUMAN [view interactions] High throughput no yes
MTM1_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
BACD3_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
AURKB_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
CSN5_HUMAN [view interactions] High throughput no yes
APR_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
NRBP_HUMAN [view interactions] High throughput no yes
HYOU1_HUMAN [view interactions] High throughput no yes
S12A3_HUMAN [view interactions] High throughput no no
BMP6_HUMAN [view interactions] High throughput no no
GNAO_HUMAN [view entry] [view interactions] High throughput yes yes
PRUN2_HUMAN [view entry] [view interactions] High throughput yes yes
IBPL1_HUMAN [view interactions] High throughput no no
SPAT2_HUMAN [view interactions] High throughput no yes
CUX2_HUMAN [view interactions] High throughput no no
DB136_HUMAN [view interactions] High throughput no no
KLHL1_HUMAN [view interactions] High throughput no no
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
CBCO1_HUMAN [view interactions] High throughput no no
RM42_HUMAN [view interactions] High throughput no yes
WASC3_HUMAN [view interactions] High throughput no yes
NTNG1_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
FSCN1_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOH_HUMAN [view interactions] High throughput no yes
SAR1B_HUMAN [view interactions] High throughput no yes
IKIP_HUMAN [view interactions] High throughput no no
DJB11_HUMAN [view interactions] High throughput no yes
SDF2L_HUMAN [view interactions] High throughput no yes
ECM29_HUMAN [view interactions] High throughput no no
TPP2_HUMAN [view interactions] High throughput no yes
TLS1_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
BAP1_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
TRI33_HUMAN [view interactions] High throughput no yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
RN149_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
CSK_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
H33_HUMAN [view interactions] High throughput no yes
HIRP3_HUMAN [view interactions] High throughput no no
AN32E_HUMAN [view entry] [view interactions] High throughput yes yes
ATG7_HUMAN [view interactions] High throughput no yes
VATC1_HUMAN [view entry] [view interactions] High throughput yes yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
NIBA2_HUMAN [view interactions] High throughput no no
ERF3A_HUMAN [view interactions] High throughput no yes
ERF3B_HUMAN [view interactions] High throughput no yes
PAWR_HUMAN [view interactions] High throughput no yes
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
GLYC_HUMAN [view interactions] High throughput no no
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
TBC15_HUMAN [view interactions] High throughput no yes
TBCD_HUMAN [view entry] [view interactions] High throughput yes no
PYRG1_HUMAN [view interactions] High throughput no no
DDB1_HUMAN [view interactions] High throughput no yes
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
IMDH2_HUMAN [view interactions] High throughput no yes
PDXK_HUMAN [view entry] [view interactions] High throughput yes yes
PUR1_HUMAN [view interactions] High throughput no yes
BRE1B_HUMAN [view interactions] High throughput no yes
RUVB2_HUMAN [view interactions] High throughput no yes
INT13_HUMAN [view interactions] High throughput no no
ENOPH_HUMAN [view interactions] High throughput no yes
RB6I2_HUMAN [view entry] [view interactions] High throughput yes yes
ERP44_HUMAN [view interactions] High throughput no yes
MA2B1_HUMAN [view interactions] High throughput no yes
NCBP1_HUMAN [view interactions] High throughput no yes
PCID2_HUMAN [view interactions] High throughput no yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
WDFY1_HUMAN [view interactions] High throughput no yes
TSN_HUMAN [view interactions] High throughput no yes
VP26B_HUMAN [view entry] [view interactions] High throughput yes yes
TAOK3_HUMAN [view interactions] High throughput no yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
TBCD5_HUMAN [view interactions] High throughput no yes
SNX3_HUMAN [view entry] [view interactions] High throughput yes no
SC24A_HUMAN [view interactions] High throughput no no
HAP28_HUMAN [view interactions] High throughput no yes
TDG_HUMAN [view interactions] High throughput no yes
RAPH1_HUMAN [view entry] [view interactions] High throughput yes yes
MTA70_HUMAN [view interactions] High throughput no no
RBM4B_HUMAN [view interactions] High throughput no yes
TRI56_HUMAN [view interactions] High throughput no yes
F1142_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
GBF1_HUMAN [view interactions] High throughput no yes
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
RN183_HUMAN [view interactions] High throughput no no
DNJC5_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
B3GA1_HUMAN [view interactions] High throughput no yes
BORC6_HUMAN [view interactions] High throughput no yes
K1C18_HUMAN [view interactions] High throughput no no
K1C19_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
PEX14_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes
IFM3_HUMAN [view interactions] High throughput no yes
ATG9A_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3A_HUMAN [view interactions] High throughput no yes
RAB25_HUMAN [view interactions] High throughput no no
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
WWTR1_HUMAN [view interactions] High throughput no yes