Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SNX2_HUMAN

GO
G2C
SynGO

Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SNX2_HUMAN
GO:0045296 cadherin binding 27.4194 4 yes
GO:0017076 purine nucleotide binding 27.4194 4 no
GO:0032555 purine ribonucleotide binding 27.4194 4 no
GO:0035639 purine ribonucleoside triphosphate binding 27.4194 4 no
GO:0035091 phosphatidylinositol binding 20.9677 4 yes
GO:0016462 pyrophosphatase activity 20.9677 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 20.9677 4 no
GO:0042803 protein homodimerization activity 17.7419 4 yes
GO:0046982 protein heterodimerization activity 11.2903 4 yes
GO:0070851 growth factor receptor binding 8.0645 4 yes
GO:0005154 epidermal growth factor receptor binding 6.4516 5 yes
GO:1990459 transferrin receptor binding 6.4516 4 yes
GO:1990460 leptin receptor binding 6.4516 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SNX2_HUMAN
GO:0016192 vesicle-mediated transport 59.6774 4 yes
GO:0048522 positive regulation of cellular process 56.4516 4 no
GO:0008104 protein localization 54.8387 4 yes
GO:0051128 regulation of cellular component organization 48.3871 4 no
GO:0071702 organic substance transport 45.1613 4 yes
GO:0071705 nitrogen compound transport 45.1613 4 yes
GO:0010646 regulation of cell communication 45.1613 4 no
GO:0031323 regulation of cellular metabolic process 45.1613 4 no
GO:0048523 negative regulation of cellular process 45.1613 4 no
GO:0060255 regulation of macromolecule metabolic process 45.1613 4 no
GO:0080090 regulation of primary metabolic process 45.1613 4 no
GO:0006996 organelle organization 45.1613 4 no
GO:0015031 protein transport 43.5484 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 43.5484 4 no
GO:0009966 regulation of signal transduction 37.0968 4 no
GO:0006886 intracellular protein transport 35.4839 4 yes
GO:0009893 positive regulation of metabolic process 35.4839 4 no
GO:0051049 regulation of transport 35.4839 4 no
GO:0016197 endosomal transport 33.8710 4 yes
GO:0022607 cellular component assembly 33.8710 4 no
GO:0010604 positive regulation of macromolecule metabolic process 32.2581 5 no
GO:0044087 regulation of cellular component biogenesis 32.2581 4 no
GO:0010468 regulation of gene expression 30.6452 5 no
GO:0030030 cell projection organization 29.0323 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 29.0323 5 no
GO:0051246 regulation of protein metabolic process 29.0323 5 no
GO:0006897 endocytosis 27.4194 5 yes
GO:0033043 regulation of organelle organization 27.4194 5 no
GO:0120036 plasma membrane bounded cell projection organization 25.8065 5 yes
GO:0031325 positive regulation of cellular metabolic process 25.8065 5 no
GO:0009889 regulation of biosynthetic process 25.8065 4 no
GO:0031326 regulation of cellular biosynthetic process 25.8065 5 no
GO:0016482 cytosolic transport 24.1935 4 yes
GO:0048584 positive regulation of response to stimulus 24.1935 4 no
GO:0051050 positive regulation of transport 24.1935 4 no
GO:0061024 membrane organization 24.1935 4 no
GO:0009894 regulation of catabolic process 24.1935 4 no
GO:1902531 regulation of intracellular signal transduction 24.1935 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.1935 5 no
GO:0010647 positive regulation of cell communication 22.5806 5 no
GO:0023056 positive regulation of signaling 22.5806 4 no
GO:0010941 regulation of cell death 22.5806 4 no
GO:0051130 positive regulation of cellular component organization 22.5806 5 no
GO:0060627 regulation of vesicle-mediated transport 22.5806 4 no
GO:0031344 regulation of cell projection organization 22.5806 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.5806 6 no
GO:0033365 protein localization to organelle 22.5806 5 no
GO:0006355 regulation of DNA-templated transcription 22.5806 6 no
GO:0010556 regulation of macromolecule biosynthetic process 22.5806 5 no
GO:0051252 regulation of RNA metabolic process 22.5806 5 no
GO:1903506 regulation of nucleic acid-templated transcription 22.5806 7 no
GO:2001141 regulation of RNA biosynthetic process 22.5806 6 no
GO:0009967 positive regulation of signal transduction 20.9677 5 no
GO:0051129 negative regulation of cellular component organization 20.9677 5 no
GO:0007010 cytoskeleton organization 20.9677 5 no
GO:0048585 negative regulation of response to stimulus 20.9677 4 no
GO:0042147 retrograde transport, endosome to Golgi 19.3548 5 yes
GO:0048193 Golgi vesicle transport 14.5161 5 yes
GO:0032990 cell part morphogenesis 12.9032 4 yes
GO:0048858 cell projection morphogenesis 12.9032 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 12.9032 6 yes
GO:0097581 lamellipodium organization 6.4516 6 yes
GO:0034498 early endosome to Golgi transport 4.8387 6 yes
GO:0072673 lamellipodium morphogenesis 4.8387 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in SNX2_HUMAN
DOID:1289 neurodegenerative disease 4.8387 4 no
DOID:331 central nervous system disease 4.8387 3 no
DOID:10595 Charcot-Marie-Tooth disease 3.2258 6 no
DOID:440 neuromuscular disease 3.2258 5 no
DOID:574 peripheral nervous system disease 3.2258 3 no
DOID:870 neuropathy 3.2258 4 no
DOID:12377 spinal muscular atrophy 3.2258 6 no
DOID:231 motor neuron disease 3.2258 5 no
DOID:332 amyotrophic lateral sclerosis 3.2258 6 no
DOID:0050539 Charcot-Marie-Tooth disease type 2 3.2258 7 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FNBP1_HUMAN [view interactions] Low throughput no yes
SNX1_HUMAN [view entry] [view interactions] Low throughput yes yes
VP26A_HUMAN [view entry] [view interactions] Low throughput yes no
SNX2_HUMAN [view entry] [view interactions] Low throughput yes no
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
LAMC1_HUMAN [view interactions] High throughput no yes
NFYC_HUMAN [view interactions] High throughput no no
ZN202_HUMAN [view interactions] High throughput no no
SNX5_HUMAN [view entry] [view interactions] High throughput yes yes
SNX6_HUMAN [view entry] [view interactions] High throughput yes no
CA122_HUMAN [view interactions] High throughput no no
OTUB1_HUMAN [view interactions] High throughput no yes
POTB3_HUMAN [view interactions] High throughput no no
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
DYT2B_HUMAN [view interactions] High throughput no no
HENMT_HUMAN [view interactions] High throughput no yes
CP1A1_HUMAN [view interactions] High throughput no yes
F221A_HUMAN [view interactions] High throughput no yes
TRML2_HUMAN [view interactions] High throughput no no
SNX32_HUMAN [view interactions] High throughput no no
CK042_HUMAN [view interactions] High throughput no no
CAST3_HUMAN [view interactions] High throughput no no
TRI17_HUMAN [view interactions] High throughput no yes
WASC5_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view interactions] High throughput no yes
T22D1_HUMAN [view interactions] High throughput no no
CDC5L_HUMAN [view interactions] High throughput no yes
INSR_HUMAN [view interactions] High throughput no yes
VPS29_HUMAN [view entry] [view interactions] High throughput yes yes
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
DUS10_HUMAN [view entry] [view interactions] High throughput yes yes
PAK6_HUMAN [view entry] [view interactions] High throughput yes yes
AR6P1_HUMAN [view interactions] High throughput no yes
YIF1A_HUMAN [view interactions] High throughput no yes
PLIN3_HUMAN [view interactions] High throughput no yes
IF3M_HUMAN [view interactions] High throughput no yes
CENPQ_HUMAN [view interactions] High throughput no yes
PNKP_HUMAN [view interactions] High throughput no yes
SMN_HUMAN [view interactions] High throughput no yes
GDAP1_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
FOXL1_HUMAN [view interactions] High throughput no no
TMM17_HUMAN [view interactions] High throughput no yes
EPHA5_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
VGFR3_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
FHI1A_HUMAN [view interactions] High throughput no yes
TM239_HUMAN [view interactions] High throughput no no
AVR2B_HUMAN [view interactions] High throughput no no
ACV1B_HUMAN [view interactions] High throughput no no
PGFRA_HUMAN [view interactions] High throughput no no
PGFRB_HUMAN [view interactions] High throughput no yes
SNX4_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
LEPR_HUMAN [view interactions] High throughput no no
CCDC8_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
UBP46_HUMAN [view entry] [view interactions] High throughput yes yes
SFXN2_HUMAN [view interactions] High throughput no no
DYN3_HUMAN [view entry] [view interactions] High throughput yes no
GNAT2_HUMAN [view interactions] High throughput no no
F90A1_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
CA087_HUMAN [view interactions] High throughput no no
CYB5_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
DRC6_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
NR2C2_HUMAN [view interactions] High throughput no yes
ZDH18_HUMAN [view interactions] High throughput no yes
ZDH23_HUMAN [view interactions] High throughput no no
ATX1_HUMAN [view interactions] High throughput no yes
MTM1_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
BACD3_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
AURKB_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
CSN5_HUMAN [view interactions] High throughput no yes
APR_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
NRBP_HUMAN [view interactions] High throughput no yes
HYOU1_HUMAN [view interactions] High throughput no yes
S12A3_HUMAN [view interactions] High throughput no no
BMP6_HUMAN [view interactions] High throughput no no
GNAO_HUMAN [view entry] [view interactions] High throughput yes yes
PRUN2_HUMAN [view entry] [view interactions] High throughput yes yes
IBPL1_HUMAN [view interactions] High throughput no no
SPAT2_HUMAN [view interactions] High throughput no yes
CUX2_HUMAN [view interactions] High throughput no no
DB136_HUMAN [view interactions] High throughput no no
KLHL1_HUMAN [view interactions] High throughput no no
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
CBCO1_HUMAN [view interactions] High throughput no no
RM42_HUMAN [view interactions] High throughput no yes
WASC3_HUMAN [view interactions] High throughput no yes
NTNG1_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
FSCN1_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOH_HUMAN [view interactions] High throughput no yes
SAR1B_HUMAN [view interactions] High throughput no yes
IKIP_HUMAN [view interactions] High throughput no no
DJB11_HUMAN [view interactions] High throughput no yes
SDF2L_HUMAN [view interactions] High throughput no yes
ECM29_HUMAN [view interactions] High throughput no no
TPP2_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
CSK_HUMAN [view interactions] High throughput no yes
H33_HUMAN [view interactions] High throughput no yes
HIRP3_HUMAN [view interactions] High throughput no no
AN32E_HUMAN [view interactions] High throughput no yes
ATG7_HUMAN [view interactions] High throughput no yes
VATC1_HUMAN [view entry] [view interactions] High throughput yes yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
NIBA2_HUMAN [view interactions] High throughput no no
ERF3A_HUMAN [view interactions] High throughput no yes
ERF3B_HUMAN [view interactions] High throughput no yes
PAWR_HUMAN [view interactions] High throughput no yes
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
GLYC_HUMAN [view interactions] High throughput no no
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
TBC15_HUMAN [view interactions] High throughput no yes
TBCD_HUMAN [view entry] [view interactions] High throughput yes no
PYRG1_HUMAN [view interactions] High throughput no no
DDB1_HUMAN [view interactions] High throughput no yes
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
IMDH2_HUMAN [view interactions] High throughput no yes
PDXK_HUMAN [view entry] [view interactions] High throughput yes yes
PUR1_HUMAN [view interactions] High throughput no yes
BRE1B_HUMAN [view interactions] High throughput no yes
RUVB2_HUMAN [view interactions] High throughput no yes
INT13_HUMAN [view interactions] High throughput no no
ENOPH_HUMAN [view interactions] High throughput no yes
RB6I2_HUMAN [view entry] [view interactions] High throughput yes yes
ERP44_HUMAN [view interactions] High throughput no yes
MA2B1_HUMAN [view interactions] High throughput no yes
NCBP1_HUMAN [view interactions] High throughput no yes
PCID2_HUMAN [view interactions] High throughput no yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
WDFY1_HUMAN [view interactions] High throughput no yes
TSN_HUMAN [view interactions] High throughput no yes
VP26B_HUMAN [view interactions] High throughput no yes
TAOK3_HUMAN [view interactions] High throughput no yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
TBCD5_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
GBF1_HUMAN [view interactions] High throughput no yes
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
RN183_HUMAN [view interactions] High throughput no no
DNJC5_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
B3GA1_HUMAN [view interactions] High throughput no yes
BORC6_HUMAN [view interactions] High throughput no yes
K1C18_HUMAN [view interactions] High throughput no no
K1C19_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
PEX14_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
TFR1_HUMAN [view interactions] High throughput no yes
IFM3_HUMAN [view interactions] High throughput no yes
NECP1_HUMAN [view interactions] Computational no no
SORT_HUMAN [view interactions] Computational no yes
AP3B1_HUMAN [view entry] [view interactions] Computational yes yes
OCRL_HUMAN [view interactions] Computational no yes
YIPF6_HUMAN [view interactions] Computational no yes
HSP7C_HUMAN [view entry] [view interactions] Computational yes yes
VAMP7_HUMAN [view interactions] Computational no yes
P3C2A_HUMAN [view interactions] Computational no yes
AP3S1_HUMAN [view entry] [view interactions] Computational yes no
SNX9_HUMAN [view entry] [view interactions] Computational yes yes
AP4B1_HUMAN [view interactions] Computational no yes
SNAPN_HUMAN [view interactions] Computational no yes
DERL1_HUMAN [view interactions] Computational no yes
PICAL_HUMAN [view entry] [view interactions] Computational yes yes
HIP1R_HUMAN [view entry] [view interactions] Computational yes yes
VAPA_HUMAN [view entry] [view interactions] Computational yes yes
GAK_HUMAN [view entry] [view interactions] Computational yes yes
CBPD_HUMAN [view interactions] Computational no yes
PAR1_HUMAN [view entry] [view interactions] Computational yes yes
MPRI_HUMAN [view interactions] Computational no yes
AUXI_HUMAN [view entry] [view interactions] Computational yes yes
AP4E1_HUMAN [view interactions] Computational no no