SNX2_HUMAN
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed). [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SNX2_HUMAN |
---|---|---|---|---|
GO:0045296 | cadherin binding | 27.4194 | 4 | yes |
GO:0017076 | purine nucleotide binding | 27.4194 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 27.4194 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 27.4194 | 4 | no |
GO:0035091 | phosphatidylinositol binding | 20.9677 | 4 | yes |
GO:0016462 | pyrophosphatase activity | 20.9677 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.9677 | 4 | no |
GO:0042803 | protein homodimerization activity | 17.7419 | 4 | yes |
GO:0046982 | protein heterodimerization activity | 11.2903 | 4 | yes |
GO:0070851 | growth factor receptor binding | 8.0645 | 4 | yes |
GO:0005154 | epidermal growth factor receptor binding | 6.4516 | 5 | yes |
GO:1990459 | transferrin receptor binding | 6.4516 | 4 | yes |
GO:1990460 | leptin receptor binding | 6.4516 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SNX2_HUMAN |
---|---|---|---|---|
GO:0016192 | vesicle-mediated transport | 59.6774 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 56.4516 | 4 | no |
GO:0008104 | protein localization | 54.8387 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 48.3871 | 4 | no |
GO:0071702 | organic substance transport | 45.1613 | 4 | yes |
GO:0071705 | nitrogen compound transport | 45.1613 | 4 | yes |
GO:0010646 | regulation of cell communication | 45.1613 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 45.1613 | 4 | no |
GO:0048523 | negative regulation of cellular process | 45.1613 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 45.1613 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 45.1613 | 4 | no |
GO:0006996 | organelle organization | 45.1613 | 4 | no |
GO:0015031 | protein transport | 43.5484 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 43.5484 | 4 | no |
GO:0009966 | regulation of signal transduction | 37.0968 | 4 | no |
GO:0006886 | intracellular protein transport | 35.4839 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 35.4839 | 4 | no |
GO:0051049 | regulation of transport | 35.4839 | 4 | no |
GO:0016197 | endosomal transport | 33.8710 | 4 | yes |
GO:0022607 | cellular component assembly | 33.8710 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 32.2581 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 32.2581 | 4 | no |
GO:0010468 | regulation of gene expression | 30.6452 | 5 | no |
GO:0030030 | cell projection organization | 29.0323 | 4 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.0323 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 29.0323 | 5 | no |
GO:0006897 | endocytosis | 27.4194 | 5 | yes |
GO:0033043 | regulation of organelle organization | 27.4194 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 25.8065 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 25.8065 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 25.8065 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 25.8065 | 5 | no |
GO:0016482 | cytosolic transport | 24.1935 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 24.1935 | 4 | no |
GO:0051050 | positive regulation of transport | 24.1935 | 4 | no |
GO:0061024 | membrane organization | 24.1935 | 4 | no |
GO:0009894 | regulation of catabolic process | 24.1935 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 24.1935 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.1935 | 5 | no |
GO:0010647 | positive regulation of cell communication | 22.5806 | 5 | no |
GO:0023056 | positive regulation of signaling | 22.5806 | 4 | no |
GO:0010941 | regulation of cell death | 22.5806 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 22.5806 | 5 | no |
GO:0060627 | regulation of vesicle-mediated transport | 22.5806 | 4 | no |
GO:0031344 | regulation of cell projection organization | 22.5806 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.5806 | 6 | no |
GO:0033365 | protein localization to organelle | 22.5806 | 5 | no |
GO:0006355 | regulation of DNA-templated transcription | 22.5806 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 22.5806 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 22.5806 | 5 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 22.5806 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 22.5806 | 6 | no |
GO:0009967 | positive regulation of signal transduction | 20.9677 | 5 | no |
GO:0051129 | negative regulation of cellular component organization | 20.9677 | 5 | no |
GO:0007010 | cytoskeleton organization | 20.9677 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 20.9677 | 4 | no |
GO:0042147 | retrograde transport, endosome to Golgi | 19.3548 | 5 | yes |
GO:0048193 | Golgi vesicle transport | 14.5161 | 5 | yes |
GO:0032990 | cell part morphogenesis | 12.9032 | 4 | yes |
GO:0048858 | cell projection morphogenesis | 12.9032 | 5 | yes |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 12.9032 | 6 | yes |
GO:0097581 | lamellipodium organization | 6.4516 | 6 | yes |
GO:0034498 | early endosome to Golgi transport | 4.8387 | 6 | yes |
GO:0072673 | lamellipodium morphogenesis | 4.8387 | 7 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in SNX2_HUMAN |
---|---|---|---|---|
DOID:1289 | neurodegenerative disease | 4.8387 | 4 | no |
DOID:331 | central nervous system disease | 4.8387 | 3 | no |
DOID:10595 | Charcot-Marie-Tooth disease | 3.2258 | 6 | no |
DOID:440 | neuromuscular disease | 3.2258 | 5 | no |
DOID:574 | peripheral nervous system disease | 3.2258 | 3 | no |
DOID:870 | neuropathy | 3.2258 | 4 | no |
DOID:12377 | spinal muscular atrophy | 3.2258 | 6 | no |
DOID:231 | motor neuron disease | 3.2258 | 5 | no |
DOID:332 | amyotrophic lateral sclerosis | 3.2258 | 6 | no |
DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 3.2258 | 7 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
FNBP1_HUMAN | [view interactions] | Low throughput | no | yes |
SNX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VP26A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SNX2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAMC1_HUMAN | [view interactions] | High throughput | no | yes |
NFYC_HUMAN | [view interactions] | High throughput | no | no |
ZN202_HUMAN | [view interactions] | High throughput | no | no |
SNX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CA122_HUMAN | [view interactions] | High throughput | no | no |
OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
POTB3_HUMAN | [view interactions] | High throughput | no | no |
VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYT2B_HUMAN | [view interactions] | High throughput | no | no |
HENMT_HUMAN | [view interactions] | High throughput | no | yes |
CP1A1_HUMAN | [view interactions] | High throughput | no | yes |
F221A_HUMAN | [view interactions] | High throughput | no | yes |
TRML2_HUMAN | [view interactions] | High throughput | no | no |
SNX32_HUMAN | [view interactions] | High throughput | no | no |
CK042_HUMAN | [view interactions] | High throughput | no | no |
CAST3_HUMAN | [view interactions] | High throughput | no | no |
TRI17_HUMAN | [view interactions] | High throughput | no | yes |
WASC5_HUMAN | [view interactions] | High throughput | no | yes |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
MECOM_HUMAN | [view interactions] | High throughput | no | yes |
DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TGON2_HUMAN | [view interactions] | High throughput | no | yes |
T22D1_HUMAN | [view interactions] | High throughput | no | no |
CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
INSR_HUMAN | [view interactions] | High throughput | no | yes |
VPS29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DUS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PAK6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AR6P1_HUMAN | [view interactions] | High throughput | no | yes |
YIF1A_HUMAN | [view interactions] | High throughput | no | yes |
PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
IF3M_HUMAN | [view interactions] | High throughput | no | yes |
CENPQ_HUMAN | [view interactions] | High throughput | no | yes |
PNKP_HUMAN | [view interactions] | High throughput | no | yes |
SMN_HUMAN | [view interactions] | High throughput | no | yes |
GDAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FOXL1_HUMAN | [view interactions] | High throughput | no | no |
TMM17_HUMAN | [view interactions] | High throughput | no | yes |
EPHA5_HUMAN | [view interactions] | High throughput | no | no |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
FGFR4_HUMAN | [view interactions] | High throughput | no | no |
VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
TM239_HUMAN | [view interactions] | High throughput | no | no |
AVR2B_HUMAN | [view interactions] | High throughput | no | no |
ACV1B_HUMAN | [view interactions] | High throughput | no | no |
PGFRA_HUMAN | [view interactions] | High throughput | no | no |
PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
LEPR_HUMAN | [view interactions] | High throughput | no | no |
CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
UBP46_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SFXN2_HUMAN | [view interactions] | High throughput | no | no |
DYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GNAT2_HUMAN | [view interactions] | High throughput | no | no |
F90A1_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
CA087_HUMAN | [view interactions] | High throughput | no | no |
CYB5_HUMAN | [view interactions] | High throughput | no | no |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
DRC6_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
ZDH18_HUMAN | [view interactions] | High throughput | no | yes |
ZDH23_HUMAN | [view interactions] | High throughput | no | no |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
MTM1_HUMAN | [view interactions] | High throughput | no | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
BACD3_HUMAN | [view interactions] | High throughput | no | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AURKB_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
CSN5_HUMAN | [view interactions] | High throughput | no | yes |
APR_HUMAN | [view interactions] | High throughput | no | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
NRBP_HUMAN | [view interactions] | High throughput | no | yes |
HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
S12A3_HUMAN | [view interactions] | High throughput | no | no |
BMP6_HUMAN | [view interactions] | High throughput | no | no |
GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRUN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IBPL1_HUMAN | [view interactions] | High throughput | no | no |
SPAT2_HUMAN | [view interactions] | High throughput | no | yes |
CUX2_HUMAN | [view interactions] | High throughput | no | no |
DB136_HUMAN | [view interactions] | High throughput | no | no |
KLHL1_HUMAN | [view interactions] | High throughput | no | no |
DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CBCO1_HUMAN | [view interactions] | High throughput | no | no |
RM42_HUMAN | [view interactions] | High throughput | no | yes |
WASC3_HUMAN | [view interactions] | High throughput | no | yes |
NTNG1_HUMAN | [view interactions] | High throughput | no | no |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
IKIP_HUMAN | [view interactions] | High throughput | no | no |
DJB11_HUMAN | [view interactions] | High throughput | no | yes |
SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
ECM29_HUMAN | [view interactions] | High throughput | no | no |
TPP2_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CSK_HUMAN | [view interactions] | High throughput | no | yes |
H33_HUMAN | [view interactions] | High throughput | no | yes |
HIRP3_HUMAN | [view interactions] | High throughput | no | no |
AN32E_HUMAN | [view interactions] | High throughput | no | yes |
ATG7_HUMAN | [view interactions] | High throughput | no | yes |
VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NIBA2_HUMAN | [view interactions] | High throughput | no | no |
ERF3A_HUMAN | [view interactions] | High throughput | no | yes |
ERF3B_HUMAN | [view interactions] | High throughput | no | yes |
PAWR_HUMAN | [view interactions] | High throughput | no | yes |
RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLYC_HUMAN | [view interactions] | High throughput | no | no |
STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TBC15_HUMAN | [view interactions] | High throughput | no | yes |
TBCD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PYRG1_HUMAN | [view interactions] | High throughput | no | no |
DDB1_HUMAN | [view interactions] | High throughput | no | yes |
HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
PDXK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PUR1_HUMAN | [view interactions] | High throughput | no | yes |
BRE1B_HUMAN | [view interactions] | High throughput | no | yes |
RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
INT13_HUMAN | [view interactions] | High throughput | no | no |
ENOPH_HUMAN | [view interactions] | High throughput | no | yes |
RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ERP44_HUMAN | [view interactions] | High throughput | no | yes |
MA2B1_HUMAN | [view interactions] | High throughput | no | yes |
NCBP1_HUMAN | [view interactions] | High throughput | no | yes |
PCID2_HUMAN | [view interactions] | High throughput | no | yes |
RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WDFY1_HUMAN | [view interactions] | High throughput | no | yes |
TSN_HUMAN | [view interactions] | High throughput | no | yes |
VP26B_HUMAN | [view interactions] | High throughput | no | yes |
TAOK3_HUMAN | [view interactions] | High throughput | no | yes |
DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TBCD5_HUMAN | [view interactions] | High throughput | no | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GBF1_HUMAN | [view interactions] | High throughput | no | yes |
HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RN183_HUMAN | [view interactions] | High throughput | no | no |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
BORC6_HUMAN | [view interactions] | High throughput | no | yes |
K1C18_HUMAN | [view interactions] | High throughput | no | no |
K1C19_HUMAN | [view interactions] | High throughput | no | no |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
LAMP3_HUMAN | [view interactions] | High throughput | no | no |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PEX14_HUMAN | [view interactions] | High throughput | no | yes |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TFR1_HUMAN | [view interactions] | High throughput | no | yes |
IFM3_HUMAN | [view interactions] | High throughput | no | yes |
NECP1_HUMAN | [view interactions] | Computational | no | no |
SORT_HUMAN | [view interactions] | Computational | no | yes |
AP3B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
OCRL_HUMAN | [view interactions] | Computational | no | yes |
YIPF6_HUMAN | [view interactions] | Computational | no | yes |
HSP7C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
VAMP7_HUMAN | [view interactions] | Computational | no | yes |
P3C2A_HUMAN | [view interactions] | Computational | no | yes |
AP3S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SNX9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AP4B1_HUMAN | [view interactions] | Computational | no | yes |
SNAPN_HUMAN | [view interactions] | Computational | no | yes |
DERL1_HUMAN | [view interactions] | Computational | no | yes |
PICAL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
HIP1R_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
VAPA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GAK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CBPD_HUMAN | [view interactions] | Computational | no | yes |
PAR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MPRI_HUMAN | [view interactions] | Computational | no | yes |
AUXI_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AP4E1_HUMAN | [view interactions] | Computational | no | no |