RAPH1_HUMAN
Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RAPH1_HUMAN |
---|---|---|---|---|
GO:0019900 | kinase binding | 41.9355 | 4 | no |
GO:0019901 | protein kinase binding | 38.7097 | 5 | no |
GO:0017076 | purine nucleotide binding | 29.0323 | 4 | no |
GO:0003723 | RNA binding | 25.8065 | 4 | no |
GO:0045296 | cadherin binding | 25.8065 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 25.8065 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 25.8065 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RAPH1_HUMAN |
---|---|---|---|---|
GO:0048523 | negative regulation of cellular process | 70.9677 | 4 | no |
GO:0048522 | positive regulation of cellular process | 67.7419 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 61.2903 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 58.0645 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 58.0645 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 58.0645 | 4 | no |
GO:0051128 | regulation of cellular component organization | 54.8387 | 4 | no |
GO:0022607 | cellular component assembly | 48.3871 | 4 | no |
GO:0010468 | regulation of gene expression | 45.1613 | 5 | no |
GO:0030030 | cell projection organization | 45.1613 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 45.1613 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 41.9355 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 41.9355 | 5 | no |
GO:0010646 | regulation of cell communication | 41.9355 | 4 | no |
GO:0006996 | organelle organization | 41.9355 | 4 | no |
GO:0051049 | regulation of transport | 38.7097 | 4 | no |
GO:0009966 | regulation of signal transduction | 38.7097 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 38.7097 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 38.7097 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 38.7097 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 35.4839 | 6 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 35.4839 | 4 | no |
GO:0042325 | regulation of phosphorylation | 35.4839 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 35.4839 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 35.4839 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 35.4839 | 5 | no |
GO:0007010 | cytoskeleton organization | 35.4839 | 5 | no |
GO:0060341 | regulation of cellular localization | 32.2581 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 32.2581 | 7 | no |
GO:0008104 | protein localization | 32.2581 | 4 | no |
GO:0031344 | regulation of cell projection organization | 32.2581 | 5 | no |
GO:0031399 | regulation of protein modification process | 32.2581 | 6 | no |
GO:0051130 | positive regulation of cellular component organization | 32.2581 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 32.2581 | 6 | no |
GO:0009889 | regulation of biosynthetic process | 32.2581 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.2581 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 32.2581 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 32.2581 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 32.2581 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 32.2581 | 5 | no |
GO:0097435 | supramolecular fiber organization | 32.2581 | 4 | no |
GO:0036211 | protein modification process | 29.0323 | 4 | no |
GO:0043412 | macromolecule modification | 29.0323 | 4 | no |
GO:0016192 | vesicle-mediated transport | 29.0323 | 4 | no |
GO:0032880 | regulation of protein localization | 29.0323 | 5 | no |
GO:0034330 | cell junction organization | 29.0323 | 4 | no |
GO:0051129 | negative regulation of cellular component organization | 29.0323 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 29.0323 | 6 | no |
GO:0007015 | actin filament organization | 29.0323 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 29.0323 | 4 | no |
GO:0043933 | protein-containing complex organization | 29.0323 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 25.8065 | 6 | no |
GO:0034329 | cell junction assembly | 25.8065 | 5 | no |
GO:0042327 | positive regulation of phosphorylation | 25.8065 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 25.8065 | 7 | no |
GO:0050807 | regulation of synapse organization | 25.8065 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 25.8065 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 25.8065 | 5 | no |
GO:0071310 | cellular response to organic substance | 25.8065 | 4 | no |
GO:0033043 | regulation of organelle organization | 25.8065 | 5 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 25.8065 | 5 | no |
GO:0006796 | phosphate-containing compound metabolic process | 22.5806 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 22.5806 | 4 | no |
GO:0045595 | regulation of cell differentiation | 22.5806 | 4 | no |
GO:0051094 | positive regulation of developmental process | 22.5806 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 22.5806 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 22.5806 | 6 | no |
GO:0010647 | positive regulation of cell communication | 22.5806 | 5 | no |
GO:0010941 | regulation of cell death | 22.5806 | 4 | no |
GO:0023056 | positive regulation of signaling | 22.5806 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 22.5806 | 4 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 22.5806 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 22.5806 | 6 | no |
GO:0031346 | positive regulation of cell projection organization | 22.5806 | 6 | no |
GO:0051493 | regulation of cytoskeleton organization | 22.5806 | 6 | no |
GO:0030334 | regulation of cell migration | 22.5806 | 5 | no |
GO:2000145 | regulation of cell motility | 22.5806 | 4 | no |
GO:0051050 | positive regulation of transport | 22.5806 | 4 | no |
GO:0022604 | regulation of cell morphogenesis | 22.5806 | 5 | no |
GO:0031175 | neuron projection development | 22.5806 | 6 | no |
GO:1990138 | neuron projection extension | 6.4516 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
VASP_HUMAN | [view interactions] | Low throughput | no | yes |
SH3G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SH3G3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SH3G2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TLN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
EGFR_HUMAN | [view interactions] | Low throughput | no | no |
ENAH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SIAH1_HUMAN | [view interactions] | High throughput | no | yes |
ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRGP1_HUMAN | [view interactions] | High throughput | no | no |
MATR3_HUMAN | [view interactions] | High throughput | no | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSF1R_HUMAN | [view interactions] | High throughput | no | yes |
FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LRP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STING_HUMAN | [view interactions] | High throughput | no | yes |
EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
SRGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHG12_HUMAN | [view interactions] | High throughput | no | yes |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLK1_HUMAN | [view interactions] | High throughput | no | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
ACTC_HUMAN | [view interactions] | High throughput | no | no |
GBF1_HUMAN | [view interactions] | High throughput | no | yes |
BICD1_HUMAN | [view interactions] | High throughput | no | yes |
BICD2_HUMAN | [view interactions] | High throughput | no | yes |
DCP1A_HUMAN | [view interactions] | High throughput | no | yes |
RET_HUMAN | [view interactions] | High throughput | no | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NAA40_HUMAN | [view interactions] | High throughput | no | no |