Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RAPH1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RAPH1_HUMAN
GO:0019900 kinase binding 42.1053 4 no
GO:0019901 protein kinase binding 39.4737 5 no
GO:0045296 cadherin binding 26.3158 4 no
GO:0043168 anion binding 26.3158 4 no
GO:0003723 RNA binding 26.3158 4 no
GO:0000166 nucleotide binding 23.6842 4 no
GO:0017076 purine nucleotide binding 23.6842 5 no
GO:0032555 purine ribonucleotide binding 23.6842 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.6842 4 no
GO:0003779 actin binding 21.0526 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in RAPH1_HUMAN
GO:0048523 negative regulation of cellular process 68.4211 4 no
GO:0048522 positive regulation of cellular process 65.7895 4 no
GO:0051128 regulation of cellular component organization 60.5263 4 no
GO:0060255 regulation of macromolecule metabolic process 60.5263 4 no
GO:0080090 regulation of primary metabolic process 57.8947 4 no
GO:0031323 regulation of cellular metabolic process 55.2632 4 no
GO:0022607 cellular component assembly 47.3684 4 no
GO:0009889 regulation of biosynthetic process 47.3684 4 no
GO:0010468 regulation of gene expression 47.3684 6 no
GO:0010556 regulation of macromolecule biosynthetic process 47.3684 5 no
GO:0031326 regulation of cellular biosynthetic process 47.3684 5 no
GO:0051246 regulation of protein metabolic process 47.3684 5 no
GO:0006996 organelle organization 44.7368 4 no
GO:0010646 regulation of cell communication 44.7368 4 no
GO:0009893 positive regulation of metabolic process 42.1053 4 no
GO:0010604 positive regulation of macromolecule metabolic process 42.1053 5 no
GO:0030030 cell projection organization 39.4737 4 no
GO:0009966 regulation of signal transduction 39.4737 4 no
GO:0031325 positive regulation of cellular metabolic process 39.4737 5 no
GO:0043933 protein-containing complex organization 36.8421 4 no
GO:0044087 regulation of cellular component biogenesis 36.8421 4 no
GO:0097435 supramolecular fiber organization 36.8421 4 no
GO:0120036 plasma membrane bounded cell projection organization 36.8421 5 no
GO:0009892 negative regulation of metabolic process 36.8421 4 no
GO:0010605 negative regulation of macromolecule metabolic process 36.8421 5 no
GO:0031324 negative regulation of cellular metabolic process 36.8421 5 no
GO:0051049 regulation of transport 36.8421 4 no
GO:0033043 regulation of organelle organization 34.2105 5 no
GO:0051130 positive regulation of cellular component organization 34.2105 5 no
GO:0001932 regulation of protein phosphorylation 34.2105 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 34.2105 5 no
GO:0019220 regulation of phosphate metabolic process 34.2105 6 no
GO:0031399 regulation of protein modification process 34.2105 6 no
GO:0042325 regulation of phosphorylation 34.2105 7 no
GO:0051174 regulation of phosphorus metabolic process 34.2105 5 no
GO:1902531 regulation of intracellular signal transduction 34.2105 5 no
GO:0007010 cytoskeleton organization 31.5789 5 no
GO:0051247 positive regulation of protein metabolic process 31.5789 6 no
GO:0051252 regulation of RNA metabolic process 31.5789 5 no
GO:0022603 regulation of anatomical structure morphogenesis 31.5789 4 no
GO:0008104 protein localization 31.5789 4 no
GO:0007015 actin filament organization 28.9474 5 no
GO:0044089 positive regulation of cellular component biogenesis 28.9474 5 no
GO:0006355 regulation of DNA-templated transcription 28.9474 7 no
GO:0009891 positive regulation of biosynthetic process 28.9474 5 no
GO:0031328 positive regulation of cellular biosynthetic process 28.9474 6 no
GO:2001141 regulation of RNA biosynthetic process 28.9474 6 no
GO:0009890 negative regulation of biosynthetic process 28.9474 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 28.9474 6 no
GO:0031327 negative regulation of cellular biosynthetic process 28.9474 6 no
GO:0060341 regulation of cellular localization 28.9474 4 no
GO:0010638 positive regulation of organelle organization 26.3158 6 no
GO:0006357 regulation of transcription by RNA polymerase II 26.3158 8 no
GO:0009968 negative regulation of signal transduction 26.3158 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 26.3158 6 no
GO:0010648 negative regulation of cell communication 26.3158 5 no
GO:0023057 negative regulation of signaling 26.3158 4 no
GO:0042981 regulation of apoptotic process 26.3158 5 no
GO:0043067 regulation of programmed cell death 26.3158 4 no
GO:0048585 negative regulation of response to stimulus 26.3158 4 no
GO:0051240 positive regulation of multicellular organismal process 26.3158 4 no
GO:0030334 regulation of cell migration 26.3158 5 no
GO:0031344 regulation of cell projection organization 26.3158 5 no
GO:0051129 negative regulation of cellular component organization 26.3158 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.3158 6 no
GO:2000145 regulation of cell motility 26.3158 4 no
GO:0032880 regulation of protein localization 26.3158 5 no
GO:0051050 positive regulation of transport 26.3158 4 no
GO:0051493 regulation of cytoskeleton organization 23.6842 6 no
GO:0065003 protein-containing complex assembly 23.6842 5 no
GO:1902903 regulation of supramolecular fiber organization 23.6842 5 no
GO:0010647 positive regulation of cell communication 23.6842 5 no
GO:0023056 positive regulation of signaling 23.6842 4 no
GO:0042127 regulation of cell population proliferation 23.6842 4 no
GO:0048584 positive regulation of response to stimulus 23.6842 4 no
GO:0043549 regulation of kinase activity 23.6842 5 no
GO:0051338 regulation of transferase activity 23.6842 4 no
GO:0071310 cellular response to organic substance 23.6842 4 no
GO:0034330 cell junction organization 23.6842 4 no
GO:0051094 positive regulation of developmental process 23.6842 4 no
GO:0031175 neuron projection development 21.0526 6 no
GO:0043254 regulation of protein-containing complex assembly 21.0526 5 no
GO:0008284 positive regulation of cell population proliferation 21.0526 5 no
GO:0010628 positive regulation of gene expression 21.0526 7 no
GO:0051248 negative regulation of protein metabolic process 21.0526 6 no
GO:1902532 negative regulation of intracellular signal transduction 21.0526 6 no
GO:0031401 positive regulation of protein modification process 21.0526 7 no
GO:0060627 regulation of vesicle-mediated transport 21.0526 4 no
GO:0141124 intracellular signaling cassette 21.0526 4 no
GO:0009894 regulation of catabolic process 21.0526 4 no
GO:0045595 regulation of cell differentiation 21.0526 4 no
GO:0045859 regulation of protein kinase activity 21.0526 6 no
GO:1901701 cellular response to oxygen-containing compound 21.0526 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 21.0526 5 no
GO:0051253 negative regulation of RNA metabolic process 21.0526 6 no
GO:0050807 regulation of synapse organization 21.0526 5 no
GO:1990138 neuron projection extension 5.2632 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EGFR_HUMAN [view interactions] Low throughput no no
ENAH_HUMAN [view entry] [view interactions] Low throughput yes yes
MYO10_HUMAN [view interactions] Low throughput no no
VASP_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G1_HUMAN [view entry] [view interactions] Low throughput yes no
SH3G3_HUMAN [view entry] [view interactions] Low throughput yes no
SH3G2_HUMAN [view entry] [view interactions] Low throughput yes yes
TLN1_HUMAN [view entry] [view interactions] Low throughput yes no
STING_HUMAN [view interactions] High throughput no yes
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
DYN3_HUMAN [view entry] [view interactions] High throughput yes no
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
STRAP_HUMAN [view entry] [view interactions] High throughput yes yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
SRGP3_HUMAN [view entry] [view interactions] High throughput yes yes
RHG12_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
CBL_HUMAN [view interactions] High throughput no yes
CLK1_HUMAN [view interactions] High throughput no yes
SNX2_HUMAN [view entry] [view interactions] High throughput yes no
MOES_HUMAN [view entry] [view interactions] High throughput yes no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
PTPRA_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
GBF1_HUMAN [view interactions] High throughput no yes
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
DCP1A_HUMAN [view interactions] High throughput no yes
RET_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
NAA40_HUMAN [view interactions] High throughput no no
PHLP1_HUMAN [view interactions] High throughput no yes
KDM1A_HUMAN [view interactions] High throughput no yes
HDAC1_HUMAN [view interactions] High throughput no no
RCOR1_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
MUC18_HUMAN [view interactions] High throughput no yes
WWTR1_HUMAN [view interactions] High throughput no yes
SIAH1_HUMAN [view interactions] High throughput no yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
SRGP1_HUMAN [view interactions] High throughput no no
MATR3_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes