SH3G3_HUMAN
Evidence for PS localization
Functions
Implicated in endocytosis. May recruit other proteins to membranes with high curvature . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SH3G3_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 31.3433 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 31.3433 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.8507 | 4 | no |
| GO:0046872 | metal ion binding | 25.3731 | 4 | no |
| GO:0003723 | RNA binding | 25.3731 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 22.3881 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.3881 | 5 | no |
| GO:0019900 | kinase binding | 22.3881 | 4 | no |
| GO:0005524 | ATP binding | 20.8955 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SH3G3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 49.2537 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 46.2687 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 41.7910 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 41.7910 | 4 | no |
| GO:0010646 | regulation of cell communication | 38.8060 | 4 | no |
| GO:0051049 | regulation of transport | 35.8209 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 35.8209 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 34.3284 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 34.3284 | 4 | no |
| GO:0009966 | regulation of signal transduction | 34.3284 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 29.8507 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.8507 | 5 | no |
| GO:0006996 | organelle organization | 26.8657 | 4 | no |
| GO:0051050 | positive regulation of transport | 26.8657 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 26.8657 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.8657 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 25.3731 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.3731 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.8806 | 4 | no |
| GO:0071310 | cellular response to organic substance | 23.8806 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 23.8806 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.8806 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.3881 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 22.3881 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 22.3881 | 5 | no |
| GO:0010941 | regulation of cell death | 22.3881 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.3881 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.3881 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.3881 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.3881 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.3881 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.8955 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.8955 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.8955 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.8955 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 20.8955 | 4 | no |
| GO:0022607 | cellular component assembly | 20.8955 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.8955 | 4 | no |
| GO:0032880 | regulation of protein localization | 20.8955 | 5 | no |
| GO:0060341 | regulation of cellular localization | 20.8955 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.8955 | 5 | no |
| GO:0043933 | protein-containing complex organization | 19.4030 | 4 | yes |
| GO:0030100 | regulation of endocytosis | 16.4179 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 16.4179 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 14.9254 | 4 | yes |
| GO:0051051 | negative regulation of transport | 14.9254 | 4 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 13.4328 | 6 | yes |
| GO:0022411 | cellular component disassembly | 11.9403 | 4 | yes |
| GO:0045597 | positive regulation of cell differentiation | 11.9403 | 5 | yes |
| GO:0007417 | central nervous system development | 7.4627 | 4 | yes |
| GO:0016191 | synaptic vesicle uncoating | 7.4627 | 9 | yes |
| GO:0032984 | protein-containing complex disassembly | 7.4627 | 5 | yes |
| GO:0051261 | protein depolymerization | 7.4627 | 6 | yes |
| GO:0072318 | clathrin coat disassembly | 7.4627 | 8 | yes |
| GO:0072319 | vesicle uncoating | 7.4627 | 7 | yes |
| GO:0045664 | regulation of neuron differentiation | 5.9701 | 5 | yes |
| GO:0045666 | positive regulation of neuron differentiation | 4.4776 | 6 | yes |
| GO:0045806 | negative regulation of endocytosis | 4.4776 | 5 | yes |
| GO:0048261 | negative regulation of receptor-mediated endocytosis | 4.4776 | 6 | yes |
| GO:2000369 | regulation of clathrin-dependent endocytosis | 4.4776 | 7 | yes |
| GO:1900186 | negative regulation of clathrin-dependent endocytosis | 2.9851 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SH3G3_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 7.4627 | 4 | no |
| DOID:331 | central nervous system disease | 7.4627 | 3 | no |
| DOID:0050890 | synucleinopathy | 4.4776 | 5 | no |
| DOID:0060894 | early-onset Parkinsons disease | 4.4776 | 7 | no |
| DOID:14330 | Parkinsons disease | 4.4776 | 6 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 2.9851 | 6 | no |
| DOID:440 | neuromuscular disease | 2.9851 | 5 | no |
| DOID:574 | peripheral nervous system disease | 2.9851 | 3 | no |
| DOID:870 | neuropathy | 2.9851 | 4 | no |
| DOID:12377 | spinal muscular atrophy | 2.9851 | 6 | no |
| DOID:231 | motor neuron disease | 2.9851 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAPH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FBX32_HUMAN | [view interactions] | Low throughput | no | no |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCNN3_HUMAN | [view interactions] | Low throughput | no | no |
| SH3K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYNJ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATX2_HUMAN | [view interactions] | Low throughput | no | yes |
| SH3G2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SH3G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VGLU1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MTA1_HUMAN | [view interactions] | Low throughput | no | yes |
| PUR9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDGF_HUMAN | [view interactions] | High throughput | no | yes |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A1_HUMAN | [view interactions] | High throughput | no | no |
| IF4A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| RL32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF5A1_HUMAN | [view interactions] | High throughput | no | yes |
| IF5AL_HUMAN | [view interactions] | High throughput | no | no |
| TYB10_HUMAN | [view interactions] | High throughput | no | no |
| CYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKA12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| MTAP_HUMAN | [view interactions] | High throughput | no | no |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| PA1B3_HUMAN | [view interactions] | High throughput | no | no |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITCH_HUMAN | [view interactions] | High throughput | no | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAT2B_HUMAN | [view interactions] | High throughput | no | yes |
| MEMO1_HUMAN | [view interactions] | High throughput | no | yes |
| RM32_HUMAN | [view interactions] | High throughput | no | yes |
| RT18A_HUMAN | [view interactions] | High throughput | no | yes |
| RFOX1_HUMAN | [view interactions] | High throughput | no | yes |
| RFOX2_HUMAN | [view interactions] | High throughput | no | yes |
| RFOX3_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| MCE1_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL36A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL36L_HUMAN | [view interactions] | High throughput | no | no |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMS1_HUMAN | [view interactions] | High throughput | no | yes |
| STK38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP6R3_HUMAN | [view interactions] | High throughput | no | yes |
| SCYL2_HUMAN | [view interactions] | High throughput | no | yes |
| PPHLN_HUMAN | [view interactions] | High throughput | no | yes |
| RM24_HUMAN | [view interactions] | High throughput | no | yes |
| SPNDC_HUMAN | [view interactions] | High throughput | no | yes |
| SUN2_HUMAN | [view interactions] | High throughput | no | yes |
| DPP2_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R1_HUMAN | [view interactions] | High throughput | no | no |
| RCL1_HUMAN | [view interactions] | High throughput | no | no |
| TR150_HUMAN | [view interactions] | High throughput | no | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADA2A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRD3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HRH1_HUMAN | [view interactions] | High throughput | no | no |
| DRD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADRB3_HUMAN | [view interactions] | High throughput | no | no |
| RSMN_HUMAN | [view interactions] | High throughput | no | yes |
| CRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| CD017_HUMAN | [view interactions] | High throughput | no | no |
| DPPA4_HUMAN | [view interactions] | High throughput | no | no |
| EGFL6_HUMAN | [view interactions] | High throughput | no | no |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| GABR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANKMT_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGT_HUMAN | [view interactions] | High throughput | no | no |
| RER1_HUMAN | [view interactions] | High throughput | no | yes |
| TOE1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR33_HUMAN | [view interactions] | High throughput | no | yes |
| TLE5_HUMAN | [view interactions] | High throughput | no | no |
| GDIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGSF2_HUMAN | [view interactions] | High throughput | no | yes |
| CACO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C9_HUMAN | [view interactions] | High throughput | no | no |
| CK068_HUMAN | [view interactions] | High throughput | no | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| SNX24_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| PIAS4_HUMAN | [view interactions] | High throughput | no | yes |
| PRAF1_HUMAN | [view interactions] | High throughput | no | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| RNF8_HUMAN | [view interactions] | High throughput | no | yes |
| T120B_HUMAN | [view interactions] | High throughput | no | yes |
| DYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHG08_HUMAN | [view interactions] | High throughput | no | yes |
| NCF1_HUMAN | [view interactions] | High throughput | no | no |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| M4K3_HUMAN | [view interactions] | High throughput | no | no |
| NUDT3_HUMAN | [view interactions] | High throughput | no | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AMPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| TNFL6_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARHG6_HUMAN | [view interactions] | High throughput | no | no |
| CBLC_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEPT8_HUMAN | [view interactions] | High throughput | no | no |
| SHC3_HUMAN | [view interactions] | High throughput | no | yes |
| TNNT1_HUMAN | [view interactions] | High throughput | no | no |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BUB3_HUMAN | [view interactions] | High throughput | no | yes |
| DHE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHE4_HUMAN | [view interactions] | High throughput | no | yes |
| KPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10A6_HUMAN | [view interactions] | High throughput | no | yes |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| HGB1A_HUMAN | [view interactions] | High throughput | no | no |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR2_HUMAN | [view interactions] | High throughput | no | yes |
| PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| BLVRB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| METK2_HUMAN | [view interactions] | High throughput | no | no |
| MET_HUMAN | [view interactions] | Computational | no | yes |
| ARC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PTN3_HUMAN | [view interactions] | Computational | no | yes |