Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ITA3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ITA3_HUMAN
GO:0043169 cation binding 35.4839 4 yes
GO:0046872 metal ion binding 35.4839 5 yes
GO:0000166 nucleotide binding 32.2581 4 no
GO:0017076 purine nucleotide binding 32.2581 5 no
GO:0032555 purine ribonucleotide binding 29.0323 4 no
GO:0035639 purine ribonucleoside triphosphate binding 29.0323 4 no
GO:0043168 anion binding 29.0323 4 no
GO:0019900 kinase binding 25.8065 4 no
GO:0019901 protein kinase binding 25.8065 5 no
GO:0002020 protease binding 9.6774 4 yes
GO:0046982 protein heterodimerization activity 6.4516 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ITA3_HUMAN
GO:0048522 positive regulation of cellular process 80.6452 4 yes
GO:0048523 negative regulation of cellular process 70.9677 4 yes
GO:0010646 regulation of cell communication 58.0645 4 yes
GO:0031323 regulation of cellular metabolic process 54.8387 4 yes
GO:0060255 regulation of macromolecule metabolic process 54.8387 4 yes
GO:0009889 regulation of biosynthetic process 51.6129 4 yes
GO:0010468 regulation of gene expression 51.6129 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 51.6129 5 yes
GO:0031326 regulation of cellular biosynthetic process 51.6129 5 yes
GO:0051128 regulation of cellular component organization 51.6129 4 yes
GO:0009966 regulation of signal transduction 48.3871 4 yes
GO:0009893 positive regulation of metabolic process 45.1613 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 45.1613 5 yes
GO:0031325 positive regulation of cellular metabolic process 45.1613 5 yes
GO:0080090 regulation of primary metabolic process 45.1613 4 no
GO:0051049 regulation of transport 41.9355 4 no
GO:0045595 regulation of cell differentiation 41.9355 4 no
GO:1902531 regulation of intracellular signal transduction 38.7097 5 yes
GO:0042127 regulation of cell population proliferation 38.7097 4 no
GO:0022607 cellular component assembly 38.7097 4 no
GO:0048584 positive regulation of response to stimulus 38.7097 4 no
GO:0030334 regulation of cell migration 35.4839 5 yes
GO:2000145 regulation of cell motility 35.4839 4 yes
GO:0051246 regulation of protein metabolic process 35.4839 5 no
GO:0042981 regulation of apoptotic process 35.4839 5 no
GO:0043067 regulation of programmed cell death 35.4839 4 no
GO:0009891 positive regulation of biosynthetic process 32.2581 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 32.2581 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 32.2581 6 yes
GO:0060341 regulation of cellular localization 32.2581 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 32.2581 4 no
GO:0051240 positive regulation of multicellular organismal process 32.2581 4 no
GO:0006355 regulation of DNA-templated transcription 32.2581 7 no
GO:0009890 negative regulation of biosynthetic process 32.2581 5 no
GO:0009892 negative regulation of metabolic process 32.2581 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 32.2581 6 no
GO:0010605 negative regulation of macromolecule metabolic process 32.2581 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.2581 5 no
GO:0031324 negative regulation of cellular metabolic process 32.2581 5 no
GO:0031327 negative regulation of cellular biosynthetic process 32.2581 6 no
GO:0051252 regulation of RNA metabolic process 32.2581 5 no
GO:2001141 regulation of RNA biosynthetic process 32.2581 6 no
GO:0009967 positive regulation of signal transduction 32.2581 5 no
GO:0010647 positive regulation of cell communication 32.2581 5 no
GO:0023056 positive regulation of signaling 32.2581 4 no
GO:0051094 positive regulation of developmental process 32.2581 4 no
GO:0010648 negative regulation of cell communication 29.0323 5 yes
GO:0023057 negative regulation of signaling 29.0323 4 yes
GO:0030030 cell projection organization 29.0323 4 yes
GO:0048585 negative regulation of response to stimulus 29.0323 4 yes
GO:0051130 positive regulation of cellular component organization 29.0323 5 yes
GO:0120036 plasma membrane bounded cell projection organization 29.0323 5 yes
GO:0141124 intracellular signaling cassette 29.0323 4 yes
GO:1902533 positive regulation of intracellular signal transduction 29.0323 6 no
GO:2000026 regulation of multicellular organismal development 29.0323 4 no
GO:0045597 positive regulation of cell differentiation 29.0323 5 no
GO:0009968 negative regulation of signal transduction 25.8065 5 yes
GO:0030155 regulation of cell adhesion 25.8065 4 yes
GO:0030335 positive regulation of cell migration 25.8065 6 yes
GO:0031344 regulation of cell projection organization 25.8065 5 yes
GO:0032880 regulation of protein localization 25.8065 5 yes
GO:0040017 positive regulation of locomotion 25.8065 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.8065 6 yes
GO:2000147 positive regulation of cell motility 25.8065 5 yes
GO:0098657 import into cell 25.8065 4 no
GO:0008285 negative regulation of cell population proliferation 25.8065 5 no
GO:0051726 regulation of cell cycle 25.8065 4 no
GO:0031399 regulation of protein modification process 25.8065 6 no
GO:0033043 regulation of organelle organization 25.8065 5 no
GO:0051241 negative regulation of multicellular organismal process 25.8065 4 no
GO:0051247 positive regulation of protein metabolic process 25.8065 6 no
GO:0050804 modulation of chemical synaptic transmission 25.8065 5 no
GO:0051050 positive regulation of transport 25.8065 4 no
GO:0099177 regulation of trans-synaptic signaling 25.8065 4 no
GO:0060284 regulation of cell development 25.8065 5 no
GO:0010628 positive regulation of gene expression 22.5806 7 yes
GO:0002684 positive regulation of immune system process 22.5806 4 no
GO:0006996 organelle organization 22.5806 4 no
GO:0007010 cytoskeleton organization 22.5806 5 no
GO:0036211 protein modification process 22.5806 4 no
GO:0043412 macromolecule modification 22.5806 4 no
GO:0001932 regulation of protein phosphorylation 22.5806 7 no
GO:0001934 positive regulation of protein phosphorylation 22.5806 8 no
GO:0010562 positive regulation of phosphorus metabolic process 22.5806 6 no
GO:0010629 negative regulation of gene expression 22.5806 7 no
GO:0019220 regulation of phosphate metabolic process 22.5806 6 no
GO:0031401 positive regulation of protein modification process 22.5806 7 no
GO:0032101 regulation of response to external stimulus 22.5806 4 no
GO:0042325 regulation of phosphorylation 22.5806 7 no
GO:0042327 positive regulation of phosphorylation 22.5806 8 no
GO:0043933 protein-containing complex organization 22.5806 4 no
GO:0045937 positive regulation of phosphate metabolic process 22.5806 7 no
GO:0051174 regulation of phosphorus metabolic process 22.5806 5 no
GO:0060627 regulation of vesicle-mediated transport 22.5806 4 no
GO:0008104 protein localization 22.5806 4 no
GO:0080134 regulation of response to stress 22.5806 4 no
GO:0045664 regulation of neuron differentiation 22.5806 5 no
GO:0050767 regulation of neurogenesis 22.5806 6 no
GO:0051960 regulation of nervous system development 22.5806 5 no
GO:0031346 positive regulation of cell projection organization 19.3548 6 yes
GO:0050890 cognition 19.3548 4 yes
GO:1902532 negative regulation of intracellular signal transduction 19.3548 6 yes
GO:1905475 regulation of protein localization to membrane 19.3548 6 yes
GO:0007264 small GTPase-mediated signal transduction 19.3548 5 yes
GO:0010975 regulation of neuron projection development 16.1290 7 yes
GO:0045785 positive regulation of cell adhesion 16.1290 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 16.1290 6 yes
GO:0051129 negative regulation of cellular component organization 16.1290 5 yes
GO:1903829 positive regulation of protein localization 16.1290 5 yes
GO:0001764 neuron migration 16.1290 4 yes
GO:0007160 cell-matrix adhesion 16.1290 4 yes
GO:0010632 regulation of epithelial cell migration 12.9032 4 yes
GO:0010634 positive regulation of epithelial cell migration 12.9032 5 yes
GO:0010810 regulation of cell-substrate adhesion 12.9032 5 yes
GO:0010811 positive regulation of cell-substrate adhesion 12.9032 6 yes
GO:0090287 regulation of cellular response to growth factor stimulus 12.9032 4 yes
GO:1904375 regulation of protein localization to cell periphery 12.9032 6 yes
GO:1905477 positive regulation of protein localization to membrane 12.9032 6 yes
GO:0007229 integrin-mediated signaling pathway 12.9032 4 yes
GO:0010976 positive regulation of neuron projection development 9.6774 7 yes
GO:0031345 negative regulation of cell projection organization 9.6774 6 yes
GO:0035023 regulation of Rho protein signal transduction 9.6774 7 yes
GO:0048333 mesodermal cell differentiation 9.6774 4 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 9.6774 4 yes
GO:0099173 postsynapse organization 9.6774 4 yes
GO:0007613 memory 9.6774 4 yes
GO:0030111 regulation of Wnt signaling pathway 6.4516 5 yes
GO:0035024 negative regulation of Rho protein signal transduction 6.4516 8 yes
GO:0043954 cellular component maintenance 6.4516 4 yes
GO:0051058 negative regulation of small GTPase mediated signal transduction 6.4516 7 yes
GO:0097061 dendritic spine organization 6.4516 5 yes
GO:0097062 dendritic spine maintenance 6.4516 5 yes
GO:0106027 neuron projection organization 6.4516 6 yes
GO:1903076 regulation of protein localization to plasma membrane 6.4516 7 yes
GO:1903078 positive regulation of protein localization to plasma membrane 6.4516 7 yes
GO:1904377 positive regulation of protein localization to cell periphery 6.4516 6 yes
GO:0007266 Rho protein signal transduction 6.4516 6 yes
GO:0007507 heart development 6.4516 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FINC_HUMAN [view interactions] Low throughput no yes
FHL2_HUMAN [view interactions] Low throughput no yes
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
CD9_HUMAN [view entry] [view interactions] Low throughput yes no
CD151_HUMAN [view interactions] Low throughput no no
BIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
MSS4_HUMAN [view interactions] Low throughput no yes
TSN4_HUMAN [view interactions] Low throughput no no
LEG8_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB4_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB5_HUMAN [view interactions] Low throughput no yes
CALR_HUMAN [view entry] [view interactions] Low throughput yes yes
VHL_HUMAN [view entry] [view interactions] Low throughput yes yes
SDC4_HUMAN [view interactions] Low throughput no yes
RELN_HUMAN [view entry] [view interactions] Low throughput yes no
SC6A4_HUMAN [view entry] [view interactions] Low throughput yes no
TGM2_HUMAN [view interactions] Low throughput no no
EFNA4_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
CAH9_HUMAN [view interactions] High throughput no no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
T106B_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
TSN5_HUMAN [view interactions] High throughput no no
TSN15_HUMAN [view interactions] High throughput no yes
TSN14_HUMAN [view interactions] High throughput no no
TSN12_HUMAN [view interactions] High throughput no yes
CREL2_HUMAN [view interactions] High throughput no yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K1_HUMAN [view entry] [view interactions] High throughput yes yes
ELK4_HUMAN [view interactions] High throughput no yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
LEG1_HUMAN [view interactions] High throughput no yes
RACK1_HUMAN [view interactions] High throughput no yes
PTPRM_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
FBX6_HUMAN [view interactions] High throughput no yes
EPHA2_HUMAN [view interactions] High throughput no no
RAD18_HUMAN [view interactions] High throughput no yes
SG1D1_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
GPC1_HUMAN [view entry] [view interactions] High throughput yes no
FBXW7_HUMAN [view interactions] High throughput no yes
BRD2_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
SMAD4_HUMAN [view interactions] High throughput no yes
BY55_HUMAN [view interactions] High throughput no no
CA054_HUMAN [view interactions] High throughput no yes
SG2A2_HUMAN [view interactions] High throughput no no
PSPC_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
EZH2_HUMAN [view interactions] High throughput no no
ACE2_HUMAN [view interactions] High throughput no no
EFNA1_HUMAN [view interactions] High throughput no no
EFNA3_HUMAN [view interactions] High throughput no yes