Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ITA3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ITA3_HUMAN
GO:0046872 metal ion binding 31.4286 4 yes
GO:0017076 purine nucleotide binding 31.4286 4 no
GO:0032555 purine ribonucleotide binding 31.4286 4 no
GO:0035639 purine ribonucleoside triphosphate binding 31.4286 4 no
GO:0019900 kinase binding 25.7143 4 no
GO:0019901 protein kinase binding 25.7143 5 no
GO:0002020 protease binding 11.4286 4 yes
GO:0046982 protein heterodimerization activity 5.7143 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ITA3_HUMAN
GO:0048522 positive regulation of cellular process 77.1429 4 yes
GO:0048523 negative regulation of cellular process 71.4286 4 yes
GO:0010646 regulation of cell communication 62.8571 4 yes
GO:0060255 regulation of macromolecule metabolic process 54.2857 4 yes
GO:0009966 regulation of signal transduction 51.4286 4 yes
GO:0009893 positive regulation of metabolic process 48.5714 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 48.5714 5 yes
GO:0010468 regulation of gene expression 45.7143 5 yes
GO:0051128 regulation of cellular component organization 45.7143 4 yes
GO:0031323 regulation of cellular metabolic process 45.7143 4 no
GO:0051171 regulation of nitrogen compound metabolic process 45.7143 4 no
GO:0080090 regulation of primary metabolic process 45.7143 4 no
GO:0022607 cellular component assembly 45.7143 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 42.8571 5 no
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 no
GO:0042127 regulation of cell population proliferation 40.0000 4 no
GO:0045595 regulation of cell differentiation 40.0000 4 no
GO:0030030 cell projection organization 37.1429 4 yes
GO:0030334 regulation of cell migration 37.1429 5 yes
GO:2000145 regulation of cell motility 37.1429 4 yes
GO:0048584 positive regulation of response to stimulus 37.1429 4 no
GO:0051246 regulation of protein metabolic process 37.1429 5 no
GO:0051049 regulation of transport 37.1429 4 no
GO:0009889 regulation of biosynthetic process 34.2857 4 no
GO:0010941 regulation of cell death 34.2857 4 no
GO:0031326 regulation of cellular biosynthetic process 34.2857 5 no
GO:0051094 positive regulation of developmental process 34.2857 4 no
GO:0009967 positive regulation of signal transduction 34.2857 5 no
GO:0010647 positive regulation of cell communication 34.2857 5 no
GO:0023056 positive regulation of signaling 34.2857 4 no
GO:0060341 regulation of cellular localization 31.4286 4 yes
GO:0120036 plasma membrane bounded cell projection organization 31.4286 5 yes
GO:1902531 regulation of intracellular signal transduction 31.4286 5 yes
GO:0042981 regulation of apoptotic process 31.4286 6 no
GO:0043067 regulation of programmed cell death 31.4286 5 no
GO:0022603 regulation of anatomical structure morphogenesis 31.4286 4 no
GO:0031399 regulation of protein modification process 31.4286 6 no
GO:0031401 positive regulation of protein modification process 31.4286 7 no
GO:0051247 positive regulation of protein metabolic process 31.4286 6 no
GO:0007229 integrin-mediated signaling pathway 28.5714 4 yes
GO:0030155 regulation of cell adhesion 28.5714 4 yes
GO:0030335 positive regulation of cell migration 28.5714 6 yes
GO:0032880 regulation of protein localization 28.5714 5 yes
GO:0040017 positive regulation of locomotion 28.5714 4 yes
GO:2000147 positive regulation of cell motility 28.5714 5 yes
GO:0006355 regulation of DNA-templated transcription 28.5714 6 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0051252 regulation of RNA metabolic process 28.5714 5 no
GO:1903506 regulation of nucleic acid-templated transcription 28.5714 7 no
GO:2001141 regulation of RNA biosynthetic process 28.5714 6 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0006996 organelle organization 28.5714 4 no
GO:0016192 vesicle-mediated transport 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 25.7143 5 yes
GO:0045597 positive regulation of cell differentiation 25.7143 5 no
GO:0001932 regulation of protein phosphorylation 25.7143 7 no
GO:0001934 positive regulation of protein phosphorylation 25.7143 8 no
GO:0010562 positive regulation of phosphorus metabolic process 25.7143 6 no
GO:0019220 regulation of phosphate metabolic process 25.7143 6 no
GO:0042325 regulation of phosphorylation 25.7143 7 no
GO:0042327 positive regulation of phosphorylation 25.7143 8 no
GO:0043085 positive regulation of catalytic activity 25.7143 4 no
GO:0045937 positive regulation of phosphate metabolic process 25.7143 7 no
GO:0051174 regulation of phosphorus metabolic process 25.7143 5 no
GO:2000026 regulation of multicellular organismal development 25.7143 4 no
GO:0007010 cytoskeleton organization 25.7143 5 no
GO:0031344 regulation of cell projection organization 22.8571 5 yes
GO:0048585 negative regulation of response to stimulus 22.8571 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.8571 6 yes
GO:0008285 negative regulation of cell population proliferation 22.8571 5 no
GO:0036211 protein modification process 22.8571 4 no
GO:0043412 macromolecule modification 22.8571 4 no
GO:0060548 negative regulation of cell death 22.8571 5 no
GO:0034330 cell junction organization 22.8571 4 no
GO:0080134 regulation of response to stress 22.8571 4 no
GO:1902533 positive regulation of intracellular signal transduction 22.8571 6 no
GO:0051240 positive regulation of multicellular organismal process 22.8571 4 no
GO:0006897 endocytosis 22.8571 5 no
GO:0050804 modulation of chemical synaptic transmission 22.8571 5 no
GO:0071310 cellular response to organic substance 22.8571 4 no
GO:0099177 regulation of trans-synaptic signaling 22.8571 4 no
GO:0051050 positive regulation of transport 22.8571 4 no
GO:0007160 cell-matrix adhesion 20.0000 4 yes
GO:0010648 negative regulation of cell communication 20.0000 5 yes
GO:0023057 negative regulation of signaling 20.0000 4 yes
GO:0050890 cognition 20.0000 4 yes
GO:1905475 regulation of protein localization to membrane 20.0000 6 yes
GO:0009968 negative regulation of signal transduction 17.1429 5 yes
GO:0010628 positive regulation of gene expression 17.1429 6 yes
GO:0010632 regulation of epithelial cell migration 17.1429 4 yes
GO:0031346 positive regulation of cell projection organization 17.1429 6 yes
GO:0051129 negative regulation of cellular component organization 17.1429 5 yes
GO:0090287 regulation of cellular response to growth factor stimulus 17.1429 4 yes
GO:1903829 positive regulation of protein localization 17.1429 5 yes
GO:0010634 positive regulation of epithelial cell migration 14.2857 5 yes
GO:0010810 regulation of cell-substrate adhesion 14.2857 5 yes
GO:0010975 regulation of neuron projection development 14.2857 7 yes
GO:0045785 positive regulation of cell adhesion 14.2857 5 yes
GO:0046578 regulation of Ras protein signal transduction 14.2857 7 yes
GO:0048333 mesodermal cell differentiation 14.2857 4 yes
GO:0051056 regulation of small GTPase mediated signal transduction 14.2857 6 yes
GO:1904375 regulation of protein localization to cell periphery 14.2857 6 yes
GO:1905477 positive regulation of protein localization to membrane 14.2857 6 yes
GO:0001764 neuron migration 11.4286 4 yes
GO:0007613 memory 11.4286 4 yes
GO:0010811 positive regulation of cell-substrate adhesion 11.4286 6 yes
GO:0010976 positive regulation of neuron projection development 8.5714 7 yes
GO:0031345 negative regulation of cell projection organization 8.5714 6 yes
GO:0035023 regulation of Rho protein signal transduction 8.5714 8 yes
GO:0043954 cellular component maintenance 8.5714 4 yes
GO:0099173 postsynapse organization 8.5714 4 yes
GO:1902532 negative regulation of intracellular signal transduction 8.5714 6 yes
GO:1903076 regulation of protein localization to plasma membrane 8.5714 7 yes
GO:1903078 positive regulation of protein localization to plasma membrane 8.5714 7 yes
GO:1904377 positive regulation of protein localization to cell periphery 8.5714 6 yes
GO:0007507 heart development 5.7143 4 yes
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 5.7143 6 yes
GO:0030111 regulation of Wnt signaling pathway 5.7143 5 yes
GO:0030324 lung development 5.7143 4 yes
GO:0035024 negative regulation of Rho protein signal transduction 5.7143 9 yes
GO:0046580 negative regulation of Ras protein signal transduction 5.7143 8 yes
GO:0051058 negative regulation of small GTPase mediated signal transduction 5.7143 7 yes
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 5.7143 5 yes
GO:0097061 dendritic spine organization 5.7143 5 yes
GO:0097062 dendritic spine maintenance 5.7143 5 yes
GO:0106027 neuron projection organization 5.7143 6 yes
GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 5.7143 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FHL2_HUMAN [view interactions] Low throughput no yes
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
CD9_HUMAN [view entry] [view interactions] Low throughput yes no
CD151_HUMAN [view interactions] Low throughput no no
BIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
MSS4_HUMAN [view interactions] Low throughput no yes
TSN4_HUMAN [view interactions] Low throughput no no
LEG8_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB4_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB5_HUMAN [view interactions] Low throughput no yes
CALR_HUMAN [view interactions] Low throughput no yes
VHL_HUMAN [view entry] [view interactions] Low throughput yes yes
SDC4_HUMAN [view interactions] Low throughput no yes
RELN_HUMAN [view interactions] Low throughput no no
SC6A4_HUMAN [view entry] [view interactions] Low throughput yes no
TGM2_HUMAN [view interactions] Low throughput no no
FINC_HUMAN [view interactions] Low throughput no yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
TSN5_HUMAN [view interactions] High throughput no no
TSN15_HUMAN [view interactions] High throughput no yes
TSN14_HUMAN [view interactions] High throughput no no
TSN12_HUMAN [view interactions] High throughput no yes
CREL2_HUMAN [view interactions] High throughput no yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ELK4_HUMAN [view interactions] High throughput no yes
MP2K1_HUMAN [view entry] [view interactions] High throughput yes yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
LEG1_HUMAN [view interactions] High throughput no yes
RACK1_HUMAN [view interactions] High throughput no yes
PTPRM_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
EPHA2_HUMAN [view interactions] High throughput no no
RAD18_HUMAN [view interactions] High throughput no yes
SG1D1_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
GPC1_HUMAN [view entry] [view interactions] High throughput yes no
FBXW7_HUMAN [view interactions] High throughput no yes
BRD2_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
SMAD4_HUMAN [view interactions] High throughput no yes
BY55_HUMAN [view interactions] High throughput no no
CA054_HUMAN [view interactions] High throughput no yes
SG2A2_HUMAN [view interactions] High throughput no no
PSPC_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
CAH9_HUMAN [view interactions] High throughput no no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
T106B_HUMAN [view interactions] High throughput no yes
MET_HUMAN [view interactions] Computational no yes
ARF6_HUMAN [view entry] [view interactions] Computational yes yes
ITA2_HUMAN [view interactions] Computational no yes
TSP1_HUMAN [view interactions] Computational no no
ITB2_HUMAN [view interactions] Computational no no
LAMA1_HUMAN [view interactions] Computational no no
VTNC_HUMAN [view interactions] Computational no no
ITB3_HUMAN [view entry] [view interactions] Computational yes no
JAM2_HUMAN [view interactions] Computational no no
HGF_HUMAN [view interactions] Computational no yes
LAMC1_HUMAN [view interactions] Computational no yes
NID1_HUMAN [view interactions] Computational no no
ITB6_HUMAN [view interactions] Computational no no
VLDLR_HUMAN [view interactions] Computational no yes
BGH3_HUMAN [view interactions] Computational no no
LAMB3_HUMAN [view interactions] Computational no yes
LAMA3_HUMAN [view interactions] Computational no no
LRP8_HUMAN [view entry] [view interactions] Computational yes no
ITAV_HUMAN [view interactions] Computational no yes
ITA11_HUMAN [view interactions] Computational no yes
ITB7_HUMAN [view interactions] Computational no no
ITAL_HUMAN [view interactions] Computational no no
LAMB1_HUMAN [view interactions] Computational no yes
ITA10_HUMAN [view interactions] Computational no no
FAK1_HUMAN [view entry] [view interactions] Computational yes yes
UROK_HUMAN [view interactions] Computational no no
ITA8_HUMAN [view entry] [view interactions] Computational yes no
ITA1_HUMAN [view interactions] Computational no yes
UPAR_HUMAN [view interactions] Computational no yes
JAM3_HUMAN [view interactions] Computational no no
LAMB2_HUMAN [view interactions] Computational no yes
ITB8_HUMAN [view interactions] Computational no no
ITA5_HUMAN [view entry] [view interactions] Computational yes no
ITAD_HUMAN [view interactions] Computational no no
LAMA5_HUMAN [view entry] [view interactions] Computational yes no
TLN1_HUMAN [view entry] [view interactions] Computational yes no
CD80_HUMAN [view interactions] Computational no no
LAMC2_HUMAN [view interactions] Computational no no
ITA4_HUMAN [view interactions] Computational no no
LAMA2_HUMAN [view interactions] Computational no no
DAB1_HUMAN [view interactions] Computational no yes
CD28_HUMAN [view interactions] Computational no no
BCAR1_HUMAN [view interactions] Computational no yes
CSPG4_HUMAN [view interactions] Computational no yes