Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RELN_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
672 Pro Leu Epilepsy,familialtemporallobe,7(ETL7) -
723 Tyr Cys Epilepsy,familialtemporallobe,7(ETL7) -
763 Asp Gly Epilepsy,familialtemporallobe,7(ETL7) -
798 His Asn Epilepsy,familialtemporallobe,7(ETL7) -
844 Pro Leu Epilepsy,familialtemporallobe,7(ETL7) -
2783 Gly Cys Epilepsy,familialtemporallobe,7(ETL7) -
3176 Glu Lys Epilepsy,familialtemporallobe,7(ETL7) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RELN_HUMAN
GO:0043169 cation binding 50.0000 4 yes
GO:0046872 metal ion binding 50.0000 5 yes
GO:0001618 virus receptor activity 25.0000 4 no
GO:0002020 protease binding 25.0000 4 no
GO:0046982 protein heterodimerization activity 25.0000 4 no
GO:0008236 serine-type peptidase activity 16.6667 4 yes
GO:0070325 lipoprotein particle receptor binding 16.6667 4 yes
GO:0070326 very-low-density lipoprotein particle receptor binding 16.6667 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RELN_HUMAN
GO:0048522 positive regulation of cellular process 83.3333 4 yes
GO:0010646 regulation of cell communication 83.3333 4 yes
GO:0030030 cell projection organization 75.0000 4 yes
GO:0045595 regulation of cell differentiation 75.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 75.0000 5 yes
GO:0051128 regulation of cellular component organization 75.0000 4 yes
GO:0051240 positive regulation of multicellular organismal process 75.0000 4 yes
GO:0099177 regulation of trans-synaptic signaling 75.0000 4 yes
GO:0048523 negative regulation of cellular process 66.6667 4 no
GO:0023056 positive regulation of signaling 58.3333 4 yes
GO:0031344 regulation of cell projection organization 58.3333 5 yes
GO:0045597 positive regulation of cell differentiation 58.3333 5 yes
GO:0050767 regulation of neurogenesis 58.3333 6 yes
GO:0050807 regulation of synapse organization 58.3333 5 yes
GO:0050890 cognition 58.3333 4 yes
GO:0051094 positive regulation of developmental process 58.3333 4 yes
GO:0051130 positive regulation of cellular component organization 58.3333 5 yes
GO:0051960 regulation of nervous system development 58.3333 5 yes
GO:0060284 regulation of cell development 58.3333 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 58.3333 6 yes
GO:0120036 plasma membrane bounded cell projection organization 58.3333 5 yes
GO:1902531 regulation of intracellular signal transduction 58.3333 5 yes
GO:2000026 regulation of multicellular organismal development 58.3333 4 yes
GO:0009966 regulation of signal transduction 58.3333 4 yes
GO:0010647 positive regulation of cell communication 58.3333 5 yes
GO:0010975 regulation of neuron projection development 58.3333 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 58.3333 4 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 yes
GO:0048584 positive regulation of response to stimulus 50.0000 4 yes
GO:0050769 positive regulation of neurogenesis 50.0000 6 yes
GO:0051962 positive regulation of nervous system development 50.0000 5 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 yes
GO:0009967 positive regulation of signal transduction 50.0000 5 yes
GO:0010468 regulation of gene expression 50.0000 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 yes
GO:0010720 positive regulation of cell development 50.0000 6 yes
GO:0030334 regulation of cell migration 41.6667 5 yes
GO:0030335 positive regulation of cell migration 41.6667 6 yes
GO:0031175 neuron projection development 41.6667 6 yes
GO:0031346 positive regulation of cell projection organization 41.6667 6 yes
GO:0031399 regulation of protein modification process 41.6667 6 yes
GO:0031401 positive regulation of protein modification process 41.6667 7 yes
GO:0040017 positive regulation of locomotion 41.6667 4 yes
GO:0042325 regulation of phosphorylation 41.6667 7 yes
GO:0042327 positive regulation of phosphorylation 41.6667 8 yes
GO:0045937 positive regulation of phosphate metabolic process 41.6667 7 yes
GO:0051049 regulation of transport 41.6667 4 yes
GO:0051056 regulation of small GTPase mediated signal transduction 41.6667 6 yes
GO:0051174 regulation of phosphorus metabolic process 41.6667 5 yes
GO:0051246 regulation of protein metabolic process 41.6667 5 yes
GO:0051247 positive regulation of protein metabolic process 41.6667 6 yes
GO:0080090 regulation of primary metabolic process 41.6667 4 yes
GO:1902533 positive regulation of intracellular signal transduction 41.6667 6 yes
GO:2000145 regulation of cell motility 41.6667 4 yes
GO:2000147 positive regulation of cell motility 41.6667 5 yes
GO:0001932 regulation of protein phosphorylation 41.6667 7 yes
GO:0001934 positive regulation of protein phosphorylation 41.6667 8 yes
GO:0007612 learning 41.6667 4 yes
GO:0008306 associative learning 41.6667 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 41.6667 6 yes
GO:0010976 positive regulation of neuron projection development 41.6667 7 yes
GO:0019220 regulation of phosphate metabolic process 41.6667 6 yes
GO:0022604 regulation of cell morphogenesis 33.3333 5 yes
GO:0022898 regulation of transmembrane transporter activity 33.3333 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 33.3333 5 yes
GO:0034762 regulation of transmembrane transport 33.3333 4 yes
GO:0036211 protein modification process 33.3333 4 yes
GO:0038026 reelin-mediated signaling pathway 33.3333 4 yes
GO:0043085 positive regulation of catalytic activity 33.3333 4 yes
GO:0043412 macromolecule modification 33.3333 4 yes
GO:0043549 regulation of kinase activity 33.3333 5 yes
GO:0044057 regulation of system process 33.3333 4 yes
GO:0045664 regulation of neuron differentiation 33.3333 5 yes
GO:0045859 regulation of protein kinase activity 33.3333 6 yes
GO:0048814 regulation of dendrite morphogenesis 33.3333 5 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 33.3333 8 yes
GO:0050773 regulation of dendrite development 33.3333 4 yes
GO:0050775 positive regulation of dendrite morphogenesis 33.3333 6 yes
GO:0050806 positive regulation of synaptic transmission 33.3333 5 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 33.3333 4 yes
GO:0051252 regulation of RNA metabolic process 33.3333 5 yes
GO:0051338 regulation of transferase activity 33.3333 4 yes
GO:0060998 regulation of dendritic spine development 33.3333 4 yes
GO:0060999 positive regulation of dendritic spine development 33.3333 5 yes
GO:0061001 regulation of dendritic spine morphogenesis 33.3333 5 yes
GO:0061003 positive regulation of dendritic spine morphogenesis 33.3333 6 yes
GO:0061097 regulation of protein tyrosine kinase activity 33.3333 7 yes
GO:0097485 neuron projection guidance 33.3333 7 yes
GO:0099175 regulation of postsynapse organization 33.3333 6 yes
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 yes
GO:0031345 negative regulation of cell projection organization 33.3333 6 no
GO:0045596 negative regulation of cell differentiation 33.3333 5 no
GO:0051093 negative regulation of developmental process 33.3333 4 no
GO:0051129 negative regulation of cellular component organization 33.3333 5 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0048812 neuron projection morphogenesis 33.3333 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 33.3333 4 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0001764 neuron migration 33.3333 4 yes
GO:0006355 regulation of DNA-templated transcription 33.3333 7 yes
GO:0006508 proteolysis 33.3333 4 yes
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 yes
GO:0007411 axon guidance 33.3333 8 yes
GO:0010770 positive regulation of cell morphogenesis 33.3333 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 yes
GO:0031644 regulation of nervous system process 25.0000 5 yes
GO:0032793 positive regulation of CREB transcription factor activity 25.0000 5 yes
GO:0033674 positive regulation of kinase activity 25.0000 6 yes
GO:0034764 positive regulation of transmembrane transport 25.0000 5 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 25.0000 5 yes
GO:0043269 regulation of monoatomic ion transport 25.0000 5 yes
GO:0045860 positive regulation of protein kinase activity 25.0000 7 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 25.0000 9 yes
GO:0051050 positive regulation of transport 25.0000 4 yes
GO:0051057 positive regulation of small GTPase mediated signal transduction 25.0000 7 yes
GO:0051347 positive regulation of transferase activity 25.0000 5 yes
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 25.0000 6 yes
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 25.0000 7 yes
GO:0061098 positive regulation of protein tyrosine kinase activity 25.0000 8 yes
GO:0098815 modulation of excitatory postsynaptic potential 25.0000 4 yes
GO:0099601 regulation of neurotransmitter receptor activity 25.0000 4 yes
GO:1900271 regulation of long-term synaptic potentiation 25.0000 4 yes
GO:1900273 positive regulation of long-term synaptic potentiation 25.0000 5 yes
GO:1904936 interneuron migration 25.0000 5 yes
GO:2000310 regulation of NMDA receptor activity 25.0000 5 yes
GO:0002684 positive regulation of immune system process 25.0000 4 no
GO:0002694 regulation of leukocyte activation 25.0000 4 no
GO:0008344 adult locomotory behavior 25.0000 4 no
GO:0010977 negative regulation of neuron projection development 25.0000 7 no
GO:0030155 regulation of cell adhesion 25.0000 4 no
GO:0045785 positive regulation of cell adhesion 25.0000 5 no
GO:0050865 regulation of cell activation 25.0000 4 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:0099536 synaptic signaling 25.0000 4 no
GO:0099537 trans-synaptic signaling 25.0000 5 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0032101 regulation of response to external stimulus 25.0000 4 no
GO:0042981 regulation of apoptotic process 25.0000 5 no
GO:0043067 regulation of programmed cell death 25.0000 4 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0098657 import into cell 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010628 positive regulation of gene expression 25.0000 7 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0141124 intracellular signaling cassette 25.0000 4 no
GO:1902532 negative regulation of intracellular signal transduction 25.0000 6 no
GO:0001667 ameboidal-type cell migration 25.0000 4 no
GO:0008284 positive regulation of cell population proliferation 25.0000 5 no
GO:0006996 organelle organization 25.0000 4 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0008542 visual learning 25.0000 4 no
GO:0009416 response to light stimulus 25.0000 4 no
GO:0006468 protein phosphorylation 25.0000 5 yes
GO:0007417 central nervous system development 25.0000 4 yes
GO:0007613 memory 25.0000 4 yes
GO:0008104 protein localization 25.0000 4 yes
GO:0016310 phosphorylation 25.0000 5 yes
GO:0032006 regulation of TOR signaling 16.6667 6 yes
GO:0032008 positive regulation of TOR signaling 16.6667 7 yes
GO:0032411 positive regulation of transporter activity 16.6667 4 yes
GO:0032414 positive regulation of ion transmembrane transporter activity 16.6667 5 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 16.6667 6 yes
GO:0035418 protein localization to synapse 16.6667 6 yes
GO:0043113 receptor clustering 16.6667 5 yes
GO:0043270 positive regulation of monoatomic ion transport 16.6667 5 yes
GO:0050795 regulation of behavior 16.6667 4 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 16.6667 6 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 16.6667 6 yes
GO:0060025 regulation of synaptic activity 16.6667 6 yes
GO:0060291 long-term synaptic potentiation 16.6667 4 yes
GO:0072578 neurotransmitter-gated ion channel clustering 16.6667 6 yes
GO:0072657 protein localization to membrane 16.6667 4 yes
GO:0090128 regulation of synapse maturation 16.6667 4 yes
GO:0090129 positive regulation of synapse maturation 16.6667 5 yes
GO:0097114 NMDA glutamate receptor clustering 16.6667 7 yes
GO:0097119 postsynaptic density protein 95 clustering 16.6667 5 yes
GO:0097475 motor neuron migration 16.6667 5 yes
GO:0097476 spinal cord motor neuron migration 16.6667 6 yes
GO:0097477 lateral motor column neuron migration 16.6667 7 yes
GO:1902076 regulation of lateral motor column neuron migration 16.6667 8 yes
GO:1902078 positive regulation of lateral motor column neuron migration 16.6667 9 yes
GO:1902414 protein localization to cell junction 16.6667 5 yes
GO:1905483 regulation of motor neuron migration 16.6667 7 yes
GO:1905485 positive regulation of motor neuron migration 16.6667 8 yes
GO:2000273 positive regulation of signaling receptor activity 16.6667 4 yes
GO:2000311 regulation of AMPA receptor activity 16.6667 5 yes
GO:2000463 positive regulation of excitatory postsynaptic potential 16.6667 5 yes
GO:2000969 positive regulation of AMPA receptor activity 16.6667 5 yes
GO:2001222 regulation of neuron migration 16.6667 6 yes
GO:2001224 positive regulation of neuron migration 16.6667 7 yes
GO:0007420 brain development 16.6667 4 yes
GO:0007616 long-term memory 16.6667 5 yes
GO:0010001 glial cell differentiation 16.6667 4 yes
GO:0018108 peptidyl-tyrosine phosphorylation 16.6667 6 yes
GO:0018193 peptidyl-amino acid modification 16.6667 5 yes
GO:0018212 peptidyl-tyrosine modification 16.6667 6 yes
GO:0021511 spinal cord patterning 16.6667 4 yes
GO:0021795 cerebral cortex cell migration 16.6667 6 yes
GO:0021800 cerebral cortex tangential migration 16.6667 7 yes
GO:0021885 forebrain cell migration 16.6667 4 yes
GO:0022029 telencephalon cell migration 16.6667 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LRP8_HUMAN [view entry] [view interactions] Low throughput yes no
VLDLR_HUMAN [view interactions] Low throughput no yes
EFNB3_HUMAN [view entry] [view interactions] Low throughput yes yes
EFNB2_HUMAN [view entry] [view interactions] Low throughput yes yes
RELN_HUMAN [view entry] [view interactions] Low throughput yes no
EFNB1_HUMAN [view interactions] Low throughput no yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
ITA3_HUMAN [view entry] [view interactions] Low throughput yes yes
PCDA4_HUMAN [view interactions] Low throughput no yes
CNR1_HUMAN [view interactions] Low throughput no yes
LIS1_HUMAN [view entry] [view interactions] Low throughput yes yes
CNR2_HUMAN [view entry] [view interactions] Low throughput yes yes
DAB1_HUMAN [view interactions] Low throughput no yes
DNMT1_HUMAN [view interactions] Low throughput no no
TET1_HUMAN [view interactions] Low throughput no no
MBD2_HUMAN [view interactions] Low throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
RSPH1_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
SQSTM_HUMAN [view interactions] High throughput no yes