LRP8_HUMAN
Evidence for PS localization
Functions
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 . Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001563 | LIG_PTB_Apo_2 | LIG | 860 | 867 | - |
| ELMI001563 | LIG_PTB_Apo_2 | LIG | 860 | 867 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LRP8_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 32.3529 | 4 | no |
| GO:0019001 | guanyl nucleotide binding | 29.4118 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 29.4118 | 4 | no |
| GO:0032561 | guanyl ribonucleotide binding | 29.4118 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.4118 | 4 | no |
| GO:0000166 | nucleotide binding | 29.4118 | 4 | no |
| GO:0003924 | GTPase activity | 29.4118 | 7 | no |
| GO:0005525 | GTP binding | 29.4118 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 29.4118 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 29.4118 | 4 | no |
| GO:0017076 | purine nucleotide binding | 29.4118 | 5 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 29.4118 | 6 | no |
| GO:0019003 | GDP binding | 26.4706 | 5 | no |
| GO:0043169 | cation binding | 20.5882 | 4 | yes |
| GO:0046872 | metal ion binding | 20.5882 | 5 | yes |
| GO:0019894 | kinesin binding | 11.7647 | 4 | yes |
| GO:0005509 | calcium ion binding | 8.8235 | 6 | yes |
| GO:0071813 | lipoprotein particle binding | 8.8235 | 4 | yes |
| GO:0008035 | high-density lipoprotein particle binding | 5.8824 | 5 | yes |
| GO:0038025 | reelin receptor activity | 5.8824 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LRP8_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 82.3529 | 4 | yes |
| GO:0010646 | regulation of cell communication | 64.7059 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 58.8235 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 52.9412 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 47.0588 | 4 | yes |
| GO:0051049 | regulation of transport | 47.0588 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 44.1176 | 5 | yes |
| GO:0008104 | protein localization | 44.1176 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 44.1176 | 5 | yes |
| GO:0030030 | cell projection organization | 41.1765 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 41.1765 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 41.1765 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 41.1765 | 5 | no |
| GO:0023056 | positive regulation of signaling | 41.1765 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 41.1765 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 41.1765 | 4 | no |
| GO:0006996 | organelle organization | 41.1765 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 41.1765 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 38.2353 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 38.2353 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 38.2353 | 6 | yes |
| GO:0009967 | positive regulation of signal transduction | 38.2353 | 5 | no |
| GO:0022607 | cellular component assembly | 38.2353 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.2353 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.2353 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 35.2941 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 35.2941 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 35.2941 | 6 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 35.2941 | 5 | no |
| GO:0071702 | organic substance transport | 35.2941 | 4 | no |
| GO:0071705 | nitrogen compound transport | 35.2941 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 32.3529 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 32.3529 | 6 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 32.3529 | 6 | yes |
| GO:0015031 | protein transport | 32.3529 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 32.3529 | 7 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.3529 | 5 | yes |
| GO:0042325 | regulation of phosphorylation | 29.4118 | 7 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 29.4118 | 5 | yes |
| GO:0051338 | regulation of transferase activity | 29.4118 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 29.4118 | 7 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 29.4118 | 6 | yes |
| GO:0031401 | positive regulation of protein modification process | 26.4706 | 7 | yes |
| GO:0042981 | regulation of apoptotic process | 26.4706 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 26.4706 | 4 | yes |
| GO:0043549 | regulation of kinase activity | 26.4706 | 5 | yes |
| GO:0045859 | regulation of protein kinase activity | 26.4706 | 6 | yes |
| GO:0050807 | regulation of synapse organization | 26.4706 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 26.4706 | 4 | yes |
| GO:0098657 | import into cell | 26.4706 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 26.4706 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.4706 | 4 | no |
| GO:0051050 | positive regulation of transport | 26.4706 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 26.4706 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.4706 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 26.4706 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.4706 | 5 | no |
| GO:0009894 | regulation of catabolic process | 26.4706 | 4 | no |
| GO:0031346 | positive regulation of cell projection organization | 23.5294 | 6 | yes |
| GO:0043085 | positive regulation of catalytic activity | 23.5294 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 23.5294 | 4 | yes |
| GO:0099536 | synaptic signaling | 23.5294 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 23.5294 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 23.5294 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 23.5294 | 4 | no |
| GO:0030334 | regulation of cell migration | 23.5294 | 5 | no |
| GO:0031175 | neuron projection development | 23.5294 | 6 | no |
| GO:0050890 | cognition | 23.5294 | 4 | no |
| GO:2000145 | regulation of cell motility | 23.5294 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.5294 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.5294 | 4 | no |
| GO:0051726 | regulation of cell cycle | 23.5294 | 4 | no |
| GO:0016050 | vesicle organization | 23.5294 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 23.5294 | 7 | yes |
| GO:0048812 | neuron projection morphogenesis | 20.5882 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 20.5882 | 4 | yes |
| GO:0051347 | positive regulation of transferase activity | 20.5882 | 5 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 20.5882 | 6 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 20.5882 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 20.5882 | 4 | yes |
| GO:0006886 | intracellular protein transport | 20.5882 | 4 | no |
| GO:0033043 | regulation of organelle organization | 20.5882 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 20.5882 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 20.5882 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.5882 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.5882 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.5882 | 4 | no |
| GO:0044057 | regulation of system process | 20.5882 | 4 | no |
| GO:0072657 | protein localization to membrane | 20.5882 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.5882 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.5882 | 6 | no |
| GO:0043933 | protein-containing complex organization | 20.5882 | 4 | no |
| GO:0010564 | regulation of cell cycle process | 20.5882 | 5 | no |
| GO:0009896 | positive regulation of catabolic process | 20.5882 | 5 | no |
| GO:0032880 | regulation of protein localization | 20.5882 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.5882 | 5 | no |
| GO:0006915 | apoptotic process | 20.5882 | 4 | no |
| GO:0007010 | cytoskeleton organization | 20.5882 | 5 | no |
| GO:0007268 | chemical synaptic transmission | 20.5882 | 7 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.5882 | 4 | yes |
| GO:0042327 | positive regulation of phosphorylation | 17.6471 | 8 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 17.6471 | 7 | yes |
| GO:0050767 | regulation of neurogenesis | 17.6471 | 6 | yes |
| GO:0051960 | regulation of nervous system development | 17.6471 | 5 | yes |
| GO:0060284 | regulation of cell development | 17.6471 | 5 | yes |
| GO:0060998 | regulation of dendritic spine development | 17.6471 | 4 | yes |
| GO:0080134 | regulation of response to stress | 17.6471 | 4 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 17.6471 | 8 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 17.6471 | 6 | yes |
| GO:0010976 | positive regulation of neuron projection development | 17.6471 | 7 | yes |
| GO:0032101 | regulation of response to external stimulus | 14.7059 | 4 | yes |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 14.7059 | 8 | yes |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | 14.7059 | 4 | yes |
| GO:0061097 | regulation of protein tyrosine kinase activity | 14.7059 | 7 | yes |
| GO:0071310 | cellular response to organic substance | 14.7059 | 4 | yes |
| GO:0099175 | regulation of postsynapse organization | 14.7059 | 6 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 14.7059 | 4 | yes |
| GO:0006508 | proteolysis | 14.7059 | 4 | yes |
| GO:0022604 | regulation of cell morphogenesis | 11.7647 | 5 | yes |
| GO:0031347 | regulation of defense response | 11.7647 | 5 | yes |
| GO:0033674 | positive regulation of kinase activity | 11.7647 | 6 | yes |
| GO:0045597 | positive regulation of cell differentiation | 11.7647 | 5 | yes |
| GO:0045860 | positive regulation of protein kinase activity | 11.7647 | 7 | yes |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 11.7647 | 9 | yes |
| GO:0050769 | positive regulation of neurogenesis | 11.7647 | 6 | yes |
| GO:0050773 | regulation of dendrite development | 11.7647 | 4 | yes |
| GO:0050776 | regulation of immune response | 11.7647 | 4 | yes |
| GO:0051962 | positive regulation of nervous system development | 11.7647 | 5 | yes |
| GO:0060999 | positive regulation of dendritic spine development | 11.7647 | 5 | yes |
| GO:0061001 | regulation of dendritic spine morphogenesis | 11.7647 | 5 | yes |
| GO:0061098 | positive regulation of protein tyrosine kinase activity | 11.7647 | 8 | yes |
| GO:0097305 | response to alcohol | 11.7647 | 4 | yes |
| GO:0010720 | positive regulation of cell development | 11.7647 | 6 | yes |
| GO:0032793 | positive regulation of CREB transcription factor activity | 8.8235 | 5 | yes |
| GO:0033993 | response to lipid | 8.8235 | 4 | yes |
| GO:0038026 | reelin-mediated signaling pathway | 8.8235 | 4 | yes |
| GO:0045088 | regulation of innate immune response | 8.8235 | 5 | yes |
| GO:0048813 | dendrite morphogenesis | 8.8235 | 6 | yes |
| GO:0048814 | regulation of dendrite morphogenesis | 8.8235 | 5 | yes |
| GO:0050775 | positive regulation of dendrite morphogenesis | 8.8235 | 6 | yes |
| GO:0061003 | positive regulation of dendritic spine morphogenesis | 8.8235 | 6 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 8.8235 | 4 | yes |
| GO:0071396 | cellular response to lipid | 8.8235 | 5 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 8.8235 | 5 | yes |
| GO:0002831 | regulation of response to biotic stimulus | 8.8235 | 4 | yes |
| GO:0010770 | positive regulation of cell morphogenesis | 8.8235 | 6 | yes |
| GO:0014070 | response to organic cyclic compound | 8.8235 | 4 | yes |
| GO:0036314 | response to sterol | 5.8824 | 4 | yes |
| GO:0036315 | cellular response to sterol | 5.8824 | 5 | yes |
| GO:0070723 | response to cholesterol | 5.8824 | 5 | yes |
| GO:0071397 | cellular response to cholesterol | 5.8824 | 6 | yes |
| GO:0097306 | cellular response to alcohol | 5.8824 | 5 | yes |
| GO:1900006 | positive regulation of dendrite development | 5.8824 | 5 | yes |
| GO:0001523 | retinoid metabolic process | 5.8824 | 7 | yes |
| GO:0006720 | isoprenoid metabolic process | 5.8824 | 4 | yes |
| GO:0006721 | terpenoid metabolic process | 5.8824 | 5 | yes |
| GO:0016101 | diterpenoid metabolic process | 5.8824 | 6 | yes |
| GO:0019221 | cytokine-mediated signaling pathway | 5.8824 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| JIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DAB1_HUMAN | [view interactions] | Low throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RELN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AMRP_HUMAN | [view interactions] | Low throughput | no | yes |
| EFNB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| APC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VGFR2_HUMAN | [view interactions] | Low throughput | no | no |
| APOH_HUMAN | [view interactions] | Low throughput | no | no |
| APOE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNX17_HUMAN | [view interactions] | Low throughput | no | yes |
| VLDLR_HUMAN | [view interactions] | Low throughput | no | yes |
| LRP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| APBA1_HUMAN | [view interactions] | Low throughput | no | no |
| APBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COPT1_HUMAN | [view interactions] | Low throughput | no | no |
| XCT_HUMAN | [view interactions] | Low throughput | no | no |
| MK_HUMAN | [view interactions] | Low throughput | no | no |
| DAB2_HUMAN | [view interactions] | Low throughput | no | yes |
| MYLIP_HUMAN | [view interactions] | Low throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALBU_HUMAN | [view interactions] | High throughput | no | no |
| CRTC3_HUMAN | [view interactions] | High throughput | no | no |
| CAMP3_HUMAN | [view interactions] | High throughput | no | no |
| PKRI1_HUMAN | [view interactions] | High throughput | no | no |
| RAD51_HUMAN | [view interactions] | High throughput | no | yes |
| PRCC_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK6_HUMAN | [view interactions] | High throughput | no | yes |
| ANGE2_HUMAN | [view interactions] | High throughput | no | yes |
| GHDC_HUMAN | [view interactions] | High throughput | no | yes |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| SSXT_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| GIPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYJ2B_HUMAN | [view interactions] | High throughput | no | no |
| CAPON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCN3A_HUMAN | [view interactions] | High throughput | no | yes |
| APBA2_HUMAN | [view interactions] | High throughput | no | yes |
| ITBP1_HUMAN | [view interactions] | High throughput | no | no |
| APC10_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| TYK2_HUMAN | [view interactions] | High throughput | no | no |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| RHG39_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CS047_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| CFAH_HUMAN | [view interactions] | High throughput | no | no |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| DEN6A_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |