Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LRP8_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 . Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI001563 LIG_PTB_Apo_2 LIG 860 867 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LRP8_HUMAN
GO:0046872 metal ion binding 34.7826 4 yes
GO:0017076 purine nucleotide binding 28.2609 4 no
GO:0032555 purine ribonucleotide binding 28.2609 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.2609 4 no
GO:0019900 kinase binding 23.9130 4 no
GO:0019901 protein kinase binding 23.9130 5 no
GO:0003924 GTPase activity 21.7391 7 no
GO:0005525 GTP binding 21.7391 5 no
GO:0016462 pyrophosphatase activity 21.7391 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.7391 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.7391 6 no
GO:0019001 guanyl nucleotide binding 21.7391 5 no
GO:0032561 guanyl ribonucleotide binding 21.7391 5 no
GO:0001540 amyloid-beta binding 17.3913 4 yes
GO:0019894 kinesin binding 10.8696 4 yes
GO:0005509 calcium ion binding 8.6957 5 yes
GO:0071813 lipoprotein particle binding 6.5217 4 yes
GO:0008035 high-density lipoprotein particle binding 4.3478 5 yes
GO:0038025 reelin receptor activity 4.3478 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in LRP8_HUMAN
GO:0048522 positive regulation of cellular process 82.6087 4 yes
GO:0010646 regulation of cell communication 76.0870 4 yes
GO:0051128 regulation of cellular component organization 69.5652 4 yes
GO:0009966 regulation of signal transduction 60.8696 4 no
GO:0060255 regulation of macromolecule metabolic process 56.5217 4 yes
GO:0048523 negative regulation of cellular process 56.5217 4 no
GO:0080090 regulation of primary metabolic process 54.3478 4 yes
GO:0009893 positive regulation of metabolic process 52.1739 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 52.1739 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 yes
GO:0051246 regulation of protein metabolic process 50.0000 5 yes
GO:0031323 regulation of cellular metabolic process 47.8261 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 47.8261 5 yes
GO:0051049 regulation of transport 47.8261 4 no
GO:0051247 positive regulation of protein metabolic process 45.6522 6 yes
GO:0010647 positive regulation of cell communication 43.4783 5 no
GO:0023056 positive regulation of signaling 43.4783 4 no
GO:1902531 regulation of intracellular signal transduction 43.4783 5 no
GO:0010468 regulation of gene expression 41.3043 5 yes
GO:0010941 regulation of cell death 41.3043 4 yes
GO:0031325 positive regulation of cellular metabolic process 41.3043 5 yes
GO:0022607 cellular component assembly 41.3043 4 no
GO:0048584 positive regulation of response to stimulus 41.3043 4 no
GO:0008104 protein localization 41.3043 4 no
GO:0030030 cell projection organization 39.1304 4 yes
GO:0031344 regulation of cell projection organization 39.1304 5 yes
GO:0043085 positive regulation of catalytic activity 39.1304 4 yes
GO:0050804 modulation of chemical synaptic transmission 39.1304 5 yes
GO:0051130 positive regulation of cellular component organization 39.1304 5 yes
GO:0099177 regulation of trans-synaptic signaling 39.1304 4 yes
GO:0009967 positive regulation of signal transduction 39.1304 5 no
GO:0009889 regulation of biosynthetic process 36.9565 4 yes
GO:0031326 regulation of cellular biosynthetic process 36.9565 5 yes
GO:0031399 regulation of protein modification process 36.9565 6 yes
GO:0042981 regulation of apoptotic process 36.9565 6 yes
GO:0043067 regulation of programmed cell death 36.9565 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 36.9565 6 yes
GO:0006996 organelle organization 36.9565 4 no
GO:0001932 regulation of protein phosphorylation 34.7826 7 yes
GO:0016192 vesicle-mediated transport 34.7826 4 yes
GO:0019220 regulation of phosphate metabolic process 34.7826 6 yes
GO:0042325 regulation of phosphorylation 34.7826 7 yes
GO:0051174 regulation of phosphorus metabolic process 34.7826 5 yes
GO:0048585 negative regulation of response to stimulus 34.7826 4 no
GO:0060341 regulation of cellular localization 32.6087 4 no
GO:0120036 plasma membrane bounded cell projection organization 32.6087 5 no
GO:0009968 negative regulation of signal transduction 32.6087 5 no
GO:0010648 negative regulation of cell communication 32.6087 5 no
GO:0023057 negative regulation of signaling 32.6087 4 no
GO:1902533 positive regulation of intracellular signal transduction 32.6087 6 no
GO:0006355 regulation of DNA-templated transcription 30.4348 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 30.4348 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.4348 5 yes
GO:0045595 regulation of cell differentiation 30.4348 4 yes
GO:0051094 positive regulation of developmental process 30.4348 4 yes
GO:0051252 regulation of RNA metabolic process 30.4348 5 yes
GO:0080134 regulation of response to stress 30.4348 4 yes
GO:1903506 regulation of nucleic acid-templated transcription 30.4348 7 yes
GO:2001141 regulation of RNA biosynthetic process 30.4348 6 yes
GO:0044087 regulation of cellular component biogenesis 30.4348 4 no
GO:0015031 protein transport 30.4348 4 no
GO:0042127 regulation of cell population proliferation 30.4348 4 no
GO:0051129 negative regulation of cellular component organization 30.4348 5 no
GO:0071702 organic substance transport 30.4348 4 no
GO:0071705 nitrogen compound transport 30.4348 4 no
GO:0060627 regulation of vesicle-mediated transport 30.4348 4 no
GO:0022603 regulation of anatomical structure morphogenesis 28.2609 4 yes
GO:0031401 positive regulation of protein modification process 28.2609 7 yes
GO:0051240 positive regulation of multicellular organismal process 28.2609 4 yes
GO:0051338 regulation of transferase activity 28.2609 4 yes
GO:0071310 cellular response to organic substance 28.2609 4 yes
GO:0050890 cognition 28.2609 4 no
GO:0032880 regulation of protein localization 28.2609 5 no
GO:0030334 regulation of cell migration 28.2609 5 no
GO:0033043 regulation of organelle organization 28.2609 5 no
GO:2000145 regulation of cell motility 28.2609 4 no
GO:0010942 positive regulation of cell death 28.2609 5 no
GO:0009892 negative regulation of metabolic process 28.2609 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.2609 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 28.2609 5 no
GO:0010975 regulation of neuron projection development 26.0870 7 yes
GO:0043549 regulation of kinase activity 26.0870 5 yes
GO:0045859 regulation of protein kinase activity 26.0870 6 yes
GO:0050807 regulation of synapse organization 26.0870 5 yes
GO:0009891 positive regulation of biosynthetic process 26.0870 5 no
GO:0031328 positive regulation of cellular biosynthetic process 26.0870 6 no
GO:0051050 positive regulation of transport 26.0870 4 no
GO:0031324 negative regulation of cellular metabolic process 26.0870 5 no
GO:0051248 negative regulation of protein metabolic process 26.0870 6 no
GO:0009894 regulation of catabolic process 26.0870 4 no
GO:0001934 positive regulation of protein phosphorylation 23.9130 8 yes
GO:0006897 endocytosis 23.9130 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 23.9130 6 yes
GO:0031346 positive regulation of cell projection organization 23.9130 6 yes
GO:0042327 positive regulation of phosphorylation 23.9130 8 yes
GO:0045937 positive regulation of phosphate metabolic process 23.9130 7 yes
GO:0099537 trans-synaptic signaling 23.9130 4 yes
GO:1901701 cellular response to oxygen-containing compound 23.9130 4 yes
GO:2000026 regulation of multicellular organismal development 23.9130 4 yes
GO:0006886 intracellular protein transport 23.9130 4 no
GO:0060548 negative regulation of cell death 23.9130 5 no
GO:0030100 regulation of endocytosis 23.9130 5 no
GO:0007268 chemical synaptic transmission 21.7391 6 yes
GO:0050776 regulation of immune response 21.7391 4 yes
GO:0098916 anterograde trans-synaptic signaling 21.7391 5 yes
GO:0010243 response to organonitrogen compound 21.7391 4 no
GO:0043933 protein-containing complex organization 21.7391 4 no
GO:0065003 protein-containing complex assembly 21.7391 5 no
GO:1905475 regulation of protein localization to membrane 21.7391 6 no
GO:0031175 neuron projection development 21.7391 6 no
GO:0030335 positive regulation of cell migration 21.7391 6 no
GO:0040017 positive regulation of locomotion 21.7391 4 no
GO:0080135 regulation of cellular response to stress 21.7391 4 no
GO:2000147 positive regulation of cell motility 21.7391 5 no
GO:0043065 positive regulation of apoptotic process 21.7391 7 no
GO:0043068 positive regulation of programmed cell death 21.7391 6 no
GO:0043408 regulation of MAPK cascade 21.7391 6 no
GO:0032990 cell part morphogenesis 19.5652 4 yes
GO:0045597 positive regulation of cell differentiation 19.5652 5 yes
GO:0048812 neuron projection morphogenesis 19.5652 7 yes
GO:0048858 cell projection morphogenesis 19.5652 5 yes
GO:0051347 positive regulation of transferase activity 19.5652 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 19.5652 6 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 17.3913 8 yes
GO:0060284 regulation of cell development 17.3913 5 yes
GO:0070848 response to growth factor 17.3913 4 yes
GO:0071363 cellular response to growth factor stimulus 17.3913 5 yes
GO:0022604 regulation of cell morphogenesis 15.2174 5 yes
GO:0033674 positive regulation of kinase activity 15.2174 6 yes
GO:0045860 positive regulation of protein kinase activity 15.2174 7 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 15.2174 9 yes
GO:0051960 regulation of nervous system development 15.2174 5 yes
GO:0097305 response to alcohol 15.2174 4 yes
GO:0099175 regulation of postsynapse organization 15.2174 6 yes
GO:0010720 positive regulation of cell development 13.0435 6 yes
GO:0010976 positive regulation of neuron projection development 13.0435 7 yes
GO:0014070 response to organic cyclic compound 13.0435 4 yes
GO:0032101 regulation of response to external stimulus 13.0435 4 yes
GO:0050767 regulation of neurogenesis 13.0435 6 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 13.0435 4 yes
GO:0031347 regulation of defense response 10.8696 5 yes
GO:0033993 response to lipid 10.8696 4 yes
GO:0048813 dendrite morphogenesis 10.8696 8 yes
GO:0050773 regulation of dendrite development 10.8696 4 yes
GO:0051962 positive regulation of nervous system development 10.8696 5 yes
GO:0060998 regulation of dendritic spine development 10.8696 4 yes
GO:0061097 regulation of protein tyrosine kinase activity 10.8696 7 yes
GO:0071407 cellular response to organic cyclic compound 10.8696 5 yes
GO:0002831 regulation of response to biotic stimulus 8.6957 4 yes
GO:0010769 regulation of cell morphogenesis involved in differentiation 8.6957 6 yes
GO:0010770 positive regulation of cell morphogenesis involved in differentiation 8.6957 7 yes
GO:0045088 regulation of innate immune response 8.6957 5 yes
GO:0050769 positive regulation of neurogenesis 8.6957 6 yes
GO:0061098 positive regulation of protein tyrosine kinase activity 8.6957 8 yes
GO:0071396 cellular response to lipid 8.6957 5 yes
GO:0006508 proteolysis 6.5217 4 yes
GO:0038026 reelin-mediated signaling pathway 6.5217 4 yes
GO:0060999 positive regulation of dendritic spine development 6.5217 5 yes
GO:0061001 regulation of dendritic spine morphogenesis 6.5217 5 yes
GO:1900006 positive regulation of dendrite development 6.5217 5 yes
GO:0001523 retinoid metabolic process 4.3478 7 yes
GO:0006720 isoprenoid metabolic process 4.3478 4 yes
GO:0006721 terpenoid metabolic process 4.3478 5 yes
GO:0016101 diterpenoid metabolic process 4.3478 6 yes
GO:0019221 cytokine-mediated signaling pathway 4.3478 4 yes
GO:0032793 positive regulation of CREB transcription factor activity 4.3478 5 yes
GO:0036314 response to sterol 4.3478 4 yes
GO:0036315 cellular response to sterol 4.3478 5 yes
GO:0048814 regulation of dendrite morphogenesis 4.3478 5 yes
GO:0050775 positive regulation of dendrite morphogenesis 4.3478 6 yes
GO:0061003 positive regulation of dendritic spine morphogenesis 4.3478 6 yes
GO:0070723 response to cholesterol 4.3478 5 yes
GO:0071397 cellular response to cholesterol 4.3478 6 yes
GO:0097306 cellular response to alcohol 4.3478 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in LRP8_HUMAN
DOID:0050686 organ system cancer 4.3478 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
JIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
JIP2_HUMAN [view entry] [view interactions] Low throughput yes no
DAB1_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
RELN_HUMAN [view interactions] Low throughput no no
AMRP_HUMAN [view interactions] Low throughput no yes
EFNB3_HUMAN [view entry] [view interactions] Low throughput yes yes
APC_HUMAN [view entry] [view interactions] Low throughput yes no
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
VGFR2_HUMAN [view interactions] Low throughput no no
APOH_HUMAN [view interactions] Low throughput no no
APOE_HUMAN [view entry] [view interactions] Low throughput yes yes
SNX17_HUMAN [view interactions] Low throughput no yes
VLDLR_HUMAN [view interactions] Low throughput no yes
LRP8_HUMAN [view entry] [view interactions] Low throughput yes no
APBA1_HUMAN [view interactions] Low throughput no no
APBB1_HUMAN [view interactions] Low throughput no yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
MK_HUMAN [view interactions] Low throughput no no
DAB2_HUMAN [view interactions] Low throughput no yes
MYLIP_HUMAN [view interactions] Low throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
GHDC_HUMAN [view interactions] High throughput no yes
ANGE2_HUMAN [view interactions] High throughput no yes
DOCK6_HUMAN [view interactions] High throughput no yes
PRCC_HUMAN [view interactions] High throughput no yes
RAD51_HUMAN [view interactions] High throughput no yes
PKRI1_HUMAN [view interactions] High throughput no no
CAMP3_HUMAN [view interactions] High throughput no no
CRTC3_HUMAN [view interactions] High throughput no no
ALBU_HUMAN [view interactions] High throughput no no
NEB1_HUMAN [view entry] [view interactions] High throughput yes yes
K2C8_HUMAN [view interactions] High throughput no no
SSXT_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
GIPC1_HUMAN [view entry] [view interactions] High throughput yes yes
SYJ2B_HUMAN [view entry] [view interactions] High throughput yes no
CAPON_HUMAN [view entry] [view interactions] High throughput yes yes
SCN3A_HUMAN [view interactions] High throughput no yes
APBA2_HUMAN [view interactions] High throughput no yes
ITBP1_HUMAN [view interactions] High throughput no no
APC10_HUMAN [view interactions] High throughput no yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
TYK2_HUMAN [view interactions] High throughput no no
UBP11_HUMAN [view interactions] High throughput no yes
RHG39_HUMAN [view entry] [view interactions] High throughput yes no
CS047_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
MKRN2_HUMAN [view interactions] High throughput no yes
RASN_HUMAN [view entry] [view interactions] High throughput yes no
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CAV1_HUMAN [view interactions] High throughput no no
DEN6A_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3B_HUMAN [view interactions] High throughput no no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
CLUS_HUMAN [view entry] [view interactions] Computational yes yes
APOA4_HUMAN [view interactions] Computational no no
APOA1_HUMAN [view interactions] Computational no no
ABL1_HUMAN [view entry] [view interactions] Computational yes yes
MP2K7_HUMAN [view entry] [view interactions] Computational yes yes
GPC4_HUMAN [view entry] [view interactions] Computational yes yes
ARHG2_HUMAN [view entry] [view interactions] Computational yes yes
AGRIN_HUMAN [view entry] [view interactions] Computational yes yes
NMDE1_HUMAN [view entry] [view interactions] Computational yes yes
FYN_HUMAN [view entry] [view interactions] Computational yes no
NCK2_HUMAN [view entry] [view interactions] Computational yes yes
MK08_HUMAN [view interactions] Computational no yes
RPGF1_HUMAN [view interactions] Computational no yes
ITB1_HUMAN [view entry] [view interactions] Computational yes no
PGBM_HUMAN [view interactions] Computational no no
M3K11_HUMAN [view interactions] Computational no yes
MAP1B_HUMAN [view entry] [view interactions] Computational yes yes
GPC6_HUMAN [view entry] [view interactions] Computational yes yes
GPC2_HUMAN [view interactions] Computational no no
GPC1_HUMAN [view entry] [view interactions] Computational yes no
GPC5_HUMAN [view interactions] Computational no yes
APOC3_HUMAN [view interactions] Computational no no
ITA3_HUMAN [view entry] [view interactions] Computational yes yes
APOB_HUMAN [view interactions] Computational no no
SDC4_HUMAN [view interactions] Computational no yes
SPON1_HUMAN [view interactions] Computational no no
SEPP1_HUMAN [view interactions] Computational no yes
APOA2_HUMAN [view interactions] Computational no no
APOC2_HUMAN [view interactions] Computational no no
GPC3_HUMAN [view interactions] Computational no no
TSP1_HUMAN [view interactions] Computational no no
SDC1_HUMAN [view interactions] Computational no no
NMDE2_HUMAN [view entry] [view interactions] Computational yes no
CRKL_HUMAN [view entry] [view interactions] Computational yes yes
SDC2_HUMAN [view interactions] Computational no yes
SDC3_HUMAN [view interactions] Computational no yes