JIP2_HUMAN
Evidence for PS localization
Functions
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in JIP2_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 32.2581 | 4 | no |
| GO:0017076 | purine nucleotide binding | 32.2581 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 32.2581 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 32.2581 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 32.2581 | 5 | no |
| GO:0043168 | anion binding | 32.2581 | 4 | no |
| GO:0043169 | cation binding | 32.2581 | 4 | no |
| GO:0019900 | kinase binding | 29.0323 | 4 | yes |
| GO:0019901 | protein kinase binding | 29.0323 | 5 | yes |
| GO:0005524 | ATP binding | 29.0323 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.0323 | 4 | no |
| GO:0046872 | metal ion binding | 29.0323 | 5 | no |
| GO:0019894 | kinesin binding | 16.1290 | 4 | yes |
| GO:0005078 | MAP-kinase scaffold activity | 12.9032 | 4 | yes |
| GO:0008432 | JUN kinase binding | 12.9032 | 6 | yes |
| GO:0019887 | protein kinase regulator activity | 12.9032 | 4 | yes |
| GO:0019209 | kinase activator activity | 9.6774 | 4 | yes |
| GO:0030295 | protein kinase activator activity | 9.6774 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in JIP2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 70.9677 | 4 | yes |
| GO:0010646 | regulation of cell communication | 67.7419 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 64.5161 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 54.8387 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 48.3871 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 48.3871 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 48.3871 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.3871 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 48.3871 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 48.3871 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 48.3871 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 45.1613 | 4 | no |
| GO:0010468 | regulation of gene expression | 45.1613 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 45.1613 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.1613 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 45.1613 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 45.1613 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 45.1613 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 41.9355 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 41.9355 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.7097 | 5 | no |
| GO:0031399 | regulation of protein modification process | 38.7097 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 38.7097 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 38.7097 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 38.7097 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 35.4839 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.4839 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 35.4839 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 35.4839 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 35.4839 | 4 | yes |
| GO:0030030 | cell projection organization | 35.4839 | 4 | yes |
| GO:0043408 | regulation of MAPK cascade | 35.4839 | 6 | yes |
| GO:0048585 | negative regulation of response to stimulus | 35.4839 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 35.4839 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 35.4839 | 6 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 32.2581 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 32.2581 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 32.2581 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 32.2581 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 32.2581 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 32.2581 | 4 | no |
| GO:0071310 | cellular response to organic substance | 32.2581 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 32.2581 | 5 | yes |
| GO:0022607 | cellular component assembly | 32.2581 | 4 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 32.2581 | 7 | yes |
| GO:0051049 | regulation of transport | 32.2581 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 32.2581 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 29.0323 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 29.0323 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 29.0323 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 29.0323 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 29.0323 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 29.0323 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 29.0323 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 29.0323 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 29.0323 | 5 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.8065 | 6 | no |
| GO:0036211 | protein modification process | 25.8065 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 25.8065 | 7 | no |
| GO:0043412 | macromolecule modification | 25.8065 | 4 | no |
| GO:0043549 | regulation of kinase activity | 25.8065 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 25.8065 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.8065 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.8065 | 7 | no |
| GO:0051338 | regulation of transferase activity | 25.8065 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 25.8065 | 4 | no |
| GO:0008104 | protein localization | 25.8065 | 4 | no |
| GO:0000165 | MAPK cascade | 25.8065 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 25.8065 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 25.8065 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 22.5806 | 8 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 22.5806 | 6 | no |
| GO:0060284 | regulation of cell development | 22.5806 | 5 | no |
| GO:0009894 | regulation of catabolic process | 22.5806 | 4 | no |
| GO:0009896 | positive regulation of catabolic process | 22.5806 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 22.5806 | 4 | no |
| GO:0033043 | regulation of organelle organization | 22.5806 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 22.5806 | 4 | no |
| GO:0048812 | neuron projection morphogenesis | 22.5806 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 22.5806 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 22.5806 | 4 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 22.5806 | 4 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 22.5806 | 8 | no |
| GO:0007254 | JNK cascade | 19.3548 | 6 | yes |
| GO:0046328 | regulation of JNK cascade | 19.3548 | 7 | yes |
| GO:0065003 | protein-containing complex assembly | 19.3548 | 5 | yes |
| GO:0080134 | regulation of response to stress | 19.3548 | 4 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 16.1290 | 4 | yes |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 16.1290 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 16.1290 | 4 | yes |
| GO:2001233 | regulation of apoptotic signaling pathway | 16.1290 | 5 | yes |
| GO:2001234 | negative regulation of apoptotic signaling pathway | 16.1290 | 6 | yes |
| GO:0050890 | cognition | 12.9032 | 4 | yes |
| GO:0099601 | regulation of neurotransmitter receptor activity | 12.9032 | 4 | yes |
| GO:0001662 | behavioral fear response | 9.6774 | 4 | yes |
| GO:0007612 | learning | 9.6774 | 4 | yes |
| GO:0007617 | mating behavior | 9.6774 | 4 | yes |
| GO:0048813 | dendrite morphogenesis | 9.6774 | 6 | yes |
| GO:0080135 | regulation of cellular response to stress | 9.6774 | 4 | yes |
| GO:2000310 | regulation of NMDA receptor activity | 9.6774 | 5 | yes |
| GO:2000311 | regulation of AMPA receptor activity | 9.6774 | 5 | yes |
| GO:0007172 | signal complex assembly | 6.4516 | 5 | yes |
| GO:0032872 | regulation of stress-activated MAPK cascade | 6.4516 | 6 | yes |
| GO:0032874 | positive regulation of stress-activated MAPK cascade | 6.4516 | 7 | yes |
| GO:0046958 | nonassociative learning | 6.4516 | 5 | yes |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 6.4516 | 6 | yes |
| GO:0060078 | regulation of postsynaptic membrane potential | 6.4516 | 4 | yes |
| GO:0060079 | excitatory postsynaptic potential | 6.4516 | 5 | yes |
| GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 6.4516 | 5 | yes |
| GO:0070304 | positive regulation of stress-activated protein kinase signaling cascade | 6.4516 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| JIP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| FGF13_HUMAN | [view interactions] | Low throughput | no | no |
| FGF12_HUMAN | [view interactions] | Low throughput | no | no |
| MP2K3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MP2K7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DUS16_HUMAN | [view interactions] | Low throughput | no | yes |
| MK13_HUMAN | [view interactions] | Low throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IL1B_HUMAN | [view interactions] | Low throughput | no | no |
| MK10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VRK2_HUMAN | [view interactions] | Low throughput | no | no |
| LRP2_HUMAN | [view interactions] | Low throughput | no | no |
| LRP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRP1B_HUMAN | [view interactions] | Low throughput | no | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBP2_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIFC2_HUMAN | [view interactions] | High throughput | no | yes |
| MAGD4_HUMAN | [view interactions] | High throughput | no | no |
| MASP1_HUMAN | [view interactions] | High throughput | no | no |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLXA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAI1_HUMAN | [view interactions] | High throughput | no | yes |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KS6B2_HUMAN | [view interactions] | High throughput | no | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| SPSY_HUMAN | [view interactions] | High throughput | no | no |
| SYNE2_HUMAN | [view interactions] | High throughput | no | no |
| ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
| U119A_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| YYAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN593_HUMAN | [view interactions] | High throughput | no | yes |
| ZN784_HUMAN | [view interactions] | High throughput | no | no |
| CSF1_HUMAN | [view interactions] | High throughput | no | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGIP_HUMAN | [view interactions] | High throughput | no | no |
| CH033_HUMAN | [view interactions] | High throughput | no | yes |
| UBD_HUMAN | [view interactions] | High throughput | no | no |
| SPSB3_HUMAN | [view interactions] | High throughput | no | yes |
| C1QT3_HUMAN | [view interactions] | High throughput | no | no |
| GALT3_HUMAN | [view interactions] | High throughput | no | yes |
| CRP_HUMAN | [view interactions] | High throughput | no | no |
| ING4_HUMAN | [view interactions] | High throughput | no | no |
| APC10_HUMAN | [view interactions] | High throughput | no | yes |
| RPA12_HUMAN | [view interactions] | High throughput | no | yes |
| RBM4_HUMAN | [view interactions] | High throughput | no | yes |
| ZN670_HUMAN | [view interactions] | High throughput | no | yes |
| S39AD_HUMAN | [view interactions] | High throughput | no | yes |
| DUS18_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| TRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP46_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRE11_HUMAN | [view interactions] | High throughput | no | yes |
| MNDA_HUMAN | [view interactions] | High throughput | no | no |
| ISK2_HUMAN | [view interactions] | High throughput | no | no |
| SRP19_HUMAN | [view interactions] | High throughput | no | yes |
| SLPI_HUMAN | [view interactions] | High throughput | no | no |
| LSM8_HUMAN | [view interactions] | High throughput | no | yes |
| SH21B_HUMAN | [view interactions] | High throughput | no | no |
| LFTY2_HUMAN | [view interactions] | High throughput | no | no |
| PRS23_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RSPH1_HUMAN | [view interactions] | High throughput | no | no |
| CV039_HUMAN | [view interactions] | High throughput | no | no |
| TM128_HUMAN | [view interactions] | High throughput | no | yes |
| ANGP1_HUMAN | [view interactions] | High throughput | no | no |
| CTBL1_HUMAN | [view interactions] | High throughput | no | yes |
| MSRB3_HUMAN | [view interactions] | High throughput | no | yes |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| HXC8_HUMAN | [view interactions] | High throughput | no | no |
| M3K11_HUMAN | [view interactions] | High throughput | no | yes |
| M3K12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K10_HUMAN | [view interactions] | High throughput | no | yes |
| MK09_HUMAN | [view interactions] | High throughput | no | yes |
| JIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| RPGF5_HUMAN | [view interactions] | High throughput | no | yes |
| TULP2_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SH3R3_HUMAN | [view interactions] | High throughput | no | yes |
| TTLL4_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| FGF11_HUMAN | [view interactions] | High throughput | no | no |
| FGF14_HUMAN | [view interactions] | High throughput | no | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SENP5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPOD1_HUMAN | [view interactions] | High throughput | no | yes |
| SEMG2_HUMAN | [view interactions] | High throughput | no | no |
| INT8_HUMAN | [view interactions] | High throughput | no | yes |
| SEMG1_HUMAN | [view interactions] | High throughput | no | no |
| INT5_HUMAN | [view interactions] | High throughput | no | no |
| RRP5_HUMAN | [view interactions] | High throughput | no | yes |
| ASPM_HUMAN | [view interactions] | High throughput | no | no |
| AMPN_HUMAN | [view interactions] | High throughput | no | no |
| LRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WTIP_HUMAN | [view interactions] | High throughput | no | no |
| AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASGL1_HUMAN | [view interactions] | High throughput | no | yes |
| BBS10_HUMAN | [view interactions] | High throughput | no | no |
| ERG28_HUMAN | [view interactions] | High throughput | no | yes |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHIN_HUMAN | [view interactions] | High throughput | no | no |