JIP2_HUMAN
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in JIP2_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 33.3333 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 33.3333 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 33.3333 | 5 | no |
GO:0046872 | metal ion binding | 30.0000 | 4 | no |
GO:0005524 | ATP binding | 30.0000 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 30.0000 | 4 | no |
GO:0019900 | kinase binding | 26.6667 | 4 | yes |
GO:0019901 | protein kinase binding | 23.3333 | 5 | yes |
GO:0001540 | amyloid-beta binding | 16.6667 | 4 | yes |
GO:0019894 | kinesin binding | 16.6667 | 4 | yes |
GO:0005078 | MAP-kinase scaffold activity | 13.3333 | 4 | yes |
GO:0019887 | protein kinase regulator activity | 13.3333 | 4 | yes |
GO:0019209 | kinase activator activity | 10.0000 | 4 | yes |
GO:0030295 | protein kinase activator activity | 10.0000 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in JIP2_HUMAN |
---|---|---|---|---|
GO:0010646 | regulation of cell communication | 73.3333 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 73.3333 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 70.0000 | 4 | yes |
GO:0009966 | regulation of signal transduction | 56.6667 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 53.3333 | 4 | no |
GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 46.6667 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 46.6667 | 4 | no |
GO:0010647 | positive regulation of cell communication | 46.6667 | 5 | yes |
GO:1902531 | regulation of intracellular signal transduction | 46.6667 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 46.6667 | 4 | no |
GO:0010468 | regulation of gene expression | 46.6667 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 46.6667 | 5 | no |
GO:0031323 | regulation of cellular metabolic process | 46.6667 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 43.3333 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 43.3333 | 5 | yes |
GO:0010648 | negative regulation of cell communication | 43.3333 | 5 | yes |
GO:0010941 | regulation of cell death | 43.3333 | 4 | yes |
GO:0023056 | positive regulation of signaling | 43.3333 | 4 | yes |
GO:0023057 | negative regulation of signaling | 43.3333 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 43.3333 | 4 | yes |
GO:0031399 | regulation of protein modification process | 43.3333 | 6 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 40.0000 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 40.0000 | 6 | no |
GO:0030030 | cell projection organization | 40.0000 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 40.0000 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 40.0000 | 5 | yes |
GO:0048585 | negative regulation of response to stimulus | 40.0000 | 4 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 40.0000 | 6 | yes |
GO:0009889 | regulation of biosynthetic process | 40.0000 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 40.0000 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 40.0000 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 36.6667 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 36.6667 | 5 | no |
GO:0071310 | cellular response to organic substance | 36.6667 | 4 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 36.6667 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 36.6667 | 6 | no |
GO:0009968 | negative regulation of signal transduction | 36.6667 | 5 | yes |
GO:0022607 | cellular component assembly | 36.6667 | 4 | yes |
GO:0051049 | regulation of transport | 36.6667 | 4 | yes |
GO:0016192 | vesicle-mediated transport | 36.6667 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 36.6667 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 36.6667 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 36.6667 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 33.3333 | 5 | no |
GO:0043408 | regulation of MAPK cascade | 33.3333 | 6 | yes |
GO:0043410 | positive regulation of MAPK cascade | 33.3333 | 7 | yes |
GO:0043933 | protein-containing complex organization | 33.3333 | 4 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 33.3333 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 33.3333 | 6 | no |
GO:0043085 | positive regulation of catalytic activity | 33.3333 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 30.0000 | 4 | no |
GO:0060548 | negative regulation of cell death | 30.0000 | 5 | yes |
GO:0045595 | regulation of cell differentiation | 30.0000 | 4 | no |
GO:0051094 | positive regulation of developmental process | 30.0000 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 30.0000 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 30.0000 | 7 | no |
GO:0031401 | positive regulation of protein modification process | 30.0000 | 7 | no |
GO:0042325 | regulation of phosphorylation | 30.0000 | 7 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 26.6667 | 7 | no |
GO:0051338 | regulation of transferase activity | 26.6667 | 4 | no |
GO:0036211 | protein modification process | 26.6667 | 4 | no |
GO:0043412 | macromolecule modification | 26.6667 | 4 | no |
GO:0033043 | regulation of organelle organization | 26.6667 | 5 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 26.6667 | 6 | no |
GO:0006796 | phosphate-containing compound metabolic process | 26.6667 | 4 | no |
GO:0043066 | negative regulation of apoptotic process | 26.6667 | 7 | yes |
GO:0043069 | negative regulation of programmed cell death | 26.6667 | 6 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 26.6667 | 5 | yes |
GO:0065003 | protein-containing complex assembly | 26.6667 | 5 | yes |
GO:0080134 | regulation of response to stress | 26.6667 | 4 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 26.6667 | 4 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 26.6667 | 6 | no |
GO:0043549 | regulation of kinase activity | 26.6667 | 5 | no |
GO:0045859 | regulation of protein kinase activity | 26.6667 | 6 | no |
GO:0045860 | positive regulation of protein kinase activity | 23.3333 | 7 | no |
GO:0051347 | positive regulation of transferase activity | 23.3333 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.3333 | 6 | no |
GO:0009894 | regulation of catabolic process | 23.3333 | 4 | no |
GO:0009896 | positive regulation of catabolic process | 23.3333 | 5 | no |
GO:0009891 | positive regulation of biosynthetic process | 23.3333 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 23.3333 | 6 | no |
GO:0051254 | positive regulation of RNA metabolic process | 23.3333 | 6 | no |
GO:0051336 | regulation of hydrolase activity | 23.3333 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 23.3333 | 4 | no |
GO:0000165 | MAPK cascade | 23.3333 | 4 | yes |
GO:0032990 | cell part morphogenesis | 23.3333 | 4 | yes |
GO:0043269 | regulation of ion transport | 23.3333 | 5 | yes |
GO:0048812 | neuron projection morphogenesis | 23.3333 | 7 | yes |
GO:0048858 | cell projection morphogenesis | 23.3333 | 5 | yes |
GO:0080135 | regulation of cellular response to stress | 23.3333 | 4 | yes |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 23.3333 | 6 | yes |
GO:0045597 | positive regulation of cell differentiation | 23.3333 | 5 | no |
GO:0001934 | positive regulation of protein phosphorylation | 23.3333 | 8 | no |
GO:0031344 | regulation of cell projection organization | 23.3333 | 5 | no |
GO:0033674 | positive regulation of kinase activity | 23.3333 | 6 | no |
GO:0042327 | positive regulation of phosphorylation | 23.3333 | 8 | no |
GO:0031098 | stress-activated protein kinase signaling cascade | 20.0000 | 4 | yes |
GO:0032872 | regulation of stress-activated MAPK cascade | 20.0000 | 6 | yes |
GO:0032874 | positive regulation of stress-activated MAPK cascade | 20.0000 | 7 | yes |
GO:0034762 | regulation of transmembrane transport | 20.0000 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 20.0000 | 5 | yes |
GO:0046328 | regulation of JNK cascade | 20.0000 | 7 | yes |
GO:0051403 | stress-activated MAPK cascade | 20.0000 | 5 | yes |
GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 20.0000 | 5 | yes |
GO:0070304 | positive regulation of stress-activated protein kinase signaling cascade | 20.0000 | 6 | yes |
GO:0007254 | JNK cascade | 16.6667 | 6 | yes |
GO:0022898 | regulation of transmembrane transporter activity | 16.6667 | 4 | yes |
GO:0032412 | regulation of ion transmembrane transporter activity | 16.6667 | 5 | yes |
GO:1904062 | regulation of cation transmembrane transport | 16.6667 | 6 | yes |
GO:2001233 | regulation of apoptotic signaling pathway | 16.6667 | 5 | yes |
GO:2001234 | negative regulation of apoptotic signaling pathway | 16.6667 | 6 | yes |
GO:2001257 | regulation of cation channel activity | 16.6667 | 6 | yes |
GO:0050890 | cognition | 13.3333 | 4 | yes |
GO:0099601 | regulation of neurotransmitter receptor activity | 13.3333 | 4 | yes |
GO:0001662 | behavioral fear response | 10.0000 | 4 | yes |
GO:0007612 | learning | 10.0000 | 4 | yes |
GO:0048813 | dendrite morphogenesis | 10.0000 | 8 | yes |
GO:0051966 | regulation of synaptic transmission, glutamatergic | 10.0000 | 6 | yes |
GO:2000310 | regulation of NMDA receptor activity | 10.0000 | 5 | yes |
GO:2000311 | regulation of AMPA receptor activity | 10.0000 | 5 | yes |
GO:0007172 | signal complex assembly | 6.6667 | 5 | yes |
GO:0046958 | nonassociative learning | 6.6667 | 5 | yes |
GO:0060078 | regulation of postsynaptic membrane potential | 6.6667 | 4 | yes |
GO:0060079 | excitatory postsynaptic potential | 6.6667 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
LRP2_HUMAN | [view interactions] | Low throughput | no | no |
LRP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
LRP1B_HUMAN | [view interactions] | Low throughput | no | yes |
JIP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
FGF13_HUMAN | [view interactions] | Low throughput | no | no |
FGF12_HUMAN | [view interactions] | Low throughput | no | no |
MP2K3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TIAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MP2K7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DUS16_HUMAN | [view interactions] | Low throughput | no | yes |
MK13_HUMAN | [view interactions] | Low throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IL1B_HUMAN | [view interactions] | Low throughput | no | no |
MK10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VRK2_HUMAN | [view interactions] | Low throughput | no | no |
LRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WTIP_HUMAN | [view interactions] | High throughput | no | no |
AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ASGL1_HUMAN | [view interactions] | High throughput | no | yes |
BBS10_HUMAN | [view interactions] | High throughput | no | no |
ERG28_HUMAN | [view interactions] | High throughput | no | yes |
COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CHIN_HUMAN | [view interactions] | High throughput | no | no |
DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EZH2_HUMAN | [view interactions] | High throughput | no | no |
FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GBP2_HUMAN | [view interactions] | High throughput | no | yes |
ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIFC2_HUMAN | [view interactions] | High throughput | no | yes |
MAGD4_HUMAN | [view interactions] | High throughput | no | no |
MASP1_HUMAN | [view interactions] | High throughput | no | no |
NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLXA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAI1_HUMAN | [view interactions] | High throughput | no | yes |
RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KS6B2_HUMAN | [view interactions] | High throughput | no | yes |
SNF5_HUMAN | [view interactions] | High throughput | no | yes |
SPSY_HUMAN | [view interactions] | High throughput | no | no |
SYNE2_HUMAN | [view interactions] | High throughput | no | no |
ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
U119A_HUMAN | [view interactions] | High throughput | no | no |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VP33B_HUMAN | [view interactions] | High throughput | no | yes |
YYAP1_HUMAN | [view interactions] | High throughput | no | yes |
ZN593_HUMAN | [view interactions] | High throughput | no | yes |
ZN784_HUMAN | [view interactions] | High throughput | no | no |
CSF1_HUMAN | [view interactions] | High throughput | no | no |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IGIP_HUMAN | [view interactions] | High throughput | no | no |
CH033_HUMAN | [view interactions] | High throughput | no | yes |
UBD_HUMAN | [view interactions] | High throughput | no | no |
SPSB3_HUMAN | [view interactions] | High throughput | no | yes |
C1QT3_HUMAN | [view interactions] | High throughput | no | no |
GALT3_HUMAN | [view interactions] | High throughput | no | yes |
CRP_HUMAN | [view interactions] | High throughput | no | no |
APC10_HUMAN | [view interactions] | High throughput | no | yes |
ING4_HUMAN | [view interactions] | High throughput | no | no |
RPA12_HUMAN | [view interactions] | High throughput | no | yes |
ZN670_HUMAN | [view interactions] | High throughput | no | yes |
RBM4_HUMAN | [view interactions] | High throughput | no | yes |
S39AD_HUMAN | [view interactions] | High throughput | no | yes |
DUS18_HUMAN | [view interactions] | High throughput | no | yes |
RYBP_HUMAN | [view interactions] | High throughput | no | no |
TRBP2_HUMAN | [view interactions] | High throughput | no | yes |
UBP46_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MRE11_HUMAN | [view interactions] | High throughput | no | yes |
MNDA_HUMAN | [view interactions] | High throughput | no | no |
ISK2_HUMAN | [view interactions] | High throughput | no | no |
SRP19_HUMAN | [view interactions] | High throughput | no | yes |
SLPI_HUMAN | [view interactions] | High throughput | no | no |
LSM8_HUMAN | [view interactions] | High throughput | no | yes |
SH21B_HUMAN | [view interactions] | High throughput | no | no |
LFTY2_HUMAN | [view interactions] | High throughput | no | no |
PRS23_HUMAN | [view interactions] | High throughput | no | no |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CV039_HUMAN | [view interactions] | High throughput | no | no |
TM128_HUMAN | [view interactions] | High throughput | no | yes |
ANGP1_HUMAN | [view interactions] | High throughput | no | no |
CTBL1_HUMAN | [view interactions] | High throughput | no | yes |
MSRB3_HUMAN | [view interactions] | High throughput | no | yes |
SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
HLAC_HUMAN | [view interactions] | High throughput | no | no |
HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
HXC8_HUMAN | [view interactions] | High throughput | no | no |
M3K11_HUMAN | [view interactions] | High throughput | no | yes |
M3K12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
M3K10_HUMAN | [view interactions] | High throughput | no | yes |
MK09_HUMAN | [view interactions] | High throughput | no | yes |
JIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
JIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
RPGF5_HUMAN | [view interactions] | High throughput | no | yes |
TULP2_HUMAN | [view interactions] | High throughput | no | no |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SH3R3_HUMAN | [view interactions] | High throughput | no | yes |
TTLL4_HUMAN | [view interactions] | High throughput | no | yes |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
FGF11_HUMAN | [view interactions] | High throughput | no | no |
FGF14_HUMAN | [view interactions] | High throughput | no | no |
CCD96_HUMAN | [view interactions] | High throughput | no | no |
ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SENP5_HUMAN | [view interactions] | High throughput | no | no |
DPOD1_HUMAN | [view interactions] | High throughput | no | yes |
SEMG2_HUMAN | [view interactions] | High throughput | no | no |
INT8_HUMAN | [view interactions] | High throughput | no | yes |
SEMG1_HUMAN | [view interactions] | High throughput | no | no |
INT5_HUMAN | [view interactions] | High throughput | no | no |
RRP5_HUMAN | [view interactions] | High throughput | no | yes |
ASPM_HUMAN | [view interactions] | High throughput | no | no |
AMPN_HUMAN | [view interactions] | High throughput | no | no |
MK08_HUMAN | [view interactions] | Computational | no | yes |
M4K1_HUMAN | [view interactions] | Computational | no | no |