Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

JIP3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins . Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development . Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI003076 DOC_MAPK_JIP1_4 DOC 204 210 -
ELMI003076 DOC_MAPK_JIP1_4 DOC 204 210 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in JIP3_HUMAN
GO:0043168 anion binding 50.0000 4 no
GO:0000166 nucleotide binding 47.2222 4 no
GO:0017076 purine nucleotide binding 47.2222 5 no
GO:0032555 purine ribonucleotide binding 47.2222 4 no
GO:0035639 purine ribonucleoside triphosphate binding 44.4444 4 no
GO:0019900 kinase binding 38.8889 4 yes
GO:0019901 protein kinase binding 38.8889 5 yes
GO:0030554 adenyl nucleotide binding 38.8889 6 no
GO:0032559 adenyl ribonucleotide binding 38.8889 5 no
GO:0005524 ATP binding 36.1111 5 no
GO:0016301 kinase activity 30.5556 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 30.5556 4 no
GO:0019894 kinesin binding 16.6667 4 yes
GO:0005078 MAP-kinase scaffold activity 13.8889 4 yes
GO:0008432 JUN kinase binding 13.8889 6 yes
GO:0030159 signaling receptor complex adaptor activity 8.3333 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in JIP3_HUMAN
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0048522 positive regulation of cellular process 61.1111 4 yes
GO:0009966 regulation of signal transduction 58.3333 4 yes
GO:0048523 negative regulation of cellular process 52.7778 4 yes
GO:0010647 positive regulation of cell communication 50.0000 5 yes
GO:1902531 regulation of intracellular signal transduction 50.0000 5 yes
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0023056 positive regulation of signaling 47.2222 4 yes
GO:0048584 positive regulation of response to stimulus 47.2222 4 yes
GO:0031323 regulation of cellular metabolic process 47.2222 4 no
GO:0009967 positive regulation of signal transduction 44.4444 5 yes
GO:0022607 cellular component assembly 44.4444 4 no
GO:0060255 regulation of macromolecule metabolic process 44.4444 4 no
GO:0043408 regulation of MAPK cascade 41.6667 6 yes
GO:0006996 organelle organization 41.6667 4 no
GO:0008104 protein localization 41.6667 4 yes
GO:0030030 cell projection organization 38.8889 4 yes
GO:1902533 positive regulation of intracellular signal transduction 38.8889 6 yes
GO:0009889 regulation of biosynthetic process 38.8889 4 no
GO:0010556 regulation of macromolecule biosynthetic process 38.8889 5 no
GO:0031326 regulation of cellular biosynthetic process 38.8889 5 no
GO:0080090 regulation of primary metabolic process 38.8889 4 no
GO:0042981 regulation of apoptotic process 36.1111 5 yes
GO:0043067 regulation of programmed cell death 36.1111 4 yes
GO:0009893 positive regulation of metabolic process 36.1111 4 no
GO:0010468 regulation of gene expression 36.1111 6 no
GO:0010604 positive regulation of macromolecule metabolic process 36.1111 5 no
GO:0031325 positive regulation of cellular metabolic process 36.1111 5 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 no
GO:0016310 phosphorylation 33.3333 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0141124 intracellular signaling cassette 33.3333 4 no
GO:0043410 positive regulation of MAPK cascade 30.5556 7 yes
GO:0000165 MAPK cascade 30.5556 5 no
GO:0031401 positive regulation of protein modification process 30.5556 7 no
GO:0036211 protein modification process 30.5556 4 no
GO:0043412 macromolecule modification 30.5556 4 no
GO:0051247 positive regulation of protein metabolic process 30.5556 6 no
GO:0051049 regulation of transport 30.5556 4 no
GO:0043066 negative regulation of apoptotic process 27.7778 6 yes
GO:0043069 negative regulation of programmed cell death 27.7778 5 yes
GO:0071702 organic substance transport 27.7778 4 yes
GO:0071705 nitrogen compound transport 27.7778 4 yes
GO:0120036 plasma membrane bounded cell projection organization 27.7778 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 27.7778 4 no
GO:0001934 positive regulation of protein phosphorylation 27.7778 8 no
GO:0006468 protein phosphorylation 27.7778 5 no
GO:0009891 positive regulation of biosynthetic process 27.7778 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 27.7778 6 no
GO:0010562 positive regulation of phosphorus metabolic process 27.7778 6 no
GO:0031328 positive regulation of cellular biosynthetic process 27.7778 6 no
GO:0042327 positive regulation of phosphorylation 27.7778 8 no
GO:0045937 positive regulation of phosphate metabolic process 27.7778 7 no
GO:0051252 regulation of RNA metabolic process 27.7778 5 no
GO:0033043 regulation of organelle organization 27.7778 5 no
GO:0051130 positive regulation of cellular component organization 27.7778 5 no
GO:0051338 regulation of transferase activity 27.7778 4 no
GO:0015031 protein transport 25.0000 4 yes
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:0006355 regulation of DNA-templated transcription 25.0000 7 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0009968 negative regulation of signal transduction 22.2222 5 no
GO:0010648 negative regulation of cell communication 22.2222 5 no
GO:0023057 negative regulation of signaling 22.2222 4 no
GO:0044087 regulation of cellular component biogenesis 22.2222 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0065003 protein-containing complex assembly 22.2222 5 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:0045859 regulation of protein kinase activity 22.2222 6 no
GO:0051094 positive regulation of developmental process 22.2222 4 no
GO:0051347 positive regulation of transferase activity 22.2222 5 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0031175 neuron projection development 19.4444 6 yes
GO:0046328 regulation of JNK cascade 19.4444 7 yes
GO:0006886 intracellular protein transport 16.6667 4 yes
GO:0046330 positive regulation of JNK cascade 13.8889 8 yes
GO:0010970 transport along microtubule 11.1111 4 yes
GO:0030705 cytoskeleton-dependent intracellular transport 11.1111 4 yes
GO:0035418 protein localization to synapse 11.1111 6 yes
GO:0098930 axonal transport 11.1111 6 yes
GO:0099111 microtubule-based transport 11.1111 4 yes
GO:1902414 protein localization to cell junction 11.1111 5 yes
GO:0008088 axo-dendritic transport 11.1111 5 yes
GO:0008089 anterograde axonal transport 11.1111 7 yes
GO:0050821 protein stabilization 8.3333 4 yes
GO:0098840 protein transport along microtubule 8.3333 4 yes
GO:0099640 axo-dendritic protein transport 8.3333 5 yes
GO:0099641 anterograde axonal protein transport 8.3333 6 yes
GO:1905383 protein localization to presynapse 8.3333 7 yes
GO:0031102 neuron projection regeneration 5.5556 4 yes
GO:0031103 axon regeneration 5.5556 5 yes
GO:0048678 response to axon injury 5.5556 4 yes
GO:0061564 axon development 5.5556 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MK10_HUMAN [view entry] [view interactions] Low throughput yes yes
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
JIP3_HUMAN [view entry] [view interactions] Low throughput yes yes
JIP2_HUMAN [view entry] [view interactions] Low throughput yes no
JIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB8A_HUMAN [view entry] [view interactions] Low throughput yes no
RAB10_HUMAN [view entry] [view interactions] Low throughput yes yes
KLC1_HUMAN [view entry] [view interactions] Low throughput yes no
KLC2_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRK2_HUMAN [view interactions] Low throughput no yes
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
MP2K1_HUMAN [view entry] [view interactions] Low throughput yes yes
RAF1_HUMAN [view entry] [view interactions] Low throughput yes no
MP2K4_HUMAN [view interactions] Low throughput no yes
M3K1_HUMAN [view interactions] Low throughput no yes
MP2K7_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K5_HUMAN [view interactions] Low throughput no yes
MP2K3_HUMAN [view entry] [view interactions] Low throughput yes yes
MK08_HUMAN [view interactions] Low throughput no yes
CABYR_HUMAN [view interactions] Low throughput no no
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
MK09_HUMAN [view interactions] Low throughput no yes
M3K11_HUMAN [view interactions] Low throughput no yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
FGFR1_HUMAN [view entry] [view interactions] Low throughput yes yes
DCTN6_HUMAN [view interactions] High throughput no no
TNKS1_HUMAN [view interactions] High throughput no yes
TNKS2_HUMAN [view interactions] High throughput no no
WDR54_HUMAN [view interactions] High throughput no no
ARP10_HUMAN [view interactions] High throughput no no
RCCD1_HUMAN [view interactions] High throughput no yes
SMCO1_HUMAN [view interactions] High throughput no no
KIF5C_HUMAN [view entry] [view interactions] High throughput yes yes
SPAT7_HUMAN [view interactions] High throughput no no
BCL6_HUMAN [view interactions] High throughput no no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
CEP63_HUMAN [view interactions] High throughput no yes
RAD51_HUMAN [view interactions] High throughput no yes
RA51D_HUMAN [view interactions] High throughput no no
ST4A1_HUMAN [view interactions] High throughput no yes
ARH_HUMAN [view interactions] High throughput no yes
ZN575_HUMAN [view interactions] High throughput no no
ARL4D_HUMAN [view interactions] High throughput no no
RIC8A_HUMAN [view entry] [view interactions] High throughput yes no
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
NRIP1_HUMAN [view interactions] High throughput no yes
BTG3_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
KAT2A_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
JIP4_HUMAN [view interactions] High throughput no yes
DCTN4_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
SH3R3_HUMAN [view interactions] High throughput no yes
AK1C2_HUMAN [view entry] [view interactions] High throughput yes no
SHOT1_HUMAN [view interactions] High throughput no no
FGF14_HUMAN [view interactions] High throughput no no
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN3_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
MTL5_HUMAN [view interactions] High throughput no no
TM192_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
TOP3B_HUMAN [view interactions] High throughput no no
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
ARI1A_HUMAN [view interactions] High throughput no yes
KIF1A_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TAOK2_HUMAN [view entry] [view interactions] High throughput yes yes