Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

JIP3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins . Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development . Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI003076 DOC_MAPK_JIP1_4 DOC 204 210 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in JIP3_HUMAN
GO:0017076 purine nucleotide binding 56.2500 4 no
GO:0032555 purine ribonucleotide binding 56.2500 4 no
GO:0035639 purine ribonucleoside triphosphate binding 53.1250 4 no
GO:0030554 adenyl nucleotide binding 46.8750 5 no
GO:0032559 adenyl ribonucleotide binding 46.8750 5 no
GO:0005524 ATP binding 43.7500 5 no
GO:0019900 kinase binding 40.6250 4 yes
GO:0019901 protein kinase binding 40.6250 5 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 37.5000 4 no
GO:0016301 kinase activity 37.5000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 37.5000 4 no
GO:0004713 protein tyrosine kinase activity 28.1250 4 no
GO:0005078 MAP-kinase scaffold activity 15.6250 4 yes
GO:0019894 kinesin binding 15.6250 4 yes
GO:0008432 JUN kinase binding 9.3750 6 yes
GO:0030159 signaling receptor complex adaptor activity 6.2500 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in JIP3_HUMAN
GO:0010646 regulation of cell communication 59.3750 4 yes
GO:0048522 positive regulation of cellular process 59.3750 4 yes
GO:0009966 regulation of signal transduction 53.1250 4 yes
GO:0048584 positive regulation of response to stimulus 53.1250 4 yes
GO:1902531 regulation of intracellular signal transduction 53.1250 5 yes
GO:0048523 negative regulation of cellular process 50.0000 4 yes
GO:0010647 positive regulation of cell communication 46.8750 5 yes
GO:0023056 positive regulation of signaling 46.8750 4 yes
GO:0031323 regulation of cellular metabolic process 46.8750 4 no
GO:0051171 regulation of nitrogen compound metabolic process 46.8750 4 no
GO:0060255 regulation of macromolecule metabolic process 46.8750 4 no
GO:0080090 regulation of primary metabolic process 46.8750 4 no
GO:0009967 positive regulation of signal transduction 43.7500 5 yes
GO:1902533 positive regulation of intracellular signal transduction 43.7500 6 yes
GO:0009889 regulation of biosynthetic process 40.6250 4 no
GO:0010468 regulation of gene expression 40.6250 5 no
GO:0031326 regulation of cellular biosynthetic process 40.6250 5 no
GO:0051128 regulation of cellular component organization 40.6250 4 no
GO:0010941 regulation of cell death 37.5000 4 yes
GO:0043408 regulation of MAPK cascade 37.5000 6 yes
GO:0080134 regulation of response to stress 37.5000 4 yes
GO:0009893 positive regulation of metabolic process 37.5000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 no
GO:0019220 regulation of phosphate metabolic process 37.5000 6 no
GO:0042325 regulation of phosphorylation 37.5000 7 no
GO:0051174 regulation of phosphorus metabolic process 37.5000 5 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0036211 protein modification process 37.5000 4 no
GO:0043412 macromolecule modification 37.5000 4 no
GO:0042981 regulation of apoptotic process 34.3750 6 yes
GO:0043067 regulation of programmed cell death 34.3750 5 yes
GO:0001932 regulation of protein phosphorylation 34.3750 7 no
GO:0010562 positive regulation of phosphorus metabolic process 34.3750 6 no
GO:0010604 positive regulation of macromolecule metabolic process 34.3750 5 no
GO:0031325 positive regulation of cellular metabolic process 34.3750 5 no
GO:0031399 regulation of protein modification process 34.3750 6 no
GO:0042327 positive regulation of phosphorylation 34.3750 8 no
GO:0045937 positive regulation of phosphate metabolic process 34.3750 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 34.3750 5 no
GO:0051247 positive regulation of protein metabolic process 34.3750 6 no
GO:0051252 regulation of RNA metabolic process 34.3750 5 no
GO:0071310 cellular response to organic substance 34.3750 4 no
GO:0006468 protein phosphorylation 34.3750 5 no
GO:0006796 phosphate-containing compound metabolic process 34.3750 4 no
GO:0016310 phosphorylation 34.3750 5 no
GO:0008104 protein localization 31.2500 4 yes
GO:0016192 vesicle-mediated transport 31.2500 4 yes
GO:0030030 cell projection organization 31.2500 4 yes
GO:0043410 positive regulation of MAPK cascade 31.2500 7 yes
GO:0001934 positive regulation of protein phosphorylation 31.2500 8 no
GO:0031401 positive regulation of protein modification process 31.2500 7 no
GO:0006996 organelle organization 31.2500 4 no
GO:0051049 regulation of transport 31.2500 4 no
GO:1901701 cellular response to oxygen-containing compound 31.2500 4 no
GO:0006355 regulation of DNA-templated transcription 31.2500 6 no
GO:1903506 regulation of nucleic acid-templated transcription 31.2500 7 no
GO:2001141 regulation of RNA biosynthetic process 31.2500 6 no
GO:0043085 positive regulation of catalytic activity 31.2500 4 no
GO:0060548 negative regulation of cell death 28.1250 5 yes
GO:0080135 regulation of cellular response to stress 28.1250 4 yes
GO:0022607 cellular component assembly 28.1250 4 no
GO:0015031 protein transport 25.0000 4 yes
GO:0043066 negative regulation of apoptotic process 25.0000 7 yes
GO:0043069 negative regulation of programmed cell death 25.0000 6 yes
GO:0071702 organic substance transport 25.0000 4 yes
GO:0071705 nitrogen compound transport 25.0000 4 yes
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 yes
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0002768 immune response-regulating cell surface receptor signaling pathway 25.0000 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 25.0000 5 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0000165 MAPK cascade 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0032872 regulation of stress-activated MAPK cascade 21.8750 6 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 21.8750 5 yes
GO:0009892 negative regulation of metabolic process 21.8750 4 no
GO:0031344 regulation of cell projection organization 21.8750 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.8750 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.8750 6 no
GO:0048585 negative regulation of response to stimulus 21.8750 4 no
GO:0033043 regulation of organelle organization 21.8750 5 no
GO:0042127 regulation of cell population proliferation 21.8750 4 no
GO:0043549 regulation of kinase activity 21.8750 5 no
GO:0051347 positive regulation of transferase activity 21.8750 5 no
GO:0006886 intracellular protein transport 18.7500 4 yes
GO:0031175 neuron projection development 15.6250 6 yes
GO:0032874 positive regulation of stress-activated MAPK cascade 15.6250 7 yes
GO:0046328 regulation of JNK cascade 15.6250 7 yes
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 15.6250 6 yes
GO:0008088 axo-dendritic transport 12.5000 5 yes
GO:0008089 anterograde axonal transport 12.5000 7 yes
GO:0010970 transport along microtubule 12.5000 4 yes
GO:0030705 cytoskeleton-dependent intracellular transport 12.5000 4 yes
GO:0035418 protein localization to synapse 12.5000 6 yes
GO:0046330 positive regulation of JNK cascade 12.5000 8 yes
GO:0098930 axonal transport 12.5000 6 yes
GO:0099111 microtubule-based transport 12.5000 4 yes
GO:1902414 protein localization to cell junction 12.5000 5 yes
GO:0098840 protein transport along microtubule 9.3750 4 yes
GO:0099640 axo-dendritic protein transport 9.3750 5 yes
GO:0099641 anterograde axonal protein transport 9.3750 6 yes
GO:1905383 protein localization to presynapse 9.3750 7 yes
GO:0031102 neuron projection regeneration 6.2500 4 yes
GO:0031103 axon regeneration 6.2500 5 yes
GO:0048678 response to axon injury 6.2500 4 yes
GO:0050821 protein stabilization 6.2500 4 yes
GO:0061564 axon development 6.2500 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in JIP3_HUMAN
DOID:331 central nervous system disease 12.5000 3 no
DOID:936 brain disease 6.2500 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
MP2K1_HUMAN [view entry] [view interactions] Low throughput yes yes
RAF1_HUMAN [view entry] [view interactions] Low throughput yes no
MP2K4_HUMAN [view interactions] Low throughput no yes
M3K1_HUMAN [view interactions] Low throughput no yes
MP2K7_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K5_HUMAN [view interactions] Low throughput no yes
MP2K3_HUMAN [view entry] [view interactions] Low throughput yes yes
MK08_HUMAN [view interactions] Low throughput no yes
CABYR_HUMAN [view interactions] Low throughput no no
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
MK09_HUMAN [view interactions] Low throughput no yes
M3K11_HUMAN [view interactions] Low throughput no yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
FGFR1_HUMAN [view interactions] Low throughput no yes
MK10_HUMAN [view entry] [view interactions] Low throughput yes yes
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
JIP3_HUMAN [view entry] [view interactions] Low throughput yes yes
JIP2_HUMAN [view entry] [view interactions] Low throughput yes no
JIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB8A_HUMAN [view entry] [view interactions] Low throughput yes no
RAB10_HUMAN [view entry] [view interactions] Low throughput yes yes
KLC2_HUMAN [view entry] [view interactions] Low throughput yes yes
KLC1_HUMAN [view entry] [view interactions] Low throughput yes no
LRRK2_HUMAN [view interactions] Low throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
RAD51_HUMAN [view interactions] High throughput no yes
RA51D_HUMAN [view interactions] High throughput no no
ST4A1_HUMAN [view interactions] High throughput no yes
ARH_HUMAN [view interactions] High throughput no yes
ZN575_HUMAN [view interactions] High throughput no no
ARL4D_HUMAN [view interactions] High throughput no no
RIC8A_HUMAN [view entry] [view interactions] High throughput yes no
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
KAT2A_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
JIP4_HUMAN [view interactions] High throughput no yes
DCTN4_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
SH3R3_HUMAN [view interactions] High throughput no yes
AK1C2_HUMAN [view entry] [view interactions] High throughput yes no
SHOT1_HUMAN [view interactions] High throughput no no
FGF14_HUMAN [view interactions] High throughput no no
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN3_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
MTL5_HUMAN [view interactions] High throughput no no
TM192_HUMAN [view interactions] High throughput no yes
KIF1A_HUMAN [view entry] [view interactions] High throughput yes no
ARP10_HUMAN [view interactions] High throughput no no
WDR54_HUMAN [view interactions] High throughput no no
TNKS2_HUMAN [view interactions] High throughput no no
TNKS1_HUMAN [view interactions] High throughput no yes
DCTN6_HUMAN [view interactions] High throughput no no
RCCD1_HUMAN [view interactions] High throughput no yes
SMCO1_HUMAN [view interactions] High throughput no no
KIF5C_HUMAN [view entry] [view interactions] High throughput yes yes
SPAT7_HUMAN [view interactions] High throughput no no
BCL6_HUMAN [view interactions] High throughput no no
FYN_HUMAN [view entry] [view interactions] Computational yes no
LCK_HUMAN [view entry] [view interactions] Computational yes no
YES_HUMAN [view entry] [view interactions] Computational yes yes