KIF1A_HUMAN
Evidence for PS localization
Functions
Motor for anterograde axonal transport of synaptic vesicle precursors. Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KIF1A_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 29.1667 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 29.1667 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 29.1667 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.1667 | 4 | yes |
| GO:0043168 | anion binding | 29.1667 | 4 | yes |
| GO:0019900 | kinase binding | 29.1667 | 4 | no |
| GO:0005524 | ATP binding | 25.0000 | 5 | yes |
| GO:0015631 | tubulin binding | 25.0000 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 25.0000 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.0000 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.0000 | 6 | yes |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | yes |
| GO:0043169 | cation binding | 25.0000 | 4 | no |
| GO:0046872 | metal ion binding | 25.0000 | 5 | no |
| GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
| GO:0008017 | microtubule binding | 20.8333 | 5 | yes |
| GO:0016887 | ATP hydrolysis activity | 20.8333 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KIF1A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 79.1667 | 4 | no |
| GO:0010646 | regulation of cell communication | 62.5000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 54.1667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.8333 | 4 | no |
| GO:0051049 | regulation of transport | 45.8333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.8333 | 4 | yes |
| GO:0008104 | protein localization | 45.8333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 45.8333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.8333 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 45.8333 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 45.8333 | 6 | no |
| GO:0080090 | regulation of primary metabolic process | 45.8333 | 4 | no |
| GO:0006996 | organelle organization | 41.6667 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 41.6667 | 5 | no |
| GO:0023056 | positive regulation of signaling | 41.6667 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 41.6667 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 37.5000 | 4 | no |
| GO:0051050 | positive regulation of transport | 33.3333 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 33.3333 | 5 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 33.3333 | 7 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 29.1667 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.1667 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.1667 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 29.1667 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 29.1667 | 6 | no |
| GO:0030030 | cell projection organization | 29.1667 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 29.1667 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 29.1667 | 5 | no |
| GO:0009057 | macromolecule catabolic process | 25.0000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
| GO:0009896 | positive regulation of catabolic process | 25.0000 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.0000 | 4 | no |
| GO:0051051 | negative regulation of transport | 25.0000 | 4 | no |
| GO:0008088 | axo-dendritic transport | 25.0000 | 5 | yes |
| GO:0010970 | transport along microtubule | 25.0000 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.0000 | 4 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 25.0000 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | yes |
| GO:0099111 | microtubule-based transport | 25.0000 | 4 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 25.0000 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 25.0000 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.0000 | 5 | no |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 20.8333 | 7 | no |
| GO:0019941 | modification-dependent protein catabolic process | 20.8333 | 6 | no |
| GO:0030163 | protein catabolic process | 20.8333 | 4 | no |
| GO:0043632 | modification-dependent macromolecule catabolic process | 20.8333 | 5 | no |
| GO:0051603 | proteolysis involved in protein catabolic process | 20.8333 | 5 | no |
| GO:1901565 | organonitrogen compound catabolic process | 20.8333 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 20.8333 | 4 | no |
| GO:0010468 | regulation of gene expression | 20.8333 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.8333 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.8333 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.8333 | 4 | no |
| GO:0033365 | protein localization to organelle | 20.8333 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.8333 | 5 | no |
| GO:0010959 | regulation of metal ion transport | 20.8333 | 6 | no |
| GO:0043269 | regulation of monoatomic ion transport | 20.8333 | 5 | no |
| GO:0043270 | positive regulation of monoatomic ion transport | 20.8333 | 5 | no |
| GO:0043933 | protein-containing complex organization | 20.8333 | 4 | no |
| GO:0071702 | organic substance transport | 20.8333 | 4 | no |
| GO:0010038 | response to metal ion | 20.8333 | 4 | no |
| GO:0043549 | regulation of kinase activity | 20.8333 | 5 | no |
| GO:0044057 | regulation of system process | 20.8333 | 4 | no |
| GO:0051338 | regulation of transferase activity | 20.8333 | 4 | no |
| GO:0008089 | anterograde axonal transport | 20.8333 | 7 | yes |
| GO:0016482 | cytosolic transport | 20.8333 | 4 | yes |
| GO:0098930 | axonal transport | 20.8333 | 6 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.8333 | 6 | yes |
| GO:0036211 | protein modification process | 20.8333 | 4 | no |
| GO:0043412 | macromolecule modification | 20.8333 | 4 | no |
| GO:0072657 | protein localization to membrane | 20.8333 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 20.8333 | 4 | no |
| GO:0006508 | proteolysis | 20.8333 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 16.6667 | 7 | yes |
| GO:0051650 | establishment of vesicle localization | 16.6667 | 4 | yes |
| GO:0008090 | retrograde axonal transport | 12.5000 | 7 | yes |
| GO:0032252 | secretory granule localization | 12.5000 | 4 | yes |
| GO:0032253 | dense core granule localization | 12.5000 | 5 | yes |
| GO:0047496 | vesicle transport along microtubule | 12.5000 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 12.5000 | 5 | yes |
| GO:0060998 | regulation of dendritic spine development | 12.5000 | 4 | yes |
| GO:0072384 | organelle transport along microtubule | 12.5000 | 4 | yes |
| GO:0099175 | regulation of postsynapse organization | 12.5000 | 6 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 12.5000 | 5 | yes |
| GO:0099519 | dense core granule cytoskeletal transport | 12.5000 | 6 | yes |
| GO:1901950 | dense core granule transport | 12.5000 | 5 | yes |
| GO:1990048 | anterograde neuronal dense core vesicle transport | 12.5000 | 6 | yes |
| GO:1990049 | retrograde neuronal dense core vesicle transport | 12.5000 | 6 | yes |
| GO:0061001 | regulation of dendritic spine morphogenesis | 8.3333 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RETR1_HUMAN | [view interactions] | Low throughput | no | no |
| KIF1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| PRPS2_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| FBSP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| JIP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APLP2_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| MKRN3_HUMAN | [view interactions] | High throughput | no | yes |
| NT2NA_HUMAN | [view interactions] | High throughput | no | no |
| PLS1_HUMAN | [view interactions] | High throughput | no | no |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| RFX6_HUMAN | [view interactions] | High throughput | no | no |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| SPY2_HUMAN | [view interactions] | High throughput | no | yes |
| TENS2_HUMAN | [view interactions] | High throughput | no | no |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| CATD_HUMAN | [view interactions] | High throughput | no | yes |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| TTHY_HUMAN | [view interactions] | High throughput | no | no |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VP26C_HUMAN | [view interactions] | High throughput | no | yes |
| DSCR9_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| PKNX1_HUMAN | [view interactions] | High throughput | no | yes |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| SP1_HUMAN | [view interactions] | High throughput | no | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| MED1_HUMAN | [view interactions] | High throughput | no | no |
| PPARG_HUMAN | [view interactions] | High throughput | no | yes |
| RXRA_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| RIMB1_HUMAN | [view interactions] | High throughput | no | yes |
| ATL4_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| RGS20_HUMAN | [view interactions] | High throughput | no | no |
| RSPH1_HUMAN | [view interactions] | High throughput | no | no |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN166_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CETN1_HUMAN | [view interactions] | High throughput | no | no |
| KBP_HUMAN | [view interactions] | High throughput | no | yes |
| TAFA3_HUMAN | [view interactions] | High throughput | no | no |
| DQX1_HUMAN | [view interactions] | High throughput | no | no |
| LYPD4_HUMAN | [view interactions] | High throughput | no | no |
| AASD1_HUMAN | [view interactions] | High throughput | no | yes |
| GALD1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI35_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| MGDP1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPC1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN3_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP4AT_HUMAN | [view interactions] | High throughput | no | no |
| PKHM3_HUMAN | [view interactions] | High throughput | no | yes |
| FGF11_HUMAN | [view interactions] | High throughput | no | no |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| SPSB4_HUMAN | [view interactions] | High throughput | no | no |
| IMP3_HUMAN | [view interactions] | High throughput | no | no |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| RILP_HUMAN | [view interactions] | High throughput | no | no |