KIF1B_HUMAN
Evidence for PS localization
Functions
Isoform 1 mediates the transport of synaptic vesicles in neuronal cells. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 98 | Gln | Leu | Charcot-Marie-Toothdisease,axonal,2A1(CMT2A1) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KIF1B_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 32.7869 | 4 | no |
| GO:0043168 | anion binding | 27.8689 | 4 | yes |
| GO:0019900 | kinase binding | 27.8689 | 4 | no |
| GO:0000166 | nucleotide binding | 26.2295 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 26.2295 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 26.2295 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.2295 | 4 | yes |
| GO:0045296 | cadherin binding | 26.2295 | 4 | no |
| GO:0019901 | protein kinase binding | 22.9508 | 5 | no |
| GO:0005524 | ATP binding | 19.6721 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 19.6721 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 19.6721 | 5 | yes |
| GO:0015631 | tubulin binding | 18.0328 | 4 | yes |
| GO:0008017 | microtubule binding | 14.7541 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 13.1148 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 13.1148 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 13.1148 | 6 | yes |
| GO:0016887 | ATP hydrolysis activity | 9.8361 | 7 | yes |
| GO:0019894 | kinesin binding | 4.9180 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KIF1B_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 63.9344 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 60.6557 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 59.0164 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 55.7377 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 55.7377 | 4 | no |
| GO:0008104 | protein localization | 47.5410 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.9016 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 42.6230 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.9836 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.9836 | 5 | no |
| GO:0010646 | regulation of cell communication | 40.9836 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 40.9836 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 40.9836 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 39.3443 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 39.3443 | 5 | no |
| GO:0006996 | organelle organization | 39.3443 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.7049 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.0656 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 36.0656 | 5 | no |
| GO:0051049 | regulation of transport | 36.0656 | 4 | no |
| GO:0009966 | regulation of signal transduction | 34.4262 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.4262 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 34.4262 | 5 | no |
| GO:0022607 | cellular component assembly | 34.4262 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 34.4262 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 29.5082 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 29.5082 | 6 | no |
| GO:0071702 | organic substance transport | 29.5082 | 4 | no |
| GO:0071705 | nitrogen compound transport | 29.5082 | 4 | no |
| GO:0051726 | regulation of cell cycle | 27.8689 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.8689 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.8689 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 27.8689 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 26.2295 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 26.2295 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 26.2295 | 6 | no |
| GO:0031399 | regulation of protein modification process | 26.2295 | 6 | no |
| GO:0007010 | cytoskeleton organization | 26.2295 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.2295 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.2295 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.5902 | 5 | no |
| GO:0015031 | protein transport | 24.5902 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.9508 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.9508 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 22.9508 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.9508 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 22.9508 | 8 | no |
| GO:0010648 | negative regulation of cell communication | 21.3115 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.3115 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 21.3115 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 21.3115 | 7 | no |
| GO:0051050 | positive regulation of transport | 21.3115 | 4 | no |
| GO:0051338 | regulation of transferase activity | 21.3115 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.3115 | 5 | no |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 11.4754 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 9.8361 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 9.8361 | 6 | yes |
| GO:0099536 | synaptic signaling | 9.8361 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 9.8361 | 5 | yes |
| GO:0006915 | apoptotic process | 8.1967 | 4 | yes |
| GO:0008088 | axo-dendritic transport | 8.1967 | 5 | yes |
| GO:0010970 | transport along microtubule | 8.1967 | 4 | yes |
| GO:0099111 | microtubule-based transport | 8.1967 | 4 | yes |
| GO:0098930 | axonal transport | 4.9180 | 6 | yes |
| GO:0008089 | anterograde axonal transport | 3.2787 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STA13_HUMAN | [view interactions] | Low throughput | no | yes |
| GIPC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CHP1_HUMAN | [view interactions] | Low throughput | no | yes |
| CLAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAGI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CPEB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DYSF_HUMAN | [view interactions] | Low throughput | no | no |
| PARK7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JKIP1_HUMAN | [view interactions] | Low throughput | no | no |
| GABR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| SPE39_HUMAN | [view interactions] | High throughput | no | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLOD1_HUMAN | [view interactions] | High throughput | no | yes |
| DEFM_HUMAN | [view interactions] | High throughput | no | yes |
| PP4R1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| TULP2_HUMAN | [view interactions] | High throughput | no | no |
| IF4A1_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN217_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| FBLN5_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PURG_HUMAN | [view interactions] | High throughput | no | yes |
| APBA1_HUMAN | [view interactions] | High throughput | no | no |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| LPXN_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC6_HUMAN | [view interactions] | High throughput | no | yes |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACVL1_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| ARK2N_HUMAN | [view interactions] | High throughput | no | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| PSA7_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI16_HUMAN | [view interactions] | High throughput | no | no |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
| PSA6_HUMAN | [view interactions] | High throughput | no | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSDE1_HUMAN | [view interactions] | High throughput | no | yes |
| BYST_HUMAN | [view interactions] | High throughput | no | yes |
| CE350_HUMAN | [view interactions] | High throughput | no | yes |
| CTIF_HUMAN | [view interactions] | High throughput | no | yes |
| F120A_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B2_HUMAN | [view interactions] | High throughput | no | yes |
| IPO8_HUMAN | [view interactions] | High throughput | no | no |
| PRC2A_HUMAN | [view interactions] | High throughput | no | yes |
| STRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TDRD3_HUMAN | [view interactions] | High throughput | no | yes |
| TDRD7_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YTHD2_HUMAN | [view interactions] | High throughput | no | yes |
| AKTIP_HUMAN | [view interactions] | High throughput | no | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCDC9_HUMAN | [view interactions] | High throughput | no | yes |
| HERC1_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUBP3_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| MI4GD_HUMAN | [view interactions] | High throughput | no | yes |
| F120C_HUMAN | [view interactions] | High throughput | no | yes |
| GTPB1_HUMAN | [view interactions] | High throughput | no | yes |
| MAGI1_HUMAN | [view interactions] | High throughput | no | no |
| MEX3B_HUMAN | [view interactions] | High throughput | no | no |
| TEX9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPP7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| RPB3_HUMAN | [view interactions] | High throughput | no | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| TRI36_HUMAN | [view interactions] | High throughput | no | no |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL10_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLK1_HUMAN | [view interactions] | High throughput | no | yes |
| RAD50_HUMAN | [view interactions] | High throughput | no | yes |
| FANCG_HUMAN | [view interactions] | High throughput | no | yes |
| RBM7_HUMAN | [view interactions] | High throughput | no | yes |
| ZSC26_HUMAN | [view interactions] | High throughput | no | no |
| UBC9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP26B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRE_HUMAN | [view interactions] | High throughput | no | no |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| SIAH1_HUMAN | [view interactions] | High throughput | no | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIP4_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR5_HUMAN | [view interactions] | High throughput | no | yes |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| POMP_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKNX1_HUMAN | [view interactions] | High throughput | no | yes |
| RSPH1_HUMAN | [view interactions] | High throughput | no | no |
| DSCR4_HUMAN | [view interactions] | High throughput | no | no |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| IF4E2_HUMAN | [view interactions] | High throughput | no | no |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| RTKN_HUMAN | [view interactions] | High throughput | no | yes |
| KI13B_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
| CING_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| PK3C3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAK2_HUMAN | [view interactions] | High throughput | no | yes |
| PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAGA1_HUMAN | [view interactions] | High throughput | no | no |
| PAR6A_HUMAN | [view interactions] | High throughput | no | yes |
| THOC2_HUMAN | [view interactions] | High throughput | no | yes |
| SMC6_HUMAN | [view interactions] | High throughput | no | no |
| NCOA4_HUMAN | [view interactions] | High throughput | no | no |
| BACH1_HUMAN | [view interactions] | High throughput | no | no |
| SMC1A_HUMAN | [view interactions] | High throughput | no | yes |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| MUS81_HUMAN | [view interactions] | High throughput | no | no |
| YPEL5_HUMAN | [view interactions] | High throughput | no | yes |
| NAV1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BIN2_HUMAN | [view interactions] | High throughput | no | no |
| CETN1_HUMAN | [view interactions] | High throughput | no | no |
| KBP_HUMAN | [view interactions] | High throughput | no | yes |