ACTN4_HUMAN
Evidence for PS localization
Functions
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions . May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 255 | Lys | Glu | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 259 | Thr | Ile | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 262 | Ser | Pro | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 262 | Ser | Phe | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 427 | Ala | Thr | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 748 | Asn | Asp | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 59 | Trp | Arg | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 72 | Glu | Gln | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACTN4_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 31.2102 | 4 | yes |
| GO:0046872 | metal ion binding | 27.3885 | 4 | yes |
| GO:0003723 | RNA binding | 26.1146 | 4 | yes |
| GO:0019900 | kinase binding | 22.9299 | 4 | no |
| GO:0045296 | cadherin binding | 22.9299 | 4 | no |
| GO:0019901 | protein kinase binding | 21.6561 | 5 | no |
| GO:0017076 | purine nucleotide binding | 21.0191 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 21.0191 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.3822 | 4 | no |
| GO:0042803 | protein homodimerization activity | 12.7389 | 4 | yes |
| GO:0005509 | calcium ion binding | 11.4650 | 5 | yes |
| GO:0140297 | DNA-binding transcription factor binding | 8.2803 | 4 | yes |
| GO:0003677 | DNA binding | 6.3694 | 4 | yes |
| GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | 6.3694 | 5 | yes |
| GO:0003690 | double-stranded DNA binding | 3.8217 | 5 | yes |
| GO:0043565 | sequence-specific DNA binding | 3.8217 | 5 | yes |
| GO:0000976 | transcription cis-regulatory region binding | 3.1847 | 5 | yes |
| GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | 3.1847 | 6 | yes |
| GO:0001067 | transcription regulatory region nucleic acid binding | 3.1847 | 4 | yes |
| GO:0016922 | nuclear receptor binding | 3.1847 | 6 | yes |
| GO:0030374 | nuclear receptor coactivator activity | 3.1847 | 4 | yes |
| GO:1990837 | sequence-specific double-stranded DNA binding | 3.1847 | 6 | yes |
| GO:0042974 | nuclear retinoic acid receptor binding | 1.2739 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACTN4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.5987 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 52.2293 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 49.6815 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 49.0446 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 46.4968 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 45.8599 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 45.2229 | 4 | no |
| GO:0010646 | regulation of cell communication | 40.7643 | 4 | yes |
| GO:0006996 | organelle organization | 39.4904 | 4 | yes |
| GO:0010468 | regulation of gene expression | 37.5796 | 5 | no |
| GO:0022607 | cellular component assembly | 37.5796 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.5796 | 4 | no |
| GO:0009966 | regulation of signal transduction | 37.5796 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.0318 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 33.7580 | 5 | no |
| GO:0051049 | regulation of transport | 32.4841 | 4 | yes |
| GO:0008104 | protein localization | 31.8471 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 29.2994 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.2994 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.6624 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 28.6624 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.6624 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 28.6624 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 28.0255 | 4 | no |
| GO:0007010 | cytoskeleton organization | 28.0255 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.3885 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.3885 | 5 | yes |
| GO:0010941 | regulation of cell death | 26.7516 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 26.1146 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 26.1146 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 26.1146 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 25.4777 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.8408 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.8408 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 24.2038 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 23.5669 | 4 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 23.5669 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.5669 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 22.9299 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 22.9299 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 22.9299 | 6 | no |
| GO:0031399 | regulation of protein modification process | 22.9299 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.9299 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.9299 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 22.9299 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 21.6561 | 6 | no |
| GO:0060341 | regulation of cellular localization | 21.6561 | 4 | no |
| GO:0043412 | macromolecule modification | 21.0191 | 4 | no |
| GO:0030030 | cell projection organization | 21.0191 | 4 | no |
| GO:0051050 | positive regulation of transport | 20.3822 | 4 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 20.3822 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 20.3822 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 20.3822 | 7 | no |
| GO:0036211 | protein modification process | 20.3822 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 20.3822 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 19.1083 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 19.1083 | 4 | yes |
| GO:0071702 | organic substance transport | 19.1083 | 4 | yes |
| GO:2000145 | regulation of cell motility | 19.1083 | 4 | yes |
| GO:0030334 | regulation of cell migration | 18.4713 | 5 | yes |
| GO:0071705 | nitrogen compound transport | 17.8344 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 16.5605 | 6 | yes |
| GO:0015031 | protein transport | 15.2866 | 4 | yes |
| GO:0022604 | regulation of cell morphogenesis | 15.2866 | 5 | yes |
| GO:0043269 | regulation of ion transport | 15.2866 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 12.1019 | 4 | yes |
| GO:0010959 | regulation of metal ion transport | 11.4650 | 6 | yes |
| GO:0030335 | positive regulation of cell migration | 11.4650 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 11.4650 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 11.4650 | 5 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 10.8280 | 5 | yes |
| GO:0060284 | regulation of cell development | 10.8280 | 5 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 10.8280 | 6 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 10.1911 | 4 | yes |
| GO:0010810 | regulation of cell-substrate adhesion | 9.5541 | 5 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 9.5541 | 5 | yes |
| GO:0051093 | negative regulation of developmental process | 9.5541 | 4 | yes |
| GO:0043270 | positive regulation of ion transport | 8.9172 | 5 | yes |
| GO:0010769 | regulation of cell morphogenesis involved in differentiation | 7.6433 | 6 | yes |
| GO:0045596 | negative regulation of cell differentiation | 7.6433 | 5 | yes |
| GO:0007162 | negative regulation of cell adhesion | 7.6433 | 5 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 7.0064 | 5 | yes |
| GO:0034767 | positive regulation of ion transmembrane transport | 6.3694 | 6 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 5.7325 | 4 | yes |
| GO:1900024 | regulation of substrate adhesion-dependent cell spreading | 5.7325 | 6 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 5.7325 | 7 | yes |
| GO:0051650 | establishment of vesicle localization | 5.0955 | 4 | yes |
| GO:0019221 | cytokine-mediated signaling pathway | 4.4586 | 4 | yes |
| GO:0032411 | positive regulation of transporter activity | 4.4586 | 4 | yes |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 4.4586 | 5 | yes |
| GO:0010721 | negative regulation of cell development | 3.8217 | 6 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 3.8217 | 5 | yes |
| GO:0010812 | negative regulation of cell-substrate adhesion | 3.1847 | 6 | yes |
| GO:0030050 | vesicle transport along actin filament | 3.1847 | 4 | yes |
| GO:0036293 | response to decreased oxygen levels | 3.1847 | 4 | yes |
| GO:0055001 | muscle cell development | 3.1847 | 4 | yes |
| GO:0099515 | actin filament-based transport | 3.1847 | 5 | yes |
| GO:1901222 | regulation of NIK/NF-kappaB signaling | 3.1847 | 6 | yes |
| GO:1901224 | positive regulation of NIK/NF-kappaB signaling | 3.1847 | 7 | yes |
| GO:0033209 | tumor necrosis factor-mediated signaling pathway | 2.5478 | 5 | yes |
| GO:0010771 | negative regulation of cell morphogenesis involved in differentiation | 1.9108 | 7 | yes |
| GO:0048384 | retinoic acid receptor signaling pathway | 1.9108 | 4 | yes |
| GO:1900025 | negative regulation of substrate adhesion-dependent cell spreading | 1.9108 | 7 | yes |
| GO:0010765 | positive regulation of sodium ion transport | 1.2739 | 6 | yes |
| GO:0032415 | regulation of sodium:proton antiporter activity | 1.2739 | 7 | yes |
| GO:0032417 | positive regulation of sodium:proton antiporter activity | 1.2739 | 7 | yes |
| GO:0035357 | peroxisome proliferator activated receptor signaling pathway | 1.2739 | 4 | yes |
| GO:1902305 | regulation of sodium ion transmembrane transport | 1.2739 | 7 | yes |
| GO:1902307 | positive regulation of sodium ion transmembrane transport | 1.2739 | 7 | yes |
| GO:2000649 | regulation of sodium ion transmembrane transporter activity | 1.2739 | 6 | yes |
| GO:2000651 | positive regulation of sodium ion transmembrane transporter activity | 1.2739 | 6 | yes |
| GO:0002028 | regulation of sodium ion transport | 1.2739 | 7 | yes |
| GO:0010155 | regulation of proton transport | 1.2739 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ACTN4_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 3.1847 | 3 | no |
| DOID:0050700 | cardiomyopathy | 2.5478 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 2.5478 | 5 | no |
| DOID:0050851 | glomerulosclerosis | 1.9108 | 6 | yes |
| DOID:10952 | nephritis | 1.9108 | 4 | yes |
| DOID:1312 | focal segmental glomerulosclerosis | 1.9108 | 7 | yes |
| DOID:2921 | glomerulonephritis | 1.9108 | 5 | yes |
| DOID:557 | kidney disease | 1.9108 | 3 | yes |
| DOID:574 | peripheral nervous system disease | 1.9108 | 3 | no |
| DOID:870 | neuropathy | 1.9108 | 4 | no |
| DOID:0050155 | sensory system disease | 1.9108 | 3 | no |
| DOID:0111128 | focal segmental glomerulosclerosis 1 | 1.2739 | 8 | yes |
| DOID:10595 | Charcot-Marie-Tooth disease | 1.2739 | 6 | no |
| DOID:440 | neuromuscular disease | 1.2739 | 5 | no |
| DOID:2843 | long QT syndrome | 1.2739 | 6 | no |
| DOID:5614 | eye disease | 1.2739 | 4 | no |
| DOID:0080000 | muscular disease | 1.2739 | 3 | no |
| DOID:3191 | nemaline myopathy | 1.2739 | 7 | no |
| DOID:422 | congenital structural myopathy | 1.2739 | 6 | no |
| DOID:423 | myopathy | 1.2739 | 5 | no |
| DOID:66 | muscle tissue disease | 1.2739 | 4 | no |
| DOID:12930 | dilated cardiomyopathy | 1.2739 | 6 | no |
| DOID:1289 | neurodegenerative disease | 1.2739 | 4 | no |
| DOID:331 | central nervous system disease | 1.2739 | 3 | no |
| DOID:1247 | blood coagulation disease | 1.2739 | 3 | no |
| DOID:2218 | blood platelet disease | 1.2739 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| OTUD3_HUMAN | [view interactions] | Low throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MILK2_HUMAN | [view interactions] | Low throughput | no | no |
| ALMS1_HUMAN | [view interactions] | Low throughput | no | no |
| GLUT4_HUMAN | [view interactions] | Low throughput | no | no |
| RAB13_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GELS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PDLI2_HUMAN | [view interactions] | Low throughput | no | no |
| IQGA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PDLI1_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTS_HUMAN | [view interactions] | Low throughput | no | no |
| RARA_HUMAN | [view interactions] | Low throughput | no | no |
| ACTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ST2B1_HUMAN | [view interactions] | Low throughput | no | yes |
| PPARG_HUMAN | [view interactions] | Low throughput | no | yes |
| ASIC1_HUMAN | [view interactions] | Low throughput | no | no |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| VINC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NHRF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RAVR1_HUMAN | [view interactions] | Low throughput | no | yes |
| COHA1_HUMAN | [view interactions] | Low throughput | no | no |
| TRIM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRRC7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HDAC7_HUMAN | [view interactions] | Low throughput | no | no |
| AA2AR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| US6NL_HUMAN | [view interactions] | Low throughput | no | yes |
| MAGI1_HUMAN | [view interactions] | Low throughput | no | no |
| INO80_HUMAN | [view interactions] | Low throughput | no | no |
| UBF1_HUMAN | [view interactions] | Low throughput | no | yes |
| MEF2A_HUMAN | [view interactions] | Low throughput | no | yes |
| VDR_HUMAN | [view interactions] | Low throughput | no | no |
| NOS2_HUMAN | [view interactions] | Low throughput | no | yes |
| NFYA_HUMAN | [view interactions] | Low throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT9_HUMAN | [view interactions] | High throughput | no | no |
| UBR5_HUMAN | [view interactions] | High throughput | no | no |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| LHPP_HUMAN | [view interactions] | High throughput | no | yes |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| CATB_HUMAN | [view interactions] | High throughput | no | yes |
| CATS_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| FBX43_HUMAN | [view interactions] | High throughput | no | no |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARC1B_HUMAN | [view interactions] | High throughput | no | no |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC5_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYTSA_HUMAN | [view interactions] | High throughput | no | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SACS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP5L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOS3_HUMAN | [view interactions] | High throughput | no | no |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX7_HUMAN | [view interactions] | High throughput | no | no |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIF1L_HUMAN | [view interactions] | High throughput | no | yes |
| MK07_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2C_HUMAN | [view interactions] | High throughput | no | no |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A_HUMAN | [view interactions] | High throughput | no | no |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| STAG1_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| PDE4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF3A3_HUMAN | [view interactions] | High throughput | no | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| AHNK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH15_HUMAN | [view interactions] | High throughput | no | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| MYH2_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| MYH7B_HUMAN | [view interactions] | High throughput | no | no |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CNDG2_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA6_HUMAN | [view interactions] | High throughput | no | yes |
| MYEF2_HUMAN | [view interactions] | High throughput | no | no |
| PSB5_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUS7_HUMAN | [view interactions] | High throughput | no | yes |
| SIN3B_HUMAN | [view interactions] | High throughput | no | yes |
| TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MCFD2_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB8_HUMAN | [view interactions] | High throughput | no | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| SYJ2B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| ATX2_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYEP_HUMAN | [view interactions] | High throughput | no | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRA1_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RO60_HUMAN | [view interactions] | High throughput | no | yes |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDN2A_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| SUN2_HUMAN | [view interactions] | High throughput | no | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPM1D_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIM3_HUMAN | [view interactions] | High throughput | no | no |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| M3K2_HUMAN | [view interactions] | High throughput | no | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMPN_HUMAN | [view interactions] | High throughput | no | no |
| MIPT3_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| MYOZ2_HUMAN | [view interactions] | High throughput | no | no |
| PER2_HUMAN | [view interactions] | High throughput | no | yes |
| CN119_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TYW4_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| MYOZ1_HUMAN | [view interactions] | High throughput | no | no |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| PE2R4_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| RIPK3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| KDM4C_HUMAN | [view interactions] | High throughput | no | no |
| TITIN_HUMAN | [view interactions] | High throughput | no | no |
| MTP_HUMAN | [view interactions] | High throughput | no | no |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| VILI_HUMAN | [view interactions] | High throughput | no | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSH1_HUMAN | [view interactions] | High throughput | no | yes |
| BMP7_HUMAN | [view interactions] | High throughput | no | no |
| SRBS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDIAS_HUMAN | [view interactions] | High throughput | no | no |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| P2RX7_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO3_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ICAM1_HUMAN | [view interactions] | High throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HACE1_HUMAN | [view interactions] | High throughput | no | no |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| LUZP4_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| CBAR1_HUMAN | [view interactions] | High throughput | no | no |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| TF3B_HUMAN | [view interactions] | High throughput | no | yes |
| TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| MGDP1_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| NFIX_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RO52_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3F_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMHD1_HUMAN | [view interactions] | High throughput | no | yes |
| INSI1_HUMAN | [view interactions] | High throughput | no | no |
| INSI2_HUMAN | [view interactions] | High throughput | no | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NPHN_HUMAN | [view interactions] | Computational | no | no |
| CTNA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ITA5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| TLN1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| FAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| P85A_HUMAN | [view interactions] | Computational | no | yes |
| INF2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PODO_HUMAN | [view interactions] | Computational | no | no |
| CD2AP_HUMAN | [view interactions] | Computational | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ACTG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| BCAR1_HUMAN | [view interactions] | Computational | no | yes |
| CRKL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LDB3_HUMAN | [view interactions] | Computational | no | no |
| TENS1_HUMAN | [view interactions] | Computational | no | no |
| PAXI_HUMAN | [view interactions] | Computational | no | yes |
| CSK_HUMAN | [view interactions] | Computational | no | yes |
| ITA1_HUMAN | [view interactions] | Computational | no | yes |
| CTNA3_HUMAN | [view interactions] | Computational | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CTNA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ADIP_HUMAN | [view interactions] | Computational | no | yes |
| NOLC1_HUMAN | [view interactions] | Computational | no | yes |
| KIRR1_HUMAN | [view interactions] | Computational | no | no |