ACTN4_HUMAN
Evidence for PS localization
Functions
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions . May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed). [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 64%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Close ✖
ACTN4_HUMAN has binary interactions with 50 proteins
Isoforms
Interacting regions
Canonical [ACTN4_HUMAN]
Isoform [H7C144] alignment
Isoform [A0A8V8TL71] alignment
Isoform [K7EP19] alignment
Isoform [O43707-2] alignment
Isoform [O43707-3] alignment
Isoform [F5GXS2] alignment
LOADING 47%
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 255 | Lys | Glu | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 259 | Thr | Ile | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 262 | Ser | Pro | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 262 | Ser | Phe | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 427 | Ala | Thr | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 748 | Asn | Asp | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 59 | Trp | Arg | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 72 | Glu | Gln | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACTN4_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 31.0345 | 4 | yes |
| GO:0043169 | cation binding | 28.7356 | 4 | yes |
| GO:0046872 | metal ion binding | 28.7356 | 5 | yes |
| GO:0003779 | actin binding | 26.4368 | 4 | yes |
| GO:0043168 | anion binding | 24.1379 | 4 | no |
| GO:0000166 | nucleotide binding | 23.5632 | 4 | no |
| GO:0019900 | kinase binding | 22.4138 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.8391 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 20.6897 | 6 | no |
| GO:0019901 | protein kinase binding | 20.1149 | 5 | no |
| GO:0042803 | protein homodimerization activity | 12.0690 | 4 | yes |
| GO:0005509 | calcium ion binding | 10.3448 | 6 | yes |
| GO:0140297 | DNA-binding transcription factor binding | 8.6207 | 4 | yes |
| GO:0003677 | DNA binding | 8.0460 | 4 | yes |
| GO:0043565 | sequence-specific DNA binding | 5.7471 | 5 | yes |
| GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | 5.7471 | 5 | yes |
| GO:0003690 | double-stranded DNA binding | 4.5977 | 5 | yes |
| GO:0000976 | transcription cis-regulatory region binding | 4.0230 | 5 | yes |
| GO:0001067 | transcription regulatory region nucleic acid binding | 4.0230 | 4 | yes |
| GO:1990837 | sequence-specific double-stranded DNA binding | 4.0230 | 6 | yes |
| GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | 2.8736 | 6 | yes |
| GO:0016922 | nuclear receptor binding | 2.8736 | 6 | yes |
| GO:0030374 | nuclear receptor coactivator activity | 2.2989 | 4 | yes |
| GO:0031490 | chromatin DNA binding | 1.7241 | 4 | yes |
| GO:0042974 | nuclear retinoic acid receptor binding | 1.1494 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACTN4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.3448 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 54.0230 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 52.8736 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 52.2989 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 44.2529 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 43.6782 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 43.6782 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 43.1034 | 4 | no |
| GO:0010468 | regulation of gene expression | 42.5287 | 6 | yes |
| GO:0010646 | regulation of cell communication | 39.0805 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 39.0805 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.3563 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 37.3563 | 5 | yes |
| GO:0022607 | cellular component assembly | 36.7816 | 4 | no |
| GO:0006996 | organelle organization | 36.2069 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 35.6322 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.1839 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 32.1839 | 5 | no |
| GO:0008104 | protein localization | 30.4598 | 4 | yes |
| GO:0051049 | regulation of transport | 29.8851 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 29.8851 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 29.3103 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 29.3103 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 29.3103 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2A5E_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AA2AR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTS_HUMAN | [view interactions] | Low throughput | no | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AHNK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIF1L_HUMAN | [view interactions] | High throughput | no | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |