ACTN4_HUMAN
Evidence for PS localization
Functions
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions . May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 255 | Lys | Glu | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 259 | Thr | Ile | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 262 | Ser | Pro | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 262 | Ser | Phe | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 427 | Ala | Thr | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 748 | Asn | Asp | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 59 | Trp | Arg | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
| 72 | Glu | Gln | Focalsegmentalglomerulosclerosis1(FSGS1) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACTN4_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 31.0345 | 4 | yes |
| GO:0043169 | cation binding | 28.7356 | 4 | yes |
| GO:0046872 | metal ion binding | 28.7356 | 5 | yes |
| GO:0003779 | actin binding | 26.4368 | 4 | yes |
| GO:0043168 | anion binding | 24.1379 | 4 | no |
| GO:0000166 | nucleotide binding | 23.5632 | 4 | no |
| GO:0019900 | kinase binding | 22.4138 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.8391 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 20.6897 | 6 | no |
| GO:0019901 | protein kinase binding | 20.1149 | 5 | no |
| GO:0042803 | protein homodimerization activity | 12.0690 | 4 | yes |
| GO:0005509 | calcium ion binding | 10.3448 | 6 | yes |
| GO:0140297 | DNA-binding transcription factor binding | 8.6207 | 4 | yes |
| GO:0003677 | DNA binding | 8.0460 | 4 | yes |
| GO:0043565 | sequence-specific DNA binding | 5.7471 | 5 | yes |
| GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | 5.7471 | 5 | yes |
| GO:0003690 | double-stranded DNA binding | 4.5977 | 5 | yes |
| GO:0000976 | transcription cis-regulatory region binding | 4.0230 | 5 | yes |
| GO:0001067 | transcription regulatory region nucleic acid binding | 4.0230 | 4 | yes |
| GO:1990837 | sequence-specific double-stranded DNA binding | 4.0230 | 6 | yes |
| GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | 2.8736 | 6 | yes |
| GO:0016922 | nuclear receptor binding | 2.8736 | 6 | yes |
| GO:0030374 | nuclear receptor coactivator activity | 2.2989 | 4 | yes |
| GO:0031490 | chromatin DNA binding | 1.7241 | 4 | yes |
| GO:0042974 | nuclear retinoic acid receptor binding | 1.1494 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACTN4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.3448 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 54.0230 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 52.8736 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 52.2989 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 44.2529 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 43.6782 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 43.6782 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 43.1034 | 4 | no |
| GO:0010468 | regulation of gene expression | 42.5287 | 6 | yes |
| GO:0010646 | regulation of cell communication | 39.0805 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 39.0805 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.3563 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 37.3563 | 5 | yes |
| GO:0022607 | cellular component assembly | 36.7816 | 4 | no |
| GO:0006996 | organelle organization | 36.2069 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 35.6322 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.1839 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 32.1839 | 5 | no |
| GO:0008104 | protein localization | 30.4598 | 4 | yes |
| GO:0051049 | regulation of transport | 29.8851 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 29.8851 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 29.3103 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 29.3103 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 29.3103 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.7356 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.5862 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.4368 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 26.4368 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.4368 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 25.8621 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 25.8621 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 24.7126 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 24.1379 | 6 | yes |
| GO:0051130 | positive regulation of cellular component organization | 24.1379 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 24.1379 | 7 | yes |
| GO:0023056 | positive regulation of signaling | 23.5632 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 23.5632 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 23.5632 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 22.9885 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 22.9885 | 4 | no |
| GO:0007010 | cytoskeleton organization | 22.9885 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 22.9885 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 22.4138 | 6 | no |
| GO:0060341 | regulation of cellular localization | 22.4138 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.2644 | 4 | no |
| GO:0043412 | macromolecule modification | 21.2644 | 4 | no |
| GO:0032880 | regulation of protein localization | 20.6897 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 20.1149 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 20.1149 | 7 | no |
| GO:0009894 | regulation of catabolic process | 20.1149 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.1149 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.1149 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.1149 | 6 | no |
| GO:0031399 | regulation of protein modification process | 20.1149 | 6 | no |
| GO:0036211 | protein modification process | 20.1149 | 4 | no |
| GO:0051050 | positive regulation of transport | 18.9655 | 4 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 18.3908 | 5 | yes |
| GO:0071702 | organic substance transport | 17.2414 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 16.6667 | 4 | yes |
| GO:0030155 | regulation of cell adhesion | 16.0920 | 4 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 15.5172 | 8 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 14.3678 | 6 | yes |
| GO:0030334 | regulation of cell migration | 13.7931 | 5 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 13.7931 | 6 | yes |
| GO:2000145 | regulation of cell motility | 13.7931 | 4 | yes |
| GO:0015031 | protein transport | 13.2184 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 12.6437 | 4 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 12.6437 | 5 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 12.6437 | 8 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 12.6437 | 7 | yes |
| GO:0010959 | regulation of metal ion transport | 11.4943 | 6 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 9.7701 | 9 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 9.1954 | 5 | yes |
| GO:0030335 | positive regulation of cell migration | 8.6207 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 8.6207 | 4 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 8.6207 | 6 | yes |
| GO:2000147 | positive regulation of cell motility | 8.6207 | 5 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 8.0460 | 4 | yes |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 7.4713 | 5 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 6.8966 | 5 | yes |
| GO:0043270 | positive regulation of monoatomic ion transport | 6.8966 | 5 | yes |
| GO:0010810 | regulation of cell-substrate adhesion | 6.3218 | 5 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 6.3218 | 4 | yes |
| GO:0007162 | negative regulation of cell adhesion | 6.3218 | 5 | yes |
| GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 5.1724 | 6 | yes |
| GO:0051650 | establishment of vesicle localization | 5.1724 | 4 | yes |
| GO:0019221 | cytokine-mediated signaling pathway | 4.5977 | 4 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 4.5977 | 7 | yes |
| GO:0032411 | positive regulation of transporter activity | 4.0230 | 4 | yes |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 4.0230 | 5 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 4.0230 | 5 | yes |
| GO:0030050 | vesicle transport along actin filament | 3.4483 | 4 | yes |
| GO:0099515 | actin filament-based transport | 3.4483 | 5 | yes |
| GO:1900024 | regulation of substrate adhesion-dependent cell spreading | 3.4483 | 6 | yes |
| GO:0010812 | negative regulation of cell-substrate adhesion | 2.8736 | 6 | yes |
| GO:0033209 | tumor necrosis factor-mediated signaling pathway | 2.8736 | 5 | yes |
| GO:0055001 | muscle cell development | 2.8736 | 4 | yes |
| GO:1901222 | regulation of non-canonical NF-kappaB signal transduction | 2.2989 | 6 | yes |
| GO:1901224 | positive regulation of non-canonical NF-kappaB signal transduction | 2.2989 | 7 | yes |
| GO:0010765 | positive regulation of sodium ion transport | 1.7241 | 6 | yes |
| GO:1900025 | negative regulation of substrate adhesion-dependent cell spreading | 1.7241 | 7 | yes |
| GO:0002028 | regulation of sodium ion transport | 1.7241 | 7 | yes |
| GO:0032415 | regulation of sodium:proton antiporter activity | 1.1494 | 7 | yes |
| GO:0032417 | positive regulation of sodium:proton antiporter activity | 1.1494 | 7 | yes |
| GO:0035357 | peroxisome proliferator activated receptor signaling pathway | 1.1494 | 4 | yes |
| GO:0048384 | retinoic acid receptor signaling pathway | 1.1494 | 4 | yes |
| GO:1902305 | regulation of sodium ion transmembrane transport | 1.1494 | 7 | yes |
| GO:1902307 | positive regulation of sodium ion transmembrane transport | 1.1494 | 7 | yes |
| GO:2000649 | regulation of sodium ion transmembrane transporter activity | 1.1494 | 6 | yes |
| GO:2000651 | positive regulation of sodium ion transmembrane transporter activity | 1.1494 | 6 | yes |
| GO:0010155 | regulation of proton transport | 1.1494 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PPARG_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTS_HUMAN | [view interactions] | Low throughput | no | no |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| NHRF2_HUMAN | [view interactions] | Low throughput | no | no |
| RAVR1_HUMAN | [view interactions] | Low throughput | no | no |
| COHA1_HUMAN | [view interactions] | Low throughput | no | no |
| TRIM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRRC7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HDAC7_HUMAN | [view interactions] | Low throughput | no | no |
| AA2AR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| US6NL_HUMAN | [view interactions] | Low throughput | no | yes |
| MAGI1_HUMAN | [view interactions] | Low throughput | no | no |
| INO80_HUMAN | [view interactions] | Low throughput | no | no |
| UBF1_HUMAN | [view interactions] | Low throughput | no | yes |
| MEF2A_HUMAN | [view interactions] | Low throughput | no | yes |
| VDR_HUMAN | [view interactions] | Low throughput | no | no |
| NOS2_HUMAN | [view interactions] | Low throughput | no | yes |
| NFYA_HUMAN | [view interactions] | Low throughput | no | yes |
| ASIC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VINC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| OTUD3_HUMAN | [view interactions] | Low throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MILK2_HUMAN | [view interactions] | Low throughput | no | no |
| ALMS1_HUMAN | [view interactions] | Low throughput | no | no |
| GLUT4_HUMAN | [view interactions] | Low throughput | no | no |
| RAB13_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PDLI1_HUMAN | [view interactions] | Low throughput | no | yes |
| RARA_HUMAN | [view interactions] | Low throughput | no | no |
| ACTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GELS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PDLI2_HUMAN | [view interactions] | Low throughput | no | no |
| ZO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ST2B1_HUMAN | [view interactions] | Low throughput | no | yes |
| PPM1D_HUMAN | [view interactions] | High throughput | no | no |
| TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCFD2_HUMAN | [view interactions] | High throughput | no | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB8_HUMAN | [view interactions] | High throughput | no | yes |
| PIM3_HUMAN | [view interactions] | High throughput | no | no |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| M3K2_HUMAN | [view interactions] | High throughput | no | yes |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIPT3_HUMAN | [view interactions] | High throughput | no | yes |
| SYJ2B_HUMAN | [view interactions] | High throughput | no | no |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| ATX2_HUMAN | [view interactions] | High throughput | no | yes |
| UD2B7_HUMAN | [view interactions] | High throughput | no | no |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| POC5_HUMAN | [view interactions] | High throughput | no | yes |
| SYEP_HUMAN | [view interactions] | High throughput | no | yes |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| RL26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOZ2_HUMAN | [view interactions] | High throughput | no | no |
| RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CN119_HUMAN | [view interactions] | High throughput | no | yes |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRA1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TYW4_HUMAN | [view interactions] | High throughput | no | yes |
| RO60_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOZ1_HUMAN | [view interactions] | High throughput | no | no |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WASL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| HMGB3_HUMAN | [view interactions] | High throughput | no | no |
| PE2R4_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPR_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK3_HUMAN | [view interactions] | High throughput | no | no |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDM4C_HUMAN | [view interactions] | High throughput | no | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TITIN_HUMAN | [view interactions] | High throughput | no | no |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSCR9_HUMAN | [view interactions] | High throughput | no | no |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSCAM_HUMAN | [view interactions] | High throughput | no | yes |
| FPPS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTP_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| YBOX3_HUMAN | [view interactions] | High throughput | no | yes |
| VILI_HUMAN | [view interactions] | High throughput | no | no |
| OSBP1_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| SSH1_HUMAN | [view interactions] | High throughput | no | yes |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F10A1_HUMAN | [view interactions] | High throughput | no | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSF1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| NCBP1_HUMAN | [view interactions] | High throughput | no | yes |
| ILF2_HUMAN | [view interactions] | High throughput | no | yes |
| PABP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMP7_HUMAN | [view interactions] | High throughput | no | no |
| TRIPC_HUMAN | [view interactions] | High throughput | no | yes |
| SRBS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2A5E_HUMAN | [view interactions] | High throughput | no | yes |
| DDIAS_HUMAN | [view interactions] | High throughput | no | no |
| RBBP7_HUMAN | [view interactions] | High throughput | no | yes |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| LAMA3_HUMAN | [view interactions] | High throughput | no | no |
| DPP8_HUMAN | [view interactions] | High throughput | no | yes |
| P2RX7_HUMAN | [view interactions] | High throughput | no | yes |
| PABP2_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| FMNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| AMPN_HUMAN | [view interactions] | High throughput | no | no |
| IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ICAM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| HACE1_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| PER2_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| NRX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| LUZP4_HUMAN | [view interactions] | High throughput | no | no |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| FOXO1_HUMAN | [view interactions] | High throughput | no | yes |
| PHOCN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| CBAR1_HUMAN | [view interactions] | High throughput | no | no |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| TF3B_HUMAN | [view interactions] | High throughput | no | yes |
| TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| MGDP1_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| NFIX_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RO52_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3F_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMHD1_HUMAN | [view interactions] | High throughput | no | yes |
| INSI1_HUMAN | [view interactions] | High throughput | no | no |
| INSI2_HUMAN | [view interactions] | High throughput | no | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT9_HUMAN | [view interactions] | High throughput | no | no |
| UBR5_HUMAN | [view interactions] | High throughput | no | no |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| LHPP_HUMAN | [view interactions] | High throughput | no | yes |
| TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATB_HUMAN | [view interactions] | High throughput | no | yes |
| CATS_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| FBX43_HUMAN | [view interactions] | High throughput | no | no |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARC1B_HUMAN | [view interactions] | High throughput | no | no |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SACS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOS3_HUMAN | [view interactions] | High throughput | no | no |
| CYTSA_HUMAN | [view interactions] | High throughput | no | yes |
| ATX7_HUMAN | [view interactions] | High throughput | no | no |
| ARPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MK07_HUMAN | [view interactions] | High throughput | no | yes |
| ARP5L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| ARC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A_HUMAN | [view interactions] | High throughput | no | no |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2C_HUMAN | [view interactions] | High throughput | no | no |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIF1L_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK1_HUMAN | [view interactions] | High throughput | no | yes |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| STAG1_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOLR1_HUMAN | [view interactions] | High throughput | no | no |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARI1A_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| RNF38_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| ARMC5_HUMAN | [view interactions] | High throughput | no | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAVN3_HUMAN | [view interactions] | High throughput | no | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
| MYEF2_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCTD9_HUMAN | [view interactions] | High throughput | no | no |
| SIN3B_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI64_HUMAN | [view interactions] | High throughput | no | no |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIAS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TET5C_HUMAN | [view interactions] | High throughput | no | yes |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| RN207_HUMAN | [view interactions] | High throughput | no | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| PDE4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF3A3_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AHNK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH15_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH2_HUMAN | [view interactions] | High throughput | no | yes |
| MYH7B_HUMAN | [view interactions] | High throughput | no | no |
| CDN2A_HUMAN | [view interactions] | High throughput | no | yes |
| CNDG2_HUMAN | [view interactions] | High throughput | no | yes |
| PSA6_HUMAN | [view interactions] | High throughput | no | yes |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| PSB5_HUMAN | [view interactions] | High throughput | no | yes |
| SUN2_HUMAN | [view interactions] | High throughput | no | yes |
| PUS7_HUMAN | [view interactions] | High throughput | no | yes |