Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ASIC1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Isoform 1 does not display proton-gated cation channel activity. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ASIC1_HUMAN
GO:0005216 monoatomic ion channel activity 42.8571 4 yes
GO:0005261 monoatomic cation channel activity 42.8571 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 42.8571 4 yes
GO:0015267 channel activity 42.8571 4 yes
GO:0022836 gated channel activity 42.8571 5 yes
GO:0043169 cation binding 42.8571 4 no
GO:0046872 metal ion binding 42.8571 5 no
GO:0043168 anion binding 42.8571 4 no
GO:0015276 ligand-gated monoatomic ion channel activity 38.0952 5 yes
GO:0022834 ligand-gated channel activity 38.0952 6 yes
GO:0099094 ligand-gated monoatomic cation channel activity 38.0952 6 yes
GO:0000166 nucleotide binding 38.0952 4 no
GO:0017076 purine nucleotide binding 38.0952 5 no
GO:0032555 purine ribonucleotide binding 38.0952 4 no
GO:0022890 inorganic cation transmembrane transporter activity 33.3333 4 yes
GO:0046873 metal ion transmembrane transporter activity 33.3333 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0030554 adenyl nucleotide binding 23.8095 6 no
GO:0032559 adenyl ribonucleotide binding 23.8095 5 no
GO:0005272 sodium channel activity 19.0476 6 yes
GO:0015081 sodium ion transmembrane transporter activity 19.0476 6 yes
GO:0015280 ligand-gated sodium channel activity 14.2857 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ASIC1_HUMAN
GO:0051049 regulation of transport 61.9048 4 yes
GO:0048522 positive regulation of cellular process 57.1429 4 no
GO:0006811 monoatomic ion transport 42.8571 4 yes
GO:0006812 monoatomic cation transport 42.8571 5 yes
GO:0010646 regulation of cell communication 42.8571 4 yes
GO:0022607 cellular component assembly 42.8571 4 yes
GO:0030001 metal ion transport 42.8571 6 yes
GO:0098655 monoatomic cation transmembrane transport 42.8571 4 yes
GO:0098662 inorganic cation transmembrane transport 42.8571 4 yes
GO:0008104 protein localization 42.8571 4 no
GO:0071702 organic substance transport 38.0952 4 no
GO:0071705 nitrogen compound transport 38.0952 4 no
GO:0034762 regulation of transmembrane transport 38.0952 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 38.0952 5 no
GO:0043269 regulation of monoatomic ion transport 38.0952 5 no
GO:0015031 protein transport 33.3333 4 no
GO:0048523 negative regulation of cellular process 33.3333 4 yes
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0051128 regulation of cellular component organization 28.5714 4 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0010243 response to organonitrogen compound 28.5714 4 yes
GO:0043933 protein-containing complex organization 28.5714 4 yes
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 yes
GO:0051046 regulation of secretion 28.5714 5 yes
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 yes
GO:1903530 regulation of secretion by cell 28.5714 4 yes
GO:0010959 regulation of metal ion transport 28.5714 6 no
GO:1904062 regulation of monoatomic cation transmembrane transport 28.5714 6 no
GO:0009966 regulation of signal transduction 23.8095 4 no
GO:1902531 regulation of intracellular signal transduction 23.8095 5 no
GO:0006996 organelle organization 23.8095 4 no
GO:0032880 regulation of protein localization 23.8095 5 no
GO:0006816 calcium ion transport 23.8095 7 yes
GO:0046903 secretion 23.8095 4 yes
GO:0065003 protein-containing complex assembly 23.8095 5 yes
GO:0070588 calcium ion transmembrane transport 23.8095 5 yes
GO:0044057 regulation of system process 23.8095 4 no
GO:1903522 regulation of blood circulation 23.8095 5 no
GO:0006814 sodium ion transport 19.0476 7 yes
GO:0007600 sensory perception 19.0476 4 yes
GO:0007606 sensory perception of chemical stimulus 19.0476 5 yes
GO:0035725 sodium ion transmembrane transport 19.0476 5 yes
GO:0050909 sensory perception of taste 19.0476 6 yes
GO:0051259 protein complex oligomerization 19.0476 6 yes
GO:0051260 protein homooligomerization 19.0476 7 yes
GO:0010447 response to acidic pH 14.2857 4 yes
GO:0023061 signal release 14.2857 4 yes
GO:0046928 regulation of neurotransmitter secretion 14.2857 5 yes
GO:0050915 sensory perception of sour taste 14.2857 7 yes
GO:0051051 negative regulation of transport 14.2857 4 yes
GO:0051588 regulation of neurotransmitter transport 14.2857 5 yes
GO:0071467 cellular response to pH 14.2857 4 yes
GO:0001662 behavioral fear response 9.5238 4 yes
GO:0001975 response to amphetamine 9.5238 6 yes
GO:0006836 neurotransmitter transport 9.5238 4 yes
GO:0007269 neurotransmitter secretion 9.5238 4 yes
GO:0007612 learning 9.5238 4 yes
GO:0007613 memory 9.5238 4 yes
GO:0008306 associative learning 9.5238 5 yes
GO:0014075 response to amine 9.5238 5 yes
GO:0046929 negative regulation of neurotransmitter secretion 9.5238 6 yes
GO:0050890 cognition 9.5238 4 yes
GO:0051048 negative regulation of secretion 9.5238 5 yes
GO:0051589 negative regulation of neurotransmitter transport 9.5238 5 yes
GO:0070206 protein trimerization 9.5238 7 yes
GO:0070207 protein homotrimerization 9.5238 8 yes
GO:0099643 signal release from synapse 9.5238 5 yes
GO:1903531 negative regulation of secretion by cell 9.5238 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCMA1_HUMAN [view entry] [view interactions] Low throughput yes no
ATX3_HUMAN [view interactions] Low throughput no yes
ASIC2_HUMAN [view entry] [view interactions] Low throughput yes yes
STOM_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTN4_HUMAN [view entry] [view interactions] Low throughput yes yes
ASIC1_HUMAN [view entry] [view interactions] Low throughput yes no
DPEP1_HUMAN [view interactions] High throughput no no
HMOX2_HUMAN [view entry] [view interactions] High throughput yes yes
S27A3_HUMAN [view interactions] High throughput no no
UFSP2_HUMAN [view interactions] High throughput no yes
E2AK3_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
KI3L3_HUMAN [view interactions] High throughput no no
MGST2_HUMAN [view interactions] High throughput no no
TECT3_HUMAN [view interactions] High throughput no yes
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
KI2S2_HUMAN [view interactions] High throughput no no
TR10B_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
TECT2_HUMAN [view interactions] High throughput no yes
CO032_HUMAN [view interactions] High throughput no no
MBLC2_HUMAN [view interactions] High throughput no yes
CLPT1_HUMAN [view entry] [view interactions] High throughput yes yes
P2RX1_HUMAN [view entry] [view interactions] High throughput yes no
ODR4_HUMAN [view interactions] High throughput no yes
NCEH1_HUMAN [view interactions] High throughput no yes
B3GT4_HUMAN [view interactions] High throughput no yes
CNNM3_HUMAN [view interactions] High throughput no yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
KLK15_HUMAN [view interactions] High throughput no no
DOXA2_HUMAN [view interactions] High throughput no no
P2RX2_HUMAN [view entry] [view interactions] High throughput yes no
SDF2L_HUMAN [view interactions] High throughput no yes
HLAG_HUMAN [view interactions] High throughput no no
HLAC_HUMAN [view interactions] High throughput no no
ASIC4_HUMAN [view interactions] High throughput no no
SIA8E_HUMAN [view interactions] High throughput no yes
DRB3_HUMAN [view interactions] High throughput no no
ENTP2_HUMAN [view interactions] High throughput no yes
APOM_HUMAN [view interactions] High throughput no no
PSPC_HUMAN [view interactions] High throughput no no
UPK2_HUMAN [view interactions] High throughput no no
PILRB_HUMAN [view interactions] High throughput no yes
B3GA2_HUMAN [view interactions] High throughput no no
GPIX_HUMAN [view interactions] High throughput no no
SC11A_HUMAN [view interactions] High throughput no no
ERMP1_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
CLC4D_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
STML1_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
DYR2_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes