Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

HMOX2_HUMAN

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in HMOX2_HUMAN
GO:0017076 purine nucleotide binding 31.0680 5 no
GO:0000166 nucleotide binding 31.0680 4 no
GO:0043168 anion binding 29.1262 4 no
GO:0032555 purine ribonucleotide binding 26.2136 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.2136 4 no
GO:0043169 cation binding 25.2427 4 yes
GO:0046872 metal ion binding 25.2427 5 yes
GO:0016462 pyrophosphatase activity 23.3010 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 23.3010 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 23.3010 6 no
GO:0020037 heme binding 2.9126 4 yes
GO:0004392 heme oxygenase (decyclizing) activity 1.9417 5 yes
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1.9417 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in HMOX2_HUMAN
GO:0048522 positive regulation of cellular process 47.5728 4 no
GO:0031323 regulation of cellular metabolic process 35.9223 4 no
GO:0060255 regulation of macromolecule metabolic process 35.9223 4 no
GO:0006996 organelle organization 34.9515 4 no
GO:0010646 regulation of cell communication 34.9515 4 no
GO:0080090 regulation of primary metabolic process 34.9515 4 no
GO:0048523 negative regulation of cellular process 32.0388 4 no
GO:0051049 regulation of transport 31.0680 4 no
GO:0008104 protein localization 29.1262 4 no
GO:0051128 regulation of cellular component organization 29.1262 4 no
GO:0009893 positive regulation of metabolic process 29.1262 4 no
GO:0060341 regulation of cellular localization 27.1845 4 no
GO:0009966 regulation of signal transduction 27.1845 4 no
GO:0010604 positive regulation of macromolecule metabolic process 27.1845 5 no
GO:0009889 regulation of biosynthetic process 25.2427 4 no
GO:0031325 positive regulation of cellular metabolic process 25.2427 5 no
GO:0051246 regulation of protein metabolic process 25.2427 5 no
GO:0010468 regulation of gene expression 24.2718 6 no
GO:0010556 regulation of macromolecule biosynthetic process 24.2718 5 no
GO:0031326 regulation of cellular biosynthetic process 24.2718 5 no
GO:0022607 cellular component assembly 24.2718 4 no
GO:0032880 regulation of protein localization 23.3010 5 no
GO:0071702 organic substance transport 23.3010 4 no
GO:0009892 negative regulation of metabolic process 23.3010 4 no
GO:0010605 negative regulation of macromolecule metabolic process 22.3301 5 no
GO:0048584 positive regulation of response to stimulus 22.3301 4 no
GO:0043067 regulation of programmed cell death 21.3592 4 no
GO:0071705 nitrogen compound transport 20.3883 4 no
GO:0042981 regulation of apoptotic process 20.3883 5 no
GO:0044087 regulation of cellular component biogenesis 20.3883 4 no
GO:1901565 organonitrogen compound catabolic process 7.7670 4 yes
GO:0036293 response to decreased oxygen levels 6.7961 4 yes
GO:1901361 organic cyclic compound catabolic process 4.8544 4 yes
GO:0006778 porphyrin-containing compound metabolic process 1.9417 5 yes
GO:0006787 porphyrin-containing compound catabolic process 1.9417 6 yes
GO:0006788 heme oxidation 1.9417 4 yes
GO:0033013 tetrapyrrole metabolic process 1.9417 4 yes
GO:0033015 tetrapyrrole catabolic process 1.9417 5 yes
GO:0042167 heme catabolic process 1.9417 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
HMOX2_HUMAN [view entry] [view interactions] Low throughput yes yes
ASGR2_HUMAN [view interactions] High throughput no no
AT1B4_HUMAN [view interactions] High throughput no no
SNG1_HUMAN [view entry] [view interactions] High throughput yes yes
ALG2_HUMAN [view interactions] High throughput no yes
ADPGK_HUMAN [view interactions] High throughput no no
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
LMF2_HUMAN [view interactions] High throughput no yes
DUS22_HUMAN [view interactions] High throughput no yes
DUS9_HUMAN [view interactions] High throughput no no
EGLN3_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
HG2A_HUMAN [view interactions] High throughput no yes
P2RY6_HUMAN [view interactions] High throughput no no
UN93B_HUMAN [view interactions] High throughput no yes
TAP1_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
NMRL1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
SYVN1_HUMAN [view interactions] High throughput no yes
MARH8_HUMAN [view interactions] High throughput no no
TRI13_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
TSN15_HUMAN [view interactions] High throughput no yes
PRPH2_HUMAN [view interactions] High throughput no no
GPC3_HUMAN [view interactions] High throughput no no
NK3R_HUMAN [view interactions] High throughput no no
ENDD1_HUMAN [view interactions] High throughput no yes
VAMP5_HUMAN [view interactions] High throughput no no
TGFA_HUMAN [view interactions] High throughput no yes
ASIC4_HUMAN [view interactions] High throughput no no
WIF1_HUMAN [view entry] [view interactions] High throughput yes no
CBCO1_HUMAN [view interactions] High throughput no no
PVR_HUMAN [view interactions] High throughput no yes
SEC63_HUMAN [view interactions] High throughput no yes
HLAC_HUMAN [view interactions] High throughput no no
CD27_HUMAN [view interactions] High throughput no no
FFAR1_HUMAN [view interactions] High throughput no no
GPV_HUMAN [view interactions] High throughput no no
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
NCEH1_HUMAN [view interactions] High throughput no yes
F234A_HUMAN [view interactions] High throughput no yes
COAA1_HUMAN [view interactions] High throughput no no
EVA1C_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
LRAD1_HUMAN [view interactions] High throughput no no
RTN3_HUMAN [view entry] [view interactions] High throughput yes yes
CCR1_HUMAN [view interactions] High throughput no no
TX264_HUMAN [view interactions] High throughput no no
CP2CI_HUMAN [view interactions] High throughput no no
KI18A_HUMAN [view interactions] High throughput no yes
LPAR2_HUMAN [view interactions] High throughput no yes
SYT6_HUMAN [view entry] [view interactions] High throughput yes no
MESH1_HUMAN [view interactions] High throughput no yes
GGH_HUMAN [view interactions] High throughput no yes
MICA_HUMAN [view interactions] High throughput no no
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
P4K2A_HUMAN [view interactions] High throughput no yes
STIM2_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOC_HUMAN [view interactions] High throughput no no
OST48_HUMAN [view entry] [view interactions] High throughput yes yes
OST4_HUMAN [view interactions] High throughput no no
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
CCD47_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
PAQR2_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
ATX1_HUMAN [view interactions] High throughput no yes
RN149_HUMAN [view interactions] High throughput no no
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
VATB2_HUMAN [view entry] [view interactions] High throughput yes yes
P4HA1_HUMAN [view interactions] High throughput no yes
ODBA_HUMAN [view interactions] High throughput no yes
NCPR_HUMAN [view entry] [view interactions] High throughput yes yes
EMC8_HUMAN [view interactions] High throughput no no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS8_HUMAN [view interactions] High throughput no yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
EMC4_HUMAN [view interactions] High throughput no yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
QCR6_HUMAN [view interactions] High throughput no yes
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
ASPH_HUMAN [view interactions] High throughput no yes
EMC2_HUMAN [view interactions] High throughput no yes
ECHM_HUMAN [view interactions] High throughput no yes
ACADM_HUMAN [view interactions] High throughput no yes
THIM_HUMAN [view interactions] High throughput no yes
APOE_HUMAN [view entry] [view interactions] High throughput yes yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
AT2A2_HUMAN [view entry] [view interactions] High throughput yes yes
ADAS_HUMAN [view interactions] High throughput no yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
RCN2_HUMAN [view interactions] High throughput no yes
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
IVD_HUMAN [view interactions] High throughput no yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
VATE1_HUMAN [view entry] [view interactions] High throughput yes yes
CPT1A_HUMAN [view entry] [view interactions] High throughput yes yes
LACTB_HUMAN [view interactions] High throughput no yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
AL9A1_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
6PGD_HUMAN [view entry] [view interactions] High throughput yes no
NDUB8_HUMAN [view entry] [view interactions] High throughput yes yes
FUMH_HUMAN [view entry] [view interactions] High throughput yes yes
NNTM_HUMAN [view entry] [view interactions] High throughput yes yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
ARMX3_HUMAN [view interactions] High throughput no no
MGST1_HUMAN [view interactions] High throughput no no
SQOR_HUMAN [view interactions] High throughput no yes
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
PALM_HUMAN [view entry] [view interactions] High throughput yes yes
SAE1_HUMAN [view entry] [view interactions] High throughput yes yes
KCC1A_HUMAN [view entry] [view interactions] High throughput yes yes
PGTB2_HUMAN [view interactions] High throughput no yes
CAH9_HUMAN [view interactions] High throughput no no
OTULL_HUMAN [view interactions] High throughput no no
ST7_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
DNJC1_HUMAN [view interactions] High throughput no yes
DJC25_HUMAN [view interactions] High throughput no yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
AT2A1_HUMAN [view entry] [view interactions] High throughput yes no
B3GA1_HUMAN [view interactions] High throughput no yes
BAP31_HUMAN [view interactions] High throughput no yes
CXAR_HUMAN [view interactions] High throughput no yes
CP2C9_HUMAN [view interactions] High throughput no no
A2MG_HUMAN [view interactions] High throughput no yes
DERL1_HUMAN [view interactions] High throughput no yes
ATPB_HUMAN [view interactions] High throughput no yes
DYR2_HUMAN [view interactions] High throughput no yes
BL1S2_HUMAN [view interactions] High throughput no yes
EMD_HUMAN [view interactions] High throughput no yes
CEBPZ_HUMAN [view interactions] High throughput no no
ERGI1_HUMAN [view interactions] High throughput no yes
EIF3C_HUMAN [view entry] [view interactions] High throughput yes yes
ERGI2_HUMAN [view interactions] High throughput no yes
GIT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
HAP1_HUMAN [view entry] [view interactions] High throughput yes yes
DHB11_HUMAN [view interactions] High throughput no yes
MIC60_HUMAN [view entry] [view interactions] High throughput yes yes
3BHS7_HUMAN [view interactions] High throughput no no
INP5K_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP2_HUMAN [view interactions] High throughput no yes
CE126_HUMAN [view interactions] High throughput no no
LAMP3_HUMAN [view interactions] High throughput no no
NDUS2_HUMAN [view entry] [view interactions] High throughput yes yes
LMAN1_HUMAN [view entry] [view interactions] High throughput yes yes
NKRF_HUMAN [view interactions] High throughput no no
LMNB1_HUMAN [view entry] [view interactions] High throughput yes yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
LNP_HUMAN [view interactions] High throughput no yes
JADE1_HUMAN [view interactions] High throughput no yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
PLXB2_HUMAN [view interactions] High throughput no yes
TMT1A_HUMAN [view interactions] High throughput no no
RBBP4_HUMAN [view interactions] High throughput no yes
PANX1_HUMAN [view interactions] High throughput no no
SHC1_HUMAN [view entry] [view interactions] High throughput yes yes
PXMP2_HUMAN [view interactions] High throughput no no
SNX5_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
SNX7_HUMAN [view interactions] High throughput no yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
ZFP28_HUMAN [view interactions] High throughput no no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
ZN746_HUMAN [view interactions] High throughput no no
RAB3B_HUMAN [view interactions] High throughput no no
ALG3_HUMAN [view interactions] High throughput no yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
UBP19_HUMAN [view interactions] High throughput no no
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
C3AR_HUMAN [view interactions] High throughput no no
RAB9A_HUMAN [view interactions] High throughput no yes
5HT2C_HUMAN [view interactions] High throughput no no
REEP5_HUMAN [view entry] [view interactions] High throughput yes yes
VIPR2_HUMAN [view interactions] High throughput no no
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
ASIC1_HUMAN [view entry] [view interactions] High throughput yes no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
PRAF2_HUMAN [view entry] [view interactions] High throughput yes yes
SC61B_HUMAN [view interactions] High throughput no yes
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
SEC62_HUMAN [view interactions] High throughput no yes
CGT_HUMAN [view interactions] High throughput no no
SSRA_HUMAN [view entry] [view interactions] High throughput yes yes
TM214_HUMAN [view interactions] High throughput no no
STIM1_HUMAN [view interactions] High throughput no yes
POTEE_HUMAN [view interactions] High throughput no no
STX4_HUMAN [view entry] [view interactions] High throughput yes no
TM205_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
CISD2_HUMAN [view interactions] High throughput no yes
LAP2A_HUMAN [view interactions] High throughput no yes
PTH2_HUMAN [view interactions] High throughput no yes
TMPS2_HUMAN [view interactions] High throughput no no
ABHD5_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
NOP56_HUMAN [view interactions] High throughput no yes
TMPS4_HUMAN [view interactions] High throughput no yes
FUBP2_HUMAN [view interactions] High throughput no yes
CLC4E_HUMAN [view interactions] High throughput no no
DOT1L_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
HSC20_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes
CNDD3_HUMAN [view interactions] High throughput no no
DHCR7_HUMAN [view interactions] High throughput no yes
SKA2_HUMAN [view interactions] High throughput no no
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
B2L13_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
TM14B_HUMAN [view interactions] High throughput no no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
SAR1A_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
ZNT8_HUMAN [view interactions] High throughput no no
CIAO1_HUMAN [view interactions] High throughput no yes
F209A_HUMAN [view interactions] High throughput no no
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
SSMM1_HUMAN [view interactions] High throughput no no
ESYT1_HUMAN [view entry] [view interactions] High throughput yes yes
ELOV5_HUMAN [view interactions] High throughput no yes
ESYT2_HUMAN [view entry] [view interactions] High throughput yes yes
GET1_HUMAN [view interactions] High throughput no yes
PDZD8_HUMAN [view interactions] High throughput no yes
LAPM5_HUMAN [view interactions] High throughput no yes
AR13B_HUMAN [view interactions] High throughput no yes
EBP_HUMAN [view interactions] High throughput no no
SYT1_HUMAN [view entry] [view interactions] High throughput yes no
KCNJ6_HUMAN [view entry] [view interactions] High throughput yes no
ELOV4_HUMAN [view interactions] High throughput no no
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
AQP6_HUMAN [view interactions] High throughput no no
ERGI3_HUMAN [view interactions] High throughput no yes
F210B_HUMAN [view interactions] High throughput no yes
RETR3_HUMAN [view interactions] High throughput no yes
CD79A_HUMAN [view interactions] High throughput no no
SGPL1_HUMAN [view interactions] High throughput no yes
GP152_HUMAN [view interactions] High throughput no no
RNK_HUMAN [view interactions] High throughput no yes
VMA21_HUMAN [view interactions] High throughput no no
GPX8_HUMAN [view interactions] High throughput no no
STOM_HUMAN [view entry] [view interactions] High throughput yes yes
TMX2_HUMAN [view interactions] High throughput no yes
COA7_HUMAN [view interactions] High throughput no yes
BAAT_HUMAN [view interactions] High throughput no no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
RPB9_HUMAN [view interactions] High throughput no yes
UBE2A_HUMAN [view interactions] High throughput no no
ELL2_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
NUP54_HUMAN [view interactions] High throughput no yes
CL004_HUMAN [view interactions] High throughput no yes
CC036_HUMAN [view interactions] High throughput no no
SPSB1_HUMAN [view interactions] High throughput no no
LRC56_HUMAN [view interactions] High throughput no no
CMA1D_HUMAN [view interactions] High throughput no no
RUAS1_HUMAN [view interactions] High throughput no no
H3C_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
EF1G_HUMAN [view entry] [view interactions] High throughput yes yes
MED31_HUMAN [view interactions] High throughput no yes
RIF1_HUMAN [view interactions] High throughput no yes
CSN6_HUMAN [view interactions] High throughput no yes
VOPP1_HUMAN [view interactions] High throughput no no
SETB1_HUMAN [view interactions] High throughput no yes
MTR1A_HUMAN [view interactions] High throughput no no
CCR2_HUMAN [view interactions] High throughput no yes
PAR2_HUMAN [view entry] [view interactions] High throughput yes yes
PE2R4_HUMAN [view interactions] High throughput no yes
SMO_HUMAN [view entry] [view interactions] High throughput yes yes
PCNT_HUMAN [view interactions] High throughput no yes
TECT3_HUMAN [view interactions] High throughput no yes
LBN_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
TECT2_HUMAN [view interactions] High throughput no yes
TM216_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
GASP1_HUMAN [view interactions] High throughput no yes
LRIF1_HUMAN [view interactions] High throughput no yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
CRUM3_HUMAN [view interactions] High throughput no no