Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SNX5_HUMAN

Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed, PubMed). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed). Plays a role in macropinocytosis (PubMed, PubMed). [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SNX5_HUMAN
GO:0035091 phosphatidylinositol binding 27.2727 4 yes
GO:0017076 purine nucleotide binding 25.4545 4 no
GO:0032555 purine ribonucleotide binding 25.4545 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.4545 4 no
GO:0045296 cadherin binding 18.1818 4 yes
GO:1901981 phosphatidylinositol phosphate binding 18.1818 5 yes
GO:0001664 G protein-coupled receptor binding 10.9091 4 yes
GO:1902936 phosphatidylinositol bisphosphate binding 9.0909 6 yes
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 7.2727 4 yes
GO:0010314 phosphatidylinositol-5-phosphate binding 5.4545 6 yes
GO:0031748 D1 dopamine receptor binding 5.4545 6 yes
GO:0034452 dynactin binding 5.4545 4 yes
GO:0050780 dopamine receptor binding 5.4545 5 yes
GO:0070273 phosphatidylinositol-4-phosphate binding 5.4545 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SNX5_HUMAN
GO:0016192 vesicle-mediated transport 69.0909 4 yes
GO:0048522 positive regulation of cellular process 63.6364 4 yes
GO:0008104 protein localization 56.3636 4 yes
GO:0051128 regulation of cellular component organization 52.7273 4 no
GO:0048523 negative regulation of cellular process 50.9091 4 yes
GO:0060255 regulation of macromolecule metabolic process 49.0909 4 yes
GO:0071702 organic substance transport 49.0909 4 yes
GO:0071705 nitrogen compound transport 49.0909 4 yes
GO:0010646 regulation of cell communication 47.2727 4 yes
GO:0015031 protein transport 47.2727 4 yes
GO:0080090 regulation of primary metabolic process 47.2727 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 45.4545 4 yes
GO:0051049 regulation of transport 43.6364 4 yes
GO:0009966 regulation of signal transduction 41.8182 4 yes
GO:0016197 endosomal transport 41.8182 4 yes
GO:0006886 intracellular protein transport 40.0000 4 yes
GO:0031323 regulation of cellular metabolic process 40.0000 4 yes
GO:0009893 positive regulation of metabolic process 38.1818 4 yes
GO:0022607 cellular component assembly 38.1818 4 no
GO:0006897 endocytosis 36.3636 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 36.3636 5 yes
GO:0006996 organelle organization 36.3636 4 no
GO:0010468 regulation of gene expression 32.7273 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 32.7273 5 yes
GO:0048584 positive regulation of response to stimulus 30.9091 4 yes
GO:0010647 positive regulation of cell communication 29.0909 5 yes
GO:0016482 cytosolic transport 29.0909 4 yes
GO:0023056 positive regulation of signaling 29.0909 4 yes
GO:0031325 positive regulation of cellular metabolic process 29.0909 5 yes
GO:0051130 positive regulation of cellular component organization 29.0909 5 no
GO:0051246 regulation of protein metabolic process 29.0909 5 no
GO:0061024 membrane organization 29.0909 4 no
GO:0009889 regulation of biosynthetic process 27.2727 4 yes
GO:0009894 regulation of catabolic process 27.2727 4 yes
GO:0009967 positive regulation of signal transduction 27.2727 5 yes
GO:0051050 positive regulation of transport 27.2727 4 yes
GO:0060627 regulation of vesicle-mediated transport 27.2727 4 no
GO:0031326 regulation of cellular biosynthetic process 25.4545 5 yes
GO:0042147 retrograde transport, endosome to Golgi 25.4545 5 yes
GO:0044087 regulation of cellular component biogenesis 25.4545 4 no
GO:0030030 cell projection organization 25.4545 4 no
GO:0031344 regulation of cell projection organization 25.4545 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.4545 6 no
GO:1902531 regulation of intracellular signal transduction 25.4545 5 no
GO:0010556 regulation of macromolecule biosynthetic process 23.6364 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.6364 5 yes
GO:0120036 plasma membrane bounded cell projection organization 23.6364 5 no
GO:0006355 regulation of DNA-templated transcription 21.8182 6 yes
GO:0051240 positive regulation of multicellular organismal process 21.8182 4 yes
GO:0051252 regulation of RNA metabolic process 21.8182 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 21.8182 7 yes
GO:2001141 regulation of RNA biosynthetic process 21.8182 6 yes
GO:0009892 negative regulation of metabolic process 21.8182 4 no
GO:0010605 negative regulation of macromolecule metabolic process 21.8182 5 no
GO:0032880 regulation of protein localization 21.8182 5 no
GO:0033043 regulation of organelle organization 21.8182 5 no
GO:0060341 regulation of cellular localization 21.8182 4 no
GO:0009891 positive regulation of biosynthetic process 18.1818 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 18.1818 6 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 18.1818 6 yes
GO:0051046 regulation of secretion 18.1818 5 yes
GO:0031329 regulation of cellular catabolic process 16.3636 5 yes
GO:0048585 negative regulation of response to stimulus 16.3636 4 yes
GO:0051254 positive regulation of RNA metabolic process 16.3636 6 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 14.5455 6 yes
GO:0010648 negative regulation of cell communication 14.5455 5 yes
GO:0023057 negative regulation of signaling 14.5455 4 yes
GO:0045893 positive regulation of DNA-templated transcription 14.5455 7 yes
GO:0051047 positive regulation of secretion 14.5455 5 yes
GO:1902680 positive regulation of RNA biosynthetic process 14.5455 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 14.5455 8 yes
GO:0009968 negative regulation of signal transduction 12.7273 5 yes
GO:0009057 macromolecule catabolic process 10.9091 4 yes
GO:0010506 regulation of autophagy 10.9091 6 yes
GO:0016241 regulation of macroautophagy 10.9091 7 yes
GO:0042058 regulation of epidermal growth factor receptor signaling pathway 9.0909 6 yes
GO:1901184 regulation of ERBB signaling pathway 9.0909 5 yes
GO:1901565 organonitrogen compound catabolic process 9.0909 4 yes
GO:0030163 protein catabolic process 7.2727 4 yes
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 7.2727 7 yes
GO:0044057 regulation of system process 7.2727 4 yes
GO:1901185 negative regulation of ERBB signaling pathway 7.2727 6 yes
GO:0007174 epidermal growth factor catabolic process 5.4545 5 yes
GO:0046626 regulation of insulin receptor signaling pathway 5.4545 5 yes
GO:0006907 pinocytosis 3.6364 6 yes
GO:0035813 regulation of renal sodium excretion 3.6364 6 yes
GO:0035815 positive regulation of renal sodium excretion 3.6364 5 yes
GO:0044062 regulation of excretion 3.6364 5 yes
GO:0045776 negative regulation of blood pressure 3.6364 4 yes
GO:0046628 positive regulation of insulin receptor signaling pathway 3.6364 6 yes
GO:0098801 regulation of renal system process 3.6364 5 yes
GO:1900076 regulation of cellular response to insulin stimulus 3.6364 4 yes
GO:1900078 positive regulation of cellular response to insulin stimulus 3.6364 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in SNX5_HUMAN
DOID:331 central nervous system disease 7.2727 3 no
DOID:1289 neurodegenerative disease 5.4545 4 no
DOID:12377 spinal muscular atrophy 3.6364 6 no
DOID:231 motor neuron disease 3.6364 5 no
DOID:332 amyotrophic lateral sclerosis 3.6364 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MIB1_HUMAN [view entry] [view interactions] Low throughput yes yes
CLH2_HUMAN [view interactions] Low throughput no no
CLH1_HUMAN [view entry] [view interactions] Low throughput yes yes
FANCA_HUMAN [view interactions] Low throughput no no
PI51C_HUMAN [view entry] [view interactions] Low throughput yes yes
DDX58_HUMAN [view interactions] Low throughput no yes
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
LAP4B_HUMAN [view interactions] Low throughput no yes
FBXW7_HUMAN [view interactions] Low throughput no yes
HLAB_HUMAN [view interactions] Low throughput no yes
B2MG_HUMAN [view interactions] Low throughput no yes
MTR1L_HUMAN [view interactions] Low throughput no no
BIN3_HUMAN [view interactions] High throughput no yes
GNAT2_HUMAN [view interactions] High throughput no no
F221A_HUMAN [view interactions] High throughput no yes
SNX1_HUMAN [view entry] [view interactions] High throughput yes yes
CK042_HUMAN [view interactions] High throughput no no
HCLS1_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
SNX5_HUMAN [view entry] [view interactions] High throughput yes yes
ROS1_HUMAN [view interactions] High throughput no no
APBP2_HUMAN [view interactions] High throughput no yes
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
LTOR5_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
STK4_HUMAN [view interactions] High throughput no yes
SCLT1_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
CATA_HUMAN [view entry] [view interactions] High throughput yes no
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
INSR_HUMAN [view interactions] High throughput no yes
AQP2_HUMAN [view interactions] High throughput no no
BANP_HUMAN [view interactions] High throughput no yes
PSB8_HUMAN [view interactions] High throughput no yes
GA2L1_HUMAN [view interactions] High throughput no yes
BIEA_HUMAN [view interactions] High throughput no yes
DYN3_HUMAN [view entry] [view interactions] High throughput yes no
F90A1_HUMAN [view interactions] High throughput no no
CA087_HUMAN [view interactions] High throughput no no
MLX_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
SMAD4_HUMAN [view interactions] High throughput no yes
ZBTB3_HUMAN [view interactions] High throughput no yes
C102A_HUMAN [view interactions] High throughput no yes
S12A3_HUMAN [view interactions] High throughput no no
ODAD1_HUMAN [view interactions] High throughput no no
IBPL1_HUMAN [view interactions] High throughput no no
SEM4C_HUMAN [view entry] [view interactions] High throughput yes no
CEA16_HUMAN [view interactions] High throughput no no
GAGE4_HUMAN [view interactions] High throughput no no
GAGE1_HUMAN [view interactions] High throughput no no
CUX2_HUMAN [view interactions] High throughput no no
GNAO_HUMAN [view entry] [view interactions] High throughput yes yes
F124A_HUMAN [view interactions] High throughput no no
DB136_HUMAN [view interactions] High throughput no no
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
TOM1_HUMAN [view interactions] High throughput no yes
HYOU1_HUMAN [view interactions] High throughput no yes
SPNXB_HUMAN [view interactions] High throughput no no
STAC2_HUMAN [view interactions] High throughput no no
NTNG1_HUMAN [view interactions] High throughput no no
PAIRB_HUMAN [view interactions] High throughput no yes
SI1L2_HUMAN [view interactions] High throughput no yes
TFR1_HUMAN [view interactions] High throughput no yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
SDF2L_HUMAN [view interactions] High throughput no yes
AT1B3_HUMAN [view interactions] High throughput no yes
ARI4B_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
VP33B_HUMAN [view interactions] High throughput no yes
ARFP2_HUMAN [view interactions] High throughput no no
NU155_HUMAN [view interactions] High throughput no yes
BOP1_HUMAN [view interactions] High throughput no yes
RNZ2_HUMAN [view interactions] High throughput no yes
SYSC_HUMAN [view interactions] High throughput no yes
XPO5_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
STRN_HUMAN [view entry] [view interactions] High throughput yes yes
MAP1S_HUMAN [view interactions] High throughput no no
SHLB2_HUMAN [view entry] [view interactions] High throughput yes no
SNX6_HUMAN [view entry] [view interactions] High throughput yes no
VP26A_HUMAN [view entry] [view interactions] High throughput yes no
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
VPS29_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
NHLC2_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC5_HUMAN [view interactions] High throughput no yes
LRC61_HUMAN [view interactions] High throughput no yes
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
ATG12_HUMAN [view interactions] High throughput no yes
ELOV5_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
3BHS7_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
WASL_HUMAN [view entry] [view interactions] High throughput yes yes
SNX2_HUMAN [view entry] [view interactions] High throughput yes no
CDC37_HUMAN [view interactions] High throughput no yes
DJB11_HUMAN [view interactions] High throughput no yes
HMOX2_HUMAN [view entry] [view interactions] High throughput yes yes
MESD_HUMAN [view interactions] High throughput no yes
PFD1_HUMAN [view interactions] High throughput no yes
PRKRA_HUMAN [view entry] [view interactions] High throughput yes yes
ZYX_HUMAN [view interactions] High throughput no no
T2EB_HUMAN [view interactions] High throughput no yes
TEX28_HUMAN [view interactions] High throughput no no
C102B_HUMAN [view interactions] High throughput no yes
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
KLH10_HUMAN [view interactions] High throughput no no
SNAPN_HUMAN [view interactions] Computational no yes
SNX4_HUMAN [view entry] [view interactions] Computational yes yes
PICAL_HUMAN [view entry] [view interactions] Computational yes yes
HIP1R_HUMAN [view entry] [view interactions] Computational yes yes
RAB5C_HUMAN [view entry] [view interactions] Computational yes yes
VP26B_HUMAN [view interactions] Computational no yes
AP4B1_HUMAN [view interactions] Computational no yes
AP4E1_HUMAN [view interactions] Computational no no
NECP1_HUMAN [view interactions] Computational no no
AP3S1_HUMAN [view entry] [view interactions] Computational yes no
AUXI_HUMAN [view entry] [view interactions] Computational yes yes
SNX9_HUMAN [view entry] [view interactions] Computational yes yes
P3C2A_HUMAN [view interactions] Computational no yes
MPRI_HUMAN [view interactions] Computational no yes
SNX3_HUMAN [view entry] [view interactions] Computational yes no
HSP7C_HUMAN [view entry] [view interactions] Computational yes yes
SNX8_HUMAN [view interactions] Computational no yes
CBPD_HUMAN [view interactions] Computational no yes
SNX32_HUMAN [view interactions] Computational no no
VPS35_HUMAN [view entry] [view interactions] Computational yes yes
TBCD5_HUMAN [view interactions] Computational no yes
GAK_HUMAN [view entry] [view interactions] Computational yes yes
YIPF6_HUMAN [view interactions] Computational no yes
SNX12_HUMAN [view entry] [view interactions] Computational yes yes
OCRL_HUMAN [view interactions] Computational no yes
SORT_HUMAN [view interactions] Computational no yes
AP3B1_HUMAN [view entry] [view interactions] Computational yes yes