SNX5_HUMAN
Evidence for PS localization
Functions
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed, PubMed). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed). Plays a role in macropinocytosis (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SNX5_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 25.4902 | 4 | no |
| GO:0043169 | cation binding | 25.4902 | 4 | no |
| GO:0046872 | metal ion binding | 25.4902 | 5 | no |
| GO:0000166 | nucleotide binding | 23.5294 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.5294 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.5686 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.5686 | 4 | no |
| GO:0035091 | phosphatidylinositol binding | 19.6078 | 4 | yes |
| GO:0045296 | cadherin binding | 13.7255 | 4 | yes |
| GO:0034452 | dynactin binding | 5.8824 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SNX5_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | yes |
| GO:0010646 | regulation of cell communication | 54.9020 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 52.9412 | 4 | no |
| GO:0008104 | protein localization | 52.9412 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 50.9804 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 49.0196 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 45.0980 | 4 | yes |
| GO:0071702 | organic substance transport | 45.0980 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 43.1373 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 41.1765 | 4 | yes |
| GO:0015031 | protein transport | 39.2157 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 39.2157 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 39.2157 | 4 | yes |
| GO:0006996 | organelle organization | 37.2549 | 4 | no |
| GO:0022607 | cellular component assembly | 37.2549 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 35.2941 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 35.2941 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 35.2941 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 35.2941 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 35.2941 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0006886 | intracellular protein transport | 33.3333 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 31.3725 | 4 | no |
| GO:0010468 | regulation of gene expression | 31.3725 | 6 | yes |
| GO:0098657 | import into cell | 31.3725 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 29.4118 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.4118 | 6 | no |
| GO:0060341 | regulation of cellular localization | 29.4118 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.4118 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 29.4118 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 27.4510 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 27.4510 | 5 | no |
| GO:0032880 | regulation of protein localization | 27.4510 | 5 | no |
| GO:0016482 | cytosolic transport | 27.4510 | 4 | yes |
| GO:0030030 | cell projection organization | 27.4510 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.4902 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.4902 | 6 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 25.4902 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.5294 | 6 | no |
| GO:0033043 | regulation of organelle organization | 23.5294 | 5 | no |
| GO:0051050 | positive regulation of transport | 23.5294 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 23.5294 | 4 | no |
| GO:0009894 | regulation of catabolic process | 23.5294 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.5294 | 6 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.5294 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 23.5294 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 21.5686 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.5686 | 4 | no |
| GO:2000145 | regulation of cell motility | 21.5686 | 4 | no |
| GO:0061024 | membrane organization | 21.5686 | 4 | no |
| GO:0051093 | negative regulation of developmental process | 21.5686 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.5686 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.5686 | 5 | yes |
| GO:0030334 | regulation of cell migration | 21.5686 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.5686 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 19.6078 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 19.6078 | 6 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 17.6471 | 5 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 13.7255 | 8 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 13.7255 | 6 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 13.7255 | 7 | yes |
| GO:0010506 | regulation of autophagy | 11.7647 | 6 | yes |
| GO:0031329 | regulation of cellular catabolic process | 11.7647 | 5 | yes |
| GO:0016241 | regulation of macroautophagy | 9.8039 | 7 | yes |
| GO:0046626 | regulation of insulin receptor signaling pathway | 5.8824 | 5 | yes |
| GO:0006907 | pinocytosis | 3.9216 | 4 | yes |
| GO:0046628 | positive regulation of insulin receptor signaling pathway | 3.9216 | 6 | yes |
| GO:1900076 | regulation of cellular response to insulin stimulus | 3.9216 | 4 | yes |
| GO:1900078 | positive regulation of cellular response to insulin stimulus | 3.9216 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LAP4B_HUMAN | [view interactions] | Low throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | Low throughput | no | yes |
| NRP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MPRI_HUMAN | [view interactions] | Low throughput | no | yes |
| HLAB_HUMAN | [view interactions] | Low throughput | no | yes |
| B2MG_HUMAN | [view interactions] | Low throughput | no | yes |
| MTR1L_HUMAN | [view interactions] | Low throughput | no | no |
| SNX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MIB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLH2_HUMAN | [view interactions] | Low throughput | no | no |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FANCA_HUMAN | [view interactions] | Low throughput | no | no |
| PI51C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RIGI_HUMAN | [view interactions] | Low throughput | no | yes |
| SPAG6_HUMAN | [view interactions] | High throughput | no | no |
| GA2L1_HUMAN | [view interactions] | High throughput | no | yes |
| BIEA_HUMAN | [view interactions] | High throughput | no | yes |
| DYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| CA087_HUMAN | [view interactions] | High throughput | no | no |
| MLX_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB3_HUMAN | [view interactions] | High throughput | no | yes |
| C102A_HUMAN | [view interactions] | High throughput | no | yes |
| S12A3_HUMAN | [view interactions] | High throughput | no | no |
| ODAD1_HUMAN | [view interactions] | High throughput | no | no |
| IBPL1_HUMAN | [view interactions] | High throughput | no | no |
| SEM4C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CEA16_HUMAN | [view interactions] | High throughput | no | no |
| GAGE4_HUMAN | [view interactions] | High throughput | no | no |
| GAGE1_HUMAN | [view interactions] | High throughput | no | no |
| CUX2_HUMAN | [view interactions] | High throughput | no | no |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F124A_HUMAN | [view interactions] | High throughput | no | no |
| DB136_HUMAN | [view interactions] | High throughput | no | no |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM1_HUMAN | [view interactions] | High throughput | no | yes |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| SPNXB_HUMAN | [view interactions] | High throughput | no | no |
| STAC2_HUMAN | [view interactions] | High throughput | no | no |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| SERB1_HUMAN | [view interactions] | High throughput | no | yes |
| SI1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| ARI4B_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| NRP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| ARFP2_HUMAN | [view interactions] | High throughput | no | no |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| BOP1_HUMAN | [view interactions] | High throughput | no | yes |
| RNZ2_HUMAN | [view interactions] | High throughput | no | yes |
| SYSC_HUMAN | [view interactions] | High throughput | no | yes |
| XPO5_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1S_HUMAN | [view interactions] | High throughput | no | no |
| SHLB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VP26A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GFRA1_HUMAN | [view interactions] | High throughput | no | no |
| SNX17_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF5_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD5_HUMAN | [view interactions] | High throughput | no | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| LRC61_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG12_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| WASL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MESD_HUMAN | [view interactions] | High throughput | no | yes |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| TEX28_HUMAN | [view interactions] | High throughput | no | no |
| C102B_HUMAN | [view interactions] | High throughput | no | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH10_HUMAN | [view interactions] | High throughput | no | no |
| BIN3_HUMAN | [view interactions] | High throughput | no | yes |
| GNAT2_HUMAN | [view interactions] | High throughput | no | no |
| F221A_HUMAN | [view interactions] | High throughput | no | yes |
| CK042_HUMAN | [view interactions] | High throughput | no | no |
| HCLS1_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| SNX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROS1_HUMAN | [view interactions] | High throughput | no | no |
| APBP2_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTOR5_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DSCR9_HUMAN | [view interactions] | High throughput | no | no |
| STK4_HUMAN | [view interactions] | High throughput | no | yes |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| AQP2_HUMAN | [view interactions] | High throughput | no | no |
| BANP_HUMAN | [view interactions] | High throughput | no | yes |
| PSB8_HUMAN | [view interactions] | High throughput | no | yes |