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VP33A_HUMAN

GO
G2C
SynGO

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed, PubMed, PubMed, PubMed). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 (PubMed). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in VP33A_HUMAN
GO:0043169 cation binding 24.0506 4 no
GO:0046872 metal ion binding 24.0506 5 no
GO:0000166 nucleotide binding 21.5190 4 no
GO:0043168 anion binding 21.5190 4 no
GO:0017076 purine nucleotide binding 20.2532 5 no
GO:0032555 purine ribonucleotide binding 20.2532 4 no
GO:0035639 purine ribonucleoside triphosphate binding 20.2532 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in VP33A_HUMAN
GO:0008104 protein localization 51.8987 4 yes
GO:0071702 organic substance transport 44.3038 4 yes
GO:0071705 nitrogen compound transport 43.0380 4 yes
GO:0015031 protein transport 41.7722 4 yes
GO:0051128 regulation of cellular component organization 41.7722 4 yes
GO:0048522 positive regulation of cellular process 40.5063 4 no
GO:0048523 negative regulation of cellular process 40.5063 4 no
GO:0006996 organelle organization 39.2405 4 yes
GO:0060255 regulation of macromolecule metabolic process 39.2405 4 no
GO:0080090 regulation of primary metabolic process 39.2405 4 no
GO:0031323 regulation of cellular metabolic process 36.7089 4 no
GO:0006886 intracellular protein transport 31.6456 4 yes
GO:0009889 regulation of biosynthetic process 31.6456 4 no
GO:0010556 regulation of macromolecule biosynthetic process 31.6456 5 no
GO:0031326 regulation of cellular biosynthetic process 31.6456 5 no
GO:0010646 regulation of cell communication 30.3797 4 no
GO:0010468 regulation of gene expression 30.3797 6 no
GO:0044087 regulation of cellular component biogenesis 29.1139 4 yes
GO:0009893 positive regulation of metabolic process 29.1139 4 no
GO:0010604 positive regulation of macromolecule metabolic process 27.8481 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.8481 5 no
GO:0009966 regulation of signal transduction 26.5823 4 no
GO:0051252 regulation of RNA metabolic process 26.5823 5 no
GO:0022607 cellular component assembly 26.5823 4 no
GO:0006355 regulation of DNA-templated transcription 25.3165 7 no
GO:2001141 regulation of RNA biosynthetic process 25.3165 6 no
GO:0009892 negative regulation of metabolic process 22.7848 4 no
GO:0031324 negative regulation of cellular metabolic process 21.5190 5 no
GO:0031325 positive regulation of cellular metabolic process 21.5190 5 no
GO:0033043 regulation of organelle organization 21.5190 5 no
GO:0009894 regulation of catabolic process 20.2532 4 no
GO:0051246 regulation of protein metabolic process 20.2532 5 no
GO:0010605 negative regulation of macromolecule metabolic process 20.2532 5 no
GO:0007034 vacuolar transport 18.9873 4 yes
GO:0061024 membrane organization 18.9873 4 yes
GO:0016050 vesicle organization 17.7215 5 yes
GO:0043254 regulation of protein-containing complex assembly 17.7215 5 yes
GO:0043933 protein-containing complex organization 17.7215 4 yes
GO:0007041 lysosomal transport 16.4557 5 yes
GO:0048284 organelle fusion 12.6582 5 yes
GO:0061025 membrane fusion 12.6582 5 yes
GO:0090174 organelle membrane fusion 12.6582 6 yes
GO:0006906 vesicle fusion 11.3924 6 yes
GO:0035542 regulation of SNARE complex assembly 10.1266 6 yes
GO:0034058 endosomal vesicle fusion 8.8608 7 yes
GO:0006873 intracellular monoatomic ion homeostasis 6.3291 4 yes
GO:0030003 intracellular monoatomic cation homeostasis 6.3291 5 yes
GO:0055080 monoatomic cation homeostasis 6.3291 4 yes
GO:0022411 cellular component disassembly 3.7975 4 yes
GO:0030099 myeloid cell differentiation 3.7975 4 yes
GO:0032984 protein-containing complex disassembly 3.7975 5 yes
GO:0097352 autophagosome maturation 3.7975 6 yes
GO:0032400 melanosome localization 2.5316 5 yes
GO:0032418 lysosome localization 2.5316 4 yes
GO:0051875 pigment granule localization 2.5316 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VPS16_HUMAN [view entry] [view interactions] Low throughput yes yes
UVRAG_HUMAN [view interactions] Low throughput no yes
VPS11_HUMAN [view entry] [view interactions] Low throughput yes no
VPS18_HUMAN [view entry] [view interactions] Low throughput yes no
VPS41_HUMAN [view entry] [view interactions] Low throughput yes yes
STX17_HUMAN [view interactions] Low throughput no yes
MON1B_HUMAN [view interactions] Low throughput no yes
MON1A_HUMAN [view interactions] Low throughput no no
RAB5C_HUMAN [view entry] [view interactions] Low throughput yes yes
SPE39_HUMAN [view interactions] Low throughput no yes
PLK2_HUMAN [view entry] [view interactions] Low throughput yes yes
WDCP_HUMAN [view interactions] High throughput no yes
XRCC5_HUMAN [view interactions] High throughput no yes
IFM1_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
RBG1L_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
RFA1_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
RFA2_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
SOX2_HUMAN [view interactions] High throughput no yes
VPS39_HUMAN [view entry] [view interactions] High throughput yes no
PKHM1_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR4_HUMAN [view interactions] High throughput no no
TENS3_HUMAN [view interactions] High throughput no no
CDC5L_HUMAN [view interactions] High throughput no yes
ROP1A_HUMAN [view interactions] High throughput no no
A2MG_HUMAN [view interactions] High throughput no yes
AACT_HUMAN [view entry] [view interactions] High throughput yes no
CASP8_HUMAN [view interactions] High throughput no yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CNTRL_HUMAN [view interactions] High throughput no yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
RASN_HUMAN [view entry] [view interactions] High throughput yes no
CT55_HUMAN [view interactions] High throughput no no
TEKT4_HUMAN [view interactions] High throughput no no
PKNX1_HUMAN [view interactions] High throughput no yes
CRYAB_HUMAN [view entry] [view interactions] High throughput yes no
FBW1B_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
AP3D1_HUMAN [view entry] [view interactions] High throughput yes no
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
TGFA1_HUMAN [view interactions] High throughput no no
MTMR7_HUMAN [view interactions] High throughput no no
CBAR1_HUMAN [view interactions] High throughput no no
TEDC2_HUMAN [view interactions] High throughput no no
ZUP1_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
UFL1_HUMAN [view interactions] High throughput no yes
SRSF2_HUMAN [view interactions] High throughput no yes
VCIP1_HUMAN [view entry] [view interactions] High throughput yes no
TCPR2_HUMAN [view interactions] High throughput no yes
PMM1_HUMAN [view interactions] High throughput no yes
MTU1_HUMAN [view interactions] High throughput no no
GALT9_HUMAN [view interactions] High throughput no no
TRI35_HUMAN [view interactions] High throughput no yes
PKHG7_HUMAN [view interactions] High throughput no no
HSPB8_HUMAN [view entry] [view interactions] High throughput yes yes
CC127_HUMAN [view entry] [view interactions] High throughput yes yes
PPM1M_HUMAN [view interactions] High throughput no yes
NPAS1_HUMAN [view interactions] High throughput no no
D2HDH_HUMAN [view interactions] High throughput no no
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
NT5C_HUMAN [view interactions] High throughput no yes
CIA2A_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes
BRD4_HUMAN [view interactions] High throughput no yes
RHOJ_HUMAN [view interactions] High throughput no yes
NRIP1_HUMAN [view interactions] High throughput no yes
VPS8_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
FITM2_HUMAN [view interactions] High throughput no no
ATG7_HUMAN [view interactions] High throughput no yes
ATG3_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
RIT1_HUMAN [view interactions] High throughput no yes
UBR7_HUMAN [view interactions] High throughput no yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
SREK1_HUMAN [view interactions] High throughput no yes
VPS45_HUMAN [view entry] [view interactions] High throughput yes yes
PURB_HUMAN [view entry] [view interactions] High throughput yes no
EIF3G_HUMAN [view interactions] High throughput no yes
GYS1_HUMAN [view interactions] High throughput no yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
PK3C3_HUMAN [view entry] [view interactions] High throughput yes yes
PI3R4_HUMAN [view interactions] High throughput no yes
2ABD_HUMAN [view interactions] High throughput no yes
VP33B_HUMAN [view interactions] High throughput no yes
BRCC3_HUMAN [view interactions] High throughput no no
DFFA_HUMAN [view interactions] High throughput no yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
HOOK1_HUMAN [view interactions] High throughput no no
AGR2_HUMAN [view interactions] High throughput no no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ADDB_HUMAN [view entry] [view interactions] High throughput yes yes
PUR8_HUMAN [view interactions] High throughput no yes
AL9A1_HUMAN [view interactions] High throughput no yes
ALG13_HUMAN [view interactions] High throughput no yes
AP3S1_HUMAN [view entry] [view interactions] High throughput yes no
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
RHG32_HUMAN [view entry] [view interactions] High throughput yes yes
ATAD2_HUMAN [view interactions] High throughput no no
ATG4C_HUMAN [view interactions] High throughput no yes
BCAS3_HUMAN [view interactions] High throughput no yes
BC11A_HUMAN [view entry] [view interactions] High throughput yes yes
BCR_HUMAN [view entry] [view interactions] High throughput yes yes
BEND3_HUMAN [view interactions] High throughput no yes
BIRC6_HUMAN [view entry] [view interactions] High throughput yes yes
BOP1_HUMAN [view interactions] High throughput no yes
CABL1_HUMAN [view interactions] High throughput no no
CSKI2_HUMAN [view interactions] High throughput no yes
CCD22_HUMAN [view entry] [view interactions] High throughput yes no
MRCKA_HUMAN [view entry] [view interactions] High throughput yes yes
CDK1_HUMAN [view interactions] High throughput no no
CK5P2_HUMAN [view interactions] High throughput no yes
CENPI_HUMAN [view interactions] High throughput no no
CE128_HUMAN [view interactions] High throughput no yes
CP131_HUMAN [view interactions] High throughput no no
CEP55_HUMAN [view interactions] High throughput no yes
CEP63_HUMAN [view interactions] High throughput no yes
CEP78_HUMAN [view interactions] High throughput no yes
CEP89_HUMAN [view interactions] High throughput no no
CEP97_HUMAN [view interactions] High throughput no yes
CNO11_HUMAN [view interactions] High throughput no yes
CUED2_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
DDHD2_HUMAN [view interactions] High throughput no yes
DDX11_HUMAN [view interactions] High throughput no yes
DHYS_HUMAN [view interactions] High throughput no no
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
DOT1L_HUMAN [view interactions] High throughput no yes
EFR3B_HUMAN [view entry] [view interactions] High throughput yes no
EIF3B_HUMAN [view interactions] High throughput no yes
EIF3E_HUMAN [view entry] [view interactions] High throughput yes yes
ELP3_HUMAN [view interactions] High throughput no no
ELP4_HUMAN [view interactions] High throughput no yes
ELP6_HUMAN [view interactions] High throughput no no
RB6I2_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC6_HUMAN [view entry] [view interactions] High throughput yes yes
WAC2C_HUMAN [view interactions] High throughput no yes
FARP1_HUMAN [view entry] [view interactions] High throughput yes no
FBX30_HUMAN [view interactions] High throughput no yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
FLII_HUMAN [view entry] [view interactions] High throughput yes yes
GBF1_HUMAN [view interactions] High throughput no yes
GDIB_HUMAN [view entry] [view interactions] High throughput yes yes
GGA2_HUMAN [view interactions] High throughput no yes
GGA3_HUMAN [view entry] [view interactions] High throughput yes yes
GIT1_HUMAN [view entry] [view interactions] High throughput yes yes
GIT2_HUMAN [view interactions] High throughput no yes
GEPH_HUMAN [view entry] [view interactions] High throughput yes yes
HAUS8_HUMAN [view interactions] High throughput no yes
HDAC2_HUMAN [view interactions] High throughput no yes
HDAC5_HUMAN [view interactions] High throughput no yes
HINT1_HUMAN [view interactions] High throughput no yes
HMMR_HUMAN [view interactions] High throughput no yes
HOOK2_HUMAN [view interactions] High throughput no yes
ICE2_HUMAN [view interactions] High throughput no no
SHIP2_HUMAN [view interactions] High throughput no yes
SYK_HUMAN [view interactions] High throughput no yes
KI16B_HUMAN [view interactions] High throughput no yes
KIF1C_HUMAN [view interactions] High throughput no yes
KIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
KIF7_HUMAN [view interactions] High throughput no yes
LMBL2_HUMAN [view interactions] High throughput no no
LIMD1_HUMAN [view interactions] High throughput no yes
LMO7_HUMAN [view entry] [view interactions] High throughput yes yes
LRCH2_HUMAN [view interactions] High throughput no no
LZTS2_HUMAN [view interactions] High throughput no no
MSH2_HUMAN [view interactions] High throughput no yes
MYBB_HUMAN [view interactions] High throughput no yes
N4BP1_HUMAN [view interactions] High throughput no yes
NAA35_HUMAN [view interactions] High throughput no yes
NCK5L_HUMAN [view interactions] High throughput no yes
NDC80_HUMAN [view interactions] High throughput no no
NEPRO_HUMAN [view interactions] High throughput no no
NIN_HUMAN [view interactions] High throughput no no
NRBF2_HUMAN [view interactions] High throughput no yes
NUD19_HUMAN [view interactions] High throughput no no
NU107_HUMAN [view interactions] High throughput no no
NU133_HUMAN [view interactions] High throughput no yes
NUP88_HUMAN [view interactions] High throughput no yes
NUP42_HUMAN [view interactions] High throughput no no
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
PFKAL_HUMAN [view entry] [view interactions] High throughput yes yes
PFKAP_HUMAN [view entry] [view interactions] High throughput yes yes
KPB1_HUMAN [view interactions] High throughput no yes
PHLB2_HUMAN [view interactions] High throughput no yes
PIBF1_HUMAN [view interactions] High throughput no yes
FYV1_HUMAN [view interactions] High throughput no no
PKN2_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
DPOE1_HUMAN [view interactions] High throughput no no
RPC1_HUMAN [view interactions] High throughput no no
PPCS_HUMAN [view interactions] High throughput no yes
LIPA1_HUMAN [view entry] [view interactions] High throughput yes yes
PRC2B_HUMAN [view interactions] High throughput no no
PRS4_HUMAN [view entry] [view interactions] High throughput yes yes
PTN14_HUMAN [view interactions] High throughput no yes
RBM11_HUMAN [view interactions] High throughput no no
RBNS5_HUMAN [view interactions] High throughput no yes
RC3H2_HUMAN [view interactions] High throughput no yes
RCOR1_HUMAN [view interactions] High throughput no yes
RCOR3_HUMAN [view interactions] High throughput no yes
FTM_HUMAN [view interactions] High throughput no yes
RREB1_HUMAN [view interactions] High throughput no yes
SC24C_HUMAN [view entry] [view interactions] High throughput yes yes
SH2B2_HUMAN [view interactions] High throughput no yes
SHLB2_HUMAN [view entry] [view interactions] High throughput yes no
SHC1_HUMAN [view entry] [view interactions] High throughput yes yes
SMC1A_HUMAN [view interactions] High throughput no yes
SNX5_HUMAN [view entry] [view interactions] High throughput yes yes
SNX6_HUMAN [view entry] [view interactions] High throughput yes no
MTCL2_HUMAN [view interactions] High throughput no yes
CYTSB_HUMAN [view entry] [view interactions] High throughput yes yes
SRPK1_HUMAN [view interactions] High throughput no yes
STAM1_HUMAN [view interactions] High throughput no yes
STRBP_HUMAN [view interactions] High throughput no yes
TAB2_HUMAN [view interactions] High throughput no yes
TBD2B_HUMAN [view interactions] High throughput no yes
TBC31_HUMAN [view interactions] High throughput no yes
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
TBKB1_HUMAN [view interactions] High throughput no no
TCHP_HUMAN [view interactions] High throughput no yes
TELO2_HUMAN [view interactions] High throughput no yes
THUM3_HUMAN [view interactions] High throughput no yes
TMCC3_HUMAN [view interactions] High throughput no yes
MACOI_HUMAN [view interactions] High throughput no no
TOM22_HUMAN [view interactions] High throughput no yes
TRAD1_HUMAN [view interactions] High throughput no yes
TRI56_HUMAN [view interactions] High throughput no yes
TARA_HUMAN [view interactions] High throughput no yes
TRIPB_HUMAN [view interactions] High throughput no yes
TT21B_HUMAN [view interactions] High throughput no yes
GCP2_HUMAN [view interactions] High throughput no yes
GCP3_HUMAN [view interactions] High throughput no yes
REN3B_HUMAN [view interactions] High throughput no yes
VPS51_HUMAN [view interactions] High throughput no yes
VPS52_HUMAN [view entry] [view interactions] High throughput yes no