MRCKA_HUMAN
Evidence for PS localization
Functions
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed, PubMed, PubMed). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed, PubMed). May play a role in TFRC-mediated iron uptake (PubMed). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation . Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MRCKA_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 51.1111 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 51.1111 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 51.1111 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 35.5556 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 35.5556 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 35.5556 | 6 | no |
| GO:0019900 | kinase binding | 33.3333 | 4 | no |
| GO:0019901 | protein kinase binding | 33.3333 | 5 | no |
| GO:0003924 | GTPase activity | 33.3333 | 7 | no |
| GO:0005525 | GTP binding | 33.3333 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 33.3333 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 33.3333 | 5 | no |
| GO:0005524 | ATP binding | 17.7778 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 17.7778 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 17.7778 | 5 | yes |
| GO:0016301 | kinase activity | 15.5556 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 15.5556 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 11.1111 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 11.1111 | 4 | yes |
| GO:0046872 | metal ion binding | 11.1111 | 4 | yes |
| GO:0000287 | magnesium ion binding | 6.6667 | 5 | yes |
| GO:0106310 | protein serine kinase activity | 6.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MRCKA_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 71.1111 | 4 | no |
| GO:0006996 | organelle organization | 55.5556 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 53.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 51.1111 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.8889 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 48.8889 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.8889 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.6667 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 46.6667 | 4 | no |
| GO:0008104 | protein localization | 46.6667 | 4 | no |
| GO:0051049 | regulation of transport | 46.6667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 46.6667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 44.4444 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 44.4444 | 5 | no |
| GO:0022607 | cellular component assembly | 44.4444 | 4 | no |
| GO:0071702 | organic substance transport | 42.2222 | 4 | no |
| GO:0007010 | cytoskeleton organization | 42.2222 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 40.0000 | 5 | no |
| GO:0071705 | nitrogen compound transport | 40.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 37.7778 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 37.7778 | 5 | no |
| GO:0010468 | regulation of gene expression | 35.5556 | 5 | no |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:0030334 | regulation of cell migration | 33.3333 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 33.3333 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:2000145 | regulation of cell motility | 33.3333 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 31.1111 | 5 | no |
| GO:0030030 | cell projection organization | 31.1111 | 4 | no |
| GO:0015031 | protein transport | 31.1111 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 31.1111 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 31.1111 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 31.1111 | 6 | no |
| GO:0031399 | regulation of protein modification process | 28.8889 | 6 | no |
| GO:0033043 | regulation of organelle organization | 28.8889 | 5 | no |
| GO:0051050 | positive regulation of transport | 28.8889 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 28.8889 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 28.8889 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 28.8889 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 28.8889 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 28.8889 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 26.6667 | 7 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 26.6667 | 7 | no |
| GO:0060341 | regulation of cellular localization | 26.6667 | 4 | no |
| GO:0006886 | intracellular protein transport | 26.6667 | 4 | no |
| GO:0071310 | cellular response to organic substance | 26.6667 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 26.6667 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 26.6667 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 26.6667 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 24.4444 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 24.4444 | 8 | no |
| GO:0008284 | positive regulation of cell population proliferation | 24.4444 | 5 | no |
| GO:0030335 | positive regulation of cell migration | 24.4444 | 6 | no |
| GO:0032880 | regulation of protein localization | 24.4444 | 5 | no |
| GO:0040017 | positive regulation of locomotion | 24.4444 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 24.4444 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 24.4444 | 4 | no |
| GO:0010941 | regulation of cell death | 24.4444 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.4444 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.4444 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 24.4444 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 24.4444 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 24.4444 | 4 | no |
| GO:0007264 | small GTPase mediated signal transduction | 24.4444 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 24.4444 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.4444 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.4444 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.4444 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 24.4444 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 24.4444 | 7 | no |
| GO:1903829 | positive regulation of protein localization | 22.2222 | 5 | no |
| GO:0007015 | actin filament organization | 22.2222 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.2222 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 22.2222 | 6 | no |
| GO:0045597 | positive regulation of cell differentiation | 22.2222 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.2222 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 22.2222 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 22.2222 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 22.2222 | 4 | no |
| GO:0007265 | Ras protein signal transduction | 22.2222 | 5 | no |
| GO:0061024 | membrane organization | 22.2222 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 22.2222 | 6 | no |
| GO:0051046 | regulation of secretion | 22.2222 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 22.2222 | 4 | no |
| GO:0036211 | protein modification process | 22.2222 | 4 | yes |
| GO:0043412 | macromolecule modification | 22.2222 | 4 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 22.2222 | 8 | no |
| GO:0006468 | protein phosphorylation | 20.0000 | 5 | yes |
| GO:0016310 | phosphorylation | 20.0000 | 5 | yes |
| GO:0018193 | peptidyl-amino acid modification | 15.5556 | 5 | yes |
| GO:0018107 | peptidyl-threonine phosphorylation | 11.1111 | 6 | yes |
| GO:0018210 | peptidyl-threonine modification | 11.1111 | 6 | yes |
| GO:0031032 | actomyosin structure organization | 11.1111 | 4 | yes |
| GO:0031532 | actin cytoskeleton reorganization | 11.1111 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MRCKA_HUMAN |
|---|---|---|---|---|
| DOID:0111962 | combined immunodeficiency | 4.4444 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 4.4444 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MRCKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LURA1_HUMAN | [view interactions] | Low throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHOQ_HUMAN | [view interactions] | Low throughput | no | no |
| MRCKB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ML12A_HUMAN | [view interactions] | Low throughput | no | no |
| LIMK1_HUMAN | [view interactions] | Low throughput | no | yes |
| LIMK2_HUMAN | [view interactions] | Low throughput | no | yes |
| PPM1A_HUMAN | [view interactions] | Low throughput | no | yes |
| MRCKG_HUMAN | [view interactions] | High throughput | no | no |
| DNJ5B_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFAD_HUMAN | [view interactions] | High throughput | no | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEP10_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT9_HUMAN | [view interactions] | High throughput | no | no |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
| SP1_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| TAF1_HUMAN | [view interactions] | High throughput | no | yes |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTPRM_HUMAN | [view interactions] | High throughput | no | yes |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| KCD17_HUMAN | [view interactions] | High throughput | no | yes |
| INKA2_HUMAN | [view interactions] | High throughput | no | yes |
| LUR1L_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| KI20B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
| CTSL2_HUMAN | [view interactions] | High throughput | no | no |
| CENPQ_HUMAN | [view interactions] | High throughput | no | yes |
| SKA3_HUMAN | [view interactions] | High throughput | no | no |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| SNUT1_HUMAN | [view interactions] | High throughput | no | yes |
| SHCAF_HUMAN | [view interactions] | High throughput | no | yes |
| CTBL1_HUMAN | [view interactions] | High throughput | no | yes |
| RABE2_HUMAN | [view interactions] | High throughput | no | yes |
| SPIR2_HUMAN | [view interactions] | High throughput | no | yes |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| RL28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCGR1_HUMAN | [view interactions] | High throughput | no | no |
| IN80B_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| HAVR2_HUMAN | [view interactions] | High throughput | no | no |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| PRPS2_HUMAN | [view interactions] | High throughput | no | no |
| MTLR_HUMAN | [view interactions] | High throughput | no | no |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDN2D_HUMAN | [view interactions] | High throughput | no | no |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B2L12_HUMAN | [view interactions] | High throughput | no | yes |
| GPC5B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| PLK4_HUMAN | [view interactions] | High throughput | no | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| EPIPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP12C_HUMAN | [view interactions] | High throughput | no | yes |
| MLRV_HUMAN | [view interactions] | Computational | no | no |