Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ARBK1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed). Key regulator of LPAR1 signaling (PubMed). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity . Inhibits relaxation of airway smooth muscle in response to blue light (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ARBK1_HUMAN
GO:0043168 anion binding 35.5556 4 yes
GO:0000166 nucleotide binding 33.3333 4 yes
GO:0017076 purine nucleotide binding 33.3333 5 yes
GO:0032555 purine ribonucleotide binding 33.3333 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 yes
GO:0005524 ATP binding 31.1111 5 yes
GO:0030554 adenyl nucleotide binding 31.1111 6 yes
GO:0032559 adenyl ribonucleotide binding 31.1111 5 yes
GO:0043169 cation binding 28.8889 4 no
GO:0046872 metal ion binding 26.6667 5 no
GO:0019900 kinase binding 26.6667 4 no
GO:0003723 RNA binding 24.4444 4 no
GO:0001664 G protein-coupled receptor binding 22.2222 4 yes
GO:0016301 kinase activity 22.2222 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 22.2222 4 yes
GO:0019901 protein kinase binding 22.2222 5 no
GO:0004674 protein serine/threonine kinase activity 15.5556 4 yes
GO:0031690 adrenergic receptor binding 8.8889 5 yes
GO:0004703 G protein-coupled receptor kinase activity 6.6667 5 yes
GO:0047696 beta-adrenergic receptor kinase activity 6.6667 4 yes
GO:0031694 alpha-2A adrenergic receptor binding 4.4444 6 yes
GO:0031753 endothelial differentiation G protein-coupled receptor binding 4.4444 5 yes
GO:0031755 Edg-2 lysophosphatidic acid receptor binding 4.4444 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ARBK1_HUMAN
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0009966 regulation of signal transduction 64.4444 4 yes
GO:0048523 negative regulation of cellular process 64.4444 4 yes
GO:0031323 regulation of cellular metabolic process 55.5556 4 no
GO:0060255 regulation of macromolecule metabolic process 55.5556 4 no
GO:0080090 regulation of primary metabolic process 53.3333 4 no
GO:0009889 regulation of biosynthetic process 48.8889 4 no
GO:0010556 regulation of macromolecule biosynthetic process 48.8889 5 no
GO:0031326 regulation of cellular biosynthetic process 48.8889 5 no
GO:0010468 regulation of gene expression 44.4444 6 no
GO:0010647 positive regulation of cell communication 44.4444 5 no
GO:0023056 positive regulation of signaling 44.4444 4 no
GO:0048584 positive regulation of response to stimulus 44.4444 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 42.2222 5 no
GO:0051246 regulation of protein metabolic process 42.2222 5 no
GO:0051049 regulation of transport 42.2222 4 yes
GO:0051128 regulation of cellular component organization 42.2222 4 no
GO:1902531 regulation of intracellular signal transduction 40.0000 5 no
GO:0009893 positive regulation of metabolic process 40.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 no
GO:0009967 positive regulation of signal transduction 40.0000 5 no
GO:0009892 negative regulation of metabolic process 37.7778 4 no
GO:0010605 negative regulation of macromolecule metabolic process 37.7778 5 no
GO:0031325 positive regulation of cellular metabolic process 37.7778 5 no
GO:0036211 protein modification process 37.7778 4 yes
GO:0043412 macromolecule modification 37.7778 4 yes
GO:0009891 positive regulation of biosynthetic process 35.5556 5 no
GO:0031324 negative regulation of cellular metabolic process 35.5556 5 no
GO:0031328 positive regulation of cellular biosynthetic process 35.5556 6 no
GO:0071310 cellular response to organic substance 35.5556 4 no
GO:0048585 negative regulation of response to stimulus 35.5556 4 yes
GO:0008104 protein localization 33.3333 4 no
GO:0009890 negative regulation of biosynthetic process 33.3333 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0031327 negative regulation of cellular biosynthetic process 33.3333 6 no
GO:0033993 response to lipid 33.3333 4 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:1901701 cellular response to oxygen-containing compound 33.3333 4 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 yes
GO:0009968 negative regulation of signal transduction 33.3333 5 yes
GO:0010648 negative regulation of cell communication 33.3333 5 yes
GO:0023057 negative regulation of signaling 33.3333 4 yes
GO:0051050 positive regulation of transport 33.3333 4 yes
GO:1902533 positive regulation of intracellular signal transduction 31.1111 6 no
GO:0006355 regulation of DNA-templated transcription 31.1111 7 no
GO:0060341 regulation of cellular localization 31.1111 4 no
GO:2001141 regulation of RNA biosynthetic process 31.1111 6 no
GO:0001932 regulation of protein phosphorylation 31.1111 7 no
GO:0031399 regulation of protein modification process 31.1111 6 no
GO:0042325 regulation of phosphorylation 31.1111 7 no
GO:0032880 regulation of protein localization 28.8889 5 no
GO:0043933 protein-containing complex organization 28.8889 4 no
GO:0010243 response to organonitrogen compound 26.6667 4 no
GO:0071705 nitrogen compound transport 24.4444 4 no
GO:0099177 regulation of trans-synaptic signaling 24.4444 4 no
GO:0006357 regulation of transcription by RNA polymerase II 24.4444 8 no
GO:0010628 positive regulation of gene expression 24.4444 7 no
GO:0014070 response to organic cyclic compound 24.4444 4 no
GO:0045595 regulation of cell differentiation 24.4444 4 no
GO:0051094 positive regulation of developmental process 24.4444 4 no
GO:1903829 positive regulation of protein localization 24.4444 5 no
GO:0001934 positive regulation of protein phosphorylation 24.4444 8 no
GO:0006996 organelle organization 24.4444 4 no
GO:0010562 positive regulation of phosphorus metabolic process 24.4444 6 no
GO:0031401 positive regulation of protein modification process 24.4444 7 no
GO:0042327 positive regulation of phosphorylation 24.4444 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 24.4444 5 no
GO:0045937 positive regulation of phosphate metabolic process 24.4444 7 no
GO:0071396 cellular response to lipid 24.4444 5 no
GO:0051130 positive regulation of cellular component organization 24.4444 5 no
GO:0098657 import into cell 24.4444 4 yes
GO:0030030 cell projection organization 24.4444 4 no
GO:0031175 neuron projection development 24.4444 6 no
GO:0120036 plasma membrane bounded cell projection organization 24.4444 5 no
GO:0050804 modulation of chemical synaptic transmission 24.4444 5 no
GO:0071702 organic substance transport 24.4444 4 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0010629 negative regulation of gene expression 22.2222 7 no
GO:0051248 negative regulation of protein metabolic process 22.2222 6 no
GO:0065003 protein-containing complex assembly 22.2222 5 no
GO:0071417 cellular response to organonitrogen compound 22.2222 4 no
GO:1901699 cellular response to nitrogen compound 22.2222 4 no
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0043549 regulation of kinase activity 22.2222 5 no
GO:0045859 regulation of protein kinase activity 22.2222 6 no
GO:0051338 regulation of transferase activity 22.2222 4 no
GO:0016310 phosphorylation 22.2222 5 yes
GO:0051241 negative regulation of multicellular organismal process 22.2222 4 yes
GO:0080134 regulation of response to stress 22.2222 4 no
GO:0006468 protein phosphorylation 20.0000 5 yes
GO:0006898 receptor-mediated endocytosis 20.0000 4 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 20.0000 5 yes
GO:0044057 regulation of system process 20.0000 4 yes
GO:0031623 receptor internalization 17.7778 5 yes
GO:0018193 peptidyl-amino acid modification 15.5556 5 yes
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 13.3333 4 yes
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 13.3333 6 yes
GO:0051046 regulation of secretion 13.3333 5 yes
GO:0095500 acetylcholine receptor signaling pathway 13.3333 4 yes
GO:1903530 regulation of secretion by cell 13.3333 4 yes
GO:0002029 desensitization of G protein-coupled receptor signaling pathway 11.1111 7 yes
GO:0008016 regulation of heart contraction 11.1111 6 yes
GO:0022401 negative adaptation of signaling pathway 11.1111 6 yes
GO:0023058 adaptation of signaling pathway 11.1111 5 yes
GO:0051047 positive regulation of secretion 11.1111 5 yes
GO:1903522 regulation of blood circulation 11.1111 5 yes
GO:1903532 positive regulation of secretion by cell 11.1111 5 yes
GO:0006936 muscle contraction 8.8889 4 yes
GO:0006937 regulation of muscle contraction 8.8889 6 yes
GO:0050433 regulation of catecholamine secretion 8.8889 5 yes
GO:0051952 regulation of amine transport 8.8889 5 yes
GO:0090257 regulation of muscle system process 8.8889 5 yes
GO:0006941 striated muscle contraction 6.6667 5 yes
GO:0006942 regulation of striated muscle contraction 6.6667 7 yes
GO:0007507 heart development 6.6667 4 yes
GO:0018105 peptidyl-serine phosphorylation 6.6667 6 yes
GO:0018209 peptidyl-serine modification 6.6667 6 yes
GO:0044409 symbiont entry into host 6.6667 4 yes
GO:0045932 negative regulation of muscle contraction 6.6667 5 yes
GO:0003057 regulation of the force of heart contraction by chemical signal 4.4444 4 yes
GO:0003108 negative regulation of the force of heart contraction by chemical signal 4.4444 5 yes
GO:0007217 tachykinin receptor signaling pathway 4.4444 4 yes
GO:0033605 positive regulation of catecholamine secretion 4.4444 6 yes
GO:0045822 negative regulation of heart contraction 4.4444 6 yes
GO:0045988 negative regulation of striated muscle contraction 4.4444 6 yes
GO:0046718 symbiont entry into host cell 4.4444 5 yes
GO:0051954 positive regulation of amine transport 4.4444 5 yes
GO:0060048 cardiac muscle contraction 4.4444 6 yes
GO:1901077 regulation of relaxation of muscle 4.4444 6 yes
GO:1901078 negative regulation of relaxation of muscle 4.4444 5 yes
GO:1901080 regulation of relaxation of smooth muscle 4.4444 7 yes
GO:1901081 negative regulation of relaxation of smooth muscle 4.4444 6 yes
GO:1903523 negative regulation of blood circulation 4.4444 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GBB2_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
FPR1_HUMAN [view interactions] Low throughput no no
PTC1_HUMAN [view entry] [view interactions] Low throughput yes yes
IKBA_HUMAN [view interactions] Low throughput no yes
OPN4_HUMAN [view interactions] Low throughput no no
MDM2_HUMAN [view entry] [view interactions] Low throughput yes yes
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
NEB2_HUMAN [view entry] [view interactions] Low throughput yes yes
HDAC6_HUMAN [view interactions] Low throughput no yes
PK3CG_HUMAN [view interactions] Low throughput no yes
TBB5_HUMAN [view interactions] Low throughput no yes
APJ_HUMAN [view interactions] Low throughput no yes
GNAQ_HUMAN [view entry] [view interactions] Low throughput yes yes
GNA15_HUMAN [view interactions] Low throughput no yes
KPCB_HUMAN [view entry] [view interactions] Low throughput yes yes
CNRG_HUMAN [view interactions] Low throughput no no
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
GIT2_HUMAN [view interactions] Low throughput no yes
CCR4_HUMAN [view interactions] Low throughput no yes
EDNRB_HUMAN [view interactions] Low throughput no no
AGTR1_HUMAN [view interactions] Low throughput no no
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
HDAC5_HUMAN [view interactions] Low throughput no yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PGFRB_HUMAN [view interactions] Low throughput no yes
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
CSEN_HUMAN [view interactions] Low throughput no no
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
PEBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
RPGF3_HUMAN [view interactions] Low throughput no yes
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
GPR17_HUMAN [view interactions] Low throughput no no
GBB3_HUMAN [view interactions] Low throughput no yes
VDR_HUMAN [view interactions] Low throughput no no
PK3CB_HUMAN [view interactions] Low throughput no yes
SMO_HUMAN [view entry] [view interactions] Low throughput yes yes
TRAF2_HUMAN [view interactions] Low throughput no yes
MALT1_HUMAN [view interactions] Low throughput no no
CLH1_HUMAN [view entry] [view interactions] Low throughput yes yes
OPSD_HUMAN [view interactions] Low throughput no no
CAV1_HUMAN [view interactions] Low throughput no no
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
PLCB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PHLP_HUMAN [view interactions] Low throughput no yes
PHOS_HUMAN [view interactions] Low throughput no no
FSHR_HUMAN [view interactions] Low throughput no no
SCNNB_HUMAN [view interactions] Low throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
DDX6_HUMAN [view entry] [view interactions] High throughput yes yes
DAAF5_HUMAN [view interactions] High throughput no no
FERM2_HUMAN [view interactions] High throughput no yes
PAPOA_HUMAN [view interactions] High throughput no yes
PPWD1_HUMAN [view interactions] High throughput no yes
PLPHP_HUMAN [view interactions] High throughput no yes
PTPRF_HUMAN [view entry] [view interactions] High throughput yes yes
SYNM_HUMAN [view interactions] High throughput no yes
WDR1_HUMAN [view entry] [view interactions] High throughput yes yes
PYGL_HUMAN [view interactions] High throughput no yes
TIMP2_HUMAN [view interactions] High throughput no no
PUR8_HUMAN [view interactions] High throughput no yes
A16A1_HUMAN [view entry] [view interactions] High throughput yes no
MED20_HUMAN [view interactions] High throughput no no
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
STING_HUMAN [view interactions] High throughput no yes
BRSK2_HUMAN [view interactions] High throughput no no
PPP5_HUMAN [view entry] [view interactions] High throughput yes yes
UBP15_HUMAN [view entry] [view interactions] High throughput yes yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
CTR9_HUMAN [view interactions] High throughput no yes
TNPO1_HUMAN [view entry] [view interactions] High throughput yes yes
PRP4_HUMAN [view interactions] High throughput no yes
SLAI2_HUMAN [view interactions] High throughput no no
RFX5_HUMAN [view interactions] High throughput no yes
RXRB_HUMAN [view interactions] High throughput no yes
PP16B_HUMAN [view interactions] High throughput no yes
TBC14_HUMAN [view interactions] High throughput no yes
ARBK2_HUMAN [view entry] [view interactions] High throughput yes yes
FRK_HUMAN [view interactions] High throughput no no
ACACA_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA2_HUMAN [view interactions] High throughput no no
RGRF1_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB3_HUMAN [view interactions] High throughput no yes
NCAM1_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
CDC37_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
MOV10_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
KBTB7_HUMAN [view interactions] High throughput no yes
SCFD2_HUMAN [view interactions] High throughput no yes
FOXR1_HUMAN [view interactions] High throughput no no
CACO1_HUMAN [view entry] [view interactions] High throughput yes yes
MRCKA_HUMAN [view entry] [view interactions] High throughput yes yes
ARBK1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
RHG24_HUMAN [view interactions] High throughput no yes
HEM2_HUMAN [view interactions] High throughput no no
PTPRJ_HUMAN [view interactions] High throughput no yes
MASP2_HUMAN [view interactions] High throughput no no
MTR1A_HUMAN [view interactions] High throughput no no
ITA2B_HUMAN [view interactions] High throughput no no
FBX25_HUMAN [view interactions] High throughput no no