Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ARBK1_HUMAN

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed). Key regulator of LPAR1 signaling (PubMed). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity . Inhibits relaxation of airway smooth muscle in response to blue light (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ARBK1_HUMAN
GO:0017076 purine nucleotide binding 37.7778 4 yes
GO:0032555 purine ribonucleotide binding 37.7778 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 37.7778 4 yes
GO:0005524 ATP binding 35.5556 5 yes
GO:0030554 adenyl nucleotide binding 35.5556 5 yes
GO:0032559 adenyl ribonucleotide binding 35.5556 5 yes
GO:0046872 metal ion binding 31.1111 4 no
GO:0016301 kinase activity 28.8889 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 28.8889 4 yes
GO:0019900 kinase binding 26.6667 4 no
GO:0001664 G protein-coupled receptor binding 24.4444 4 yes
GO:0019901 protein kinase binding 24.4444 5 no
GO:0004674 protein serine/threonine kinase activity 22.2222 4 yes
GO:0031690 adrenergic receptor binding 11.1111 5 yes
GO:0004703 G protein-coupled receptor kinase activity 6.6667 5 yes
GO:0047696 beta-adrenergic receptor kinase activity 6.6667 4 yes
GO:0031694 alpha-2A adrenergic receptor binding 4.4444 6 yes
GO:0031753 endothelial differentiation G protein-coupled receptor binding 4.4444 5 yes
GO:0031755 Edg-2 lysophosphatidic acid receptor binding 4.4444 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ARBK1_HUMAN
GO:0010646 regulation of cell communication 68.8889 4 yes
GO:0048523 negative regulation of cellular process 68.8889 4 yes
GO:0009966 regulation of signal transduction 66.6667 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0031323 regulation of cellular metabolic process 62.2222 4 no
GO:0051171 regulation of nitrogen compound metabolic process 62.2222 4 no
GO:0060255 regulation of macromolecule metabolic process 62.2222 4 no
GO:0080090 regulation of primary metabolic process 62.2222 4 no
GO:0051049 regulation of transport 48.8889 4 yes
GO:0009893 positive regulation of metabolic process 48.8889 4 no
GO:0009889 regulation of biosynthetic process 48.8889 4 no
GO:0010604 positive regulation of macromolecule metabolic process 46.6667 5 no
GO:0010647 positive regulation of cell communication 46.6667 5 no
GO:0023056 positive regulation of signaling 46.6667 4 no
GO:0031325 positive regulation of cellular metabolic process 46.6667 5 no
GO:0048584 positive regulation of response to stimulus 46.6667 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 46.6667 5 no
GO:0051246 regulation of protein metabolic process 46.6667 5 no
GO:0010556 regulation of macromolecule biosynthetic process 46.6667 5 no
GO:0010468 regulation of gene expression 46.6667 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 46.6667 5 no
GO:0031326 regulation of cellular biosynthetic process 46.6667 5 no
GO:0051128 regulation of cellular component organization 44.4444 4 no
GO:0010648 negative regulation of cell communication 42.2222 5 yes
GO:0023057 negative regulation of signaling 42.2222 4 yes
GO:0048585 negative regulation of response to stimulus 42.2222 4 yes
GO:0009967 positive regulation of signal transduction 42.2222 5 no
GO:0009892 negative regulation of metabolic process 42.2222 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 42.2222 5 no
GO:0009968 negative regulation of signal transduction 40.0000 5 yes
GO:0036211 protein modification process 40.0000 4 yes
GO:0043412 macromolecule modification 40.0000 4 yes
GO:0019220 regulation of phosphate metabolic process 40.0000 6 no
GO:0042325 regulation of phosphorylation 40.0000 7 no
GO:0051174 regulation of phosphorus metabolic process 40.0000 5 no
GO:0071310 cellular response to organic substance 40.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 40.0000 5 no
GO:0009891 positive regulation of biosynthetic process 40.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 40.0000 6 no
GO:1902531 regulation of intracellular signal transduction 40.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 37.7778 4 yes
GO:0051050 positive regulation of transport 37.7778 4 yes
GO:0031399 regulation of protein modification process 37.7778 6 no
GO:0051247 positive regulation of protein metabolic process 37.7778 6 no
GO:0051252 regulation of RNA metabolic process 37.7778 5 no
GO:0001932 regulation of protein phosphorylation 35.5556 7 no
GO:0010243 response to organonitrogen compound 35.5556 4 no
GO:1901701 cellular response to oxygen-containing compound 35.5556 4 no
GO:0060341 regulation of cellular localization 35.5556 4 no
GO:0031324 negative regulation of cellular metabolic process 35.5556 5 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 33.3333 6 no
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 no
GO:0001934 positive regulation of protein phosphorylation 31.1111 8 no
GO:0031401 positive regulation of protein modification process 31.1111 7 no
GO:0006355 regulation of DNA-templated transcription 31.1111 6 no
GO:0080134 regulation of response to stress 31.1111 4 no
GO:1903506 regulation of nucleic acid-templated transcription 31.1111 7 no
GO:2001141 regulation of RNA biosynthetic process 31.1111 6 no
GO:0006468 protein phosphorylation 28.8889 5 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 28.8889 5 yes
GO:0016310 phosphorylation 28.8889 5 yes
GO:0051241 negative regulation of multicellular organismal process 28.8889 4 yes
GO:0033993 response to lipid 28.8889 4 no
GO:0009894 regulation of catabolic process 28.8889 4 no
GO:0043085 positive regulation of catalytic activity 28.8889 4 no
GO:0043549 regulation of kinase activity 28.8889 5 no
GO:0051094 positive regulation of developmental process 28.8889 4 no
GO:0051338 regulation of transferase activity 28.8889 4 no
GO:0032101 regulation of response to external stimulus 28.8889 4 no
GO:0050804 modulation of chemical synaptic transmission 28.8889 5 no
GO:0099177 regulation of trans-synaptic signaling 28.8889 4 no
GO:0043408 regulation of MAPK cascade 28.8889 6 no
GO:0016192 vesicle-mediated transport 26.6667 4 yes
GO:0051336 regulation of hydrolase activity 26.6667 4 no
GO:0014070 response to organic cyclic compound 26.6667 4 no
GO:0071417 cellular response to organonitrogen compound 26.6667 4 no
GO:1901699 cellular response to nitrogen compound 26.6667 4 no
GO:0008104 protein localization 26.6667 4 no
GO:0033674 positive regulation of kinase activity 26.6667 6 no
GO:0045859 regulation of protein kinase activity 26.6667 6 no
GO:0051248 negative regulation of protein metabolic process 26.6667 6 no
GO:0051347 positive regulation of transferase activity 26.6667 5 no
GO:0006897 endocytosis 24.4444 5 yes
GO:0018193 peptidyl-amino acid modification 24.4444 5 yes
GO:0042127 regulation of cell population proliferation 24.4444 4 no
GO:0043933 protein-containing complex organization 24.4444 4 no
GO:0071396 cellular response to lipid 24.4444 5 no
GO:0051726 regulation of cell cycle 24.4444 4 no
GO:0071702 organic substance transport 24.4444 4 no
GO:0010941 regulation of cell death 24.4444 4 no
GO:0045595 regulation of cell differentiation 24.4444 4 no
GO:0045860 positive regulation of protein kinase activity 24.4444 7 no
GO:0051240 positive regulation of multicellular organismal process 24.4444 4 no
GO:0030030 cell projection organization 24.4444 4 no
GO:0051130 positive regulation of cellular component organization 24.4444 5 no
GO:0043410 positive regulation of MAPK cascade 24.4444 7 no
GO:0006898 receptor-mediated endocytosis 22.2222 6 yes
GO:0044057 regulation of system process 22.2222 4 yes
GO:0065003 protein-containing complex assembly 22.2222 5 no
GO:0033043 regulation of organelle organization 22.2222 5 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 7 no
GO:0006996 organelle organization 22.2222 4 no
GO:0010628 positive regulation of gene expression 22.2222 6 no
GO:0031329 regulation of cellular catabolic process 22.2222 5 no
GO:0034762 regulation of transmembrane transport 22.2222 4 no
GO:0042981 regulation of apoptotic process 22.2222 6 no
GO:0043067 regulation of programmed cell death 22.2222 5 no
GO:0043269 regulation of ion transport 22.2222 5 no
GO:0045893 positive regulation of DNA-templated transcription 22.2222 7 no
GO:0051254 positive regulation of RNA metabolic process 22.2222 6 no
GO:0060548 negative regulation of cell death 22.2222 5 no
GO:1902680 positive regulation of RNA biosynthetic process 22.2222 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 22.2222 8 no
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 no
GO:0031623 receptor internalization 20.0000 7 yes
GO:0051046 regulation of secretion 20.0000 5 yes
GO:1903530 regulation of secretion by cell 20.0000 4 yes
GO:0018105 peptidyl-serine phosphorylation 17.7778 6 yes
GO:0018209 peptidyl-serine modification 17.7778 6 yes
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 15.5556 4 yes
GO:0018107 peptidyl-threonine phosphorylation 15.5556 6 yes
GO:0018210 peptidyl-threonine modification 15.5556 6 yes
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 15.5556 6 yes
GO:0095500 acetylcholine receptor signaling pathway 15.5556 4 yes
GO:0002029 desensitization of G protein-coupled receptor signaling pathway 11.1111 7 yes
GO:0022401 negative adaptation of signaling pathway 11.1111 6 yes
GO:0023058 adaptation of signaling pathway 11.1111 5 yes
GO:0050433 regulation of catecholamine secretion 8.8889 5 yes
GO:0051047 positive regulation of secretion 8.8889 5 yes
GO:0051952 regulation of amine transport 8.8889 5 yes
GO:0090257 regulation of muscle system process 8.8889 5 yes
GO:1903522 regulation of blood circulation 8.8889 5 yes
GO:1903532 positive regulation of secretion by cell 8.8889 5 yes
GO:0006936 muscle contraction 6.6667 4 yes
GO:0006937 regulation of muscle contraction 6.6667 6 yes
GO:0007507 heart development 6.6667 4 yes
GO:0008016 regulation of heart contraction 6.6667 6 yes
GO:0044000 movement in host 6.6667 4 yes
GO:0044409 entry into host 6.6667 5 yes
GO:0045932 negative regulation of muscle contraction 6.6667 5 yes
GO:0051954 positive regulation of amine transport 6.6667 5 yes
GO:1903523 negative regulation of blood circulation 6.6667 5 yes
GO:0003057 regulation of the force of heart contraction by chemical signal 4.4444 4 yes
GO:0003108 negative regulation of the force of heart contraction by chemical signal 4.4444 5 yes
GO:0006941 striated muscle contraction 4.4444 5 yes
GO:0006942 regulation of striated muscle contraction 4.4444 7 yes
GO:0007217 tachykinin receptor signaling pathway 4.4444 4 yes
GO:0033605 positive regulation of catecholamine secretion 4.4444 6 yes
GO:0045822 negative regulation of heart contraction 4.4444 6 yes
GO:0045988 negative regulation of striated muscle contraction 4.4444 6 yes
GO:0046718 viral entry into host cell 4.4444 6 yes
GO:0060048 cardiac muscle contraction 4.4444 6 yes
GO:1901077 regulation of relaxation of muscle 4.4444 6 yes
GO:1901078 negative regulation of relaxation of muscle 4.4444 5 yes
GO:1901080 regulation of relaxation of smooth muscle 4.4444 7 yes
GO:1901081 negative regulation of relaxation of smooth muscle 4.4444 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in ARBK1_HUMAN
DOID:0050686 organ system cancer 4.4444 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PK3CB_HUMAN [view interactions] Low throughput no yes
SMO_HUMAN [view interactions] Low throughput no yes
TRAF2_HUMAN [view interactions] Low throughput no yes
MALT1_HUMAN [view interactions] Low throughput no no
CLH1_HUMAN [view entry] [view interactions] Low throughput yes yes
OPSD_HUMAN [view interactions] Low throughput no no
CAV1_HUMAN [view interactions] Low throughput no no
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
PLCB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PHLP_HUMAN [view interactions] Low throughput no yes
PHOS_HUMAN [view interactions] Low throughput no no
FSHR_HUMAN [view interactions] Low throughput no no
SCNNB_HUMAN [view interactions] Low throughput no yes
GBB2_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
FPR1_HUMAN [view interactions] Low throughput no no
PTC1_HUMAN [view entry] [view interactions] Low throughput yes yes
IKBA_HUMAN [view interactions] Low throughput no yes
OPN4_HUMAN [view interactions] Low throughput no no
MDM2_HUMAN [view interactions] Low throughput no yes
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
NEB2_HUMAN [view entry] [view interactions] Low throughput yes yes
HDAC6_HUMAN [view interactions] Low throughput no yes
PK3CG_HUMAN [view interactions] Low throughput no yes
TBB5_HUMAN [view interactions] Low throughput no yes
APJ_HUMAN [view interactions] Low throughput no yes
GNAQ_HUMAN [view entry] [view interactions] Low throughput yes yes
GNA15_HUMAN [view interactions] Low throughput no yes
KPCB_HUMAN [view entry] [view interactions] Low throughput yes yes
CNRG_HUMAN [view interactions] Low throughput no no
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
GIT2_HUMAN [view interactions] Low throughput no yes
CCR4_HUMAN [view interactions] Low throughput no yes
EDNRB_HUMAN [view interactions] Low throughput no no
AGTR1_HUMAN [view interactions] Low throughput no no
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
HDAC5_HUMAN [view interactions] Low throughput no yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PGFRB_HUMAN [view interactions] Low throughput no yes
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
CSEN_HUMAN [view interactions] Low throughput no no
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
PEBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
RPGF3_HUMAN [view interactions] Low throughput no yes
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
GPR17_HUMAN [view interactions] Low throughput no no
GBB3_HUMAN [view interactions] Low throughput no yes
VDR_HUMAN [view interactions] Low throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
KBTB7_HUMAN [view interactions] High throughput no yes
SCFD2_HUMAN [view interactions] High throughput no yes
FOXR1_HUMAN [view interactions] High throughput no no
CACO1_HUMAN [view entry] [view interactions] High throughput yes yes
MRCKA_HUMAN [view entry] [view interactions] High throughput yes yes
ARBK1_HUMAN [view entry] [view interactions] High throughput yes yes
HEM2_HUMAN [view interactions] High throughput no no
PTPRJ_HUMAN [view interactions] High throughput no yes
MASP2_HUMAN [view interactions] High throughput no no
MTR1A_HUMAN [view interactions] High throughput no no
ITA2B_HUMAN [view interactions] High throughput no no
FBX25_HUMAN [view interactions] High throughput no no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
DDX6_HUMAN [view entry] [view interactions] High throughput yes yes
DAAF5_HUMAN [view interactions] High throughput no no
FERM2_HUMAN [view interactions] High throughput no yes
PAPOA_HUMAN [view interactions] High throughput no yes
PPWD1_HUMAN [view interactions] High throughput no yes
PLPHP_HUMAN [view interactions] High throughput no yes
PTPRF_HUMAN [view entry] [view interactions] High throughput yes yes
SYNM_HUMAN [view interactions] High throughput no yes
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
CTR9_HUMAN [view interactions] High throughput no yes
TNPO1_HUMAN [view entry] [view interactions] High throughput yes yes
PRP4_HUMAN [view interactions] High throughput no yes
SLAI2_HUMAN [view interactions] High throughput no no
RFX5_HUMAN [view interactions] High throughput no yes
RXRB_HUMAN [view interactions] High throughput no yes
PP16B_HUMAN [view interactions] High throughput no yes
TBC14_HUMAN [view interactions] High throughput no yes
ARBK2_HUMAN [view entry] [view interactions] High throughput yes yes
ACACA_HUMAN [view entry] [view interactions] High throughput yes yes
FRK_HUMAN [view interactions] High throughput no no
EPHA2_HUMAN [view interactions] High throughput no no
RGRF1_HUMAN [view interactions] High throughput no yes
NCAM1_HUMAN [view entry] [view interactions] High throughput yes no
ERBB3_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
CDC37_HUMAN [view interactions] High throughput no yes
MOV10_HUMAN [view interactions] High throughput no no
GBG1_HUMAN [view interactions] Computational no no
CXCR2_HUMAN [view interactions] Computational no no
IL8_HUMAN [view interactions] Computational no no
EDN1_HUMAN [view interactions] Computational no no
CXCR4_HUMAN [view interactions] Computational no no
PE2R1_HUMAN [view interactions] Computational no no
NCS1_HUMAN [view entry] [view interactions] Computational yes yes
CCR3_HUMAN [view interactions] Computational no yes
CCR5_HUMAN [view interactions] Computational no no
SDF1_HUMAN [view interactions] Computational no no
CXCR1_HUMAN [view interactions] Computational no yes
ACM1_HUMAN [view entry] [view interactions] Computational yes yes
GLP1R_HUMAN [view interactions] Computational no no
CCL4_HUMAN [view interactions] Computational no no
NEU2_HUMAN [view interactions] Computational no no
DRD2_HUMAN [view entry] [view interactions] Computational yes no
TA2R_HUMAN [view interactions] Computational no no
5HT2C_HUMAN [view interactions] Computational no no
ANGT_HUMAN [view interactions] Computational no no
IRS1_HUMAN [view entry] [view interactions] Computational yes yes
ARRS_HUMAN [view interactions] Computational no no
OPRM_HUMAN [view entry] [view interactions] Computational yes no
KPCD_HUMAN [view entry] [view interactions] Computational yes yes
AGTR2_HUMAN [view interactions] Computational no no
ADA1B_HUMAN [view interactions] Computational no no
THRB_HUMAN [view interactions] Computational no no
GRK5_HUMAN [view interactions] Computational no yes
KPCG_HUMAN [view entry] [view interactions] Computational yes yes
SUCB2_HUMAN [view interactions] Computational no no
CCL11_HUMAN [view interactions] Computational no no
GRK6_HUMAN [view interactions] Computational no yes
KPCA_HUMAN [view entry] [view interactions] Computational yes yes
P2RY2_HUMAN [view interactions] Computational no no