Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SMO_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

G protein-coupled receptor which associates with the patched protein (PTCH) to transduce hedgehog protein signaling. Binding of sonic hedgehog (SHH) to its receptor patched prevents inhibition of smoothened (SMO) by patched. When active, SMO binds to and sequesters protein kinase A catalytic subunit PRKACA at the cell membrane, preventing PRKACA-mediated phosphorylation of GLI transcription factors which releases the GLI proteins from PRKACA-mediated inhibition and allows for transcriptional activation of hedgehog pathway target genes . Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
412 Leu Phe Curry-Jonessyndrome(CRJS) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SMO_HUMAN
GO:0043169 cation binding 27.7778 4 no
GO:0046872 metal ion binding 25.0000 5 no
GO:0043168 anion binding 22.2222 4 no
GO:0004930 G protein-coupled receptor activity 5.5556 4 yes
GO:0005113 patched binding 5.5556 4 yes
GO:0019900 kinase binding 5.5556 4 yes
GO:0019901 protein kinase binding 5.5556 5 yes
GO:0032934 sterol binding 5.5556 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SMO_HUMAN
GO:0048522 positive regulation of cellular process 52.7778 4 yes
GO:0010646 regulation of cell communication 44.4444 4 yes
GO:0051049 regulation of transport 41.6667 4 yes
GO:0048523 negative regulation of cellular process 38.8889 4 yes
GO:0009966 regulation of signal transduction 38.8889 4 yes
GO:0008104 protein localization 36.1111 4 yes
GO:0015031 protein transport 30.5556 4 yes
GO:0051050 positive regulation of transport 30.5556 4 yes
GO:0060255 regulation of macromolecule metabolic process 30.5556 4 yes
GO:0071702 organic substance transport 30.5556 4 yes
GO:0071705 nitrogen compound transport 30.5556 4 yes
GO:0080090 regulation of primary metabolic process 30.5556 4 yes
GO:0036211 protein modification process 27.7778 4 no
GO:0043412 macromolecule modification 27.7778 4 no
GO:0051128 regulation of cellular component organization 27.7778 4 no
GO:0031323 regulation of cellular metabolic process 25.0000 4 yes
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 yes
GO:0048584 positive regulation of response to stimulus 25.0000 4 yes
GO:0051246 regulation of protein metabolic process 25.0000 5 yes
GO:0060341 regulation of cellular localization 25.0000 4 yes
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0006508 proteolysis 25.0000 4 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0009889 regulation of biosynthetic process 25.0000 4 yes
GO:0009892 negative regulation of metabolic process 25.0000 4 yes
GO:0010468 regulation of gene expression 25.0000 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 yes
GO:0023056 positive regulation of signaling 22.2222 4 yes
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 yes
GO:0032880 regulation of protein localization 22.2222 5 yes
GO:0010648 negative regulation of cell communication 22.2222 5 no
GO:0023057 negative regulation of signaling 22.2222 4 no
GO:0009057 macromolecule catabolic process 22.2222 4 no
GO:0019941 modification-dependent protein catabolic process 22.2222 6 no
GO:0043632 modification-dependent macromolecule catabolic process 22.2222 5 no
GO:0051603 proteolysis involved in protein catabolic process 22.2222 5 no
GO:0009893 positive regulation of metabolic process 22.2222 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 22.2222 5 yes
GO:0010647 positive regulation of cell communication 22.2222 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 19.4444 5 yes
GO:0030030 cell projection organization 19.4444 4 yes
GO:0051241 negative regulation of multicellular organismal process 19.4444 4 yes
GO:0051252 regulation of RNA metabolic process 19.4444 5 yes
GO:0006886 intracellular protein transport 19.4444 4 yes
GO:0009967 positive regulation of signal transduction 19.4444 5 yes
GO:0014070 response to organic cyclic compound 16.6667 4 yes
GO:0031325 positive regulation of cellular metabolic process 16.6667 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 16.6667 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 16.6667 6 yes
GO:0031399 regulation of protein modification process 16.6667 6 yes
GO:0033365 protein localization to organelle 16.6667 5 yes
GO:0045595 regulation of cell differentiation 16.6667 4 yes
GO:0051248 negative regulation of protein metabolic process 16.6667 6 yes
GO:0071310 cellular response to organic substance 16.6667 4 yes
GO:0071407 cellular response to organic cyclic compound 16.6667 5 yes
GO:0097305 response to alcohol 16.6667 4 yes
GO:0120036 plasma membrane bounded cell projection organization 16.6667 5 yes
GO:1901701 cellular response to oxygen-containing compound 16.6667 4 yes
GO:2001141 regulation of RNA biosynthetic process 16.6667 6 yes
GO:0006355 regulation of DNA-templated transcription 16.6667 7 yes
GO:0009890 negative regulation of biosynthetic process 16.6667 5 yes
GO:0009891 positive regulation of biosynthetic process 16.6667 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 16.6667 6 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 16.6667 6 yes
GO:0019220 regulation of phosphate metabolic process 13.8889 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 13.8889 4 yes
GO:0031175 neuron projection development 13.8889 6 yes
GO:0031400 negative regulation of protein modification process 13.8889 7 yes
GO:0033993 response to lipid 13.8889 4 yes
GO:0042325 regulation of phosphorylation 13.8889 7 yes
GO:0051174 regulation of phosphorus metabolic process 13.8889 5 yes
GO:0071396 cellular response to lipid 13.8889 5 yes
GO:0097306 cellular response to alcohol 13.8889 5 yes
GO:2000026 regulation of multicellular organismal development 13.8889 4 yes
GO:0001932 regulation of protein phosphorylation 13.8889 7 yes
GO:0006357 regulation of transcription by RNA polymerase II 13.8889 8 yes
GO:0009059 macromolecule biosynthetic process 13.8889 4 yes
GO:0032386 regulation of intracellular transport 11.1111 5 yes
GO:0042326 negative regulation of phosphorylation 11.1111 8 yes
GO:0042981 regulation of apoptotic process 11.1111 5 yes
GO:0043067 regulation of programmed cell death 11.1111 4 yes
GO:0045597 positive regulation of cell differentiation 11.1111 5 yes
GO:0045892 negative regulation of DNA-templated transcription 11.1111 8 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 11.1111 5 yes
GO:0045936 negative regulation of phosphate metabolic process 11.1111 7 yes
GO:0048638 regulation of developmental growth 11.1111 4 yes
GO:0051093 negative regulation of developmental process 11.1111 4 yes
GO:0051094 positive regulation of developmental process 11.1111 4 yes
GO:0051240 positive regulation of multicellular organismal process 11.1111 4 yes
GO:0051253 negative regulation of RNA metabolic process 11.1111 6 yes
GO:0060284 regulation of cell development 11.1111 5 yes
GO:0072594 establishment of protein localization to organelle 11.1111 4 yes
GO:1902679 negative regulation of RNA biosynthetic process 11.1111 7 yes
GO:0000122 negative regulation of transcription by RNA polymerase II 11.1111 9 yes
GO:0001933 negative regulation of protein phosphorylation 11.1111 8 yes
GO:0010563 negative regulation of phosphorus metabolic process 11.1111 6 yes
GO:0010628 positive regulation of gene expression 11.1111 7 yes
GO:0021904 dorsal/ventral neural tube patterning 8.3333 5 yes
GO:0032388 positive regulation of intracellular transport 8.3333 5 yes
GO:0042127 regulation of cell population proliferation 8.3333 4 yes
GO:0043066 negative regulation of apoptotic process 8.3333 6 yes
GO:0043069 negative regulation of programmed cell death 8.3333 5 yes
GO:0045596 negative regulation of cell differentiation 8.3333 5 yes
GO:0045893 positive regulation of DNA-templated transcription 8.3333 8 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 8.3333 5 yes
GO:0050767 regulation of neurogenesis 8.3333 6 yes
GO:0051100 negative regulation of binding 8.3333 4 yes
GO:0051254 positive regulation of RNA metabolic process 8.3333 6 yes
GO:0051960 regulation of nervous system development 8.3333 5 yes
GO:1902680 positive regulation of RNA biosynthetic process 8.3333 7 yes
GO:1903829 positive regulation of protein localization 8.3333 5 yes
GO:0007224 smoothened signaling pathway 8.3333 4 yes
GO:0009953 dorsal/ventral pattern formation 8.3333 4 yes
GO:0010629 negative regulation of gene expression 8.3333 7 yes
GO:0021953 central nervous system neuron differentiation 5.5556 5 yes
GO:0030182 neuron differentiation 5.5556 4 yes
GO:0030334 regulation of cell migration 5.5556 5 yes
GO:0030335 positive regulation of cell migration 5.5556 6 yes
GO:0030855 epithelial cell differentiation 5.5556 4 yes
GO:0030856 regulation of epithelial cell differentiation 5.5556 5 yes
GO:0036314 response to sterol 5.5556 4 yes
GO:0036315 cellular response to sterol 5.5556 5 yes
GO:0040014 regulation of multicellular organism growth 5.5556 4 yes
GO:0040017 positive regulation of locomotion 5.5556 4 yes
GO:0043009 chordate embryonic development 5.5556 5 yes
GO:0045927 positive regulation of growth 5.5556 4 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 5.5556 9 yes
GO:0046822 regulation of nucleocytoplasmic transport 5.5556 6 yes
GO:0046824 positive regulation of nucleocytoplasmic transport 5.5556 6 yes
GO:0048639 positive regulation of developmental growth 5.5556 5 yes
GO:0048745 smooth muscle tissue development 5.5556 5 yes
GO:0050678 regulation of epithelial cell proliferation 5.5556 5 yes
GO:0050769 positive regulation of neurogenesis 5.5556 6 yes
GO:0051222 positive regulation of protein transport 5.5556 5 yes
GO:0051223 regulation of protein transport 5.5556 5 yes
GO:0051962 positive regulation of nervous system development 5.5556 5 yes
GO:0060429 epithelium development 5.5556 4 yes
GO:0060537 muscle tissue development 5.5556 4 yes
GO:0060562 epithelial tube morphogenesis 5.5556 4 yes
GO:0060644 mammary gland epithelial cell differentiation 5.5556 5 yes
GO:0061005 cell differentiation involved in kidney development 5.5556 4 yes
GO:0061053 somite development 5.5556 5 yes
GO:0070201 regulation of establishment of protein localization 5.5556 6 yes
GO:0070723 response to cholesterol 5.5556 5 yes
GO:0071397 cellular response to cholesterol 5.5556 6 yes
GO:0071679 commissural neuron axon guidance 5.5556 9 yes
GO:0097485 neuron projection guidance 5.5556 7 yes
GO:1904951 positive regulation of establishment of protein localization 5.5556 6 yes
GO:2000145 regulation of cell motility 5.5556 4 yes
GO:2000147 positive regulation of cell motility 5.5556 5 yes
GO:0001649 osteoblast differentiation 5.5556 4 yes
GO:0001701 in utero embryonic development 5.5556 6 yes
GO:0002009 morphogenesis of an epithelium 5.5556 4 yes
GO:0002064 epithelial cell development 5.5556 4 yes
GO:0006915 apoptotic process 5.5556 4 yes
GO:0007411 axon guidance 5.5556 8 yes
GO:0008589 regulation of smoothened signaling pathway 5.5556 5 yes
GO:0009792 embryo development ending in birth or egg hatching 5.5556 4 yes
GO:0010720 positive regulation of cell development 5.5556 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UBB_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
RS27A_HUMAN [view entry] [view interactions] Low throughput yes yes
RL40_HUMAN [view entry] [view interactions] Low throughput yes yes
PTC1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
ILK_HUMAN [view interactions] Low throughput no no
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
PTC2_HUMAN [view interactions] Low throughput no no
HERC4_HUMAN [view interactions] Low throughput no no
ARBK1_HUMAN [view entry] [view interactions] Low throughput yes yes
MTAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
ITSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
MAST1_HUMAN [view interactions] Low throughput no yes
FRM4A_HUMAN [view interactions] Low throughput no no
CDKL5_HUMAN [view entry] [view interactions] Low throughput yes yes
DGKZ_HUMAN [view entry] [view interactions] Low throughput yes yes
GLI3_HUMAN [view interactions] Low throughput no yes
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG1_HUMAN [view interactions] Low throughput no no
BBS5_HUMAN [view interactions] High throughput no yes
BBS7_HUMAN [view interactions] High throughput no no
BBS1_HUMAN [view interactions] High throughput no no
BBS4_HUMAN [view interactions] High throughput no no
AT5EL_HUMAN [view interactions] High throughput no no
PANX1_HUMAN [view interactions] High throughput no no
AP2S1_HUMAN [view entry] [view interactions] High throughput yes no
CE164_HUMAN [view interactions] High throughput no yes
VPS4A_HUMAN [view entry] [view interactions] High throughput yes yes
CATC_HUMAN [view interactions] High throughput no yes
ENY2_HUMAN [view interactions] High throughput no yes
MOGS_HUMAN [view interactions] High throughput no yes
BCL6_HUMAN [view interactions] High throughput no no
ARV1_HUMAN [view interactions] High throughput no yes
CR032_HUMAN [view interactions] High throughput no yes
S41A3_HUMAN [view interactions] High throughput no yes
TIDC1_HUMAN [view interactions] High throughput no yes
S1PR5_HUMAN [view interactions] High throughput no no
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
WLS_HUMAN [view entry] [view interactions] High throughput yes no
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
GABR1_HUMAN [view entry] [view interactions] High throughput yes yes
CD003_HUMAN [view interactions] High throughput no yes
HMOX1_HUMAN [view interactions] High throughput no no
HMOX2_HUMAN [view entry] [view interactions] High throughput yes yes
HMGN4_HUMAN [view interactions] High throughput no no
ITBP1_HUMAN [view interactions] High throughput no no
JPH3_HUMAN [view interactions] High throughput no no
OBRG_HUMAN [view interactions] High throughput no no
NFIP1_HUMAN [view interactions] High throughput no yes
NGEF_HUMAN [view entry] [view interactions] High throughput yes yes
NIPA1_HUMAN [view interactions] High throughput no yes
PLPP7_HUMAN [view interactions] High throughput no yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
SSPN_HUMAN [view entry] [view interactions] High throughput yes no
EMC10_HUMAN [view interactions] High throughput no yes
TSN7_HUMAN [view entry] [view interactions] High throughput yes yes
TMCC2_HUMAN [view interactions] High throughput no yes
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
PDE4D_HUMAN [view entry] [view interactions] High throughput yes yes
RL10_HUMAN [view entry] [view interactions] High throughput yes yes
TLK2_HUMAN [view interactions] High throughput no no
DERL1_HUMAN [view interactions] High throughput no yes
EREP3_HUMAN [view interactions] High throughput no no
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
TTMP_HUMAN [view interactions] High throughput no no
ACHA4_HUMAN [view entry] [view interactions] High throughput yes no
CLGN_HUMAN [view interactions] High throughput no no
O10H2_HUMAN [view interactions] High throughput no no
SCN4A_HUMAN [view interactions] High throughput no no
CHK1_HUMAN [view interactions] High throughput no no
ATM_HUMAN [view interactions] High throughput no yes
KIT_HUMAN [view interactions] High throughput no no
RNC_HUMAN [view entry] [view interactions] High throughput yes no
MTMR6_HUMAN [view interactions] High throughput no no
HELZ2_HUMAN [view interactions] High throughput no no
KMT2B_HUMAN [view interactions] High throughput no no
TRIB3_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes