CDKL5_HUMAN
Evidence for PS localization
Functions
Mediates phosphorylation of MECP2 (PubMed, PubMed). May regulate ciliogenesis (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003669 | MOD_DYRK1A_RPxSP_1 | MOD | 717 | 721 | - |
| ELMI003669 | MOD_DYRK1A_RPxSP_1 | MOD | 717 | 721 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CDKL5_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 22.0779 | 4 | no |
| GO:0043168 | anion binding | 20.7792 | 4 | yes |
| GO:0000166 | nucleotide binding | 14.2857 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 14.2857 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 14.2857 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 14.2857 | 4 | yes |
| GO:0005524 | ATP binding | 12.9870 | 5 | yes |
| GO:0016301 | kinase activity | 12.9870 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 12.9870 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 12.9870 | 5 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 11.6883 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 7.7922 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 7.7922 | 4 | yes |
| GO:0031267 | small GTPase binding | 5.1948 | 5 | yes |
| GO:0051020 | GTPase binding | 5.1948 | 4 | yes |
| GO:0004693 | cyclin-dependent protein serine/threonine kinase activity | 2.5974 | 5 | yes |
| GO:0097472 | cyclin-dependent protein kinase activity | 2.5974 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CDKL5_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.0390 | 4 | yes |
| GO:0010646 | regulation of cell communication | 53.2468 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 40.2597 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 40.2597 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.0649 | 4 | no |
| GO:0008104 | protein localization | 33.7662 | 4 | no |
| GO:0022607 | cellular component assembly | 33.7662 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.7662 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 33.7662 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 31.1688 | 4 | no |
| GO:0006996 | organelle organization | 28.5714 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 28.5714 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.2727 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 27.2727 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.2727 | 4 | no |
| GO:0051049 | regulation of transport | 27.2727 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.9740 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 25.9740 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 25.9740 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 25.9740 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 25.9740 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.9740 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.9740 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.9740 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 24.6753 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 24.6753 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 24.6753 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 24.6753 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.3766 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 23.3766 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 22.0779 | 4 | yes |
| GO:0034330 | cell junction organization | 22.0779 | 4 | no |
| GO:0010468 | regulation of gene expression | 22.0779 | 6 | no |
| GO:0060341 | regulation of cellular localization | 22.0779 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 20.7792 | 5 | yes |
| GO:0007010 | cytoskeleton organization | 20.7792 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.7792 | 5 | no |
| GO:0033043 | regulation of organelle organization | 19.4805 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 19.4805 | 6 | yes |
| GO:0010975 | regulation of neuron projection development | 18.1818 | 7 | yes |
| GO:0050807 | regulation of synapse organization | 18.1818 | 5 | yes |
| GO:0051960 | regulation of nervous system development | 18.1818 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 16.8831 | 4 | yes |
| GO:0036211 | protein modification process | 16.8831 | 4 | yes |
| GO:0043412 | macromolecule modification | 16.8831 | 4 | yes |
| GO:0060284 | regulation of cell development | 16.8831 | 5 | yes |
| GO:0045597 | positive regulation of cell differentiation | 15.5844 | 5 | yes |
| GO:0051962 | positive regulation of nervous system development | 15.5844 | 5 | yes |
| GO:0043085 | positive regulation of catalytic activity | 14.2857 | 4 | yes |
| GO:0050767 | regulation of neurogenesis | 14.2857 | 6 | yes |
| GO:0010720 | positive regulation of cell development | 12.9870 | 6 | yes |
| GO:0031346 | positive regulation of cell projection organization | 12.9870 | 6 | yes |
| GO:0050769 | positive regulation of neurogenesis | 11.6883 | 6 | yes |
| GO:0099175 | regulation of postsynapse organization | 11.6883 | 6 | yes |
| GO:0006468 | protein phosphorylation | 10.3896 | 5 | yes |
| GO:0016310 | phosphorylation | 10.3896 | 5 | yes |
| GO:0022604 | regulation of cell morphogenesis | 10.3896 | 5 | yes |
| GO:0048638 | regulation of developmental growth | 10.3896 | 4 | yes |
| GO:0050773 | regulation of dendrite development | 10.3896 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 10.3896 | 4 | yes |
| GO:0001558 | regulation of cell growth | 7.7922 | 4 | yes |
| GO:0001764 | neuron migration | 7.7922 | 4 | yes |
| GO:0048814 | regulation of dendrite morphogenesis | 7.7922 | 5 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 7.7922 | 5 | yes |
| GO:0030516 | regulation of axon extension | 6.4935 | 5 | yes |
| GO:0045927 | positive regulation of growth | 6.4935 | 4 | yes |
| GO:0046777 | protein autophosphorylation | 6.4935 | 6 | yes |
| GO:0048639 | positive regulation of developmental growth | 6.4935 | 5 | yes |
| GO:0050770 | regulation of axonogenesis | 6.4935 | 5 | yes |
| GO:0061387 | regulation of extent of cell growth | 6.4935 | 5 | yes |
| GO:1902115 | regulation of organelle assembly | 6.4935 | 5 | yes |
| GO:0010770 | positive regulation of cell morphogenesis | 5.1948 | 6 | yes |
| GO:0050775 | positive regulation of dendrite morphogenesis | 5.1948 | 6 | yes |
| GO:0060998 | regulation of dendritic spine development | 5.1948 | 4 | yes |
| GO:0060999 | positive regulation of dendritic spine development | 5.1948 | 5 | yes |
| GO:0030307 | positive regulation of cell growth | 3.8961 | 5 | yes |
| GO:0043087 | regulation of GTPase activity | 3.8961 | 5 | yes |
| GO:0045773 | positive regulation of axon extension | 3.8961 | 6 | yes |
| GO:0050772 | positive regulation of axonogenesis | 3.8961 | 6 | yes |
| GO:0060491 | regulation of cell projection assembly | 3.8961 | 5 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 3.8961 | 6 | yes |
| GO:0043547 | positive regulation of GTPase activity | 2.5974 | 6 | yes |
| GO:1902017 | regulation of cilium assembly | 2.5974 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GEPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARHG9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MECP2_HUMAN | [view interactions] | Low throughput | no | yes |
| CDKL5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SMO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHOT1_HUMAN | [view interactions] | Low throughput | no | no |
| ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX16_HUMAN | [view interactions] | High throughput | no | yes |
| SPB8_HUMAN | [view interactions] | High throughput | no | no |
| PRP16_HUMAN | [view interactions] | High throughput | no | yes |
| MACF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH20_HUMAN | [view interactions] | High throughput | no | yes |
| HDGR3_HUMAN | [view interactions] | High throughput | no | yes |
| PTX3_HUMAN | [view interactions] | High throughput | no | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| SKI2_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLH1_HUMAN | [view interactions] | High throughput | no | yes |
| TACC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGMT_HUMAN | [view interactions] | High throughput | no | no |
| HDGR2_HUMAN | [view interactions] | High throughput | no | yes |
| GPAM1_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| RABL6_HUMAN | [view interactions] | High throughput | no | yes |
| UBAP2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| ADDA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR13B_HUMAN | [view interactions] | High throughput | no | yes |
| SANBR_HUMAN | [view interactions] | High throughput | no | yes |
| RTRAF_HUMAN | [view interactions] | High throughput | no | yes |
| AGRB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGRL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG39_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATX2L_HUMAN | [view interactions] | High throughput | no | no |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CACB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP131_HUMAN | [view interactions] | High throughput | no | no |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DAB2P_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIFCL_HUMAN | [view interactions] | High throughput | no | yes |
| ELFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPR29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AJM1_HUMAN | [view interactions] | High throughput | no | no |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GSTM1_HUMAN | [view interactions] | High throughput | no | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQEC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQEC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNB2_HUMAN | [view interactions] | High throughput | no | no |
| LRC4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRRC7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LZTS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K4_HUMAN | [view interactions] | High throughput | no | yes |
| MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUFP2_HUMAN | [view interactions] | High throughput | no | no |
| PCKGM_HUMAN | [view interactions] | High throughput | no | no |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| PLPR4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRC2C_HUMAN | [view interactions] | High throughput | no | yes |
| PSD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBGP1_HUMAN | [view interactions] | High throughput | no | yes |
| RBP2_HUMAN | [view interactions] | High throughput | no | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| RP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLIK5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAU2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP2L_HUMAN | [view interactions] | High throughput | no | yes |
| QCR8_HUMAN | [view interactions] | High throughput | no | yes |
| XRN1_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD1_HUMAN | [view interactions] | High throughput | no | no |