Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DLGP2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DLGP2_HUMAN
GO:0019900 kinase binding 38.8889 4 no
GO:0043169 cation binding 27.7778 4 no
GO:0046872 metal ion binding 27.7778 5 no
GO:0043168 anion binding 25.0000 4 no
GO:0017124 SH3 domain binding 22.2222 4 no
GO:0016301 kinase activity 22.2222 4 no
GO:0019901 protein kinase binding 22.2222 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in DLGP2_HUMAN
GO:0048522 positive regulation of cellular process 72.2222 4 no
GO:0010646 regulation of cell communication 69.4444 4 no
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0009966 regulation of signal transduction 52.7778 4 no
GO:0051128 regulation of cellular component organization 52.7778 4 no
GO:0008104 protein localization 47.2222 4 no
GO:0060255 regulation of macromolecule metabolic process 44.4444 4 no
GO:0050804 modulation of chemical synaptic transmission 44.4444 5 no
GO:0099177 regulation of trans-synaptic signaling 44.4444 4 no
GO:0080090 regulation of primary metabolic process 41.6667 4 no
GO:0031323 regulation of cellular metabolic process 38.8889 4 no
GO:0051049 regulation of transport 38.8889 4 no
GO:0009893 positive regulation of metabolic process 36.1111 4 no
GO:0048584 positive regulation of response to stimulus 36.1111 4 no
GO:0050890 cognition 36.1111 4 no
GO:0006996 organelle organization 36.1111 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0141124 intracellular signaling cassette 33.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 30.5556 5 no
GO:0043085 positive regulation of catalytic activity 30.5556 4 no
GO:0009967 positive regulation of signal transduction 30.5556 5 no
GO:0051130 positive regulation of cellular component organization 30.5556 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 30.5556 6 no
GO:1902531 regulation of intracellular signal transduction 30.5556 5 no
GO:0007268 chemical synaptic transmission 27.7778 7 yes
GO:0098916 anterograde trans-synaptic signaling 27.7778 6 yes
GO:0099536 synaptic signaling 27.7778 4 yes
GO:0099537 trans-synaptic signaling 27.7778 5 yes
GO:0042127 regulation of cell population proliferation 27.7778 4 no
GO:0051247 positive regulation of protein metabolic process 27.7778 6 no
GO:0007612 learning 27.7778 4 no
GO:0033043 regulation of organelle organization 27.7778 5 no
GO:0034762 regulation of transmembrane transport 27.7778 4 no
GO:0043269 regulation of monoatomic ion transport 27.7778 5 no
GO:0048585 negative regulation of response to stimulus 27.7778 4 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0072657 protein localization to membrane 25.0000 4 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0010975 regulation of neuron projection development 25.0000 7 no
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0031401 positive regulation of protein modification process 22.2222 7 no
GO:0042325 regulation of phosphorylation 22.2222 7 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0031175 neuron projection development 22.2222 6 no
GO:0034330 cell junction organization 22.2222 4 no
GO:0051493 regulation of cytoskeleton organization 22.2222 6 no
GO:0006796 phosphate-containing compound metabolic process 22.2222 4 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0010243 response to organonitrogen compound 22.2222 4 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0010648 negative regulation of cell communication 22.2222 5 no
GO:0023057 negative regulation of signaling 22.2222 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 22.2222 5 no
GO:0050807 regulation of synapse organization 22.2222 5 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0051336 regulation of hydrolase activity 22.2222 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SHAN1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
SHAN2_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
NMDE4_HUMAN [view entry] [view interactions] Low throughput yes yes
MAP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG3_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
K1C40_HUMAN [view interactions] High throughput no no
KRA42_HUMAN [view interactions] High throughput no no
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
DGCR6_HUMAN [view interactions] High throughput no no
RIMB1_HUMAN [view interactions] High throughput no yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
DLG2_HUMAN [view entry] [view interactions] High throughput yes yes
UBS3B_HUMAN [view interactions] High throughput no yes
CRTP1_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
TEDC2_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
PLCG1_HUMAN [view entry] [view interactions] High throughput yes yes
MPP7_HUMAN [view entry] [view interactions] High throughput yes no
VINEX_HUMAN [view interactions] High throughput no no
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
USO1_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP4_HUMAN [view entry] [view interactions] High throughput yes yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
TSP50_HUMAN [view interactions] High throughput no no
TNR6B_HUMAN [view interactions] High throughput no yes
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
PPP5_HUMAN [view entry] [view interactions] High throughput yes yes