Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DLGP2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DLGP2_HUMAN
GO:0019900 kinase binding 37.8378 4 no
GO:0046872 metal ion binding 29.7297 4 no
GO:0019901 protein kinase binding 27.0270 5 no
GO:0017124 SH3 domain binding 21.6216 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in DLGP2_HUMAN
GO:0010646 regulation of cell communication 72.9730 4 yes
GO:0048522 positive regulation of cellular process 70.2703 4 no
GO:0009966 regulation of signal transduction 59.4595 4 yes
GO:0050804 modulation of chemical synaptic transmission 56.7568 5 yes
GO:0099177 regulation of trans-synaptic signaling 56.7568 4 yes
GO:0048523 negative regulation of cellular process 54.0541 4 no
GO:0051128 regulation of cellular component organization 54.0541 4 no
GO:0008104 protein localization 48.6486 4 no
GO:0060255 regulation of macromolecule metabolic process 43.2432 4 no
GO:0050890 cognition 43.2432 4 no
GO:0051171 regulation of nitrogen compound metabolic process 40.5405 4 no
GO:0080090 regulation of primary metabolic process 40.5405 4 no
GO:0022607 cellular component assembly 40.5405 4 no
GO:0009893 positive regulation of metabolic process 37.8378 4 no
GO:0031323 regulation of cellular metabolic process 37.8378 4 no
GO:0051049 regulation of transport 37.8378 4 no
GO:0007612 learning 37.8378 4 no
GO:0044057 regulation of system process 35.1351 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 35.1351 5 no
GO:0051246 regulation of protein metabolic process 35.1351 5 no
GO:0007268 chemical synaptic transmission 32.4324 6 yes
GO:0098916 anterograde trans-synaptic signaling 32.4324 5 yes
GO:0099537 trans-synaptic signaling 32.4324 4 yes
GO:0043085 positive regulation of catalytic activity 32.4324 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 32.4324 5 no
GO:0034330 cell junction organization 32.4324 4 no
GO:0051130 positive regulation of cellular component organization 32.4324 5 no
GO:0006996 organelle organization 32.4324 4 no
GO:0022603 regulation of anatomical structure morphogenesis 32.4324 4 no
GO:0010647 positive regulation of cell communication 32.4324 5 no
GO:0023056 positive regulation of signaling 32.4324 4 no
GO:0031644 regulation of nervous system process 29.7297 5 yes
GO:0031325 positive regulation of cellular metabolic process 29.7297 5 no
GO:0051247 positive regulation of protein metabolic process 29.7297 6 no
GO:0031344 regulation of cell projection organization 29.7297 5 no
GO:0043269 regulation of ion transport 29.7297 5 no
GO:0048585 negative regulation of response to stimulus 29.7297 4 no
GO:0019220 regulation of phosphate metabolic process 27.0270 6 no
GO:0031399 regulation of protein modification process 27.0270 6 no
GO:0051174 regulation of phosphorus metabolic process 27.0270 5 no
GO:0072657 protein localization to membrane 27.0270 4 no
GO:0044087 regulation of cellular component biogenesis 27.0270 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.0270 6 no
GO:0048584 positive regulation of response to stimulus 27.0270 4 no
GO:0051050 positive regulation of transport 27.0270 4 no
GO:0030030 cell projection organization 27.0270 4 no
GO:0120036 plasma membrane bounded cell projection organization 27.0270 5 no
GO:1902531 regulation of intracellular signal transduction 27.0270 5 no
GO:0001932 regulation of protein phosphorylation 24.3243 7 no
GO:0010562 positive regulation of phosphorus metabolic process 24.3243 6 no
GO:0031401 positive regulation of protein modification process 24.3243 7 no
GO:0042127 regulation of cell population proliferation 24.3243 4 no
GO:0042325 regulation of phosphorylation 24.3243 7 no
GO:0043113 receptor clustering 24.3243 5 no
GO:0045937 positive regulation of phosphate metabolic process 24.3243 7 no
GO:0034329 cell junction assembly 24.3243 5 no
GO:1902414 protein localization to cell junction 24.3243 5 no
GO:0033043 regulation of organelle organization 24.3243 5 no
GO:0050807 regulation of synapse organization 24.3243 5 no
GO:0034762 regulation of transmembrane transport 24.3243 4 no
GO:0034765 regulation of ion transmembrane transport 24.3243 5 no
GO:0051094 positive regulation of developmental process 24.3243 4 no
GO:1904062 regulation of cation transmembrane transport 24.3243 6 no
GO:0051336 regulation of hydrolase activity 24.3243 4 no
GO:0009967 positive regulation of signal transduction 24.3243 5 no
GO:0031175 neuron projection development 24.3243 6 no
GO:0016192 vesicle-mediated transport 24.3243 4 no
GO:0009892 negative regulation of metabolic process 24.3243 4 no
GO:0010605 negative regulation of macromolecule metabolic process 24.3243 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 24.3243 5 no
GO:0099601 regulation of neurotransmitter receptor activity 21.6216 4 yes
GO:0001934 positive regulation of protein phosphorylation 21.6216 8 no
GO:0042327 positive regulation of phosphorylation 21.6216 8 no
GO:0044089 positive regulation of cellular component biogenesis 21.6216 5 no
GO:0007010 cytoskeleton organization 21.6216 5 no
GO:0010975 regulation of neuron projection development 21.6216 7 no
GO:0051493 regulation of cytoskeleton organization 21.6216 6 no
GO:0010941 regulation of cell death 21.6216 4 no
GO:0071310 cellular response to organic substance 21.6216 4 no
GO:0050806 positive regulation of synaptic transmission 21.6216 5 no
GO:0050808 synapse organization 21.6216 5 no
GO:0051248 negative regulation of protein metabolic process 21.6216 6 no
GO:0010648 negative regulation of cell communication 21.6216 5 no
GO:0023057 negative regulation of signaling 21.6216 4 no
GO:0035418 protein localization to synapse 21.6216 6 no
GO:0098962 regulation of postsynaptic neurotransmitter receptor activity 10.8108 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SHAN1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
SHAN2_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
NMDE4_HUMAN [view entry] [view interactions] Low throughput yes yes
MAP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG3_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
KRA42_HUMAN [view interactions] High throughput no no
K1C40_HUMAN [view interactions] High throughput no no
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
DGCR6_HUMAN [view interactions] High throughput no no
RIMB1_HUMAN [view interactions] High throughput no yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
DLG2_HUMAN [view entry] [view interactions] High throughput yes yes
UBS3B_HUMAN [view interactions] High throughput no yes
CRTP1_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
TEDC2_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
PLCG1_HUMAN [view entry] [view interactions] High throughput yes yes
MPP7_HUMAN [view entry] [view interactions] High throughput yes no
VINEX_HUMAN [view interactions] High throughput no no
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
USO1_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP4_HUMAN [view entry] [view interactions] High throughput yes yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
TSP50_HUMAN [view interactions] High throughput no no
TNR6B_HUMAN [view interactions] High throughput no yes
NRX1A_HUMAN [view entry] [view interactions] Computational yes no
NRX2A_HUMAN [view entry] [view interactions] Computational yes no
NLGN3_HUMAN [view entry] [view interactions] Computational yes yes
NLGNX_HUMAN [view entry] [view interactions] Computational yes yes