Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NMDE4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed, PubMed, PubMed, PubMed). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NMDE4_HUMAN
GO:0043168 anion binding 28.5714 4 yes
GO:0019900 kinase binding 28.5714 4 no
GO:0019902 phosphatase binding 28.5714 4 no
GO:0004970 glutamate-gated receptor activity 21.4286 4 yes
GO:0004972 NMDA glutamate receptor activity 21.4286 5 yes
GO:0005216 monoatomic ion channel activity 21.4286 4 yes
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 21.4286 6 yes
GO:0005244 voltage-gated monoatomic ion channel activity 21.4286 5 yes
GO:0005261 monoatomic cation channel activity 21.4286 5 yes
GO:0005262 calcium channel activity 21.4286 6 yes
GO:0008066 glutamate receptor activity 21.4286 4 yes
GO:0008324 monoatomic cation transmembrane transporter activity 21.4286 4 yes
GO:0015085 calcium ion transmembrane transporter activity 21.4286 6 yes
GO:0015267 channel activity 21.4286 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 21.4286 5 yes
GO:0022824 transmitter-gated monoatomic ion channel activity 21.4286 5 yes
GO:0022832 voltage-gated channel activity 21.4286 6 yes
GO:0022834 ligand-gated channel activity 21.4286 6 yes
GO:0022835 transmitter-gated channel activity 21.4286 4 yes
GO:0022836 gated channel activity 21.4286 5 yes
GO:0022849 glutamate-gated calcium ion channel activity 21.4286 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 21.4286 4 yes
GO:0031406 carboxylic acid binding 21.4286 4 yes
GO:0046873 metal ion transmembrane transporter activity 21.4286 5 yes
GO:0046943 carboxylic acid transmembrane transporter activity 21.4286 4 yes
GO:0099094 ligand-gated monoatomic cation channel activity 21.4286 6 yes
GO:0099604 ligand-gated calcium channel activity 21.4286 7 yes
GO:0031625 ubiquitin protein ligase binding 21.4286 5 no
GO:0044389 ubiquitin-like protein ligase binding 21.4286 4 no
GO:0022843 voltage-gated monoatomic cation channel activity 14.2857 6 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 14.2857 4 yes
GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 14.2857 6 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 14.2857 5 yes
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 14.2857 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NMDE4_HUMAN
GO:0031323 regulation of cellular metabolic process 64.2857 4 no
GO:0060255 regulation of macromolecule metabolic process 64.2857 4 no
GO:0080090 regulation of primary metabolic process 64.2857 4 no
GO:0009966 regulation of signal transduction 64.2857 4 yes
GO:0010646 regulation of cell communication 64.2857 4 yes
GO:0048522 positive regulation of cellular process 64.2857 4 yes
GO:0098916 anterograde trans-synaptic signaling 57.1429 6 yes
GO:0099536 synaptic signaling 57.1429 4 yes
GO:0099537 trans-synaptic signaling 57.1429 5 yes
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0007268 chemical synaptic transmission 57.1429 7 yes
GO:0008104 protein localization 50.0000 4 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 no
GO:0009967 positive regulation of signal transduction 50.0000 5 yes
GO:0010647 positive regulation of cell communication 50.0000 5 yes
GO:0023056 positive regulation of signaling 50.0000 4 yes
GO:0048584 positive regulation of response to stimulus 50.0000 4 yes
GO:0010468 regulation of gene expression 42.8571 6 no
GO:0010556 regulation of macromolecule biosynthetic process 42.8571 5 no
GO:0031326 regulation of cellular biosynthetic process 42.8571 5 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0051252 regulation of RNA metabolic process 42.8571 5 no
GO:0034762 regulation of transmembrane transport 42.8571 4 yes
GO:0051049 regulation of transport 42.8571 4 yes
GO:0099177 regulation of trans-synaptic signaling 35.7143 4 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 35.7143 6 yes
GO:0006355 regulation of DNA-templated transcription 35.7143 7 no
GO:0006357 regulation of transcription by RNA polymerase II 35.7143 8 no
GO:0006996 organelle organization 35.7143 4 no
GO:0022603 regulation of anatomical structure morphogenesis 35.7143 4 no
GO:0022607 cellular component assembly 35.7143 4 no
GO:0048585 negative regulation of response to stimulus 35.7143 4 no
GO:0060341 regulation of cellular localization 35.7143 4 no
GO:0072657 protein localization to membrane 35.7143 4 no
GO:2001141 regulation of RNA biosynthetic process 35.7143 6 no
GO:0009893 positive regulation of metabolic process 35.7143 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.7143 5 no
GO:0034765 regulation of monoatomic ion transmembrane transport 35.7143 5 yes
GO:0043269 regulation of monoatomic ion transport 35.7143 5 yes
GO:0044057 regulation of system process 35.7143 4 yes
GO:0048168 regulation of neuronal synaptic plasticity 35.7143 4 yes
GO:0050804 modulation of chemical synaptic transmission 35.7143 5 yes
GO:0098815 modulation of excitatory postsynaptic potential 28.5714 4 yes
GO:2000463 positive regulation of excitatory postsynaptic potential 28.5714 5 yes
GO:0030030 cell projection organization 28.5714 4 no
GO:0031175 neuron projection development 28.5714 6 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0009968 negative regulation of signal transduction 28.5714 5 no
GO:0010648 negative regulation of cell communication 28.5714 5 no
GO:0023057 negative regulation of signaling 28.5714 4 no
GO:0043113 receptor clustering 28.5714 5 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0031644 regulation of nervous system process 28.5714 5 yes
GO:0050806 positive regulation of synaptic transmission 28.5714 5 yes
GO:0097553 calcium ion transmembrane import into cytosol 21.4286 6 yes
GO:0098655 monoatomic cation transmembrane transport 21.4286 4 yes
GO:0098662 inorganic cation transmembrane transport 21.4286 4 yes
GO:0098976 excitatory chemical synaptic transmission 21.4286 8 yes
GO:0007010 cytoskeleton organization 21.4286 5 no
GO:0010243 response to organonitrogen compound 21.4286 4 no
GO:0010975 regulation of neuron projection development 21.4286 7 no
GO:0022604 regulation of cell morphogenesis 21.4286 5 no
GO:0032880 regulation of protein localization 21.4286 5 no
GO:0043408 regulation of MAPK cascade 21.4286 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.4286 6 no
GO:0000122 negative regulation of transcription by RNA polymerase II 21.4286 9 no
GO:0008285 negative regulation of cell population proliferation 21.4286 5 no
GO:0009890 negative regulation of biosynthetic process 21.4286 5 no
GO:0009892 negative regulation of metabolic process 21.4286 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0010605 negative regulation of macromolecule metabolic process 21.4286 5 no
GO:0010959 regulation of metal ion transport 21.4286 6 no
GO:0022898 regulation of transmembrane transporter activity 21.4286 4 no
GO:0031324 negative regulation of cellular metabolic process 21.4286 5 no
GO:0031327 negative regulation of cellular biosynthetic process 21.4286 6 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 21.4286 5 no
GO:0033365 protein localization to organelle 21.4286 5 no
GO:0034330 cell junction organization 21.4286 4 no
GO:0035088 establishment or maintenance of apical/basal cell polarity 21.4286 4 no
GO:0042127 regulation of cell population proliferation 21.4286 4 no
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 21.4286 5 no
GO:0045892 negative regulation of DNA-templated transcription 21.4286 8 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0051130 positive regulation of cellular component organization 21.4286 5 no
GO:0051253 negative regulation of RNA metabolic process 21.4286 6 no
GO:0065003 protein-containing complex assembly 21.4286 5 no
GO:1902679 negative regulation of RNA biosynthetic process 21.4286 7 no
GO:0010562 positive regulation of phosphorus metabolic process 21.4286 6 no
GO:0019220 regulation of phosphate metabolic process 21.4286 6 no
GO:0031399 regulation of protein modification process 21.4286 6 no
GO:0031401 positive regulation of protein modification process 21.4286 7 no
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0045937 positive regulation of phosphate metabolic process 21.4286 7 no
GO:0051174 regulation of phosphorus metabolic process 21.4286 5 no
GO:0007612 learning 21.4286 4 no
GO:0050890 cognition 21.4286 4 no
GO:0009416 response to light stimulus 21.4286 4 no
GO:0036211 protein modification process 21.4286 4 no
GO:0043412 macromolecule modification 21.4286 4 no
GO:0006811 monoatomic ion transport 21.4286 4 yes
GO:0006812 monoatomic cation transport 21.4286 5 yes
GO:0006816 calcium ion transport 21.4286 7 yes
GO:0007215 glutamate receptor signaling pathway 21.4286 4 yes
GO:0007420 brain development 21.4286 4 yes
GO:0030001 metal ion transport 21.4286 6 yes
GO:0035235 ionotropic glutamate receptor signaling pathway 21.4286 4 yes
GO:0050905 neuromuscular process 21.4286 4 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 21.4286 6 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 21.4286 6 yes
GO:0060078 regulation of postsynaptic membrane potential 21.4286 4 yes
GO:0060079 excitatory postsynaptic potential 21.4286 5 yes
GO:0070588 calcium ion transmembrane transport 21.4286 5 yes
GO:0008344 adult locomotory behavior 14.2857 4 yes
GO:0035249 synaptic transmission, glutamatergic 14.2857 8 yes
GO:0051930 regulation of sensory perception of pain 14.2857 7 yes
GO:0051931 regulation of sensory perception 14.2857 6 yes
GO:0060291 long-term synaptic potentiation 14.2857 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
INADL_HUMAN [view interactions] Low throughput no no
IL16_HUMAN [view interactions] Low throughput no no
DLGP2_HUMAN [view entry] [view interactions] Low throughput yes no
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE4_HUMAN [view entry] [view interactions] Low throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
DLG3_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
TOP3B_HUMAN [view interactions] High throughput no no