Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DLGP1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Part of the postsynaptic scaffold in neuronal cells. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004040 LIG_DLG_GKlike_1 LIG 372 380 -
ELMI004041 LIG_DLG_GKlike_1 LIG 403 411 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DLGP1_HUMAN
GO:0017076 purine nucleotide binding 21.9512 4 no
GO:0032555 purine ribonucleotide binding 21.9512 4 no
GO:0035639 purine ribonucleoside triphosphate binding 20.7317 4 no
GO:0019900 kinase binding 20.1220 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in DLGP1_HUMAN
GO:0010646 regulation of cell communication 54.2683 4 yes
GO:0048522 positive regulation of cellular process 53.0488 4 no
GO:0051128 regulation of cellular component organization 43.2927 4 no
GO:0009966 regulation of signal transduction 42.0732 4 yes
GO:0048523 negative regulation of cellular process 39.6341 4 no
GO:0060255 regulation of macromolecule metabolic process 37.1951 4 no
GO:0080090 regulation of primary metabolic process 33.5366 4 no
GO:0008104 protein localization 32.9268 4 no
GO:0051171 regulation of nitrogen compound metabolic process 32.9268 4 no
GO:0051049 regulation of transport 32.3171 4 no
GO:0006996 organelle organization 32.3171 4 no
GO:0031323 regulation of cellular metabolic process 31.7073 4 no
GO:0022607 cellular component assembly 31.7073 4 no
GO:0050804 modulation of chemical synaptic transmission 31.0976 5 yes
GO:0099177 regulation of trans-synaptic signaling 31.0976 4 yes
GO:0010647 positive regulation of cell communication 26.8293 5 no
GO:0023056 positive regulation of signaling 26.8293 4 no
GO:0010468 regulation of gene expression 26.2195 5 no
GO:0030030 cell projection organization 26.2195 4 no
GO:0009893 positive regulation of metabolic process 24.3902 4 no
GO:0010604 positive regulation of macromolecule metabolic process 23.7805 5 no
GO:0051246 regulation of protein metabolic process 23.7805 5 no
GO:1902531 regulation of intracellular signal transduction 23.7805 5 no
GO:0048584 positive regulation of response to stimulus 23.1707 4 no
GO:0051130 positive regulation of cellular component organization 23.1707 5 no
GO:0031344 regulation of cell projection organization 22.5610 5 no
GO:0007010 cytoskeleton organization 22.5610 5 no
GO:0009889 regulation of biosynthetic process 21.3415 4 no
GO:0031326 regulation of cellular biosynthetic process 21.3415 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 21.3415 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.3415 6 no
GO:0120036 plasma membrane bounded cell projection organization 21.3415 5 no
GO:0022603 regulation of anatomical structure morphogenesis 20.7317 4 no
GO:0033043 regulation of organelle organization 20.7317 5 no
GO:0010556 regulation of macromolecule biosynthetic process 20.1220 5 no
GO:0044087 regulation of cellular component biogenesis 20.1220 4 no
GO:0044057 regulation of system process 15.8537 4 yes
GO:0099537 trans-synaptic signaling 14.6341 4 yes
GO:0007268 chemical synaptic transmission 14.0244 6 yes
GO:0098916 anterograde trans-synaptic signaling 14.0244 5 yes
GO:0031644 regulation of nervous system process 10.3659 5 yes
GO:0099601 regulation of neurotransmitter receptor activity 7.9268 4 yes
GO:0098962 regulation of postsynaptic neurotransmitter receptor activity 4.2683 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in DLGP1_HUMAN
DOID:331 central nervous system disease 4.8780 3 no
DOID:0060038 specific developmental disorder 3.0488 3 no
DOID:1059 intellectual disability 3.0488 4 no
DOID:936 brain disease 3.0488 4 no
DOID:0060307 autosomal dominant intellectual developmental disorder 1.8293 5 no
DOID:0050951 hereditary ataxia 1.2195 5 no
DOID:1289 neurodegenerative disease 1.2195 4 no
DOID:1826 epilepsy 1.2195 5 no
DOID:0090131 complex cortical dysplasia with other brain malformations 1.2195 5 no
DOID:0050888 syndromic intellectual disability 1.2195 5 no
DOID:0060309 syndromic X-linked intellectual disability 1.2195 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SHAN2_HUMAN [view entry] [view interactions] Low throughput yes yes
DYL2_HUMAN [view entry] [view interactions] Low throughput yes no
DYL1_HUMAN [view entry] [view interactions] Low throughput yes no
APC_HUMAN [view entry] [view interactions] Low throughput yes no
TANC1_HUMAN [view entry] [view interactions] Low throughput yes yes
MPP2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLGP2_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG2_HUMAN [view entry] [view interactions] Low throughput yes yes
NHRF3_HUMAN [view interactions] Low throughput no no
SHAN1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRASP_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
SRBS2_HUMAN [view entry] [view interactions] Low throughput yes no
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
ARC_HUMAN [view entry] [view interactions] Low throughput yes no
CNKR3_HUMAN [view interactions] High throughput no yes
USP9X_HUMAN [view entry] [view interactions] High throughput yes yes
M4K4_HUMAN [view interactions] High throughput no yes
HUWE1_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP5_HUMAN [view interactions] High throughput no no
CAPR1_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
WASF1_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2N_HUMAN [view entry] [view interactions] High throughput yes yes
TRIO_HUMAN [view entry] [view interactions] High throughput yes yes
T132B_HUMAN [view entry] [view interactions] High throughput yes no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
SYNE1_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN2_HUMAN [view entry] [view interactions] High throughput yes yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
SRBS1_HUMAN [view entry] [view interactions] High throughput yes yes
AP180_HUMAN [view entry] [view interactions] High throughput yes yes
SKT_HUMAN [view entry] [view interactions] High throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT7_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT5_HUMAN [view interactions] High throughput no no
SEPT3_HUMAN [view interactions] High throughput no no
SEPT2_HUMAN [view interactions] High throughput no no
SEP11_HUMAN [view entry] [view interactions] High throughput yes yes
NGAP_HUMAN [view entry] [view interactions] High throughput yes yes
RPGF4_HUMAN [view entry] [view interactions] High throughput yes yes
RAP1A_HUMAN [view entry] [view interactions] High throughput yes no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
PURA_HUMAN [view entry] [view interactions] High throughput yes no
FAK1_HUMAN [view entry] [view interactions] High throughput yes yes
KPCG_HUMAN [view entry] [view interactions] High throughput yes yes
KPCB_HUMAN [view entry] [view interactions] High throughput yes yes
PP2BB_HUMAN [view entry] [view interactions] High throughput yes yes
PP2BA_HUMAN [view entry] [view interactions] High throughput yes yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
PDE4B_HUMAN [view entry] [view interactions] High throughput yes yes
NFL_HUMAN [view entry] [view interactions] High throughput yes yes
NFH_HUMAN [view entry] [view interactions] High throughput yes yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
NCDN_HUMAN [view entry] [view interactions] High throughput yes yes
NBEA_HUMAN [view entry] [view interactions] High throughput yes yes
MPRIP_HUMAN [view entry] [view interactions] High throughput yes yes
MINK1_HUMAN [view entry] [view interactions] High throughput yes yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
LRRT1_HUMAN [view entry] [view interactions] High throughput yes yes
LRRC7_HUMAN [view entry] [view interactions] High throughput yes no
LRC15_HUMAN [view interactions] High throughput no no
LGI1_HUMAN [view entry] [view interactions] High throughput yes no
KIF5C_HUMAN [view entry] [view interactions] High throughput yes yes
KIF5A_HUMAN [view entry] [view interactions] High throughput yes yes
KCNJ4_HUMAN [view entry] [view interactions] High throughput yes no
KCJ10_HUMAN [view interactions] High throughput no no
KCAB1_HUMAN [view interactions] High throughput no no
KCNA4_HUMAN [view entry] [view interactions] High throughput yes yes
KCNA2_HUMAN [view entry] [view interactions] High throughput yes yes
KCNA1_HUMAN [view entry] [view interactions] High throughput yes yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
IQEC3_HUMAN [view entry] [view interactions] High throughput yes no
IQEC2_HUMAN [view entry] [view interactions] High throughput yes no
IQEC1_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA2_HUMAN [view interactions] High throughput no yes
GELS_HUMAN [view entry] [view interactions] High throughput yes no
NMDE4_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA3_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
RACK1_HUMAN [view interactions] High throughput no yes
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
GBB1_HUMAN [view entry] [view interactions] High throughput yes yes
GLNA_HUMAN [view entry] [view interactions] High throughput yes yes
GIT1_HUMAN [view entry] [view interactions] High throughput yes yes
GDIB_HUMAN [view entry] [view interactions] High throughput yes yes
FBX41_HUMAN [view entry] [view interactions] High throughput yes no
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
FHL2_HUMAN [view interactions] High throughput no yes
MAGAB_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CTNA2_HUMAN [view entry] [view interactions] High throughput yes yes
NRX1A_HUMAN [view entry] [view interactions] High throughput yes no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
TRIM9_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
MYO5A_HUMAN [view entry] [view interactions] High throughput yes yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
PLCG1_HUMAN [view entry] [view interactions] High throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
SPAT7_HUMAN [view interactions] High throughput no no
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
GRIP1_HUMAN [view entry] [view interactions] High throughput yes yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes
DZAN1_HUMAN [view interactions] High throughput no yes
AGRB2_HUMAN [view interactions] High throughput no no
ARVC_HUMAN [view entry] [view interactions] High throughput yes yes
RHG32_HUMAN [view entry] [view interactions] High throughput yes yes
ARF5_HUMAN [view entry] [view interactions] High throughput yes no
NED4L_HUMAN [view interactions] High throughput no yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2O_HUMAN [view interactions] High throughput no yes
MPDZ_HUMAN [view entry] [view interactions] High throughput yes yes
ITIH4_HUMAN [view interactions] High throughput no no
FARP1_HUMAN [view entry] [view interactions] High throughput yes no
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
DEST_HUMAN [view entry] [view interactions] High throughput yes yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
DYN1_HUMAN [view entry] [view interactions] High throughput yes yes
AUXI_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP3_HUMAN [view entry] [view interactions] High throughput yes yes
DIAP1_HUMAN [view interactions] High throughput no yes
DEND_HUMAN [view entry] [view interactions] High throughput yes no
DAB2P_HUMAN [view entry] [view interactions] High throughput yes no
CYH3_HUMAN [view entry] [view interactions] High throughput yes yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
CTND2_HUMAN [view entry] [view interactions] High throughput yes no
CTND1_HUMAN [view entry] [view interactions] High throughput yes no
CNTP1_HUMAN [view entry] [view interactions] High throughput yes yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
CSKI1_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2G_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2B_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
BTBDB_HUMAN [view interactions] High throughput no no
BEGIN_HUMAN [view entry] [view interactions] High throughput yes no
BAIP2_HUMAN [view entry] [view interactions] High throughput yes yes
AGRB3_HUMAN [view entry] [view interactions] High throughput yes no
RHG39_HUMAN [view entry] [view interactions] High throughput yes no
ARF3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ADA22_HUMAN [view entry] [view interactions] High throughput yes no
ABLM1_HUMAN [view entry] [view interactions] High throughput yes yes
KIF2A_HUMAN [view entry] [view interactions] High throughput yes yes
DCX_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
PPP6_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
KCNJ1_HUMAN [view interactions] High throughput no no
HOME3_HUMAN [view entry] [view interactions] High throughput yes yes
GRM1_HUMAN [view entry] [view interactions] Computational yes yes
GRM5_HUMAN [view entry] [view interactions] Computational yes no
CDK2_HUMAN [view interactions] Computational no yes
HOME2_HUMAN [view entry] [view interactions] Computational yes yes
NLGN1_HUMAN [view entry] [view interactions] Computational yes yes