1433B_HUMAN
Evidence for PS localization
Functions
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 28%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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1433B_HUMAN has binary interactions with 50 proteins
Isoforms
Interacting regions
Canonical [1433B_HUMAN]
Isoform [P31946-2] alignment
Isoform [A0A0J9YWE8] alignment
Isoform [A0A0J9YWZ2] alignment
Isoform [Q4VY19] alignment
Isoform [Q4VY20] alignment
LOADING 8%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in 1433B_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 30.6189 | 4 | no |
| GO:0000166 | nucleotide binding | 29.9674 | 4 | no |
| GO:0017076 | purine nucleotide binding | 29.3160 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 28.0130 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.0358 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 26.7101 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.4072 | 5 | no |
| GO:0005524 | ATP binding | 24.4300 | 5 | no |
| GO:0043169 | cation binding | 21.8241 | 4 | no |
| GO:0046872 | metal ion binding | 21.4984 | 5 | no |
| GO:0019900 | kinase binding | 20.1954 | 4 | no |
| GO:0045296 | cadherin binding | 17.5896 | 4 | yes |
| GO:0019887 | protein kinase regulator activity | 6.8404 | 4 | yes |
| GO:0045309 | protein phosphorylated amino acid binding | 3.9088 | 4 | yes |
| GO:0042826 | histone deacetylase binding | 3.2573 | 4 | yes |
| GO:0004860 | protein kinase inhibitor activity | 1.9544 | 5 | yes |
| GO:0019210 | kinase inhibitor activity | 1.9544 | 4 | yes |
| GO:0050815 | phosphoserine residue binding | 1.9544 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in 1433B_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.3062 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.8599 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.5570 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 46.9055 | 4 | yes |
| GO:0010646 | regulation of cell communication | 46.5798 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 46.5798 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 43.9739 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 42.9967 | 4 | yes |
| GO:0006996 | organelle organization | 42.6710 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.8306 | 4 | no |
| GO:0022607 | cellular component assembly | 34.8534 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 34.5277 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 33.5505 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 33.5505 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.2248 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.2248 | 5 | no |
| GO:0010468 | regulation of gene expression | 31.5961 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.9674 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.9674 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.9674 | 5 | no |
| GO:0008104 | protein localization | 29.6417 | 4 | yes |
| GO:0051049 | regulation of transport | 27.6873 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 27.0358 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 26.3844 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.4072 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2A5D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2A5G_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 3BP5L_HUMAN | [view interactions] | High throughput | no | yes |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| AASS_HUMAN | [view interactions] | High throughput | no | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| ACINU_HUMAN | [view interactions] | High throughput | no | yes |