Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ABL2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ABL2_HUMAN
GO:0019900 kinase binding 41.5385 4 no
GO:0000166 nucleotide binding 40.0000 4 yes
GO:0017076 purine nucleotide binding 40.0000 5 yes
GO:0032555 purine ribonucleotide binding 38.4615 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 38.4615 4 yes
GO:0043168 anion binding 38.4615 4 yes
GO:0019901 protein kinase binding 38.4615 5 no
GO:0030554 adenyl nucleotide binding 30.7692 6 yes
GO:0005524 ATP binding 29.2308 5 yes
GO:0032559 adenyl ribonucleotide binding 29.2308 5 yes
GO:0045309 protein phosphorylated amino acid binding 21.5385 4 yes
GO:0003723 RNA binding 21.5385 4 no
GO:0045296 cadherin binding 21.5385 4 no
GO:0004713 protein tyrosine kinase activity 20.0000 4 yes
GO:0016301 kinase activity 20.0000 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 20.0000 4 yes
GO:0043169 cation binding 16.9231 4 yes
GO:0046872 metal ion binding 16.9231 5 yes
GO:0001784 phosphotyrosine residue binding 13.8462 5 yes
GO:0004715 non-membrane spanning protein tyrosine kinase activity 9.2308 5 yes
GO:0003779 actin binding 7.6923 4 yes
GO:0046914 transition metal ion binding 6.1538 6 yes
GO:0000287 magnesium ion binding 4.6154 6 yes
GO:0003785 actin monomer binding 4.6154 5 yes
GO:0030145 manganese ion binding 4.6154 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ABL2_HUMAN
GO:0048522 positive regulation of cellular process 83.0769 4 yes
GO:0031323 regulation of cellular metabolic process 80.0000 4 yes
GO:0048523 negative regulation of cellular process 80.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 76.9231 4 no
GO:0080090 regulation of primary metabolic process 76.9231 4 no
GO:0010646 regulation of cell communication 69.2308 4 yes
GO:0009966 regulation of signal transduction 64.6154 4 yes
GO:0051128 regulation of cellular component organization 64.6154 4 yes
GO:0051246 regulation of protein metabolic process 61.5385 5 no
GO:0009893 positive regulation of metabolic process 60.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 56.9231 5 no
GO:0009889 regulation of biosynthetic process 55.3846 4 no
GO:0010556 regulation of macromolecule biosynthetic process 55.3846 5 no
GO:0031326 regulation of cellular biosynthetic process 55.3846 5 no
GO:0010468 regulation of gene expression 53.8462 6 no
GO:0031325 positive regulation of cellular metabolic process 53.8462 5 no
GO:1902531 regulation of intracellular signal transduction 52.3077 5 yes
GO:0009892 negative regulation of metabolic process 50.7692 4 no
GO:0010605 negative regulation of macromolecule metabolic process 49.2308 5 no
GO:0031399 regulation of protein modification process 49.2308 6 no
GO:0048584 positive regulation of response to stimulus 49.2308 4 no
GO:0051247 positive regulation of protein metabolic process 49.2308 6 no
GO:0042981 regulation of apoptotic process 46.1538 5 yes
GO:0043067 regulation of programmed cell death 46.1538 4 yes
GO:0051049 regulation of transport 44.6154 4 yes
GO:0019220 regulation of phosphate metabolic process 43.0769 6 no
GO:0031324 negative regulation of cellular metabolic process 43.0769 5 no
GO:0051174 regulation of phosphorus metabolic process 43.0769 5 no
GO:0031344 regulation of cell projection organization 41.5385 5 yes
GO:0051130 positive regulation of cellular component organization 41.5385 5 yes
GO:0010647 positive regulation of cell communication 41.5385 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 41.5385 5 no
GO:0023056 positive regulation of signaling 41.5385 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 40.0000 6 yes
GO:0009967 positive regulation of signal transduction 40.0000 5 no
GO:0042127 regulation of cell population proliferation 40.0000 4 no
GO:0048585 negative regulation of response to stimulus 38.4615 4 yes
GO:0001932 regulation of protein phosphorylation 38.4615 7 no
GO:0042325 regulation of phosphorylation 38.4615 7 no
GO:0022607 cellular component assembly 36.9231 4 no
GO:0141124 intracellular signaling cassette 36.9231 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 35.3846 4 no
GO:0051252 regulation of RNA metabolic process 35.3846 5 no
GO:0006996 organelle organization 35.3846 4 no
GO:0071310 cellular response to organic substance 33.8462 4 yes
GO:0006355 regulation of DNA-templated transcription 33.8462 7 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 33.8462 5 no
GO:0051248 negative regulation of protein metabolic process 33.8462 6 no
GO:2001141 regulation of RNA biosynthetic process 33.8462 6 no
GO:0008104 protein localization 33.8462 4 no
GO:0022603 regulation of anatomical structure morphogenesis 33.8462 4 no
GO:0030334 regulation of cell migration 32.3077 5 yes
GO:0043085 positive regulation of catalytic activity 32.3077 4 yes
GO:0051240 positive regulation of multicellular organismal process 32.3077 4 yes
GO:2000145 regulation of cell motility 32.3077 4 yes
GO:0009891 positive regulation of biosynthetic process 32.3077 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 32.3077 6 no
GO:0030030 cell projection organization 32.3077 4 no
GO:0031328 positive regulation of cellular biosynthetic process 32.3077 6 no
GO:0044087 regulation of cellular component biogenesis 32.3077 4 no
GO:0001934 positive regulation of protein phosphorylation 32.3077 8 no
GO:0010562 positive regulation of phosphorus metabolic process 32.3077 6 no
GO:0031401 positive regulation of protein modification process 32.3077 7 no
GO:0042327 positive regulation of phosphorylation 32.3077 8 no
GO:0045937 positive regulation of phosphate metabolic process 32.3077 7 no
GO:0060341 regulation of cellular localization 32.3077 4 no
GO:0006796 phosphate-containing compound metabolic process 30.7692 4 yes
GO:0009968 negative regulation of signal transduction 30.7692 5 yes
GO:0010648 negative regulation of cell communication 30.7692 5 yes
GO:0023057 negative regulation of signaling 30.7692 4 yes
GO:0033043 regulation of organelle organization 30.7692 5 yes
GO:0009890 negative regulation of biosynthetic process 30.7692 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 30.7692 6 no
GO:0031327 negative regulation of cellular biosynthetic process 30.7692 6 no
GO:0045595 regulation of cell differentiation 30.7692 4 no
GO:0043066 negative regulation of apoptotic process 30.7692 6 no
GO:0043069 negative regulation of programmed cell death 30.7692 5 no
GO:0032880 regulation of protein localization 30.7692 5 no
GO:0002684 positive regulation of immune system process 29.2308 4 yes
GO:0009894 regulation of catabolic process 29.2308 4 yes
GO:0010975 regulation of neuron projection development 29.2308 7 yes
GO:0051336 regulation of hydrolase activity 29.2308 4 yes
GO:0008284 positive regulation of cell population proliferation 29.2308 5 no
GO:0080134 regulation of response to stress 29.2308 4 no
GO:0120036 plasma membrane bounded cell projection organization 29.2308 5 no
GO:1902533 positive regulation of intracellular signal transduction 29.2308 6 no
GO:0051338 regulation of transferase activity 29.2308 4 no
GO:0030155 regulation of cell adhesion 27.6923 4 yes
GO:0036211 protein modification process 27.6923 4 yes
GO:0043412 macromolecule modification 27.6923 4 yes
GO:0032101 regulation of response to external stimulus 27.6923 4 no
GO:0051094 positive regulation of developmental process 27.6923 4 no
GO:2000026 regulation of multicellular organismal development 27.6923 4 no
GO:0051129 negative regulation of cellular component organization 27.6923 5 no
GO:0031346 positive regulation of cell projection organization 26.1538 6 yes
GO:0031400 negative regulation of protein modification process 26.1538 7 no
GO:0051726 regulation of cell cycle 26.1538 4 no
GO:0043408 regulation of MAPK cascade 26.1538 6 no
GO:0043549 regulation of kinase activity 26.1538 5 no
GO:0045859 regulation of protein kinase activity 26.1538 6 no
GO:0050776 regulation of immune response 26.1538 4 no
GO:0051050 positive regulation of transport 26.1538 4 no
GO:0016310 phosphorylation 24.6154 5 yes
GO:0030335 positive regulation of cell migration 24.6154 6 yes
GO:0040017 positive regulation of locomotion 24.6154 4 yes
GO:0051493 regulation of cytoskeleton organization 24.6154 6 yes
GO:1902532 negative regulation of intracellular signal transduction 24.6154 6 yes
GO:2000147 positive regulation of cell motility 24.6154 5 yes
GO:0010628 positive regulation of gene expression 24.6154 7 no
GO:0044089 positive regulation of cellular component biogenesis 24.6154 5 no
GO:1903829 positive regulation of protein localization 24.6154 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0010243 response to organonitrogen compound 23.0769 4 no
GO:0031175 neuron projection development 23.0769 6 no
GO:0006468 protein phosphorylation 21.5385 5 yes
GO:0018193 peptidyl-amino acid modification 21.5385 5 yes
GO:0032956 regulation of actin cytoskeleton organization 21.5385 5 yes
GO:0032970 regulation of actin filament-based process 21.5385 4 yes
GO:0033993 response to lipid 21.5385 4 yes
GO:1901701 cellular response to oxygen-containing compound 21.5385 4 yes
GO:0010629 negative regulation of gene expression 21.5385 7 no
GO:0030162 regulation of proteolysis 21.5385 6 no
GO:0031347 regulation of defense response 21.5385 5 no
GO:0060284 regulation of cell development 21.5385 5 no
GO:0033674 positive regulation of kinase activity 21.5385 6 no
GO:0034762 regulation of transmembrane transport 21.5385 4 no
GO:0045860 positive regulation of protein kinase activity 21.5385 7 no
GO:0051347 positive regulation of transferase activity 21.5385 5 no
GO:0018108 peptidyl-tyrosine phosphorylation 20.0000 6 yes
GO:0018212 peptidyl-tyrosine modification 20.0000 6 yes
GO:0045785 positive regulation of cell adhesion 20.0000 5 yes
GO:0051345 positive regulation of hydrolase activity 20.0000 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 16.9231 6 yes
GO:0060627 regulation of vesicle-mediated transport 16.9231 4 yes
GO:0002694 regulation of leukocyte activation 15.3846 4 yes
GO:0022407 regulation of cell-cell adhesion 15.3846 5 yes
GO:0030100 regulation of endocytosis 15.3846 5 yes
GO:0050865 regulation of cell activation 15.3846 4 yes
GO:0051249 regulation of lymphocyte activation 15.3846 5 yes
GO:0050863 regulation of T cell activation 13.8462 6 yes
GO:0071396 cellular response to lipid 13.8462 5 yes
GO:0002685 regulation of leukocyte migration 12.3077 4 yes
GO:0002696 positive regulation of leukocyte activation 10.7692 5 yes
GO:0010976 positive regulation of neuron projection development 10.7692 7 yes
GO:0050867 positive regulation of cell activation 10.7692 5 yes
GO:0051251 positive regulation of lymphocyte activation 10.7692 6 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 10.7692 6 yes
GO:0010506 regulation of autophagy 9.2308 6 yes
GO:0022409 positive regulation of cell-cell adhesion 9.2308 6 yes
GO:0031329 regulation of cellular catabolic process 9.2308 5 yes
GO:0035023 regulation of Rho protein signal transduction 9.2308 7 yes
GO:0050870 positive regulation of T cell activation 9.2308 7 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 9.2308 7 yes
GO:0002687 positive regulation of leukocyte migration 7.6923 5 yes
GO:0010517 regulation of phospholipase activity 7.6923 6 yes
GO:0060191 regulation of lipase activity 7.6923 5 yes
GO:0071675 regulation of mononuclear cell migration 7.6923 5 yes
GO:1900274 regulation of phospholipase C activity 7.6923 7 yes
GO:2000401 regulation of lymphocyte migration 7.6923 6 yes
GO:2000404 regulation of T cell migration 7.6923 7 yes
GO:0010518 positive regulation of phospholipase activity 6.1538 7 yes
GO:0010863 positive regulation of phospholipase C activity 6.1538 8 yes
GO:0051058 negative regulation of small GTPase mediated signal transduction 6.1538 7 yes
GO:0060193 positive regulation of lipase activity 6.1538 6 yes
GO:0032878 regulation of establishment or maintenance of cell polarity 4.6154 4 yes
GO:0035024 negative regulation of Rho protein signal transduction 4.6154 8 yes
GO:0051341 regulation of oxidoreductase activity 4.6154 4 yes
GO:0051353 positive regulation of oxidoreductase activity 4.6154 5 yes
GO:0071677 positive regulation of mononuclear cell migration 4.6154 6 yes
GO:1903903 regulation of establishment of T cell polarity 4.6154 6 yes
GO:1903905 positive regulation of establishment of T cell polarity 4.6154 7 yes
GO:2000114 regulation of establishment of cell polarity 4.6154 5 yes
GO:2000403 positive regulation of lymphocyte migration 4.6154 7 yes
GO:2000406 positive regulation of T cell migration 4.6154 8 yes
GO:0032526 response to retinoic acid 3.0769 4 yes
GO:0071300 cellular response to retinoic acid 3.0769 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CRK_HUMAN [view entry] [view interactions] Low throughput yes no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
EPHB2_HUMAN [view entry] [view interactions] Low throughput yes yes
RIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
RASH_HUMAN [view entry] [view interactions] Low throughput yes no
CADH1_HUMAN [view entry] [view interactions] Low throughput yes no
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
FLT3_HUMAN [view interactions] Low throughput no no
SRC8_HUMAN [view entry] [view interactions] Low throughput yes yes
ABL1_HUMAN [view entry] [view interactions] Low throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] Low throughput yes no
CAV1_HUMAN [view interactions] Low throughput no no
SRBS2_HUMAN [view entry] [view interactions] Low throughput yes no
JAK1_HUMAN [view interactions] Low throughput no yes
GPX1_HUMAN [view entry] [view interactions] Low throughput yes yes
CATA_HUMAN [view entry] [view interactions] Low throughput yes no
PSA7_HUMAN [view interactions] Low throughput no yes
UFO_HUMAN [view interactions] Low throughput no no
SIVA_HUMAN [view interactions] Low throughput no no
ABL2_HUMAN [view entry] [view interactions] Low throughput yes yes
PGFRB_HUMAN [view interactions] Low throughput no yes
MDM2_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
NCK1_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
MED28_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
TMG4_HUMAN [view interactions] High throughput no yes
CIP4_HUMAN [view interactions] High throughput no no
CDC37_HUMAN [view interactions] High throughput no yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
HPBP1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CUL4A_HUMAN [view interactions] High throughput no no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
SLAF5_HUMAN [view interactions] High throughput no no
CASS4_HUMAN [view interactions] High throughput no yes
PECA1_HUMAN [view interactions] High throughput no no
PTN18_HUMAN [view interactions] High throughput no yes
G6B_HUMAN [view interactions] High throughput no no
PRP4B_HUMAN [view interactions] High throughput no yes
CRKL_HUMAN [view entry] [view interactions] High throughput yes yes
TAGL2_HUMAN [view entry] [view interactions] High throughput yes no
AGFG1_HUMAN [view interactions] High throughput no yes
DP13B_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
HCK_HUMAN [view entry] [view interactions] High throughput yes no
TPD53_HUMAN [view entry] [view interactions] High throughput yes yes
NMES1_HUMAN [view interactions] High throughput no no
FBX38_HUMAN [view interactions] High throughput no yes
MS18B_HUMAN [view interactions] High throughput no no
M3K10_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
ERBB3_HUMAN [view interactions] High throughput no yes
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
ANDR_HUMAN [view interactions] High throughput no no
KIT_HUMAN [view interactions] High throughput no no
MET_HUMAN [view interactions] High throughput no yes
SF01_HUMAN [view interactions] High throughput no yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
EPHB4_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR4_HUMAN [view interactions] High throughput no no
STT3B_HUMAN [view interactions] High throughput no yes
FHI2A_HUMAN [view interactions] High throughput no yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
P55G_HUMAN [view interactions] High throughput no yes
STAT3_HUMAN [view entry] [view interactions] High throughput yes yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
ZMAT1_HUMAN [view interactions] High throughput no no
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
NTRK1_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
BAG1_HUMAN [view interactions] High throughput no yes
MD2L1_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
VINEX_HUMAN [view interactions] High throughput no no
IASPP_HUMAN [view interactions] High throughput no yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
PARPT_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
SHC1_HUMAN [view entry] [view interactions] High throughput yes yes
CBL_HUMAN [view interactions] High throughput no yes
TF3C4_HUMAN [view interactions] High throughput no no
BST2_HUMAN [view interactions] High throughput no yes
SCAI_HUMAN [view entry] [view interactions] High throughput yes yes
PAXI_HUMAN [view interactions] High throughput no yes
BCAR3_HUMAN [view interactions] High throughput no yes
SPRE_HUMAN [view interactions] High throughput no yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
NED4L_HUMAN [view entry] [view interactions] High throughput yes yes
DOK1_HUMAN [view interactions] High throughput no yes
MBP_HUMAN [view entry] [view interactions] High throughput yes no
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
TYRO3_HUMAN [view interactions] High throughput no yes