Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ABL2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ABL2_HUMAN
GO:0017076 purine nucleotide binding 47.2727 4 yes
GO:0032555 purine ribonucleotide binding 43.6364 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 43.6364 4 yes
GO:0019900 kinase binding 40.0000 4 no
GO:0019901 protein kinase binding 38.1818 5 no
GO:0030554 adenyl nucleotide binding 36.3636 5 yes
GO:0005524 ATP binding 32.7273 5 yes
GO:0032559 adenyl ribonucleotide binding 32.7273 5 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 21.8182 4 yes
GO:0004713 protein tyrosine kinase activity 21.8182 4 yes
GO:0016301 kinase activity 21.8182 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 21.8182 4 yes
GO:0016462 pyrophosphatase activity 21.8182 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.8182 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.8182 6 no
GO:0046872 metal ion binding 18.1818 4 yes
GO:0045309 protein phosphorylated amino acid binding 16.3636 4 yes
GO:0001784 phosphotyrosine residue binding 14.5455 5 yes
GO:0003779 actin binding 10.9091 4 yes
GO:0004715 non-membrane spanning protein tyrosine kinase activity 10.9091 5 yes
GO:0000287 magnesium ion binding 5.4545 5 yes
GO:0003785 actin monomer binding 5.4545 5 yes
GO:0030145 manganese ion binding 5.4545 6 yes
GO:0046914 transition metal ion binding 5.4545 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ABL2_HUMAN
GO:0048522 positive regulation of cellular process 83.6364 4 yes
GO:0031323 regulation of cellular metabolic process 74.5455 4 yes
GO:0048523 negative regulation of cellular process 72.7273 4 yes
GO:0060255 regulation of macromolecule metabolic process 70.9091 4 no
GO:0080090 regulation of primary metabolic process 70.9091 4 no
GO:0051171 regulation of nitrogen compound metabolic process 69.0909 4 no
GO:0051128 regulation of cellular component organization 69.0909 4 yes
GO:0010646 regulation of cell communication 67.2727 4 yes
GO:0009966 regulation of signal transduction 65.4545 4 yes
GO:0009893 positive regulation of metabolic process 63.6364 4 no
GO:0051246 regulation of protein metabolic process 58.1818 5 no
GO:1902531 regulation of intracellular signal transduction 58.1818 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 58.1818 5 no
GO:0031325 positive regulation of cellular metabolic process 56.3636 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 56.3636 5 no
GO:0010468 regulation of gene expression 52.7273 5 no
GO:0048584 positive regulation of response to stimulus 50.9091 4 no
GO:0051247 positive regulation of protein metabolic process 50.9091 6 no
GO:0023056 positive regulation of signaling 47.2727 4 no
GO:0031399 regulation of protein modification process 47.2727 6 no
GO:0043085 positive regulation of catalytic activity 47.2727 4 yes
GO:0051130 positive regulation of cellular component organization 47.2727 5 yes
GO:0010647 positive regulation of cell communication 47.2727 5 no
GO:0051049 regulation of transport 45.4545 4 yes
GO:0071310 cellular response to organic substance 45.4545 4 yes
GO:0009967 positive regulation of signal transduction 45.4545 5 no
GO:0042325 regulation of phosphorylation 43.6364 7 no
GO:0051174 regulation of phosphorus metabolic process 43.6364 5 no
GO:0009892 negative regulation of metabolic process 43.6364 4 no
GO:0019220 regulation of phosphate metabolic process 43.6364 6 no
GO:0030030 cell projection organization 41.8182 4 no
GO:0010941 regulation of cell death 41.8182 4 no
GO:0031344 regulation of cell projection organization 41.8182 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 41.8182 5 no
GO:0042327 positive regulation of phosphorylation 40.0000 8 no
GO:0045937 positive regulation of phosphate metabolic process 40.0000 7 no
GO:1902533 positive regulation of intracellular signal transduction 40.0000 6 no
GO:0006996 organelle organization 40.0000 4 no
GO:0042981 regulation of apoptotic process 40.0000 6 no
GO:0043067 regulation of programmed cell death 40.0000 5 no
GO:0009889 regulation of biosynthetic process 40.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 40.0000 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 40.0000 6 yes
GO:0010562 positive regulation of phosphorus metabolic process 40.0000 6 no
GO:0042127 regulation of cell population proliferation 38.1818 4 no
GO:0051338 regulation of transferase activity 38.1818 4 no
GO:0044087 regulation of cellular component biogenesis 38.1818 4 no
GO:0022607 cellular component assembly 38.1818 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.1818 5 no
GO:0006796 phosphate-containing compound metabolic process 38.1818 4 yes
GO:0033043 regulation of organelle organization 38.1818 5 yes
GO:0001932 regulation of protein phosphorylation 38.1818 7 no
GO:0022603 regulation of anatomical structure morphogenesis 38.1818 4 no
GO:0031401 positive regulation of protein modification process 36.3636 7 no
GO:0051172 negative regulation of nitrogen compound metabolic process 36.3636 5 no
GO:0120036 plasma membrane bounded cell projection organization 36.3636 5 no
GO:0010556 regulation of macromolecule biosynthetic process 36.3636 5 no
GO:0045595 regulation of cell differentiation 34.5455 4 no
GO:0080134 regulation of response to stress 34.5455 4 no
GO:0048585 negative regulation of response to stimulus 34.5455 4 yes
GO:0051336 regulation of hydrolase activity 34.5455 4 yes
GO:0001934 positive regulation of protein phosphorylation 34.5455 8 no
GO:0007167 enzyme-linked receptor protein signaling pathway 34.5455 4 no
GO:0043549 regulation of kinase activity 32.7273 5 no
GO:0051094 positive regulation of developmental process 32.7273 4 no
GO:0051347 positive regulation of transferase activity 32.7273 5 no
GO:0051252 regulation of RNA metabolic process 32.7273 5 no
GO:0030155 regulation of cell adhesion 32.7273 4 yes
GO:0036211 protein modification process 32.7273 4 yes
GO:0043412 macromolecule modification 32.7273 4 yes
GO:0051493 regulation of cytoskeleton organization 32.7273 6 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 32.7273 5 no
GO:0033674 positive regulation of kinase activity 30.9091 6 no
GO:0051129 negative regulation of cellular component organization 30.9091 5 no
GO:0051248 negative regulation of protein metabolic process 30.9091 6 no
GO:0031324 negative regulation of cellular metabolic process 30.9091 5 no
GO:0044089 positive regulation of cellular component biogenesis 30.9091 5 no
GO:0051050 positive regulation of transport 30.9091 4 no
GO:0006355 regulation of DNA-templated transcription 30.9091 6 no
GO:1903506 regulation of nucleic acid-templated transcription 30.9091 7 no
GO:2001141 regulation of RNA biosynthetic process 30.9091 6 no
GO:0009894 regulation of catabolic process 30.9091 4 yes
GO:0016310 phosphorylation 30.9091 5 yes
GO:0050776 regulation of immune response 29.0909 4 no
GO:0010628 positive regulation of gene expression 29.0909 6 no
GO:0060341 regulation of cellular localization 29.0909 4 no
GO:0016192 vesicle-mediated transport 29.0909 4 no
GO:0031346 positive regulation of cell projection organization 29.0909 6 yes
GO:0032956 regulation of actin cytoskeleton organization 29.0909 5 yes
GO:0032970 regulation of actin filament-based process 29.0909 4 yes
GO:2000145 regulation of cell motility 29.0909 4 yes
GO:0031175 neuron projection development 27.2727 6 no
GO:0051240 positive regulation of multicellular organismal process 27.2727 4 no
GO:0060548 negative regulation of cell death 27.2727 5 no
GO:0010638 positive regulation of organelle organization 27.2727 6 no
GO:0051726 regulation of cell cycle 27.2727 4 no
GO:0032880 regulation of protein localization 27.2727 5 no
GO:0006468 protein phosphorylation 27.2727 5 yes
GO:0010648 negative regulation of cell communication 27.2727 5 yes
GO:0010975 regulation of neuron projection development 27.2727 7 yes
GO:0023057 negative regulation of signaling 27.2727 4 yes
GO:0033993 response to lipid 27.2727 4 yes
GO:0051345 positive regulation of hydrolase activity 27.2727 5 yes
GO:0008284 positive regulation of cell population proliferation 27.2727 5 no
GO:0030334 regulation of cell migration 25.4545 5 no
GO:0043408 regulation of MAPK cascade 25.4545 6 no
GO:0045859 regulation of protein kinase activity 25.4545 6 no
GO:0043066 negative regulation of apoptotic process 25.4545 7 no
GO:0043069 negative regulation of programmed cell death 25.4545 6 no
GO:0007010 cytoskeleton organization 25.4545 5 no
GO:0097435 supramolecular fiber organization 25.4545 4 no
GO:1902903 regulation of supramolecular fiber organization 25.4545 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.4545 6 no
GO:0009968 negative regulation of signal transduction 25.4545 5 yes
GO:0010243 response to organonitrogen compound 25.4545 4 no
GO:0022604 regulation of cell morphogenesis 23.6364 5 no
GO:0032101 regulation of response to external stimulus 23.6364 4 no
GO:0045597 positive regulation of cell differentiation 23.6364 5 no
GO:2000026 regulation of multicellular organismal development 23.6364 4 no
GO:0031400 negative regulation of protein modification process 23.6364 7 no
GO:0051495 positive regulation of cytoskeleton organization 23.6364 7 no
GO:1902905 positive regulation of supramolecular fiber organization 23.6364 6 no
GO:0002684 positive regulation of immune system process 23.6364 4 no
GO:0043254 regulation of protein-containing complex assembly 23.6364 5 no
GO:0008104 protein localization 23.6364 4 no
GO:0014070 response to organic cyclic compound 23.6364 4 no
GO:0030162 regulation of proteolysis 21.8182 6 no
GO:0034330 cell junction organization 21.8182 4 no
GO:0045860 positive regulation of protein kinase activity 21.8182 7 no
GO:0060284 regulation of cell development 21.8182 5 no
GO:0007015 actin filament organization 21.8182 5 no
GO:0009891 positive regulation of biosynthetic process 21.8182 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.8182 6 no
GO:0031328 positive regulation of cellular biosynthetic process 21.8182 6 no
GO:0001817 regulation of cytokine production 21.8182 4 no
GO:0018108 peptidyl-tyrosine phosphorylation 21.8182 6 yes
GO:0018193 peptidyl-amino acid modification 21.8182 5 yes
GO:0018212 peptidyl-tyrosine modification 21.8182 6 yes
GO:1901701 cellular response to oxygen-containing compound 21.8182 4 yes
GO:0031329 regulation of cellular catabolic process 20.0000 5 yes
GO:0060627 regulation of vesicle-mediated transport 20.0000 4 yes
GO:0030100 regulation of endocytosis 16.3636 5 yes
GO:0071396 cellular response to lipid 16.3636 5 yes
GO:1902532 negative regulation of intracellular signal transduction 16.3636 6 yes
GO:0051056 regulation of small GTPase mediated signal transduction 14.5455 6 yes
GO:0046578 regulation of Ras protein signal transduction 12.7273 7 yes
GO:0010506 regulation of autophagy 10.9091 6 yes
GO:0010976 positive regulation of neuron projection development 10.9091 7 yes
GO:2000249 regulation of actin cytoskeleton reorganization 10.9091 6 yes
GO:0010517 regulation of phospholipase activity 7.2727 6 yes
GO:0035023 regulation of Rho protein signal transduction 7.2727 8 yes
GO:0051341 regulation of oxidoreductase activity 7.2727 4 yes
GO:0051353 positive regulation of oxidoreductase activity 7.2727 5 yes
GO:0060191 regulation of lipase activity 7.2727 5 yes
GO:1900274 regulation of phospholipase C activity 7.2727 7 yes
GO:0010518 positive regulation of phospholipase activity 5.4545 7 yes
GO:0010863 positive regulation of phospholipase C activity 5.4545 8 yes
GO:0046580 negative regulation of Ras protein signal transduction 5.4545 8 yes
GO:0051058 negative regulation of small GTPase mediated signal transduction 5.4545 7 yes
GO:0060193 positive regulation of lipase activity 5.4545 6 yes
GO:0032526 response to retinoic acid 3.6364 4 yes
GO:0035024 negative regulation of Rho protein signal transduction 3.6364 9 yes
GO:0071300 cellular response to retinoic acid 3.6364 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in ABL2_HUMAN
DOID:0050700 cardiomyopathy 3.6364 4 no
DOID:0060036 intrinsic cardiomyopathy 3.6364 5 no
DOID:114 heart disease 3.6364 3 no
DOID:2843 long QT syndrome 3.6364 6 no
DOID:612 primary immunodeficiency disease 3.6364 3 no
DOID:0050686 organ system cancer 3.6364 3 no
DOID:193 reproductive organ cancer 3.6364 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CRK_HUMAN [view entry] [view interactions] Low throughput yes no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
EPHB2_HUMAN [view entry] [view interactions] Low throughput yes yes
RIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
RASH_HUMAN [view entry] [view interactions] Low throughput yes no
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
CADH1_HUMAN [view entry] [view interactions] Low throughput yes no
FLT3_HUMAN [view interactions] Low throughput no no
SRC8_HUMAN [view entry] [view interactions] Low throughput yes yes
ABL1_HUMAN [view entry] [view interactions] Low throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] Low throughput yes no
CAV1_HUMAN [view interactions] Low throughput no no
SRBS2_HUMAN [view entry] [view interactions] Low throughput yes no
JAK1_HUMAN [view interactions] Low throughput no yes
GPX1_HUMAN [view entry] [view interactions] Low throughput yes yes
CATA_HUMAN [view entry] [view interactions] Low throughput yes no
PSA7_HUMAN [view interactions] Low throughput no yes
UFO_HUMAN [view interactions] Low throughput no no
SIVA_HUMAN [view interactions] Low throughput no no
ABL2_HUMAN [view entry] [view interactions] Low throughput yes yes
PGFRB_HUMAN [view interactions] Low throughput no yes
MDM2_HUMAN [view interactions] Low throughput no yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
NCK1_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
MED28_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
TMG4_HUMAN [view interactions] High throughput no yes
CIP4_HUMAN [view interactions] High throughput no no
CDC37_HUMAN [view interactions] High throughput no yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
HPBP1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CUL4A_HUMAN [view interactions] High throughput no no
G6B_HUMAN [view interactions] High throughput no no
PTN18_HUMAN [view interactions] High throughput no yes
PECA1_HUMAN [view interactions] High throughput no no
CASS4_HUMAN [view interactions] High throughput no yes
SLAF5_HUMAN [view interactions] High throughput no no
PRP4B_HUMAN [view interactions] High throughput no yes
TAGL2_HUMAN [view entry] [view interactions] High throughput yes no
DP13B_HUMAN [view entry] [view interactions] High throughput yes yes
AGFG1_HUMAN [view interactions] High throughput no yes
USE1_HUMAN [view interactions] High throughput no yes
CRKL_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
HCK_HUMAN [view entry] [view interactions] High throughput yes no
TPD53_HUMAN [view entry] [view interactions] High throughput yes yes
FBX38_HUMAN [view interactions] High throughput no yes
NMES1_HUMAN [view interactions] High throughput no no
MS18B_HUMAN [view interactions] High throughput no no
M3K10_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
ERBB3_HUMAN [view interactions] High throughput no yes
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
ANDR_HUMAN [view interactions] High throughput no no
KIT_HUMAN [view interactions] High throughput no no
MET_HUMAN [view interactions] High throughput no yes
SF01_HUMAN [view interactions] High throughput no yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
EPHB4_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
STT3B_HUMAN [view interactions] High throughput no yes
FHI2A_HUMAN [view interactions] High throughput no yes
P55G_HUMAN [view interactions] High throughput no yes
STAT3_HUMAN [view entry] [view interactions] High throughput yes yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
ZMAT1_HUMAN [view interactions] High throughput no no
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
NTRK1_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
BAG1_HUMAN [view interactions] High throughput no yes
MD2L1_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
VINEX_HUMAN [view interactions] High throughput no no
IASPP_HUMAN [view interactions] High throughput no yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
NED4L_HUMAN [view interactions] High throughput no yes
DOK1_HUMAN [view interactions] High throughput no yes
MBP_HUMAN [view entry] [view interactions] High throughput yes no
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
ENAH_HUMAN [view entry] [view interactions] Computational yes yes
WASF2_HUMAN [view entry] [view interactions] Computational yes yes
PIR_HUMAN [view interactions] Computational no no
IGDC3_HUMAN [view interactions] Computational no no