ABL2_HUMAN
Evidence for PS localization
Functions
Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ABL2_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 41.5385 | 4 | no |
| GO:0000166 | nucleotide binding | 40.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 40.0000 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 38.4615 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 38.4615 | 4 | yes |
| GO:0043168 | anion binding | 38.4615 | 4 | yes |
| GO:0019901 | protein kinase binding | 38.4615 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 30.7692 | 6 | yes |
| GO:0005524 | ATP binding | 29.2308 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 29.2308 | 5 | yes |
| GO:0045309 | protein phosphorylated amino acid binding | 21.5385 | 4 | yes |
| GO:0003723 | RNA binding | 21.5385 | 4 | no |
| GO:0045296 | cadherin binding | 21.5385 | 4 | no |
| GO:0004713 | protein tyrosine kinase activity | 20.0000 | 4 | yes |
| GO:0016301 | kinase activity | 20.0000 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 20.0000 | 4 | yes |
| GO:0043169 | cation binding | 16.9231 | 4 | yes |
| GO:0046872 | metal ion binding | 16.9231 | 5 | yes |
| GO:0001784 | phosphotyrosine residue binding | 13.8462 | 5 | yes |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 9.2308 | 5 | yes |
| GO:0003779 | actin binding | 7.6923 | 4 | yes |
| GO:0046914 | transition metal ion binding | 6.1538 | 6 | yes |
| GO:0000287 | magnesium ion binding | 4.6154 | 6 | yes |
| GO:0003785 | actin monomer binding | 4.6154 | 5 | yes |
| GO:0030145 | manganese ion binding | 4.6154 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ABL2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 83.0769 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 80.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 80.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 76.9231 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 76.9231 | 4 | no |
| GO:0010646 | regulation of cell communication | 69.2308 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 64.6154 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 64.6154 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 61.5385 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 60.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 56.9231 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 55.3846 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 55.3846 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 55.3846 | 5 | no |
| GO:0010468 | regulation of gene expression | 53.8462 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 53.8462 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 52.3077 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 50.7692 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 49.2308 | 5 | no |
| GO:0031399 | regulation of protein modification process | 49.2308 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 49.2308 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 49.2308 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 46.1538 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 46.1538 | 4 | yes |
| GO:0051049 | regulation of transport | 44.6154 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGFG1_HUMAN | [view interactions] | High throughput | no | yes |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| BST2_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |