ALK_HUMAN
Evidence for PS localization
Functions
Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. Thinness gene involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 1091 | Asp | Asn | Neuroblastoma3(NBLST3) | - |
| 1128 | Gly | Ala | Neuroblastoma3(NBLST3) | - |
| 1151 | Thr | Met | Neuroblastoma3(NBLST3) | - |
| 1166 | Met | Arg | Neuroblastoma3(NBLST3) | - |
| 1171 | Ile | Asn | Neuroblastoma3(NBLST3) | - |
| 1174 | Phe | Cys | Neuroblastoma3(NBLST3) | - |
| 1174 | Phe | Ile | Neuroblastoma3(NBLST3) | - |
| 1174 | Phe | Leu | Neuroblastoma3(NBLST3) | - |
| 1174 | Phe | Val | Neuroblastoma3(NBLST3) | - |
| 1192 | Arg | Pro | Neuroblastoma3(NBLST3) | - |
| 1234 | Ala | Thr | Neuroblastoma3(NBLST3) | - |
| 1245 | Phe | Cys | Neuroblastoma3(NBLST3) | - |
| 1245 | Phe | Val | Neuroblastoma3(NBLST3) | - |
| 1250 | Ile | Thr | Neuroblastoma3(NBLST3) | - |
| 1275 | Arg | Gln | Neuroblastoma3(NBLST3) | - |
| 1278 | Tyr | Ser | Neuroblastoma3(NBLST3) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ALK_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 40.0000 | 4 | yes |
| GO:0000166 | nucleotide binding | 36.8421 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 36.8421 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 36.8421 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 34.7368 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 33.6842 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 33.6842 | 5 | yes |
| GO:0005524 | ATP binding | 31.5789 | 5 | yes |
| GO:0043169 | cation binding | 27.3684 | 4 | no |
| GO:0046872 | metal ion binding | 27.3684 | 5 | no |
| GO:0019900 | kinase binding | 26.3158 | 4 | no |
| GO:0019901 | protein kinase binding | 26.3158 | 5 | no |
| GO:0003723 | RNA binding | 22.1053 | 4 | no |
| GO:0016301 | kinase activity | 16.8421 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 16.8421 | 4 | yes |
| GO:0004713 | protein tyrosine kinase activity | 12.6316 | 4 | yes |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 6.3158 | 5 | yes |
| GO:0019199 | transmembrane receptor protein kinase activity | 6.3158 | 4 | yes |
| GO:0019887 | protein kinase regulator activity | 6.3158 | 4 | yes |
| GO:0019209 | kinase activator activity | 5.2632 | 4 | yes |
| GO:0030295 | protein kinase activator activity | 5.2632 | 5 | yes |
| GO:0030296 | protein tyrosine kinase activator activity | 2.1053 | 6 | yes |
| GO:0030298 | receptor signaling protein tyrosine kinase activator activity | 2.1053 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ALK_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.1053 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 49.4737 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 48.4211 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.3684 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 47.3684 | 4 | yes |
| GO:0010646 | regulation of cell communication | 43.1579 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 43.1579 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.0526 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 37.8947 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 37.8947 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 37.8947 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 37.8947 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 37.8947 | 5 | no |
| GO:0008104 | protein localization | 37.8947 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.8421 | 5 | yes |
| GO:0010468 | regulation of gene expression | 31.5789 | 6 | yes |
| GO:0006996 | organelle organization | 31.5789 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 31.5789 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.5789 | 4 | no |
| GO:0051049 | regulation of transport | 31.5789 | 4 | no |
| GO:0031399 | regulation of protein modification process | 30.5263 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 29.4737 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 29.4737 | 6 | no |
| GO:0071702 | organic substance transport | 29.4737 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 28.4211 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 28.4211 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 28.4211 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 27.3684 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 27.3684 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.3684 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.3684 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.2632 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 25.2632 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 25.2632 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 25.2632 | 4 | no |
| GO:0015031 | protein transport | 25.2632 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.2632 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.2632 | 7 | no |
| GO:0010647 | positive regulation of cell communication | 25.2632 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.2632 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 25.2632 | 7 | no |
| GO:0022607 | cellular component assembly | 25.2632 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 24.2105 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 24.2105 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 24.2105 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 24.2105 | 7 | no |
| GO:0060341 | regulation of cellular localization | 23.1579 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.1579 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 22.1053 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.1053 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.1053 | 5 | no |
| GO:0036211 | protein modification process | 21.0526 | 4 | yes |
| GO:0043412 | macromolecule modification | 21.0526 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 21.0526 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.0526 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.0526 | 6 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.0526 | 7 | no |
| GO:0080134 | regulation of response to stress | 21.0526 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.0000 | 7 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 20.0000 | 4 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 20.0000 | 6 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 18.9474 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 18.9474 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 17.8947 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 16.8421 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 16.8421 | 6 | yes |
| GO:0016310 | phosphorylation | 15.7895 | 5 | yes |
| GO:0006468 | protein phosphorylation | 11.5789 | 5 | yes |
| GO:0010975 | regulation of neuron projection development | 11.5789 | 7 | yes |
| GO:0018193 | peptidyl-amino acid modification | 11.5789 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 11.5789 | 6 | yes |
| GO:0018108 | peptidyl-tyrosine phosphorylation | 9.4737 | 6 | yes |
| GO:0018212 | peptidyl-tyrosine modification | 9.4737 | 6 | yes |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | 8.4211 | 4 | yes |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 8.4211 | 5 | yes |
| GO:0009895 | negative regulation of catabolic process | 7.3684 | 5 | yes |
| GO:0010976 | positive regulation of neuron projection development | 7.3684 | 7 | yes |
| GO:0046777 | protein autophosphorylation | 6.3158 | 6 | yes |
| GO:0045664 | regulation of neuron differentiation | 5.2632 | 5 | yes |
| GO:0048666 | neuron development | 5.2632 | 4 | yes |
| GO:0050773 | regulation of dendrite development | 5.2632 | 4 | yes |
| GO:0019216 | regulation of lipid metabolic process | 4.2105 | 5 | yes |
| GO:0050994 | regulation of lipid catabolic process | 3.1579 | 5 | yes |
| GO:1900006 | positive regulation of dendrite development | 3.1579 | 5 | yes |
| GO:0036269 | swimming behavior | 2.1053 | 4 | yes |
| GO:0038083 | peptidyl-tyrosine autophosphorylation | 2.1053 | 7 | yes |
| GO:0045833 | negative regulation of lipid metabolic process | 2.1053 | 5 | yes |
| GO:0050995 | negative regulation of lipid catabolic process | 2.1053 | 6 | yes |
| GO:0060159 | regulation of dopamine receptor signaling pathway | 2.1053 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JAK3_HUMAN | [view interactions] | Low throughput | no | no |
| SHC3_HUMAN | [view interactions] | Low throughput | no | yes |
| ZC3C1_HUMAN | [view interactions] | Low throughput | no | yes |
| PTN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK_HUMAN | [view interactions] | Low throughput | no | no |
| HES1_HUMAN | [view interactions] | Low throughput | no | no |
| FRS3_HUMAN | [view interactions] | Low throughput | no | no |
| HLAB_HUMAN | [view interactions] | Low throughput | no | yes |
| B2MG_HUMAN | [view interactions] | Low throughput | no | yes |
| ALKL1_HUMAN | [view interactions] | Low throughput | no | no |
| ALKL2_HUMAN | [view interactions] | Low throughput | no | no |
| LTK_HUMAN | [view interactions] | Low throughput | no | no |
| VAV3_HUMAN | [view interactions] | Low throughput | no | yes |
| PTPRZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HLAA_HUMAN | [view interactions] | Low throughput | no | no |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| ALK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CRKL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI13_HUMAN | [view interactions] | High throughput | no | no |
| CLCC1_HUMAN | [view interactions] | High throughput | no | yes |
| NUD19_HUMAN | [view interactions] | High throughput | no | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M4K5_HUMAN | [view interactions] | High throughput | no | no |
| GAB1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRPRA_HUMAN | [view interactions] | High throughput | no | no |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| IF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUMBL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFD3_HUMAN | [view interactions] | High throughput | no | yes |
| PFD6_HUMAN | [view interactions] | High throughput | no | yes |
| GGA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC3_HUMAN | [view interactions] | High throughput | no | yes |
| ARF4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGA_HUMAN | [view interactions] | High throughput | no | yes |
| NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDCL3_HUMAN | [view interactions] | High throughput | no | yes |
| UNC5B_HUMAN | [view interactions] | High throughput | no | yes |
| SCFD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SERPH_HUMAN | [view interactions] | High throughput | no | no |
| AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| VEZA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK5P3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S23IP_HUMAN | [view interactions] | High throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS74L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GCP60_HUMAN | [view interactions] | High throughput | no | yes |
| TACC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC23B_HUMAN | [view interactions] | High throughput | no | yes |
| COPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UN45A_HUMAN | [view interactions] | High throughput | no | yes |
| SC24B_HUMAN | [view interactions] | High throughput | no | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| LRBA_HUMAN | [view interactions] | High throughput | no | yes |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K4_HUMAN | [view interactions] | High throughput | no | yes |
| SOCS1_HUMAN | [view interactions] | High throughput | no | yes |
| PK3CB_HUMAN | [view interactions] | High throughput | no | yes |
| RAD17_HUMAN | [view interactions] | High throughput | no | yes |
| IRF7_HUMAN | [view interactions] | High throughput | no | yes |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JIP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLCB2_HUMAN | [view interactions] | High throughput | no | no |
| PDX1_HUMAN | [view interactions] | High throughput | no | no |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K5_HUMAN | [view interactions] | High throughput | no | yes |
| MEP1B_HUMAN | [view interactions] | High throughput | no | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| UBS3A_HUMAN | [view interactions] | High throughput | no | no |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| MYLK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M3K1_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOCS5_HUMAN | [view interactions] | High throughput | no | yes |
| CDK13_HUMAN | [view interactions] | High throughput | no | no |
| SMC6_HUMAN | [view interactions] | High throughput | no | no |
| IRS4_HUMAN | [view interactions] | High throughput | no | no |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| K2C74_HUMAN | [view interactions] | High throughput | no | no |
| IRS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCT_HUMAN | [view interactions] | High throughput | no | no |
| MYPC2_HUMAN | [view interactions] | High throughput | no | no |
| ACK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERRFI_HUMAN | [view interactions] | High throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDLI3_HUMAN | [view interactions] | High throughput | no | no |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GCP2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLII_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| CSPG4_HUMAN | [view interactions] | High throughput | no | yes |
| GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VGF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HBA_HUMAN | [view interactions] | High throughput | no | no |
| MTR1L_HUMAN | [view interactions] | High throughput | no | no |
| ERAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| NAGK_HUMAN | [view interactions] | High throughput | no | no |
| NPY4R_HUMAN | [view interactions] | High throughput | no | yes |
| SYLM_HUMAN | [view interactions] | High throughput | no | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| EPHB3_HUMAN | [view interactions] | High throughput | no | yes |
| FES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| KIT_HUMAN | [view interactions] | High throughput | no | no |
| MATK_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| MERTK_HUMAN | [view interactions] | High throughput | no | yes |
| RON_HUMAN | [view interactions] | High throughput | no | yes |
| PTK7_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| H15_HUMAN | [view interactions] | High throughput | no | no |
| RASF7_HUMAN | [view interactions] | High throughput | no | no |
| SDC4_HUMAN | [view interactions] | High throughput | no | yes |
| GPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTPCR_HUMAN | [view interactions] | High throughput | no | yes |
| GXLT1_HUMAN | [view interactions] | High throughput | no | no |
| S61A1_HUMAN | [view interactions] | High throughput | no | no |
| FP100_HUMAN | [view interactions] | High throughput | no | yes |
| DHB12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P4HA2_HUMAN | [view interactions] | High throughput | no | no |
| TM201_HUMAN | [view interactions] | High throughput | no | no |
| DJB12_HUMAN | [view interactions] | High throughput | no | yes |
| NISCH_HUMAN | [view interactions] | High throughput | no | yes |
| PFKAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC3_HUMAN | [view interactions] | High throughput | no | yes |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| P85B_HUMAN | [view interactions] | High throughput | no | yes |
| P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
| SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1A_HUMAN | [view interactions] | High throughput | no | yes |
| DUS19_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| PTPRG_HUMAN | [view interactions] | High throughput | no | no |
| PTPRB_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
| CENPF_HUMAN | [view interactions] | High throughput | no | no |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| SUMO5_HUMAN | [view interactions] | High throughput | no | no |
| DPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M21D2_HUMAN | [view interactions] | High throughput | no | yes |
| KTNB1_HUMAN | [view interactions] | High throughput | no | yes |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DD19A_HUMAN | [view interactions] | High throughput | no | yes |
| NUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| SMCR8_HUMAN | [view interactions] | High throughput | no | yes |
| NUP37_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| SEC63_HUMAN | [view interactions] | High throughput | no | yes |
| F1711_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB3GP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDC1_HUMAN | [view interactions] | High throughput | no | yes |
| LSG1_HUMAN | [view interactions] | High throughput | no | yes |
| ANKL2_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FRS2_HUMAN | [view interactions] | High throughput | no | no |
| ARFG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CC115_HUMAN | [view interactions] | High throughput | no | no |
| C10_HUMAN | [view interactions] | High throughput | no | yes |
| ABL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR41_HUMAN | [view interactions] | High throughput | no | yes |
| PDZD8_HUMAN | [view interactions] | High throughput | no | yes |
| PFD4_HUMAN | [view interactions] | High throughput | no | yes |
| SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STIM2_HUMAN | [view interactions] | High throughput | no | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSMA3_HUMAN | [view interactions] | High throughput | no | yes |
| TGO1_HUMAN | [view interactions] | High throughput | no | yes |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACSL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFG_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP1_HUMAN | [view interactions] | High throughput | no | yes |
| AAAS_HUMAN | [view interactions] | High throughput | no | yes |
| SYAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEAK1_HUMAN | [view interactions] | High throughput | no | yes |
| OSBL8_HUMAN | [view interactions] | High throughput | no | yes |
| CDCA3_HUMAN | [view interactions] | High throughput | no | no |