ALK_HUMAN
Evidence for PS localization
Functions
Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. Thinness gene involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 1091 | Asp | Asn | Neuroblastoma3(NBLST3) | - |
| 1128 | Gly | Ala | Neuroblastoma3(NBLST3) | - |
| 1151 | Thr | Met | Neuroblastoma3(NBLST3) | - |
| 1166 | Met | Arg | Neuroblastoma3(NBLST3) | - |
| 1171 | Ile | Asn | Neuroblastoma3(NBLST3) | - |
| 1174 | Phe | Cys | Neuroblastoma3(NBLST3) | - |
| 1174 | Phe | Ile | Neuroblastoma3(NBLST3) | - |
| 1174 | Phe | Leu | Neuroblastoma3(NBLST3) | - |
| 1174 | Phe | Val | Neuroblastoma3(NBLST3) | - |
| 1192 | Arg | Pro | Neuroblastoma3(NBLST3) | - |
| 1234 | Ala | Thr | Neuroblastoma3(NBLST3) | - |
| 1245 | Phe | Cys | Neuroblastoma3(NBLST3) | - |
| 1245 | Phe | Val | Neuroblastoma3(NBLST3) | - |
| 1250 | Ile | Thr | Neuroblastoma3(NBLST3) | - |
| 1275 | Arg | Gln | Neuroblastoma3(NBLST3) | - |
| 1278 | Tyr | Ser | Neuroblastoma3(NBLST3) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ALK_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 36.2637 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 36.2637 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.1648 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 29.6703 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 29.6703 | 5 | yes |
| GO:0005524 | ATP binding | 28.5714 | 5 | yes |
| GO:0019900 | kinase binding | 26.3736 | 4 | no |
| GO:0019901 | protein kinase binding | 26.3736 | 5 | no |
| GO:0046872 | metal ion binding | 23.0769 | 4 | no |
| GO:0016301 | kinase activity | 15.3846 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 15.3846 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 13.1868 | 4 | yes |
| GO:0004713 | protein tyrosine kinase activity | 10.9890 | 4 | yes |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 5.4945 | 5 | yes |
| GO:0019199 | transmembrane receptor protein kinase activity | 5.4945 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ALK_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.7363 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 51.6484 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.5495 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 50.5495 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 49.4505 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 49.4505 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 45.0549 | 4 | yes |
| GO:0010646 | regulation of cell communication | 45.0549 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 40.6593 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.6593 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.6593 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 39.5604 | 5 | yes |
| GO:0008104 | protein localization | 39.5604 | 4 | no |
| GO:0010468 | regulation of gene expression | 37.3626 | 5 | yes |
| GO:0006996 | organelle organization | 37.3626 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 37.3626 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 36.2637 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 35.1648 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 35.1648 | 5 | yes |
| GO:0042325 | regulation of phosphorylation | 34.0659 | 7 | yes |
| GO:0009889 | regulation of biosynthetic process | 32.9670 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 32.9670 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 32.9670 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 31.8681 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 31.8681 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 31.8681 | 4 | yes |
| GO:0071702 | organic substance transport | 31.8681 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 31.8681 | 6 | no |
| GO:0071705 | nitrogen compound transport | 29.6703 | 4 | no |
| GO:0051049 | regulation of transport | 29.6703 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 29.6703 | 7 | no |
| GO:0016192 | vesicle-mediated transport | 29.6703 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 28.5714 | 5 | yes |
| GO:0010941 | regulation of cell death | 28.5714 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 28.5714 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 28.5714 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 28.5714 | 5 | yes |
| GO:0043085 | positive regulation of catalytic activity | 28.5714 | 4 | yes |
| GO:0015031 | protein transport | 28.5714 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 27.4725 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 27.4725 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 26.3736 | 6 | yes |
| GO:0045595 | regulation of cell differentiation | 26.3736 | 4 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 26.3736 | 7 | yes |
| GO:0051338 | regulation of transferase activity | 26.3736 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 25.2747 | 5 | yes |
| GO:0042327 | positive regulation of phosphorylation | 25.2747 | 8 | yes |
| GO:0031401 | positive regulation of protein modification process | 25.2747 | 7 | no |
| GO:0009892 | negative regulation of metabolic process | 24.1758 | 4 | yes |
| GO:0043549 | regulation of kinase activity | 24.1758 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 24.1758 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 24.1758 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.0769 | 4 | yes |
| GO:0036211 | protein modification process | 23.0769 | 4 | yes |
| GO:0043412 | macromolecule modification | 23.0769 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 23.0769 | 5 | yes |
| GO:0032880 | regulation of protein localization | 23.0769 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 23.0769 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.0769 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.9780 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 21.9780 | 6 | yes |
| GO:0006886 | intracellular protein transport | 21.9780 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.9780 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.8791 | 6 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 20.8791 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 20.8791 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 20.8791 | 6 | yes |
| GO:0022607 | cellular component assembly | 20.8791 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.8791 | 4 | no |
| GO:2000145 | regulation of cell motility | 20.8791 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 20.8791 | 8 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.8791 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 20.8791 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.8791 | 6 | no |
| GO:0080134 | regulation of response to stress | 20.8791 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 20.8791 | 5 | no |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 19.7802 | 5 | yes |
| GO:0043408 | regulation of MAPK cascade | 19.7802 | 6 | yes |
| GO:0051130 | positive regulation of cellular component organization | 18.6813 | 5 | yes |
| GO:0051347 | positive regulation of transferase activity | 18.6813 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 17.5824 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 17.5824 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 17.5824 | 6 | yes |
| GO:0033674 | positive regulation of kinase activity | 16.4835 | 6 | yes |
| GO:0016310 | phosphorylation | 15.3846 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 13.1868 | 6 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 13.1868 | 7 | yes |
| GO:0006468 | protein phosphorylation | 12.0879 | 5 | yes |
| GO:0010975 | regulation of neuron projection development | 12.0879 | 7 | yes |
| GO:0009895 | negative regulation of catabolic process | 8.7912 | 5 | yes |
| GO:0010976 | positive regulation of neuron projection development | 8.7912 | 7 | yes |
| GO:0046777 | protein autophosphorylation | 8.7912 | 6 | yes |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | 8.7912 | 4 | yes |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 7.6923 | 5 | yes |
| GO:0019216 | regulation of lipid metabolic process | 5.4945 | 5 | yes |
| GO:0050773 | regulation of dendrite development | 5.4945 | 4 | yes |
| GO:0045664 | regulation of neuron differentiation | 4.3956 | 5 | yes |
| GO:0048666 | neuron development | 3.2967 | 4 | yes |
| GO:0050994 | regulation of lipid catabolic process | 3.2967 | 5 | yes |
| GO:1900006 | positive regulation of dendrite development | 3.2967 | 5 | yes |
| GO:0036269 | swimming behavior | 2.1978 | 4 | yes |
| GO:0045833 | negative regulation of lipid metabolic process | 2.1978 | 5 | yes |
| GO:0050995 | negative regulation of lipid catabolic process | 2.1978 | 6 | yes |
| GO:0060159 | regulation of dopamine receptor signaling pathway | 2.1978 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ALK_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 3.2967 | 3 | no |
| DOID:557 | kidney disease | 2.1978 | 3 | no |
| DOID:0050700 | cardiomyopathy | 2.1978 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 2.1978 | 5 | no |
| DOID:114 | heart disease | 2.1978 | 3 | no |
| DOID:2843 | long QT syndrome | 2.1978 | 6 | no |
| DOID:193 | reproductive organ cancer | 2.1978 | 4 | no |
| DOID:0050155 | sensory system disease | 2.1978 | 3 | no |
| DOID:0050563 | nonsyndromic deafness | 2.1978 | 5 | no |
| DOID:0050564 | autosomal dominant nonsyndromic deafness | 2.1978 | 6 | no |
| DOID:2742 | auditory system disease | 2.1978 | 4 | no |
| DOID:2978 | carbohydrate metabolic disorder | 2.1978 | 3 | no |
| DOID:0050851 | glomerulosclerosis | 2.1978 | 6 | no |
| DOID:10952 | nephritis | 2.1978 | 4 | no |
| DOID:1312 | focal segmental glomerulosclerosis | 2.1978 | 7 | no |
| DOID:2921 | glomerulonephritis | 2.1978 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JAK3_HUMAN | [view interactions] | Low throughput | no | no |
| SHC3_HUMAN | [view interactions] | Low throughput | no | yes |
| NIPA_HUMAN | [view interactions] | Low throughput | no | yes |
| PTN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK_HUMAN | [view interactions] | Low throughput | no | no |
| FRS3_HUMAN | [view interactions] | Low throughput | no | no |
| HLAB_HUMAN | [view interactions] | Low throughput | no | yes |
| B2MG_HUMAN | [view interactions] | Low throughput | no | yes |
| ALKL1_HUMAN | [view interactions] | Low throughput | no | no |
| ALKL2_HUMAN | [view interactions] | Low throughput | no | no |
| LTK_HUMAN | [view interactions] | Low throughput | no | no |
| VAV3_HUMAN | [view interactions] | Low throughput | no | yes |
| PTPRZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| HLAA_HUMAN | [view interactions] | Low throughput | no | no |
| SHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ALK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| TACC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCP60_HUMAN | [view interactions] | High throughput | no | yes |
| HS74L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S23IP_HUMAN | [view interactions] | High throughput | no | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK5P3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| VEZA_HUMAN | [view interactions] | High throughput | no | yes |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SERPH_HUMAN | [view interactions] | High throughput | no | no |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCFD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UNC5B_HUMAN | [view interactions] | High throughput | no | yes |
| PDCL3_HUMAN | [view interactions] | High throughput | no | yes |
| NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHGA_HUMAN | [view interactions] | High throughput | no | yes |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| MAN1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUDC3_HUMAN | [view interactions] | High throughput | no | yes |
| GGA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFD6_HUMAN | [view interactions] | High throughput | no | yes |
| PFD3_HUMAN | [view interactions] | High throughput | no | yes |
| NUMBL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| SRPRA_HUMAN | [view interactions] | High throughput | no | no |
| EGLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAB1_HUMAN | [view interactions] | High throughput | no | yes |
| M4K5_HUMAN | [view interactions] | High throughput | no | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUD19_HUMAN | [view interactions] | High throughput | no | no |
| CLCC1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI13_HUMAN | [view interactions] | High throughput | no | no |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| CRKL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDCA3_HUMAN | [view interactions] | High throughput | no | no |
| OSBL8_HUMAN | [view interactions] | High throughput | no | yes |
| PEAK1_HUMAN | [view interactions] | High throughput | no | yes |
| SYAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAAS_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFG_HUMAN | [view interactions] | High throughput | no | yes |
| ACSL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| TGO1_HUMAN | [view interactions] | High throughput | no | yes |
| NSMA3_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM2_HUMAN | [view interactions] | High throughput | no | yes |
| SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PFD4_HUMAN | [view interactions] | High throughput | no | yes |
| PDZD8_HUMAN | [view interactions] | High throughput | no | yes |
| WDR41_HUMAN | [view interactions] | High throughput | no | yes |
| ABL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C10_HUMAN | [view interactions] | High throughput | no | yes |
| CC115_HUMAN | [view interactions] | High throughput | no | no |
| ARFG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FRS2_HUMAN | [view interactions] | High throughput | no | no |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANKL2_HUMAN | [view interactions] | High throughput | no | yes |
| LSG1_HUMAN | [view interactions] | High throughput | no | yes |
| NDC1_HUMAN | [view interactions] | High throughput | no | yes |
| RB3GP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F1711_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC63_HUMAN | [view interactions] | High throughput | no | yes |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP37_HUMAN | [view interactions] | High throughput | no | yes |
| SMCR8_HUMAN | [view interactions] | High throughput | no | yes |
| NUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| DD19A_HUMAN | [view interactions] | High throughput | no | yes |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KTNB1_HUMAN | [view interactions] | High throughput | no | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUMO5_HUMAN | [view interactions] | High throughput | no | no |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| CENPF_HUMAN | [view interactions] | High throughput | no | no |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K4_HUMAN | [view interactions] | High throughput | no | yes |
| SOCS1_HUMAN | [view interactions] | High throughput | no | yes |
| PK3CB_HUMAN | [view interactions] | High throughput | no | yes |
| RAD17_HUMAN | [view interactions] | High throughput | no | yes |
| IRF7_HUMAN | [view interactions] | High throughput | no | yes |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JIP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLCB2_HUMAN | [view interactions] | High throughput | no | no |
| PDX1_HUMAN | [view interactions] | High throughput | no | no |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K5_HUMAN | [view interactions] | High throughput | no | yes |
| MEP1B_HUMAN | [view interactions] | High throughput | no | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| UBS3A_HUMAN | [view interactions] | High throughput | no | no |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| MYLK_HUMAN | [view interactions] | High throughput | no | no |
| M3K1_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOCS5_HUMAN | [view interactions] | High throughput | no | yes |
| CDK13_HUMAN | [view interactions] | High throughput | no | no |
| SMC6_HUMAN | [view interactions] | High throughput | no | no |
| IRS4_HUMAN | [view interactions] | High throughput | no | no |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| K2C74_HUMAN | [view interactions] | High throughput | no | no |
| IRS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCT_HUMAN | [view interactions] | High throughput | no | no |
| MYPC2_HUMAN | [view interactions] | High throughput | no | no |
| ACK1_HUMAN | [view interactions] | High throughput | no | yes |
| ERRFI_HUMAN | [view interactions] | High throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDLI3_HUMAN | [view interactions] | High throughput | no | no |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GCP2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLII_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| CSPG4_HUMAN | [view interactions] | High throughput | no | yes |
| GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VGF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HBA_HUMAN | [view interactions] | High throughput | no | no |
| MTR1L_HUMAN | [view interactions] | High throughput | no | no |
| ERAP1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| NAGK_HUMAN | [view interactions] | High throughput | no | no |
| NPY4R_HUMAN | [view interactions] | High throughput | no | yes |
| SYLM_HUMAN | [view interactions] | High throughput | no | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| EPHB3_HUMAN | [view interactions] | High throughput | no | yes |
| FES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| KIT_HUMAN | [view interactions] | High throughput | no | no |
| MATK_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| MERTK_HUMAN | [view interactions] | High throughput | no | yes |
| RON_HUMAN | [view interactions] | High throughput | no | yes |
| PTK7_HUMAN | [view interactions] | High throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| H15_HUMAN | [view interactions] | High throughput | no | no |
| DNJC3_HUMAN | [view interactions] | High throughput | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
| P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
| P85B_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| PFKAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NISCH_HUMAN | [view interactions] | High throughput | no | yes |
| DJB12_HUMAN | [view interactions] | High throughput | no | yes |
| TM201_HUMAN | [view interactions] | High throughput | no | no |
| P4HA2_HUMAN | [view interactions] | High throughput | no | no |
| DHB12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FP100_HUMAN | [view interactions] | High throughput | no | yes |
| S61A1_HUMAN | [view interactions] | High throughput | no | no |
| GXLT1_HUMAN | [view interactions] | High throughput | no | no |
| NTPCR_HUMAN | [view interactions] | High throughput | no | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDC4_HUMAN | [view interactions] | High throughput | no | yes |
| RASF7_HUMAN | [view interactions] | High throughput | no | no |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| DUS19_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1A_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| PTPRG_HUMAN | [view interactions] | High throughput | no | no |
| PTPRB_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
| M21D2_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRBA_HUMAN | [view interactions] | High throughput | no | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| SC24B_HUMAN | [view interactions] | High throughput | no | yes |
| UN45A_HUMAN | [view interactions] | High throughput | no | yes |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC23B_HUMAN | [view interactions] | High throughput | no | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EMAL4_HUMAN | [view interactions] | Computational | no | yes |
| PLCG2_HUMAN | [view interactions] | Computational | no | yes |
| NF1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| TNR8_HUMAN | [view interactions] | Computational | no | no |
| BMP7_HUMAN | [view interactions] | Computational | no | no |
| JAK1_HUMAN | [view interactions] | Computational | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PK3CD_HUMAN | [view interactions] | Computational | no | no |
| NPM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RASH_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| TGFR1_HUMAN | [view interactions] | Computational | no | no |