Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

EGLN1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
317 Pro Arg Erythrocytosis,familial,3(ECYT3) -
371 Arg His Erythrocytosis,familial,3(ECYT3) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in EGLN1_HUMAN
GO:0043168 anion binding 64.2857 4 yes
GO:0000166 nucleotide binding 53.5714 4 no
GO:0017076 purine nucleotide binding 53.5714 5 no
GO:0032555 purine ribonucleotide binding 53.5714 4 no
GO:0035639 purine ribonucleoside triphosphate binding 53.5714 4 no
GO:0005524 ATP binding 42.8571 5 no
GO:0030554 adenyl nucleotide binding 42.8571 6 no
GO:0032559 adenyl ribonucleotide binding 42.8571 5 no
GO:0016301 kinase activity 32.1429 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 32.1429 4 no
GO:0019900 kinase binding 28.5714 4 no
GO:0019901 protein kinase binding 28.5714 5 no
GO:0003723 RNA binding 25.0000 4 no
GO:0043169 cation binding 21.4286 4 yes
GO:0046872 metal ion binding 21.4286 5 yes
GO:0004713 protein tyrosine kinase activity 21.4286 4 no
GO:0005506 iron ion binding 7.1429 7 yes
GO:0008198 ferrous iron binding 7.1429 8 yes
GO:0016706 2-oxoglutarate-dependent dioxygenase activity 7.1429 4 yes
GO:0031406 carboxylic acid binding 7.1429 4 yes
GO:0031545 peptidyl-proline 4-dioxygenase activity 7.1429 4 yes
GO:0046914 transition metal ion binding 7.1429 6 yes
GO:0160082 hypoxia-inducible factor-proline dioxygenase activity 7.1429 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in EGLN1_HUMAN
GO:0048522 positive regulation of cellular process 82.1429 4 yes
GO:0060255 regulation of macromolecule metabolic process 75.0000 4 yes
GO:0009889 regulation of biosynthetic process 71.4286 4 yes
GO:0031323 regulation of cellular metabolic process 71.4286 4 yes
GO:0031326 regulation of cellular biosynthetic process 71.4286 5 yes
GO:0080090 regulation of primary metabolic process 71.4286 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 67.8571 5 yes
GO:0010646 regulation of cell communication 64.2857 4 no
GO:0048523 negative regulation of cellular process 64.2857 4 no
GO:0009893 positive regulation of metabolic process 64.2857 4 yes
GO:0010468 regulation of gene expression 64.2857 6 yes
GO:0009966 regulation of signal transduction 60.7143 4 no
GO:0010604 positive regulation of macromolecule metabolic process 60.7143 5 yes
GO:0031325 positive regulation of cellular metabolic process 57.1429 5 yes
GO:0009891 positive regulation of biosynthetic process 53.5714 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 53.5714 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 53.5714 6 yes
GO:0051128 regulation of cellular component organization 53.5714 4 yes
GO:0010647 positive regulation of cell communication 50.0000 5 no
GO:0023056 positive regulation of signaling 50.0000 4 no
GO:0048584 positive regulation of response to stimulus 50.0000 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 50.0000 6 yes
GO:0009967 positive regulation of signal transduction 46.4286 5 no
GO:1902531 regulation of intracellular signal transduction 46.4286 5 no
GO:0009894 regulation of catabolic process 46.4286 4 yes
GO:0042127 regulation of cell population proliferation 42.8571 4 no
GO:0042981 regulation of apoptotic process 42.8571 5 no
GO:0043067 regulation of programmed cell death 42.8571 4 no
GO:0009892 negative regulation of metabolic process 42.8571 4 no
GO:0051247 positive regulation of protein metabolic process 42.8571 6 no
GO:0036211 protein modification process 42.8571 4 yes
GO:0043412 macromolecule modification 42.8571 4 yes
GO:0051240 positive regulation of multicellular organismal process 39.2857 4 no
GO:0006996 organelle organization 39.2857 4 no
GO:0010605 negative regulation of macromolecule metabolic process 39.2857 5 no
GO:0019220 regulation of phosphate metabolic process 39.2857 6 no
GO:0031399 regulation of protein modification process 39.2857 6 no
GO:0051174 regulation of phosphorus metabolic process 39.2857 5 no
GO:0006355 regulation of DNA-templated transcription 39.2857 7 yes
GO:0051252 regulation of RNA metabolic process 39.2857 5 yes
GO:2001141 regulation of RNA biosynthetic process 39.2857 6 yes
GO:0008284 positive regulation of cell population proliferation 35.7143 5 no
GO:0051094 positive regulation of developmental process 35.7143 4 no
GO:1902533 positive regulation of intracellular signal transduction 35.7143 6 no
GO:0006915 apoptotic process 35.7143 4 no
GO:0008104 protein localization 35.7143 4 no
GO:0010562 positive regulation of phosphorus metabolic process 35.7143 6 no
GO:0031324 negative regulation of cellular metabolic process 35.7143 5 no
GO:0031401 positive regulation of protein modification process 35.7143 7 no
GO:0042325 regulation of phosphorylation 35.7143 7 no
GO:0045937 positive regulation of phosphate metabolic process 35.7143 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 35.7143 5 yes
GO:0016310 phosphorylation 32.1429 5 no
GO:0031344 regulation of cell projection organization 32.1429 5 no
GO:0043066 negative regulation of apoptotic process 32.1429 6 no
GO:0043069 negative regulation of programmed cell death 32.1429 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 32.1429 6 no
GO:0001932 regulation of protein phosphorylation 32.1429 7 no
GO:0010628 positive regulation of gene expression 32.1429 7 no
GO:0042327 positive regulation of phosphorylation 32.1429 8 no
GO:0018193 peptidyl-amino acid modification 32.1429 5 yes
GO:0006796 phosphate-containing compound metabolic process 32.1429 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 32.1429 4 no
GO:0048585 negative regulation of response to stimulus 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0007010 cytoskeleton organization 28.5714 5 no
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 no
GO:0009890 negative regulation of biosynthetic process 28.5714 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0031327 negative regulation of cellular biosynthetic process 28.5714 6 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0045595 regulation of cell differentiation 28.5714 4 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:1903829 positive regulation of protein localization 28.5714 5 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0006357 regulation of transcription by RNA polymerase II 28.5714 8 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 28.5714 5 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:0030335 positive regulation of cell migration 25.0000 6 no
GO:0032101 regulation of response to external stimulus 25.0000 4 no
GO:0040017 positive regulation of locomotion 25.0000 4 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:1902532 negative regulation of intracellular signal transduction 25.0000 6 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:2000147 positive regulation of cell motility 25.0000 5 no
GO:0009059 macromolecule biosynthetic process 25.0000 4 no
GO:0010629 negative regulation of gene expression 25.0000 7 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0051049 regulation of transport 25.0000 4 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0045893 positive regulation of DNA-templated transcription 25.0000 8 yes
GO:0051254 positive regulation of RNA metabolic process 25.0000 6 yes
GO:0051336 regulation of hydrolase activity 25.0000 4 yes
GO:1902680 positive regulation of RNA biosynthetic process 25.0000 7 yes
GO:0006468 protein phosphorylation 25.0000 5 no
GO:0010243 response to organonitrogen compound 21.4286 4 no
GO:0010975 regulation of neuron projection development 21.4286 7 no
GO:0030030 cell projection organization 21.4286 4 no
GO:0031346 positive regulation of cell projection organization 21.4286 6 no
GO:0043408 regulation of MAPK cascade 21.4286 6 no
GO:0051726 regulation of cell cycle 21.4286 4 no
GO:0071310 cellular response to organic substance 21.4286 4 no
GO:0071363 cellular response to growth factor stimulus 21.4286 4 no
GO:0141124 intracellular signaling cassette 21.4286 4 no
GO:0002684 positive regulation of immune system process 21.4286 4 no
GO:0097435 supramolecular fiber organization 21.4286 4 no
GO:0009896 positive regulation of catabolic process 21.4286 5 no
GO:0031329 regulation of cellular catabolic process 21.4286 5 no
GO:0033674 positive regulation of kinase activity 21.4286 6 no
GO:0043549 regulation of kinase activity 21.4286 5 no
GO:0045597 positive regulation of cell differentiation 21.4286 5 no
GO:0045859 regulation of protein kinase activity 21.4286 6 no
GO:0045860 positive regulation of protein kinase activity 21.4286 7 no
GO:0050776 regulation of immune response 21.4286 4 no
GO:0051338 regulation of transferase activity 21.4286 4 no
GO:0051347 positive regulation of transferase activity 21.4286 5 no
GO:0001817 regulation of cytokine production 21.4286 4 no
GO:0072657 protein localization to membrane 21.4286 4 no
GO:0022603 regulation of anatomical structure morphogenesis 21.4286 4 yes
GO:0036293 response to decreased oxygen levels 21.4286 4 yes
GO:2000026 regulation of multicellular organismal development 21.4286 4 yes
GO:0036294 cellular response to decreased oxygen levels 17.8571 5 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 17.8571 9 yes
GO:0071453 cellular response to oxygen levels 17.8571 4 yes
GO:0006873 intracellular monoatomic ion homeostasis 14.2857 4 yes
GO:0030003 intracellular monoatomic cation homeostasis 14.2857 5 yes
GO:0043086 negative regulation of catalytic activity 14.2857 4 yes
GO:0050807 regulation of synapse organization 14.2857 5 yes
GO:0051346 negative regulation of hydrolase activity 14.2857 5 yes
GO:0055080 monoatomic cation homeostasis 14.2857 4 yes
GO:0071456 cellular response to hypoxia 14.2857 4 yes
GO:0045765 regulation of angiogenesis 10.7143 5 yes
GO:0140250 regulation protein catabolic process at synapse 10.7143 5 yes
GO:0140252 regulation protein catabolic process at postsynapse 10.7143 6 yes
GO:1901342 regulation of vasculature development 10.7143 5 yes
GO:0006879 intracellular iron ion homeostasis 7.1429 4 yes
GO:0018126 protein hydroxylation 7.1429 5 yes
GO:0018208 peptidyl-proline modification 7.1429 6 yes
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 7.1429 5 yes
GO:0019471 4-hydroxyproline metabolic process 7.1429 4 yes
GO:0019511 peptidyl-proline hydroxylation 7.1429 6 yes
GO:0019752 carboxylic acid metabolic process 7.1429 5 yes
GO:0032364 intracellular oxygen homeostasis 7.1429 4 yes
GO:0043433 negative regulation of DNA-binding transcription factor activity 7.1429 4 yes
GO:0043436 oxoacid metabolic process 7.1429 4 yes
GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity 7.1429 5 yes
GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity 7.1429 6 yes
GO:0055008 cardiac muscle tissue morphogenesis 7.1429 5 yes
GO:0060347 heart trabecula formation 7.1429 4 yes
GO:0060412 ventricular septum morphogenesis 7.1429 4 yes
GO:0060415 muscle tissue morphogenesis 7.1429 4 yes
GO:0071731 response to nitric oxide 7.1429 4 yes
GO:0099159 regulation of modification of postsynaptic structure 7.1429 7 yes
GO:0170033 L-amino acid metabolic process 7.1429 5 yes
GO:0170041 non-proteinogenic amino acid metabolic process 7.1429 4 yes
GO:1901605 alpha-amino acid metabolic process 7.1429 4 yes
GO:1905244 regulation of modification of synaptic structure 7.1429 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FKBP8_HUMAN [view entry] [view interactions] Low throughput yes yes
HIF1A_HUMAN [view interactions] Low throughput no no
OS9_HUMAN [view interactions] Low throughput no yes
EPAS1_HUMAN [view interactions] Low throughput no no
KPYM_HUMAN [view interactions] Low throughput no yes
ING4_HUMAN [view interactions] Low throughput no no
MAGAB_HUMAN [view interactions] Low throughput no no
RPB1_HUMAN [view interactions] Low throughput no no
OSR1_HUMAN [view interactions] Low throughput no no
SIAH2_HUMAN [view interactions] Low throughput no no
EGLN1_HUMAN [view entry] [view interactions] Low throughput yes yes
EGLN3_HUMAN [view interactions] Low throughput no no
SPY2_HUMAN [view interactions] Low throughput no yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
VHL_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGA9_HUMAN [view interactions] Low throughput no no
PLD1_HUMAN [view interactions] Low throughput no no
PLD2_HUMAN [view interactions] Low throughput no yes
PHLD_HUMAN [view interactions] Low throughput no no
TEBP_HUMAN [view interactions] Low throughput no yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
HS90B_HUMAN [view entry] [view interactions] Low throughput yes yes
MTG16_HUMAN [view interactions] Low throughput no yes
RUNX3_HUMAN [view interactions] Low throughput no no
SH3K1_HUMAN [view entry] [view interactions] Low throughput yes yes
TET2_HUMAN [view interactions] Low throughput no yes
TET3_HUMAN [view interactions] Low throughput no yes
TBK1_HUMAN [view entry] [view interactions] Low throughput yes yes
MTG8_HUMAN [view interactions] Low throughput no yes
IASPP_HUMAN [view interactions] Low throughput no yes
YAP1_HUMAN [view interactions] Low throughput no yes
TAZ_HUMAN [view interactions] Low throughput no yes
NACAM_HUMAN [view interactions] Low throughput no no
H31_HUMAN [view interactions] Low throughput no yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP5_HUMAN [view interactions] High throughput no yes
ERP29_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
ZN281_HUMAN [view interactions] High throughput no no
MKS1_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
FGFR3_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
VGFR3_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
LMTK1_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
LIMD1_HUMAN [view interactions] High throughput no yes
RFPLB_HUMAN [view interactions] High throughput no no
PEX19_HUMAN [view interactions] High throughput no yes
SPN1_HUMAN [view interactions] High throughput no yes
ZNG1A_HUMAN [view interactions] High throughput no yes
ZNG1B_HUMAN [view interactions] High throughput no no
RHBT3_HUMAN [view interactions] High throughput no no
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
EFMT1_HUMAN [view interactions] High throughput no no
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
AKT2_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
ARNT_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
KEAP1_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
ABC3C_HUMAN [view interactions] High throughput no no
BTF3_HUMAN [view interactions] High throughput no yes
CITE1_HUMAN [view interactions] High throughput no no
CLU_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
DVL2_HUMAN [view interactions] High throughput no yes
SPOP_HUMAN [view interactions] High throughput no no
ATG12_HUMAN [view interactions] High throughput no yes
SPPL3_HUMAN [view interactions] High throughput no no
ANKY2_HUMAN [view interactions] High throughput no no
PYGL_HUMAN [view interactions] High throughput no yes
OXSR1_HUMAN [view interactions] High throughput no yes
BPNT1_HUMAN [view interactions] High throughput no yes
KPRA_HUMAN [view interactions] High throughput no no
FA98B_HUMAN [view interactions] High throughput no yes
RMD3_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
RPB3_HUMAN [view interactions] High throughput no yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
NAA40_HUMAN [view interactions] High throughput no no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes