EGLN1_HUMAN
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
317 | Pro | Arg | Erythrocytosis,familial,3(ECYT3) | - |
371 | Arg | His | Erythrocytosis,familial,3(ECYT3) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in EGLN1_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 64.2857 | 4 | yes |
GO:0000166 | nucleotide binding | 53.5714 | 4 | no |
GO:0017076 | purine nucleotide binding | 53.5714 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 53.5714 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 53.5714 | 4 | no |
GO:0005524 | ATP binding | 42.8571 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 42.8571 | 6 | no |
GO:0032559 | adenyl ribonucleotide binding | 42.8571 | 5 | no |
GO:0016301 | kinase activity | 32.1429 | 4 | no |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 32.1429 | 4 | no |
GO:0019900 | kinase binding | 28.5714 | 4 | no |
GO:0019901 | protein kinase binding | 28.5714 | 5 | no |
GO:0003723 | RNA binding | 25.0000 | 4 | no |
GO:0043169 | cation binding | 21.4286 | 4 | yes |
GO:0046872 | metal ion binding | 21.4286 | 5 | yes |
GO:0004713 | protein tyrosine kinase activity | 21.4286 | 4 | no |
GO:0005506 | iron ion binding | 7.1429 | 7 | yes |
GO:0008198 | ferrous iron binding | 7.1429 | 8 | yes |
GO:0016706 | 2-oxoglutarate-dependent dioxygenase activity | 7.1429 | 4 | yes |
GO:0031406 | carboxylic acid binding | 7.1429 | 4 | yes |
GO:0031545 | peptidyl-proline 4-dioxygenase activity | 7.1429 | 4 | yes |
GO:0046914 | transition metal ion binding | 7.1429 | 6 | yes |
GO:0160082 | hypoxia-inducible factor-proline dioxygenase activity | 7.1429 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in EGLN1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 82.1429 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 75.0000 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 71.4286 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 71.4286 | 4 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 71.4286 | 5 | yes |
GO:0080090 | regulation of primary metabolic process | 71.4286 | 4 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 67.8571 | 5 | yes |
GO:0010646 | regulation of cell communication | 64.2857 | 4 | no |
GO:0048523 | negative regulation of cellular process | 64.2857 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 64.2857 | 4 | yes |
GO:0010468 | regulation of gene expression | 64.2857 | 6 | yes |
GO:0009966 | regulation of signal transduction | 60.7143 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 60.7143 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 57.1429 | 5 | yes |
GO:0009891 | positive regulation of biosynthetic process | 53.5714 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 53.5714 | 5 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 53.5714 | 6 | yes |
GO:0051128 | regulation of cellular component organization | 53.5714 | 4 | yes |
GO:0010647 | positive regulation of cell communication | 50.0000 | 5 | no |
GO:0023056 | positive regulation of signaling | 50.0000 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 50.0000 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 50.0000 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 50.0000 | 6 | yes |
GO:0009967 | positive regulation of signal transduction | 46.4286 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 46.4286 | 5 | no |
GO:0009894 | regulation of catabolic process | 46.4286 | 4 | yes |
GO:0042127 | regulation of cell population proliferation | 42.8571 | 4 | no |
GO:0042981 | regulation of apoptotic process | 42.8571 | 5 | no |
GO:0043067 | regulation of programmed cell death | 42.8571 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 42.8571 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 42.8571 | 6 | no |
GO:0036211 | protein modification process | 42.8571 | 4 | yes |
GO:0043412 | macromolecule modification | 42.8571 | 4 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 39.2857 | 4 | no |
GO:0006996 | organelle organization | 39.2857 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 39.2857 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 39.2857 | 6 | no |
GO:0031399 | regulation of protein modification process | 39.2857 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 39.2857 | 5 | no |
GO:0006355 | regulation of DNA-templated transcription | 39.2857 | 7 | yes |
GO:0051252 | regulation of RNA metabolic process | 39.2857 | 5 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 39.2857 | 6 | yes |
GO:0008284 | positive regulation of cell population proliferation | 35.7143 | 5 | no |
GO:0051094 | positive regulation of developmental process | 35.7143 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 35.7143 | 6 | no |
GO:0006915 | apoptotic process | 35.7143 | 4 | no |
GO:0008104 | protein localization | 35.7143 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 35.7143 | 6 | no |
GO:0031324 | negative regulation of cellular metabolic process | 35.7143 | 5 | no |
GO:0031401 | positive regulation of protein modification process | 35.7143 | 7 | no |
GO:0042325 | regulation of phosphorylation | 35.7143 | 7 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 35.7143 | 7 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 35.7143 | 5 | yes |
GO:0016310 | phosphorylation | 32.1429 | 5 | no |
GO:0031344 | regulation of cell projection organization | 32.1429 | 5 | no |
GO:0043066 | negative regulation of apoptotic process | 32.1429 | 6 | no |
GO:0043069 | negative regulation of programmed cell death | 32.1429 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 32.1429 | 6 | no |
GO:0001932 | regulation of protein phosphorylation | 32.1429 | 7 | no |
GO:0010628 | positive regulation of gene expression | 32.1429 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 32.1429 | 8 | no |
GO:0018193 | peptidyl-amino acid modification | 32.1429 | 5 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 32.1429 | 4 | no |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 32.1429 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 28.5714 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 28.5714 | 5 | no |
GO:0007010 | cytoskeleton organization | 28.5714 | 5 | no |
GO:0001934 | positive regulation of protein phosphorylation | 28.5714 | 8 | no |
GO:0009890 | negative regulation of biosynthetic process | 28.5714 | 5 | no |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 28.5714 | 6 | no |
GO:0031327 | negative regulation of cellular biosynthetic process | 28.5714 | 6 | no |
GO:0032880 | regulation of protein localization | 28.5714 | 5 | no |
GO:0033043 | regulation of organelle organization | 28.5714 | 5 | no |
GO:0045595 | regulation of cell differentiation | 28.5714 | 4 | no |
GO:0060341 | regulation of cellular localization | 28.5714 | 4 | no |
GO:1903829 | positive regulation of protein localization | 28.5714 | 5 | no |
GO:0022607 | cellular component assembly | 28.5714 | 4 | no |
GO:0006357 | regulation of transcription by RNA polymerase II | 28.5714 | 8 | yes |
GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 28.5714 | 5 | no |
GO:0009968 | negative regulation of signal transduction | 25.0000 | 5 | no |
GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
GO:0030334 | regulation of cell migration | 25.0000 | 5 | no |
GO:0030335 | positive regulation of cell migration | 25.0000 | 6 | no |
GO:0032101 | regulation of response to external stimulus | 25.0000 | 4 | no |
GO:0040017 | positive regulation of locomotion | 25.0000 | 4 | no |
GO:0080134 | regulation of response to stress | 25.0000 | 4 | no |
GO:1902532 | negative regulation of intracellular signal transduction | 25.0000 | 6 | no |
GO:2000145 | regulation of cell motility | 25.0000 | 4 | no |
GO:2000147 | positive regulation of cell motility | 25.0000 | 5 | no |
GO:0009059 | macromolecule biosynthetic process | 25.0000 | 4 | no |
GO:0010629 | negative regulation of gene expression | 25.0000 | 7 | no |
GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
GO:0051049 | regulation of transport | 25.0000 | 4 | no |
GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
GO:0045893 | positive regulation of DNA-templated transcription | 25.0000 | 8 | yes |
GO:0051254 | positive regulation of RNA metabolic process | 25.0000 | 6 | yes |
GO:0051336 | regulation of hydrolase activity | 25.0000 | 4 | yes |
GO:1902680 | positive regulation of RNA biosynthetic process | 25.0000 | 7 | yes |
GO:0006468 | protein phosphorylation | 25.0000 | 5 | no |
GO:0010243 | response to organonitrogen compound | 21.4286 | 4 | no |
GO:0010975 | regulation of neuron projection development | 21.4286 | 7 | no |
GO:0030030 | cell projection organization | 21.4286 | 4 | no |
GO:0031346 | positive regulation of cell projection organization | 21.4286 | 6 | no |
GO:0043408 | regulation of MAPK cascade | 21.4286 | 6 | no |
GO:0051726 | regulation of cell cycle | 21.4286 | 4 | no |
GO:0071310 | cellular response to organic substance | 21.4286 | 4 | no |
GO:0071363 | cellular response to growth factor stimulus | 21.4286 | 4 | no |
GO:0141124 | intracellular signaling cassette | 21.4286 | 4 | no |
GO:0002684 | positive regulation of immune system process | 21.4286 | 4 | no |
GO:0097435 | supramolecular fiber organization | 21.4286 | 4 | no |
GO:0009896 | positive regulation of catabolic process | 21.4286 | 5 | no |
GO:0031329 | regulation of cellular catabolic process | 21.4286 | 5 | no |
GO:0033674 | positive regulation of kinase activity | 21.4286 | 6 | no |
GO:0043549 | regulation of kinase activity | 21.4286 | 5 | no |
GO:0045597 | positive regulation of cell differentiation | 21.4286 | 5 | no |
GO:0045859 | regulation of protein kinase activity | 21.4286 | 6 | no |
GO:0045860 | positive regulation of protein kinase activity | 21.4286 | 7 | no |
GO:0050776 | regulation of immune response | 21.4286 | 4 | no |
GO:0051338 | regulation of transferase activity | 21.4286 | 4 | no |
GO:0051347 | positive regulation of transferase activity | 21.4286 | 5 | no |
GO:0001817 | regulation of cytokine production | 21.4286 | 4 | no |
GO:0072657 | protein localization to membrane | 21.4286 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 21.4286 | 4 | yes |
GO:0036293 | response to decreased oxygen levels | 21.4286 | 4 | yes |
GO:2000026 | regulation of multicellular organismal development | 21.4286 | 4 | yes |
GO:0036294 | cellular response to decreased oxygen levels | 17.8571 | 5 | yes |
GO:0045944 | positive regulation of transcription by RNA polymerase II | 17.8571 | 9 | yes |
GO:0071453 | cellular response to oxygen levels | 17.8571 | 4 | yes |
GO:0006873 | intracellular monoatomic ion homeostasis | 14.2857 | 4 | yes |
GO:0030003 | intracellular monoatomic cation homeostasis | 14.2857 | 5 | yes |
GO:0043086 | negative regulation of catalytic activity | 14.2857 | 4 | yes |
GO:0050807 | regulation of synapse organization | 14.2857 | 5 | yes |
GO:0051346 | negative regulation of hydrolase activity | 14.2857 | 5 | yes |
GO:0055080 | monoatomic cation homeostasis | 14.2857 | 4 | yes |
GO:0071456 | cellular response to hypoxia | 14.2857 | 4 | yes |
GO:0045765 | regulation of angiogenesis | 10.7143 | 5 | yes |
GO:0140250 | regulation protein catabolic process at synapse | 10.7143 | 5 | yes |
GO:0140252 | regulation protein catabolic process at postsynapse | 10.7143 | 6 | yes |
GO:1901342 | regulation of vasculature development | 10.7143 | 5 | yes |
GO:0006879 | intracellular iron ion homeostasis | 7.1429 | 4 | yes |
GO:0018126 | protein hydroxylation | 7.1429 | 5 | yes |
GO:0018208 | peptidyl-proline modification | 7.1429 | 6 | yes |
GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | 7.1429 | 5 | yes |
GO:0019471 | 4-hydroxyproline metabolic process | 7.1429 | 4 | yes |
GO:0019511 | peptidyl-proline hydroxylation | 7.1429 | 6 | yes |
GO:0019752 | carboxylic acid metabolic process | 7.1429 | 5 | yes |
GO:0032364 | intracellular oxygen homeostasis | 7.1429 | 4 | yes |
GO:0043433 | negative regulation of DNA-binding transcription factor activity | 7.1429 | 4 | yes |
GO:0043436 | oxoacid metabolic process | 7.1429 | 4 | yes |
GO:0051342 | regulation of cyclic-nucleotide phosphodiesterase activity | 7.1429 | 5 | yes |
GO:0051344 | negative regulation of cyclic-nucleotide phosphodiesterase activity | 7.1429 | 6 | yes |
GO:0055008 | cardiac muscle tissue morphogenesis | 7.1429 | 5 | yes |
GO:0060347 | heart trabecula formation | 7.1429 | 4 | yes |
GO:0060412 | ventricular septum morphogenesis | 7.1429 | 4 | yes |
GO:0060415 | muscle tissue morphogenesis | 7.1429 | 4 | yes |
GO:0071731 | response to nitric oxide | 7.1429 | 4 | yes |
GO:0099159 | regulation of modification of postsynaptic structure | 7.1429 | 7 | yes |
GO:0170033 | L-amino acid metabolic process | 7.1429 | 5 | yes |
GO:0170041 | non-proteinogenic amino acid metabolic process | 7.1429 | 4 | yes |
GO:1901605 | alpha-amino acid metabolic process | 7.1429 | 4 | yes |
GO:1905244 | regulation of modification of synaptic structure | 7.1429 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
FKBP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HIF1A_HUMAN | [view interactions] | Low throughput | no | no |
OS9_HUMAN | [view interactions] | Low throughput | no | yes |
EPAS1_HUMAN | [view interactions] | Low throughput | no | no |
KPYM_HUMAN | [view interactions] | Low throughput | no | yes |
ING4_HUMAN | [view interactions] | Low throughput | no | no |
MAGAB_HUMAN | [view interactions] | Low throughput | no | no |
RPB1_HUMAN | [view interactions] | Low throughput | no | no |
OSR1_HUMAN | [view interactions] | Low throughput | no | no |
SIAH2_HUMAN | [view interactions] | Low throughput | no | no |
EGLN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EGLN3_HUMAN | [view interactions] | Low throughput | no | no |
SPY2_HUMAN | [view interactions] | Low throughput | no | yes |
SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
VHL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MAGA9_HUMAN | [view interactions] | Low throughput | no | no |
PLD1_HUMAN | [view interactions] | Low throughput | no | no |
PLD2_HUMAN | [view interactions] | Low throughput | no | yes |
PHLD_HUMAN | [view interactions] | Low throughput | no | no |
TEBP_HUMAN | [view interactions] | Low throughput | no | yes |
HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HS90B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MTG16_HUMAN | [view interactions] | Low throughput | no | yes |
RUNX3_HUMAN | [view interactions] | Low throughput | no | no |
SH3K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TET2_HUMAN | [view interactions] | Low throughput | no | yes |
TET3_HUMAN | [view interactions] | Low throughput | no | yes |
TBK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MTG8_HUMAN | [view interactions] | Low throughput | no | yes |
IASPP_HUMAN | [view interactions] | Low throughput | no | yes |
YAP1_HUMAN | [view interactions] | Low throughput | no | yes |
TAZ_HUMAN | [view interactions] | Low throughput | no | yes |
NACAM_HUMAN | [view interactions] | Low throughput | no | no |
H31_HUMAN | [view interactions] | Low throughput | no | yes |
SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
ERP29_HUMAN | [view interactions] | High throughput | no | yes |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZN281_HUMAN | [view interactions] | High throughput | no | no |
MKS1_HUMAN | [view interactions] | High throughput | no | no |
CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
FGFR4_HUMAN | [view interactions] | High throughput | no | no |
VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
LIMD1_HUMAN | [view interactions] | High throughput | no | yes |
RFPLB_HUMAN | [view interactions] | High throughput | no | no |
PEX19_HUMAN | [view interactions] | High throughput | no | yes |
SPN1_HUMAN | [view interactions] | High throughput | no | yes |
ZNG1A_HUMAN | [view interactions] | High throughput | no | yes |
ZNG1B_HUMAN | [view interactions] | High throughput | no | no |
RHBT3_HUMAN | [view interactions] | High throughput | no | no |
FKBP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EFMT1_HUMAN | [view interactions] | High throughput | no | no |
AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
ARNT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KEAP1_HUMAN | [view interactions] | High throughput | no | yes |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
ABC3C_HUMAN | [view interactions] | High throughput | no | no |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
CITE1_HUMAN | [view interactions] | High throughput | no | no |
CLU_HUMAN | [view interactions] | High throughput | no | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
DVL2_HUMAN | [view interactions] | High throughput | no | yes |
SPOP_HUMAN | [view interactions] | High throughput | no | no |
ATG12_HUMAN | [view interactions] | High throughput | no | yes |
SPPL3_HUMAN | [view interactions] | High throughput | no | no |
ANKY2_HUMAN | [view interactions] | High throughput | no | no |
PYGL_HUMAN | [view interactions] | High throughput | no | yes |
OXSR1_HUMAN | [view interactions] | High throughput | no | yes |
BPNT1_HUMAN | [view interactions] | High throughput | no | yes |
KPRA_HUMAN | [view interactions] | High throughput | no | no |
FA98B_HUMAN | [view interactions] | High throughput | no | yes |
RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RPB3_HUMAN | [view interactions] | High throughput | no | yes |
TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |