TBK1_HUMAN
Evidence for PS localization
Functions
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed, PubMed, PubMed, PubMed). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed, PubMed, PubMed). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed, PubMed). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed, PubMed). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on Ser-177, thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed). Phosphorylates and activates AKT1 (PubMed). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity . Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed). Phosphorylates Borna disease virus (BDV) P protein (PubMed). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TBK1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 30.7692 | 4 | no |
| GO:0017076 | purine nucleotide binding | 28.5714 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 28.5714 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 28.5714 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 28.5714 | 5 | yes |
| GO:0005524 | ATP binding | 27.4725 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.4725 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 9.8901 | 4 | yes |
| GO:0016301 | kinase activity | 9.8901 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 9.8901 | 4 | yes |
| GO:0019902 | phosphatase binding | 8.7912 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 7.6923 | 4 | yes |
| GO:0019903 | protein phosphatase binding | 7.6923 | 5 | yes |
| GO:0106310 | protein serine kinase activity | 7.6923 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TBK1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.9341 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 62.6374 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 61.5385 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 61.5385 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 61.5385 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 53.8462 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 51.6484 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 47.2527 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 46.1538 | 4 | no |
| GO:0010646 | regulation of cell communication | 46.1538 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 46.1538 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 43.9560 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 43.9560 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 43.9560 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 41.7582 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 41.7582 | 4 | no |
| GO:0010468 | regulation of gene expression | 41.7582 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 41.7582 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 40.6593 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 36.2637 | 4 | yes |
| GO:0036211 | protein modification process | 36.2637 | 4 | yes |
| GO:0043412 | macromolecule modification | 36.2637 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 35.1648 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 34.0659 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 34.0659 | 6 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 32.9670 | 6 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 32.9670 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 32.9670 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 32.9670 | 6 | yes |
| GO:0048584 | positive regulation of response to stimulus | 31.8681 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 31.8681 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 31.8681 | 5 | no |
| GO:0080134 | regulation of response to stress | 30.7692 | 4 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 30.7692 | 6 | yes |
| GO:0051252 | regulation of RNA metabolic process | 29.6703 | 5 | yes |
| GO:0010941 | regulation of cell death | 29.6703 | 4 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 28.5714 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 28.5714 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 28.5714 | 6 | yes |
| GO:0023056 | positive regulation of signaling | 28.5714 | 4 | yes |
| GO:0022607 | cellular component assembly | 27.4725 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 27.4725 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 27.4725 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.4725 | 5 | no |
| GO:0060341 | regulation of cellular localization | 27.4725 | 4 | no |
| GO:0009894 | regulation of catabolic process | 27.4725 | 4 | yes |
| GO:0008104 | protein localization | 26.3736 | 4 | no |
| GO:0032880 | regulation of protein localization | 26.3736 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 26.3736 | 7 | yes |
| GO:0010628 | positive regulation of gene expression | 26.3736 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 26.3736 | 7 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 25.2747 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 25.2747 | 6 | yes |
| GO:0051049 | regulation of transport | 25.2747 | 4 | no |
| GO:0006996 | organelle organization | 25.2747 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.2747 | 6 | yes |
| GO:0031401 | positive regulation of protein modification process | 25.2747 | 7 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 24.1758 | 6 | no |
| GO:0033043 | regulation of organelle organization | 24.1758 | 5 | no |
| GO:0071702 | organic substance transport | 24.1758 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 24.1758 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 23.0769 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 23.0769 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.0769 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.0769 | 4 | no |
| GO:0051338 | regulation of transferase activity | 23.0769 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.0769 | 4 | no |
| GO:0070201 | regulation of establishment of protein localization | 23.0769 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 23.0769 | 5 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 20.8791 | 6 | yes |
| GO:0048585 | negative regulation of response to stimulus | 20.8791 | 4 | no |
| GO:0015031 | protein transport | 20.8791 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.8791 | 4 | no |
| GO:0071310 | cellular response to organic substance | 20.8791 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 20.8791 | 8 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.8791 | 6 | yes |
| GO:0032101 | regulation of response to external stimulus | 20.8791 | 4 | yes |
| GO:0042327 | positive regulation of phosphorylation | 20.8791 | 8 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.8791 | 7 | yes |
| GO:0050776 | regulation of immune response | 19.7802 | 4 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 18.6813 | 6 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 18.6813 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 17.5824 | 4 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 17.5824 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 17.5824 | 8 | yes |
| GO:0010629 | negative regulation of gene expression | 17.5824 | 6 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 17.5824 | 7 | yes |
| GO:0001817 | regulation of cytokine production | 16.4835 | 4 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 16.4835 | 7 | yes |
| GO:0031347 | regulation of defense response | 16.4835 | 5 | yes |
| GO:0002684 | positive regulation of immune system process | 15.3846 | 4 | yes |
| GO:0016310 | phosphorylation | 15.3846 | 5 | yes |
| GO:0002831 | regulation of response to biotic stimulus | 14.2857 | 4 | yes |
| GO:0006468 | protein phosphorylation | 14.2857 | 5 | yes |
| GO:0009896 | positive regulation of catabolic process | 14.2857 | 5 | yes |
| GO:0018193 | peptidyl-amino acid modification | 14.2857 | 5 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 14.2857 | 8 | yes |
| GO:0001819 | positive regulation of cytokine production | 13.1868 | 5 | yes |
| GO:0010506 | regulation of autophagy | 13.1868 | 6 | yes |
| GO:0032103 | positive regulation of response to external stimulus | 13.1868 | 5 | yes |
| GO:0031331 | positive regulation of cellular catabolic process | 10.9890 | 6 | yes |
| GO:0050778 | positive regulation of immune response | 9.8901 | 5 | yes |
| GO:0032479 | regulation of type I interferon production | 9.8901 | 5 | yes |
| GO:0045088 | regulation of innate immune response | 9.8901 | 5 | yes |
| GO:1901214 | regulation of neuron death | 8.7912 | 5 | yes |
| GO:0002833 | positive regulation of response to biotic stimulus | 8.7912 | 5 | yes |
| GO:0016241 | regulation of macroautophagy | 8.7912 | 7 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 8.7912 | 6 | yes |
| GO:0018209 | peptidyl-serine modification | 8.7912 | 6 | yes |
| GO:0031349 | positive regulation of defense response | 7.6923 | 5 | yes |
| GO:0032481 | positive regulation of type I interferon production | 7.6923 | 6 | yes |
| GO:0033135 | regulation of peptidyl-serine phosphorylation | 7.6923 | 8 | yes |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 7.6923 | 9 | yes |
| GO:0043122 | regulation of I-kappaB kinase/NF-kappaB signaling | 7.6923 | 6 | yes |
| GO:0060759 | regulation of response to cytokine stimulus | 6.5934 | 4 | yes |
| GO:0001959 | regulation of cytokine-mediated signaling pathway | 6.5934 | 5 | yes |
| GO:0006954 | inflammatory response | 6.5934 | 4 | yes |
| GO:0010508 | positive regulation of autophagy | 6.5934 | 7 | yes |
| GO:0018107 | peptidyl-threonine phosphorylation | 6.5934 | 6 | yes |
| GO:0018210 | peptidyl-threonine modification | 6.5934 | 6 | yes |
| GO:0032648 | regulation of interferon-beta production | 6.5934 | 6 | yes |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 6.5934 | 7 | yes |
| GO:0045089 | positive regulation of innate immune response | 6.5934 | 6 | yes |
| GO:0051607 | defense response to virus | 5.4945 | 4 | yes |
| GO:0140546 | defense response to symbiont | 5.4945 | 4 | yes |
| GO:0007249 | I-kappaB kinase/NF-kappaB signaling | 5.4945 | 4 | yes |
| GO:0032728 | positive regulation of interferon-beta production | 5.4945 | 7 | yes |
| GO:0050830 | defense response to Gram-positive bacterium | 4.3956 | 5 | yes |
| GO:0060338 | regulation of type I interferon-mediated signaling pathway | 4.3956 | 6 | yes |
| GO:0042742 | defense response to bacterium | 4.3956 | 4 | yes |
| GO:0060760 | positive regulation of response to cytokine stimulus | 3.2967 | 5 | yes |
| GO:0001961 | positive regulation of cytokine-mediated signaling pathway | 3.2967 | 6 | yes |
| GO:0016239 | positive regulation of macroautophagy | 3.2967 | 8 | yes |
| GO:0032647 | regulation of interferon-alpha production | 3.2967 | 6 | yes |
| GO:0032727 | positive regulation of interferon-alpha production | 3.2967 | 7 | yes |
| GO:0032943 | mononuclear cell proliferation | 3.2967 | 4 | yes |
| GO:0044565 | dendritic cell proliferation | 3.2967 | 5 | yes |
| GO:0060340 | positive regulation of type I interferon-mediated signaling pathway | 2.1978 | 7 | yes |
| GO:1904415 | regulation of xenophagy | 2.1978 | 5 | yes |
| GO:1904417 | positive regulation of xenophagy | 2.1978 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in TBK1_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 3.2967 | 4 | yes |
| DOID:331 | central nervous system disease | 3.2967 | 3 | yes |
| DOID:0050686 | organ system cancer | 3.2967 | 3 | no |
| DOID:0110069 | frontotemporal dementia and/or amyotrophic lateral sclerosis-4 | 2.1978 | 7 | yes |
| DOID:231 | motor neuron disease | 2.1978 | 5 | yes |
| DOID:332 | amyotrophic lateral sclerosis | 2.1978 | 6 | yes |
| DOID:10780 | primary polycythemia | 2.1978 | 5 | no |
| DOID:4961 | bone marrow disease | 2.1978 | 3 | no |
| DOID:8432 | polycythemia | 2.1978 | 4 | no |
| DOID:0050700 | cardiomyopathy | 2.1978 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 2.1978 | 5 | no |
| DOID:114 | heart disease | 2.1978 | 3 | no |
| DOID:2843 | long QT syndrome | 2.1978 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| PELI1_HUMAN | [view interactions] | Low throughput | no | yes |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| TRI26_HUMAN | [view interactions] | Low throughput | no | yes |
| DYRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| TRI14_HUMAN | [view interactions] | Low throughput | no | yes |
| CTBL1_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF6_HUMAN | [view interactions] | Low throughput | no | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GSK3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RN128_HUMAN | [view interactions] | Low throughput | no | yes |
| HERP1_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF5_HUMAN | [view interactions] | Low throughput | no | yes |
| TRI23_HUMAN | [view interactions] | Low throughput | no | yes |
| YAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| WDR48_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBP1_HUMAN | [view interactions] | Low throughput | no | yes |
| ZC12A_HUMAN | [view interactions] | Low throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KS6B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| R144B_HUMAN | [view interactions] | Low throughput | no | yes |
| TFG_HUMAN | [view interactions] | Low throughput | no | yes |
| NACC1_HUMAN | [view interactions] | Low throughput | no | yes |
| PSMF1_HUMAN | [view interactions] | Low throughput | no | yes |
| SC16A_HUMAN | [view interactions] | Low throughput | no | yes |
| UBE2S_HUMAN | [view interactions] | Low throughput | no | no |
| UBP15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | Low throughput | no | yes |
| VHL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EGLN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PPM1B_HUMAN | [view interactions] | Low throughput | no | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TANK_HUMAN | [view interactions] | Low throughput | no | yes |
| IRF7_HUMAN | [view interactions] | Low throughput | no | yes |
| CDC20_HUMAN | [view interactions] | Low throughput | no | no |
| DAPK3_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | Low throughput | no | yes |
| UBP19_HUMAN | [view interactions] | Low throughput | no | no |
| TBKB1_HUMAN | [view interactions] | Low throughput | no | no |
| OPTN_HUMAN | [view interactions] | Low throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RBCC1_HUMAN | [view interactions] | Low throughput | no | no |
| IRF3_HUMAN | [view interactions] | Low throughput | no | yes |
| TCAM1_HUMAN | [view interactions] | Low throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | Low throughput | no | yes |
| STAT6_HUMAN | [view interactions] | Low throughput | no | yes |
| IRF1_HUMAN | [view interactions] | Low throughput | no | yes |
| CACO2_HUMAN | [view interactions] | Low throughput | no | yes |
| MBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AZI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IKBA_HUMAN | [view interactions] | Low throughput | no | yes |
| STING_HUMAN | [view interactions] | Low throughput | no | yes |
| MAVS_HUMAN | [view interactions] | Low throughput | no | yes |
| SMCR8_HUMAN | [view interactions] | Low throughput | no | yes |
| RO52_HUMAN | [view interactions] | Low throughput | no | yes |
| RIPK1_HUMAN | [view interactions] | Low throughput | no | yes |
| CRTC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | Low throughput | no | no |
| LMO7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LEG3_HUMAN | [view interactions] | Low throughput | no | yes |
| IKKE_HUMAN | [view interactions] | Low throughput | no | yes |
| MIB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MIB2_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K14_HUMAN | [view interactions] | Low throughput | no | yes |
| RIOK3_HUMAN | [view interactions] | Low throughput | no | yes |
| ZBP1_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DDX41_HUMAN | [view interactions] | Low throughput | no | yes |
| ICOS_HUMAN | [view interactions] | Low throughput | no | no |
| TTC4_HUMAN | [view interactions] | Low throughput | no | yes |
| T3JAM_HUMAN | [view interactions] | Low throughput | no | no |
| XIAP_HUMAN | [view interactions] | Low throughput | no | yes |
| CI072_HUMAN | [view interactions] | Low throughput | no | no |
| G3P_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IKKB_HUMAN | [view interactions] | Low throughput | no | yes |
| TNAP3_HUMAN | [view interactions] | Low throughput | no | yes |
| PBIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TF65_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCK1_HUMAN | [view interactions] | Low throughput | no | yes |
| NCOA2_HUMAN | [view interactions] | Low throughput | no | no |
| NALP4_HUMAN | [view interactions] | Low throughput | no | no |
| DTX4_HUMAN | [view interactions] | Low throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | Low throughput | no | yes |
| RNF41_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAIP_HUMAN | [view interactions] | Low throughput | no | yes |
| TRI27_HUMAN | [view interactions] | Low throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RNF11_HUMAN | [view interactions] | Low throughput | no | yes |
| CIKS_HUMAN | [view interactions] | Low throughput | no | yes |
| DDX58_HUMAN | [view interactions] | Low throughput | no | yes |
| TRI11_HUMAN | [view interactions] | Low throughput | no | yes |
| AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SOCS3_HUMAN | [view interactions] | Low throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| CLC14_HUMAN | [view interactions] | High throughput | no | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| MYD88_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ULK1_HUMAN | [view interactions] | High throughput | no | no |
| RRAGD_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| PHIP_HUMAN | [view interactions] | High throughput | no | yes |
| IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LR10B_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| S10A6_HUMAN | [view interactions] | High throughput | no | yes |
| BL1S6_HUMAN | [view interactions] | High throughput | no | yes |
| CENPQ_HUMAN | [view interactions] | High throughput | no | yes |
| FLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IRAK3_HUMAN | [view interactions] | High throughput | no | yes |
| HVCN1_HUMAN | [view interactions] | High throughput | no | yes |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KR197_HUMAN | [view interactions] | High throughput | no | no |
| S100P_HUMAN | [view interactions] | High throughput | no | no |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| PIP_HUMAN | [view interactions] | High throughput | no | no |
| NAA10_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| D2HDH_HUMAN | [view interactions] | High throughput | no | no |
| CRBB3_HUMAN | [view interactions] | High throughput | no | no |
| ARL4D_HUMAN | [view interactions] | High throughput | no | no |
| ST1C4_HUMAN | [view interactions] | High throughput | no | no |
| GROA_HUMAN | [view interactions] | High throughput | no | no |
| LEG8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| PROS_HUMAN | [view interactions] | High throughput | no | no |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| STX11_HUMAN | [view interactions] | High throughput | no | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG12_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP3_HUMAN | [view interactions] | High throughput | no | no |
| ATG3_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| AGO2_HUMAN | [view interactions] | High throughput | no | yes |
| TXLNA_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP5_HUMAN | [view interactions] | High throughput | no | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMMR_HUMAN | [view interactions] | High throughput | no | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRCKG_HUMAN | [view interactions] | High throughput | no | no |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| PAPD1_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| TXLNG_HUMAN | [view interactions] | High throughput | no | no |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT9_HUMAN | [view interactions] | High throughput | no | yes |
| GRRE1_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| MEX3B_HUMAN | [view interactions] | High throughput | no | no |
| PATL1_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| PRP19_HUMAN | [view interactions] | High throughput | no | yes |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OBI1_HUMAN | [view interactions] | High throughput | no | yes |
| APBA3_HUMAN | [view interactions] | High throughput | no | yes |
| SMAG2_HUMAN | [view interactions] | High throughput | no | yes |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| STX19_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXLNB_HUMAN | [view interactions] | High throughput | no | no |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BODG_HUMAN | [view interactions] | High throughput | no | no |
| DPCD_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA3_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNR6B_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6C_HUMAN | [view interactions] | High throughput | no | no |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| TTP_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| DCP1A_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARF1_HUMAN | [view interactions] | High throughput | no | yes |
| RN214_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO1_HUMAN | [view interactions] | High throughput | no | yes |
| SIR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RARA_HUMAN | [view interactions] | High throughput | no | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PO210_HUMAN | [view interactions] | High throughput | no | yes |
| AMOT_HUMAN | [view interactions] | High throughput | no | no |
| PXK_HUMAN | [view interactions] | High throughput | no | yes |
| BORC6_HUMAN | [view interactions] | High throughput | no | yes |
| SKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
| RPB3_HUMAN | [view interactions] | High throughput | no | yes |
| CASL_HUMAN | [view interactions] | High throughput | no | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| OSBL3_HUMAN | [view interactions] | High throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M3K4_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| FMNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOXJ3_HUMAN | [view interactions] | High throughput | no | no |
| UBR5_HUMAN | [view interactions] | High throughput | no | no |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NONO_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| TBB4A_HUMAN | [view interactions] | High throughput | no | yes |
| RLA0L_HUMAN | [view interactions] | High throughput | no | no |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA3C_HUMAN | [view interactions] | High throughput | no | no |
| TBA3D_HUMAN | [view interactions] | High throughput | no | no |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| ODFP2_HUMAN | [view interactions] | High throughput | no | no |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| STIL_HUMAN | [view interactions] | High throughput | no | no |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| SAS6_HUMAN | [view interactions] | High throughput | no | no |
| CNTRB_HUMAN | [view interactions] | High throughput | no | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| CEP44_HUMAN | [view interactions] | High throughput | no | yes |
| ADIP_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| WHRN_HUMAN | [view interactions] | High throughput | no | no |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| REL_HUMAN | [view interactions] | High throughput | no | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| PP6R1_HUMAN | [view interactions] | High throughput | no | no |
| NFKB2_HUMAN | [view interactions] | High throughput | no | yes |
| PPP6_HUMAN | [view interactions] | High throughput | no | yes |
| SKP1_HUMAN | [view interactions] | High throughput | no | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| TLR4_HUMAN | [view interactions] | High throughput | no | yes |
| TLR9_HUMAN | [view interactions] | High throughput | no | no |
| TLR3_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM70_HUMAN | [view interactions] | High throughput | no | yes |
| KSYK_HUMAN | [view interactions] | High throughput | no | no |
| EXOC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| STX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI10_HUMAN | [view interactions] | High throughput | no | no |
| IFIT3_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC6_HUMAN | [view interactions] | Computational | no | yes |
| IL37_HUMAN | [view interactions] | Computational | no | no |
| IF16_HUMAN | [view interactions] | Computational | no | no |
| RN135_HUMAN | [view interactions] | Computational | no | yes |
| TCAM2_HUMAN | [view interactions] | Computational | no | no |
| IL18R_HUMAN | [view interactions] | Computational | no | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SIKE1_HUMAN | [view interactions] | Computational | no | yes |
| IFNB_HUMAN | [view interactions] | Computational | no | no |
| NLRC3_HUMAN | [view interactions] | Computational | no | no |
| TRI25_HUMAN | [view interactions] | Computational | no | yes |
| RALB_HUMAN | [view interactions] | Computational | no | no |
| CGAS_HUMAN | [view interactions] | Computational | no | yes |
| PRKDC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PTN11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SIGIR_HUMAN | [view interactions] | Computational | no | no |
| XRCC5_HUMAN | [view interactions] | Computational | no | yes |
| MRE11_HUMAN | [view interactions] | Computational | no | yes |