Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ABR_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed, PubMed). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed). Functions as an important negative regulator of neuronal RAC1 activity . Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ABR_HUMAN
GO:0000166 nucleotide binding 36.0000 4 no
GO:0017076 purine nucleotide binding 36.0000 5 no
GO:0032555 purine ribonucleotide binding 36.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 36.0000 4 no
GO:0043168 anion binding 36.0000 4 no
GO:0019900 kinase binding 24.0000 4 no
GO:0005096 GTPase activator activity 12.0000 4 yes
GO:0030695 GTPase regulator activity 12.0000 4 yes
GO:0005085 guanyl-nucleotide exchange factor activity 8.0000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ABR_HUMAN
GO:0010646 regulation of cell communication 72.0000 4 yes
GO:0048523 negative regulation of cellular process 68.0000 4 no
GO:0009966 regulation of signal transduction 64.0000 4 yes
GO:0048522 positive regulation of cellular process 64.0000 4 no
GO:0031323 regulation of cellular metabolic process 60.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 56.0000 4 no
GO:0009892 negative regulation of metabolic process 52.0000 4 no
GO:0009889 regulation of biosynthetic process 48.0000 4 no
GO:0010468 regulation of gene expression 48.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 48.0000 5 no
GO:0010647 positive regulation of cell communication 48.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 48.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 48.0000 5 no
GO:0080090 regulation of primary metabolic process 48.0000 4 no
GO:1902531 regulation of intracellular signal transduction 44.0000 5 yes
GO:0009893 positive regulation of metabolic process 44.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 44.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 44.0000 5 no
GO:0023056 positive regulation of signaling 44.0000 4 no
GO:0051128 regulation of cellular component organization 44.0000 4 no
GO:0051246 regulation of protein metabolic process 44.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 no
GO:0141124 intracellular signaling cassette 40.0000 4 yes
GO:0009890 negative regulation of biosynthetic process 40.0000 5 no
GO:0009967 positive regulation of signal transduction 40.0000 5 no
GO:0048584 positive regulation of response to stimulus 40.0000 4 no
GO:0051247 positive regulation of protein metabolic process 40.0000 6 no
GO:0051240 positive regulation of multicellular organismal process 36.0000 4 no
GO:2000145 regulation of cell motility 36.0000 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 36.0000 6 no
GO:0010629 negative regulation of gene expression 36.0000 7 no
GO:0031327 negative regulation of cellular biosynthetic process 36.0000 6 no
GO:0008104 protein localization 36.0000 4 no
GO:0022607 cellular component assembly 36.0000 4 no
GO:0030334 regulation of cell migration 36.0000 5 no
GO:0031399 regulation of protein modification process 32.0000 6 no
GO:0031401 positive regulation of protein modification process 32.0000 7 no
GO:0040017 positive regulation of locomotion 32.0000 4 no
GO:0042325 regulation of phosphorylation 32.0000 7 no
GO:0042327 positive regulation of phosphorylation 32.0000 8 no
GO:0045937 positive regulation of phosphate metabolic process 32.0000 7 no
GO:0051174 regulation of phosphorus metabolic process 32.0000 5 no
GO:0051252 regulation of RNA metabolic process 32.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 32.0000 6 no
GO:2000147 positive regulation of cell motility 32.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 32.0000 6 no
GO:0006915 apoptotic process 32.0000 4 no
GO:0051726 regulation of cell cycle 32.0000 4 no
GO:0001817 regulation of cytokine production 32.0000 4 no
GO:0001932 regulation of protein phosphorylation 32.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 32.0000 8 no
GO:0006355 regulation of DNA-templated transcription 32.0000 7 no
GO:0006996 organelle organization 32.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 32.0000 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.0000 5 no
GO:0019220 regulation of phosphate metabolic process 32.0000 6 no
GO:0030335 positive regulation of cell migration 32.0000 6 no
GO:0031344 regulation of cell projection organization 28.0000 5 no
GO:0044057 regulation of system process 28.0000 4 no
GO:0051049 regulation of transport 28.0000 4 no
GO:0051130 positive regulation of cellular component organization 28.0000 5 no
GO:0051241 negative regulation of multicellular organismal process 28.0000 4 no
GO:0043085 positive regulation of catalytic activity 28.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 28.0000 5 yes
GO:0051336 regulation of hydrolase activity 28.0000 4 yes
GO:0099177 regulation of trans-synaptic signaling 28.0000 4 yes
GO:0009894 regulation of catabolic process 28.0000 4 no
GO:0009968 negative regulation of signal transduction 28.0000 5 no
GO:0010648 negative regulation of cell communication 28.0000 5 no
GO:0023057 negative regulation of signaling 28.0000 4 no
GO:0036211 protein modification process 28.0000 4 no
GO:0042127 regulation of cell population proliferation 28.0000 4 no
GO:0042981 regulation of apoptotic process 28.0000 5 no
GO:0043067 regulation of programmed cell death 28.0000 4 no
GO:0043412 macromolecule modification 28.0000 4 no
GO:0048585 negative regulation of response to stimulus 28.0000 4 no
GO:0006357 regulation of transcription by RNA polymerase II 28.0000 8 no
GO:0030030 cell projection organization 28.0000 4 no
GO:0031328 positive regulation of cellular biosynthetic process 24.0000 6 no
GO:0033043 regulation of organelle organization 24.0000 5 no
GO:0043408 regulation of MAPK cascade 24.0000 6 no
GO:0043549 regulation of kinase activity 24.0000 5 no
GO:0044087 regulation of cellular component biogenesis 24.0000 4 no
GO:0045859 regulation of protein kinase activity 24.0000 6 no
GO:0051094 positive regulation of developmental process 24.0000 4 no
GO:0051338 regulation of transferase activity 24.0000 4 no
GO:0097435 supramolecular fiber organization 24.0000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 24.0000 6 no
GO:0120036 plasma membrane bounded cell projection organization 24.0000 5 no
GO:0007264 small GTPase-mediated signal transduction 24.0000 5 yes
GO:0006468 protein phosphorylation 24.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 24.0000 4 no
GO:0016310 phosphorylation 24.0000 5 no
GO:0002684 positive regulation of immune system process 24.0000 4 no
GO:0009891 positive regulation of biosynthetic process 24.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 24.0000 6 no
GO:0010628 positive regulation of gene expression 24.0000 7 no
GO:0022603 regulation of anatomical structure morphogenesis 24.0000 4 no
GO:0051345 positive regulation of hydrolase activity 20.0000 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 16.0000 6 yes
GO:0043087 regulation of GTPase activity 8.0000 5 yes
GO:0043547 positive regulation of GTPase activity 8.0000 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ADA1A_HUMAN [view entry] [view interactions] Low throughput yes no
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
TRPV2_HUMAN [view interactions] High throughput no yes
RAB38_HUMAN [view interactions] High throughput no no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
TOM20_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2_HUMAN [view interactions] High throughput no no
AURKB_HUMAN [view interactions] High throughput no yes
CDN1A_HUMAN [view interactions] High throughput no no
CP250_HUMAN [view interactions] High throughput no no
CEP57_HUMAN [view interactions] High throughput no yes
CEP76_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CCAR1_HUMAN [view interactions] High throughput no yes
CHCH2_HUMAN [view interactions] High throughput no yes
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
DOCK4_HUMAN [view entry] [view interactions] High throughput yes no
IMDH2_HUMAN [view interactions] High throughput no yes
KCD12_HUMAN [view entry] [view interactions] High throughput yes no
MCM3_HUMAN [view interactions] High throughput no no
IASPP_HUMAN [view interactions] High throughput no yes
SMRC1_HUMAN [view interactions] High throughput no yes
ATIF1_HUMAN [view interactions] High throughput no yes
BOLA2_HUMAN [view interactions] High throughput no yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
HAX1_HUMAN [view interactions] High throughput no no
MGAP_HUMAN [view interactions] High throughput no yes
PRC2A_HUMAN [view interactions] High throughput no yes
TOM40_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
CSK23_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
PJA1_HUMAN [view interactions] High throughput no yes
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes
SRGP3_HUMAN [view entry] [view interactions] High throughput yes yes
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes