ABR_HUMAN
Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed, PubMed). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed). Functions as an important negative regulator of neuronal RAC1 activity . Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ABR_HUMAN |
---|---|---|---|---|
GO:0019900 | kinase binding | 35.0000 | 4 | no |
GO:0019901 | protein kinase binding | 35.0000 | 5 | no |
GO:0017076 | purine nucleotide binding | 30.0000 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 30.0000 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 30.0000 | 4 | no |
GO:0030695 | GTPase regulator activity | 15.0000 | 4 | yes |
GO:0005085 | guanyl-nucleotide exchange factor activity | 10.0000 | 5 | yes |
GO:0005096 | GTPase activator activity | 10.0000 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ABR_HUMAN |
---|---|---|---|---|
GO:0010646 | regulation of cell communication | 65.0000 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 65.0000 | 4 | no |
GO:0009966 | regulation of signal transduction | 60.0000 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 60.0000 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 55.0000 | 5 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 55.0000 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | no |
GO:0010647 | positive regulation of cell communication | 50.0000 | 5 | no |
GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
GO:0010468 | regulation of gene expression | 45.0000 | 5 | no |
GO:0051049 | regulation of transport | 45.0000 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 45.0000 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 45.0000 | 5 | no |
GO:0023056 | positive regulation of signaling | 45.0000 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 45.0000 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 45.0000 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 45.0000 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 45.0000 | 6 | no |
GO:0008104 | protein localization | 40.0000 | 4 | no |
GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 40.0000 | 7 | no |
GO:0001934 | positive regulation of protein phosphorylation | 40.0000 | 8 | no |
GO:0006996 | organelle organization | 40.0000 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 40.0000 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 40.0000 | 6 | no |
GO:0019220 | regulation of phosphate metabolic process | 40.0000 | 6 | no |
GO:0030334 | regulation of cell migration | 40.0000 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 40.0000 | 5 | no |
GO:0031399 | regulation of protein modification process | 40.0000 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 40.0000 | 7 | no |
GO:0042325 | regulation of phosphorylation | 40.0000 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 40.0000 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 40.0000 | 7 | no |
GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 40.0000 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 40.0000 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 40.0000 | 6 | no |
GO:2000145 | regulation of cell motility | 40.0000 | 4 | no |
GO:0043085 | positive regulation of catalytic activity | 35.0000 | 4 | yes |
GO:0010628 | positive regulation of gene expression | 35.0000 | 6 | no |
GO:0030030 | cell projection organization | 35.0000 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 35.0000 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 35.0000 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.0000 | 5 | no |
GO:0030335 | positive regulation of cell migration | 35.0000 | 6 | no |
GO:0031344 | regulation of cell projection organization | 35.0000 | 5 | no |
GO:0033043 | regulation of organelle organization | 35.0000 | 5 | no |
GO:0040017 | positive regulation of locomotion | 35.0000 | 4 | no |
GO:0051094 | positive regulation of developmental process | 35.0000 | 4 | no |
GO:0051241 | negative regulation of multicellular organismal process | 35.0000 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 35.0000 | 5 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 35.0000 | 7 | no |
GO:2000147 | positive regulation of cell motility | 35.0000 | 5 | no |
GO:2001141 | regulation of RNA biosynthetic process | 35.0000 | 6 | no |
GO:0001817 | regulation of cytokine production | 35.0000 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 35.0000 | 5 | no |
GO:0007264 | small GTPase mediated signal transduction | 30.0000 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 30.0000 | 5 | yes |
GO:0051056 | regulation of small GTPase mediated signal transduction | 30.0000 | 6 | yes |
GO:0051336 | regulation of hydrolase activity | 30.0000 | 4 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 30.0000 | 4 | yes |
GO:0071702 | organic substance transport | 30.0000 | 4 | no |
GO:0016192 | vesicle-mediated transport | 30.0000 | 4 | no |
GO:0002684 | positive regulation of immune system process | 30.0000 | 4 | no |
GO:0006357 | regulation of transcription by RNA polymerase II | 30.0000 | 7 | no |
GO:0007010 | cytoskeleton organization | 30.0000 | 5 | no |
GO:0009968 | negative regulation of signal transduction | 30.0000 | 5 | no |
GO:0010243 | response to organonitrogen compound | 30.0000 | 4 | no |
GO:0010648 | negative regulation of cell communication | 30.0000 | 5 | no |
GO:0010941 | regulation of cell death | 30.0000 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 30.0000 | 4 | no |
GO:0022604 | regulation of cell morphogenesis | 30.0000 | 5 | no |
GO:0023057 | negative regulation of signaling | 30.0000 | 4 | no |
GO:0033674 | positive regulation of kinase activity | 30.0000 | 6 | no |
GO:0043549 | regulation of kinase activity | 30.0000 | 5 | no |
GO:0044057 | regulation of system process | 30.0000 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 30.0000 | 4 | no |
GO:0045859 | regulation of protein kinase activity | 30.0000 | 6 | no |
GO:0045860 | positive regulation of protein kinase activity | 30.0000 | 7 | no |
GO:0048585 | negative regulation of response to stimulus | 30.0000 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 30.0000 | 5 | no |
GO:0051338 | regulation of transferase activity | 30.0000 | 4 | no |
GO:0051347 | positive regulation of transferase activity | 30.0000 | 5 | no |
GO:0097435 | supramolecular fiber organization | 30.0000 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.0000 | 6 | no |
GO:0010629 | negative regulation of gene expression | 30.0000 | 6 | no |
GO:0050776 | regulation of immune response | 30.0000 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 30.0000 | 4 | no |
GO:0051345 | positive regulation of hydrolase activity | 25.0000 | 5 | yes |
GO:0015031 | protein transport | 25.0000 | 4 | no |
GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
GO:0043269 | regulation of ion transport | 25.0000 | 5 | no |
GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
GO:1903829 | positive regulation of protein localization | 25.0000 | 5 | no |
GO:0007015 | actin filament organization | 25.0000 | 5 | no |
GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
GO:0014070 | response to organic cyclic compound | 25.0000 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 25.0000 | 5 | no |
GO:0032970 | regulation of actin filament-based process | 25.0000 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | no |
GO:0042981 | regulation of apoptotic process | 25.0000 | 6 | no |
GO:0043067 | regulation of programmed cell death | 25.0000 | 5 | no |
GO:0051493 | regulation of cytoskeleton organization | 25.0000 | 6 | no |
GO:0051726 | regulation of cell cycle | 25.0000 | 4 | no |
GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
GO:1901214 | regulation of neuron death | 25.0000 | 5 | no |
GO:1901701 | cellular response to oxygen-containing compound | 25.0000 | 4 | no |
GO:1902532 | negative regulation of intracellular signal transduction | 25.0000 | 6 | no |
GO:1903522 | regulation of blood circulation | 25.0000 | 5 | no |
GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
GO:0043408 | regulation of MAPK cascade | 25.0000 | 6 | no |
GO:0070372 | regulation of ERK1 and ERK2 cascade | 25.0000 | 7 | no |
GO:0080134 | regulation of response to stress | 25.0000 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 25.0000 | 5 | no |
GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
GO:0065003 | protein-containing complex assembly | 25.0000 | 5 | no |
GO:0043087 | regulation of GTPase activity | 10.0000 | 5 | yes |
GO:0043547 | positive regulation of GTPase activity | 10.0000 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ADA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
MOV10_HUMAN | [view interactions] | High throughput | no | no |
NXF1_HUMAN | [view interactions] | High throughput | no | yes |
HERC2_HUMAN | [view interactions] | High throughput | no | yes |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
CCAR1_HUMAN | [view interactions] | High throughput | no | yes |
CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
MIC19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DOCK4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
KCD12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MCM3_HUMAN | [view interactions] | High throughput | no | no |
IASPP_HUMAN | [view interactions] | High throughput | no | yes |
SMRC1_HUMAN | [view interactions] | High throughput | no | yes |
ATIF1_HUMAN | [view interactions] | High throughput | no | yes |
BOLA2_HUMAN | [view interactions] | High throughput | no | yes |
CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HAX1_HUMAN | [view interactions] | High throughput | no | no |
MGAP_HUMAN | [view interactions] | High throughput | no | yes |
PRC2A_HUMAN | [view interactions] | High throughput | no | yes |
TOM40_HUMAN | [view interactions] | High throughput | no | yes |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PJA1_HUMAN | [view interactions] | High throughput | no | yes |
ERBIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOP3B_HUMAN | [view interactions] | High throughput | no | no |
ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRPV2_HUMAN | [view interactions] | High throughput | no | yes |
RAB38_HUMAN | [view interactions] | High throughput | no | no |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
LNX1_HUMAN | [view interactions] | High throughput | no | yes |
ECT2_HUMAN | [view interactions] | High throughput | no | no |
AURKB_HUMAN | [view interactions] | High throughput | no | yes |
CDN1A_HUMAN | [view interactions] | High throughput | no | no |
CP250_HUMAN | [view interactions] | High throughput | no | no |
CEP57_HUMAN | [view interactions] | High throughput | no | yes |
CEP76_HUMAN | [view interactions] | High throughput | no | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |