Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ABR_HUMAN

Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed, PubMed). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed). Functions as an important negative regulator of neuronal RAC1 activity . Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ABR_HUMAN
GO:0019900 kinase binding 35.0000 4 no
GO:0019901 protein kinase binding 35.0000 5 no
GO:0017076 purine nucleotide binding 30.0000 4 no
GO:0032555 purine ribonucleotide binding 30.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.0000 4 no
GO:0030695 GTPase regulator activity 15.0000 4 yes
GO:0005085 guanyl-nucleotide exchange factor activity 10.0000 5 yes
GO:0005096 GTPase activator activity 10.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ABR_HUMAN
GO:0010646 regulation of cell communication 65.0000 4 yes
GO:0048522 positive regulation of cellular process 65.0000 4 no
GO:0009966 regulation of signal transduction 60.0000 4 yes
GO:0048523 negative regulation of cellular process 60.0000 4 no
GO:1902531 regulation of intracellular signal transduction 55.0000 5 yes
GO:0060255 regulation of macromolecule metabolic process 55.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0010647 positive regulation of cell communication 50.0000 5 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0010468 regulation of gene expression 45.0000 5 no
GO:0051049 regulation of transport 45.0000 4 no
GO:0009892 negative regulation of metabolic process 45.0000 4 no
GO:0009967 positive regulation of signal transduction 45.0000 5 no
GO:0023056 positive regulation of signaling 45.0000 4 no
GO:0048584 positive regulation of response to stimulus 45.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 45.0000 5 no
GO:0051246 regulation of protein metabolic process 45.0000 5 no
GO:0051247 positive regulation of protein metabolic process 45.0000 6 no
GO:0008104 protein localization 40.0000 4 no
GO:0022607 cellular component assembly 40.0000 4 no
GO:0001932 regulation of protein phosphorylation 40.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 40.0000 8 no
GO:0006996 organelle organization 40.0000 4 no
GO:0009889 regulation of biosynthetic process 40.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 40.0000 6 no
GO:0019220 regulation of phosphate metabolic process 40.0000 6 no
GO:0030334 regulation of cell migration 40.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 40.0000 5 no
GO:0031399 regulation of protein modification process 40.0000 6 no
GO:0031401 positive regulation of protein modification process 40.0000 7 no
GO:0042325 regulation of phosphorylation 40.0000 7 no
GO:0042327 positive regulation of phosphorylation 40.0000 8 no
GO:0045937 positive regulation of phosphate metabolic process 40.0000 7 no
GO:0051128 regulation of cellular component organization 40.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 40.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 40.0000 4 no
GO:1902533 positive regulation of intracellular signal transduction 40.0000 6 no
GO:2000145 regulation of cell motility 40.0000 4 no
GO:0043085 positive regulation of catalytic activity 35.0000 4 yes
GO:0010628 positive regulation of gene expression 35.0000 6 no
GO:0030030 cell projection organization 35.0000 4 no
GO:0006355 regulation of DNA-templated transcription 35.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 35.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 35.0000 5 no
GO:0030335 positive regulation of cell migration 35.0000 6 no
GO:0031344 regulation of cell projection organization 35.0000 5 no
GO:0033043 regulation of organelle organization 35.0000 5 no
GO:0040017 positive regulation of locomotion 35.0000 4 no
GO:0051094 positive regulation of developmental process 35.0000 4 no
GO:0051241 negative regulation of multicellular organismal process 35.0000 4 no
GO:0051252 regulation of RNA metabolic process 35.0000 5 no
GO:1903506 regulation of nucleic acid-templated transcription 35.0000 7 no
GO:2000147 positive regulation of cell motility 35.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 35.0000 6 no
GO:0001817 regulation of cytokine production 35.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.0000 5 no
GO:0007264 small GTPase mediated signal transduction 30.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 30.0000 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 30.0000 6 yes
GO:0051336 regulation of hydrolase activity 30.0000 4 yes
GO:0099177 regulation of trans-synaptic signaling 30.0000 4 yes
GO:0071702 organic substance transport 30.0000 4 no
GO:0016192 vesicle-mediated transport 30.0000 4 no
GO:0002684 positive regulation of immune system process 30.0000 4 no
GO:0006357 regulation of transcription by RNA polymerase II 30.0000 7 no
GO:0007010 cytoskeleton organization 30.0000 5 no
GO:0009968 negative regulation of signal transduction 30.0000 5 no
GO:0010243 response to organonitrogen compound 30.0000 4 no
GO:0010648 negative regulation of cell communication 30.0000 5 no
GO:0010941 regulation of cell death 30.0000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 30.0000 4 no
GO:0022604 regulation of cell morphogenesis 30.0000 5 no
GO:0023057 negative regulation of signaling 30.0000 4 no
GO:0033674 positive regulation of kinase activity 30.0000 6 no
GO:0043549 regulation of kinase activity 30.0000 5 no
GO:0044057 regulation of system process 30.0000 4 no
GO:0044087 regulation of cellular component biogenesis 30.0000 4 no
GO:0045859 regulation of protein kinase activity 30.0000 6 no
GO:0045860 positive regulation of protein kinase activity 30.0000 7 no
GO:0048585 negative regulation of response to stimulus 30.0000 4 no
GO:0051130 positive regulation of cellular component organization 30.0000 5 no
GO:0051338 regulation of transferase activity 30.0000 4 no
GO:0051347 positive regulation of transferase activity 30.0000 5 no
GO:0097435 supramolecular fiber organization 30.0000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 30.0000 6 no
GO:0010629 negative regulation of gene expression 30.0000 6 no
GO:0050776 regulation of immune response 30.0000 4 no
GO:0060627 regulation of vesicle-mediated transport 30.0000 4 no
GO:0051345 positive regulation of hydrolase activity 25.0000 5 yes
GO:0015031 protein transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0043269 regulation of ion transport 25.0000 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:0007015 actin filament organization 25.0000 5 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0014070 response to organic cyclic compound 25.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0032956 regulation of actin cytoskeleton organization 25.0000 5 no
GO:0032970 regulation of actin filament-based process 25.0000 4 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0051493 regulation of cytoskeleton organization 25.0000 6 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:1901214 regulation of neuron death 25.0000 5 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:1902532 negative regulation of intracellular signal transduction 25.0000 6 no
GO:1903522 regulation of blood circulation 25.0000 5 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0070372 regulation of ERK1 and ERK2 cascade 25.0000 7 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0065003 protein-containing complex assembly 25.0000 5 no
GO:0043087 regulation of GTPase activity 10.0000 5 yes
GO:0043547 positive regulation of GTPase activity 10.0000 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ADA1A_HUMAN [view entry] [view interactions] Low throughput yes no
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CCAR1_HUMAN [view interactions] High throughput no yes
CHCH2_HUMAN [view interactions] High throughput no yes
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
DOCK4_HUMAN [view entry] [view interactions] High throughput yes no
IMDH2_HUMAN [view interactions] High throughput no yes
KCD12_HUMAN [view entry] [view interactions] High throughput yes no
MCM3_HUMAN [view interactions] High throughput no no
IASPP_HUMAN [view interactions] High throughput no yes
SMRC1_HUMAN [view interactions] High throughput no yes
ATIF1_HUMAN [view interactions] High throughput no yes
BOLA2_HUMAN [view interactions] High throughput no yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
HAX1_HUMAN [view interactions] High throughput no no
MGAP_HUMAN [view interactions] High throughput no yes
PRC2A_HUMAN [view interactions] High throughput no yes
TOM40_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
PJA1_HUMAN [view interactions] High throughput no yes
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes
SRGP3_HUMAN [view entry] [view interactions] High throughput yes yes
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
TOP3B_HUMAN [view interactions] High throughput no no
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
TRPV2_HUMAN [view interactions] High throughput no yes
RAB38_HUMAN [view interactions] High throughput no no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
TOM20_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view interactions] High throughput no yes
LNX1_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
AURKB_HUMAN [view interactions] High throughput no yes
CDN1A_HUMAN [view interactions] High throughput no no
CP250_HUMAN [view interactions] High throughput no no
CEP57_HUMAN [view interactions] High throughput no yes
CEP76_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no