Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ADA1A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ADA1A_HUMAN
GO:0001664 G protein-coupled receptor binding 26.6667 4 no
GO:0030695 GTPase regulator activity 26.6667 4 no
GO:0046872 metal ion binding 26.6667 4 no
GO:0004930 G protein-coupled receptor activity 13.3333 4 yes
GO:0004935 adrenergic receptor activity 13.3333 6 yes
GO:0004936 alpha-adrenergic receptor activity 13.3333 7 yes
GO:0004937 alpha1-adrenergic receptor activity 13.3333 8 yes
GO:0008227 G protein-coupled amine receptor activity 13.3333 5 yes
GO:0046982 protein heterodimerization activity 13.3333 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ADA1A_HUMAN
GO:0010646 regulation of cell communication 53.3333 4 yes
GO:0048523 negative regulation of cellular process 46.6667 4 yes
GO:0060255 regulation of macromolecule metabolic process 46.6667 4 yes
GO:0009966 regulation of signal transduction 46.6667 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 40.0000 4 yes
GO:0080090 regulation of primary metabolic process 40.0000 4 yes
GO:1902531 regulation of intracellular signal transduction 40.0000 5 yes
GO:0031323 regulation of cellular metabolic process 33.3333 4 yes
GO:0043085 positive regulation of catalytic activity 33.3333 4 yes
GO:0048522 positive regulation of cellular process 33.3333 4 yes
GO:0051056 regulation of small GTPase mediated signal transduction 33.3333 6 yes
GO:0051246 regulation of protein metabolic process 33.3333 5 yes
GO:0051336 regulation of hydrolase activity 33.3333 4 yes
GO:0051345 positive regulation of hydrolase activity 33.3333 5 yes
GO:0022607 cellular component assembly 33.3333 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 33.3333 4 yes
GO:0009892 negative regulation of metabolic process 33.3333 4 yes
GO:0009893 positive regulation of metabolic process 33.3333 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 yes
GO:0031325 positive regulation of cellular metabolic process 26.6667 5 yes
GO:0031399 regulation of protein modification process 26.6667 6 yes
GO:0042325 regulation of phosphorylation 26.6667 7 yes
GO:0043408 regulation of MAPK cascade 26.6667 6 yes
GO:0048584 positive regulation of response to stimulus 26.6667 4 yes
GO:0050804 modulation of chemical synaptic transmission 26.6667 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 26.6667 5 yes
GO:0051174 regulation of phosphorus metabolic process 26.6667 5 yes
GO:0051247 positive regulation of protein metabolic process 26.6667 6 yes
GO:0060191 regulation of lipase activity 26.6667 5 yes
GO:0060193 positive regulation of lipase activity 26.6667 6 yes
GO:0099177 regulation of trans-synaptic signaling 26.6667 4 yes
GO:0006897 endocytosis 26.6667 5 no
GO:0006898 receptor-mediated endocytosis 26.6667 6 no
GO:0008104 protein localization 26.6667 4 no
GO:0015031 protein transport 26.6667 4 no
GO:0016192 vesicle-mediated transport 26.6667 4 no
GO:0051128 regulation of cellular component organization 26.6667 4 no
GO:0071702 organic substance transport 26.6667 4 no
GO:0071705 nitrogen compound transport 26.6667 4 no
GO:0006996 organelle organization 26.6667 4 no
GO:0001932 regulation of protein phosphorylation 26.6667 7 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 26.6667 5 yes
GO:0009967 positive regulation of signal transduction 26.6667 5 yes
GO:0010517 regulation of phospholipase activity 26.6667 6 yes
GO:0010518 positive regulation of phospholipase activity 26.6667 7 yes
GO:0010647 positive regulation of cell communication 26.6667 5 yes
GO:0019220 regulation of phosphate metabolic process 26.6667 6 yes
GO:0023056 positive regulation of signaling 26.6667 4 yes
GO:0030001 metal ion transport 20.0000 6 yes
GO:0031324 negative regulation of cellular metabolic process 20.0000 5 yes
GO:0031329 regulation of cellular catabolic process 20.0000 5 yes
GO:0031401 positive regulation of protein modification process 20.0000 7 yes
GO:0035023 regulation of Rho protein signal transduction 20.0000 8 yes
GO:0042127 regulation of cell population proliferation 20.0000 4 yes
GO:0042327 positive regulation of phosphorylation 20.0000 8 yes
GO:0043410 positive regulation of MAPK cascade 20.0000 7 yes
GO:0043549 regulation of kinase activity 20.0000 5 yes
GO:0045859 regulation of protein kinase activity 20.0000 6 yes
GO:0045937 positive regulation of phosphate metabolic process 20.0000 7 yes
GO:0046578 regulation of Ras protein signal transduction 20.0000 7 yes
GO:0048585 negative regulation of response to stimulus 20.0000 4 yes
GO:0051049 regulation of transport 20.0000 4 yes
GO:0051240 positive regulation of multicellular organismal process 20.0000 4 yes
GO:0051241 negative regulation of multicellular organismal process 20.0000 4 yes
GO:0051338 regulation of transferase activity 20.0000 4 yes
GO:0060627 regulation of vesicle-mediated transport 20.0000 4 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 20.0000 7 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 20.0000 8 yes
GO:1900274 regulation of phospholipase C activity 20.0000 7 yes
GO:1902533 positive regulation of intracellular signal transduction 20.0000 6 yes
GO:0001934 positive regulation of protein phosphorylation 20.0000 8 yes
GO:0006811 ion transport 20.0000 4 yes
GO:0006812 cation transport 20.0000 5 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 20.0000 4 yes
GO:0007202 activation of phospholipase C activity 20.0000 9 yes
GO:0007507 heart development 20.0000 4 yes
GO:0008285 negative regulation of cell population proliferation 20.0000 5 yes
GO:0009894 regulation of catabolic process 20.0000 4 yes
GO:0009968 negative regulation of signal transduction 20.0000 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 20.0000 6 yes
GO:0010648 negative regulation of cell communication 20.0000 5 yes
GO:0010863 positive regulation of phospholipase C activity 20.0000 8 yes
GO:0023057 negative regulation of signaling 20.0000 4 yes
GO:0031330 negative regulation of cellular catabolic process 13.3333 6 yes
GO:0032228 regulation of synaptic transmission, GABAergic 13.3333 6 yes
GO:0032230 positive regulation of synaptic transmission, GABAergic 13.3333 6 yes
GO:0033674 positive regulation of kinase activity 13.3333 6 yes
GO:0035024 negative regulation of Rho protein signal transduction 13.3333 9 yes
GO:0035150 regulation of tube size 13.3333 4 yes
GO:0035296 regulation of tube diameter 13.3333 5 yes
GO:0042310 vasoconstriction 13.3333 6 yes
GO:0043502 regulation of muscle adaptation 13.3333 4 yes
GO:0044057 regulation of system process 13.3333 4 yes
GO:0045760 positive regulation of action potential 13.3333 4 yes
GO:0045777 positive regulation of blood pressure 13.3333 4 yes
GO:0045822 negative regulation of heart contraction 13.3333 6 yes
GO:0045823 positive regulation of heart contraction 13.3333 6 yes
GO:0045860 positive regulation of protein kinase activity 13.3333 7 yes
GO:0045907 positive regulation of vasoconstriction 13.3333 5 yes
GO:0045933 positive regulation of muscle contraction 13.3333 5 yes
GO:0045987 positive regulation of smooth muscle contraction 13.3333 6 yes
GO:0045989 positive regulation of striated muscle contraction 13.3333 6 yes
GO:0046580 negative regulation of Ras protein signal transduction 13.3333 8 yes
GO:0046928 regulation of neurotransmitter secretion 13.3333 4 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 13.3333 8 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 13.3333 9 yes
GO:0050806 positive regulation of synaptic transmission 13.3333 5 yes
GO:0051046 regulation of secretion 13.3333 5 yes
GO:0051058 negative regulation of small GTPase mediated signal transduction 13.3333 7 yes
GO:0051347 positive regulation of transferase activity 13.3333 5 yes
GO:0051588 regulation of neurotransmitter transport 13.3333 5 yes
GO:0055117 regulation of cardiac muscle contraction 13.3333 7 yes
GO:0060073 micturition 13.3333 4 yes
GO:0060402 calcium ion transport into cytosol 13.3333 4 yes
GO:0060452 positive regulation of cardiac muscle contraction 13.3333 7 yes
GO:0061049 cell growth involved in cardiac muscle cell development 13.3333 4 yes
GO:0061097 regulation of protein tyrosine kinase activity 13.3333 7 yes
GO:0061098 positive regulation of protein tyrosine kinase activity 13.3333 8 yes
GO:0070588 calcium ion transmembrane transport 13.3333 6 yes
GO:0071875 adrenergic receptor signaling pathway 13.3333 4 yes
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 13.3333 5 yes
GO:0090036 regulation of protein kinase C signaling 13.3333 6 yes
GO:0090037 positive regulation of protein kinase C signaling 13.3333 7 yes
GO:0090257 regulation of muscle system process 13.3333 5 yes
GO:0097195 pilomotor reflex 13.3333 4 yes
GO:0097553 calcium ion transmembrane import into cytosol 13.3333 7 yes
GO:0097746 blood vessel diameter maintenance 13.3333 5 yes
GO:0098655 cation transmembrane transport 13.3333 4 yes
GO:0098660 inorganic ion transmembrane transport 13.3333 4 yes
GO:0098662 inorganic cation transmembrane transport 13.3333 5 yes
GO:1902532 negative regulation of intracellular signal transduction 13.3333 6 yes
GO:1903305 regulation of regulated secretory pathway 13.3333 6 yes
GO:1903522 regulation of blood circulation 13.3333 5 yes
GO:1903523 negative regulation of blood circulation 13.3333 5 yes
GO:1903524 positive regulation of blood circulation 13.3333 5 yes
GO:1903530 regulation of secretion by cell 13.3333 4 yes
GO:1903995 regulation of non-membrane spanning protein tyrosine kinase activity 13.3333 8 yes
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity 13.3333 9 yes
GO:2000300 regulation of synaptic vesicle exocytosis 13.3333 5 yes
GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure 13.3333 5 yes
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure 13.3333 7 yes
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine 13.3333 5 yes
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine 13.3333 6 yes
GO:0003018 vascular process in circulatory system 13.3333 4 yes
GO:0003057 regulation of the force of heart contraction by chemical signal 13.3333 4 yes
GO:0003084 positive regulation of systemic arterial blood pressure 13.3333 5 yes
GO:0003099 positive regulation of the force of heart contraction by chemical signal 13.3333 5 yes
GO:0006816 calcium ion transport 13.3333 7 yes
GO:0006915 apoptotic process 13.3333 4 yes
GO:0006936 muscle contraction 13.3333 4 yes
GO:0006937 regulation of muscle contraction 13.3333 6 yes
GO:0006939 smooth muscle contraction 13.3333 5 yes
GO:0006940 regulation of smooth muscle contraction 13.3333 7 yes
GO:0006942 regulation of striated muscle contraction 13.3333 7 yes
GO:0007512 adult heart development 13.3333 5 yes
GO:0008016 regulation of heart contraction 13.3333 6 yes
GO:0009895 negative regulation of catabolic process 13.3333 5 yes
GO:0010459 negative regulation of heart rate 13.3333 4 yes
GO:0010460 positive regulation of heart rate 13.3333 4 yes
GO:0010506 regulation of autophagy 13.3333 6 yes
GO:0010507 negative regulation of autophagy 13.3333 7 yes
GO:0010611 regulation of cardiac muscle hypertrophy 13.3333 5 yes
GO:0010613 positive regulation of cardiac muscle hypertrophy 13.3333 6 yes
GO:0014742 positive regulation of muscle hypertrophy 13.3333 5 yes
GO:0014743 regulation of muscle hypertrophy 13.3333 6 yes
GO:0017157 regulation of exocytosis 13.3333 5 yes
GO:0019229 regulation of vasoconstriction 13.3333 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BMP1_HUMAN [view interactions] Low throughput no yes
ABR_HUMAN [view entry] [view interactions] Low throughput yes yes
FLNC_HUMAN [view entry] [view interactions] Low throughput yes no
CREL1_HUMAN [view interactions] Low throughput no yes
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ADA1A_HUMAN [view entry] [view interactions] Low throughput yes no
ADA1B_HUMAN [view interactions] Low throughput no no
CLH1_HUMAN [view entry] [view interactions] Low throughput yes yes
CLCA_HUMAN [view entry] [view interactions] Low throughput yes no
CLCB_HUMAN [view entry] [view interactions] Low throughput yes yes
ACKR3_HUMAN [view interactions] Low throughput no no
CXCR4_HUMAN [view interactions] Low throughput no no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
CD81_HUMAN [view interactions] High throughput no no
TM234_HUMAN [view interactions] High throughput no yes
FA50B_HUMAN [view interactions] High throughput no yes
F241B_HUMAN [view interactions] High throughput no yes
GDE1_HUMAN [view interactions] High throughput no no
GPR37_HUMAN [view interactions] High throughput no no
AGRA3_HUMAN [view interactions] High throughput no yes
HHATL_HUMAN [view interactions] High throughput no no
KLH22_HUMAN [view interactions] High throughput no no
K2013_HUMAN [view interactions] High throughput no yes
TBC20_HUMAN [view interactions] High throughput no yes
MBOA7_HUMAN [view interactions] High throughput no no
ANO8_HUMAN [view interactions] High throughput no no
TPC2_HUMAN [view interactions] High throughput no no
SGCB_HUMAN [view interactions] High throughput no no
SCN1B_HUMAN [view interactions] High throughput no no
NTNG2_HUMAN [view entry] [view interactions] High throughput yes no
CGT_HUMAN [view interactions] High throughput no no
UBR4_HUMAN [view entry] [view interactions] High throughput yes yes
RN123_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
RAB31_HUMAN [view interactions] High throughput no yes
ADA1D_HUMAN [view interactions] Computational no no
ARHGC_HUMAN [view interactions] Computational no yes
RGS2_HUMAN [view interactions] Computational no no
GNA11_HUMAN [view entry] [view interactions] Computational yes yes
GNAQ_HUMAN [view entry] [view interactions] Computational yes yes
GNA13_HUMAN [view entry] [view interactions] Computational yes yes
GNA12_HUMAN [view interactions] Computational no no