Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ADA1A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ADA1A_HUMAN
GO:0004930 G protein-coupled receptor activity 15.3846 4 yes
GO:0004935 adrenergic receptor activity 15.3846 6 yes
GO:0004936 alpha-adrenergic receptor activity 15.3846 7 yes
GO:0004937 alpha1-adrenergic receptor activity 15.3846 8 yes
GO:0008227 G protein-coupled amine receptor activity 15.3846 5 yes
GO:0046982 protein heterodimerization activity 15.3846 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ADA1A_HUMAN
GO:0031323 regulation of cellular metabolic process 61.5385 4 yes
GO:0010646 regulation of cell communication 53.8462 4 yes
GO:0048523 negative regulation of cellular process 53.8462 4 yes
GO:0009892 negative regulation of metabolic process 46.1538 4 yes
GO:0009966 regulation of signal transduction 46.1538 4 yes
GO:0031324 negative regulation of cellular metabolic process 46.1538 5 yes
GO:0048522 positive regulation of cellular process 46.1538 4 yes
GO:1902531 regulation of intracellular signal transduction 46.1538 5 yes
GO:0009889 regulation of biosynthetic process 46.1538 4 no
GO:0031326 regulation of cellular biosynthetic process 46.1538 5 no
GO:0010556 regulation of macromolecule biosynthetic process 38.4615 5 no
GO:0060255 regulation of macromolecule metabolic process 38.4615 4 no
GO:0080090 regulation of primary metabolic process 38.4615 4 no
GO:0006811 monoatomic ion transport 30.7692 4 yes
GO:0006812 monoatomic cation transport 30.7692 5 yes
GO:0009894 regulation of catabolic process 30.7692 4 yes
GO:0009967 positive regulation of signal transduction 30.7692 5 yes
GO:0010647 positive regulation of cell communication 30.7692 5 yes
GO:0023056 positive regulation of signaling 30.7692 4 yes
GO:0043408 regulation of MAPK cascade 30.7692 6 yes
GO:0048584 positive regulation of response to stimulus 30.7692 4 yes
GO:0050804 modulation of chemical synaptic transmission 30.7692 5 yes
GO:0099177 regulation of trans-synaptic signaling 30.7692 4 yes
GO:0141124 intracellular signaling cassette 30.7692 4 yes
GO:0006508 proteolysis 30.7692 4 no
GO:0009890 negative regulation of biosynthetic process 30.7692 5 no
GO:0009891 positive regulation of biosynthetic process 30.7692 5 no
GO:0009893 positive regulation of metabolic process 30.7692 4 no
GO:0010468 regulation of gene expression 30.7692 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 30.7692 6 no
GO:0010604 positive regulation of macromolecule metabolic process 30.7692 5 no
GO:0031325 positive regulation of cellular metabolic process 30.7692 5 no
GO:0031327 negative regulation of cellular biosynthetic process 30.7692 6 no
GO:0031328 positive regulation of cellular biosynthetic process 30.7692 6 no
GO:0006898 receptor-mediated endocytosis 30.7692 4 no
GO:0008104 protein localization 30.7692 4 no
GO:0015031 protein transport 30.7692 4 no
GO:0022607 cellular component assembly 30.7692 4 no
GO:0051128 regulation of cellular component organization 30.7692 4 no
GO:0071702 organic substance transport 30.7692 4 no
GO:0071705 nitrogen compound transport 30.7692 4 no
GO:0098657 import into cell 30.7692 4 no
GO:0006996 organelle organization 30.7692 4 no
GO:0008285 negative regulation of cell population proliferation 23.0769 5 yes
GO:0009895 negative regulation of catabolic process 23.0769 5 yes
GO:0010506 regulation of autophagy 23.0769 6 yes
GO:0010507 negative regulation of autophagy 23.0769 7 yes
GO:0030001 metal ion transport 23.0769 6 yes
GO:0031329 regulation of cellular catabolic process 23.0769 5 yes
GO:0031330 negative regulation of cellular catabolic process 23.0769 6 yes
GO:0042127 regulation of cell population proliferation 23.0769 4 yes
GO:0043085 positive regulation of catalytic activity 23.0769 4 yes
GO:0043410 positive regulation of MAPK cascade 23.0769 7 yes
GO:0051240 positive regulation of multicellular organismal process 23.0769 4 yes
GO:0051241 negative regulation of multicellular organismal process 23.0769 4 yes
GO:0051336 regulation of hydrolase activity 23.0769 4 yes
GO:0051345 positive regulation of hydrolase activity 23.0769 5 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 23.0769 7 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 23.0769 8 yes
GO:0098655 monoatomic cation transmembrane transport 23.0769 4 yes
GO:0098662 inorganic cation transmembrane transport 23.0769 4 yes
GO:1902533 positive regulation of intracellular signal transduction 23.0769 6 yes
GO:0006511 ubiquitin-dependent protein catabolic process 23.0769 7 no
GO:0009057 macromolecule catabolic process 23.0769 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.0769 6 no
GO:0010605 negative regulation of macromolecule metabolic process 23.0769 5 no
GO:0016567 protein ubiquitination 23.0769 8 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0019941 modification-dependent protein catabolic process 23.0769 6 no
GO:0032446 protein modification by small protein conjugation 23.0769 7 no
GO:0036211 protein modification process 23.0769 4 no
GO:0043412 macromolecule modification 23.0769 4 no
GO:0043632 modification-dependent macromolecule catabolic process 23.0769 5 no
GO:0043687 post-translational protein modification 23.0769 5 no
GO:0051252 regulation of RNA metabolic process 23.0769 5 no
GO:0051603 proteolysis involved in protein catabolic process 23.0769 5 no
GO:0070647 protein modification by small protein conjugation or removal 23.0769 6 no
GO:0097435 supramolecular fiber organization 23.0769 4 no
GO:0006886 intracellular protein transport 23.0769 4 no
GO:0072583 clathrin-dependent endocytosis 23.0769 5 no
GO:0007010 cytoskeleton organization 23.0769 5 no
GO:0000165 MAPK cascade 15.3846 5 yes
GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure 15.3846 5 yes
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure 15.3846 7 yes
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine 15.3846 5 yes
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine 15.3846 6 yes
GO:0003018 vascular process in circulatory system 15.3846 4 yes
GO:0003057 regulation of the force of heart contraction by chemical signal 15.3846 4 yes
GO:0003099 positive regulation of the force of heart contraction by chemical signal 15.3846 5 yes
GO:0006816 calcium ion transport 15.3846 7 yes
GO:0006915 apoptotic process 15.3846 4 yes
GO:0006936 muscle contraction 15.3846 4 yes
GO:0006937 regulation of muscle contraction 15.3846 6 yes
GO:0006939 smooth muscle contraction 15.3846 5 yes
GO:0006940 regulation of smooth muscle contraction 15.3846 7 yes
GO:0006942 regulation of striated muscle contraction 15.3846 7 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 15.3846 4 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 15.3846 5 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 15.3846 4 yes
GO:0007202 activation of phospholipase C activity 15.3846 9 yes
GO:0007507 heart development 15.3846 4 yes
GO:0007512 adult heart development 15.3846 5 yes
GO:0008016 regulation of heart contraction 15.3846 6 yes
GO:0010459 negative regulation of heart rate 15.3846 4 yes
GO:0010460 positive regulation of heart rate 15.3846 4 yes
GO:0010517 regulation of phospholipase activity 15.3846 6 yes
GO:0010518 positive regulation of phospholipase activity 15.3846 7 yes
GO:0010611 regulation of cardiac muscle hypertrophy 15.3846 5 yes
GO:0010613 positive regulation of cardiac muscle hypertrophy 15.3846 6 yes
GO:0010863 positive regulation of phospholipase C activity 15.3846 8 yes
GO:0014742 positive regulation of muscle hypertrophy 15.3846 5 yes
GO:0014743 regulation of muscle hypertrophy 15.3846 6 yes
GO:0019229 regulation of vasoconstriction 15.3846 6 yes
GO:0032228 regulation of synaptic transmission, GABAergic 15.3846 6 yes
GO:0032230 positive regulation of synaptic transmission, GABAergic 15.3846 6 yes
GO:0035150 regulation of tube size 15.3846 4 yes
GO:0035296 regulation of tube diameter 15.3846 5 yes
GO:0042310 vasoconstriction 15.3846 6 yes
GO:0043502 regulation of muscle adaptation 15.3846 4 yes
GO:0044057 regulation of system process 15.3846 4 yes
GO:0045760 positive regulation of action potential 15.3846 4 yes
GO:0045822 negative regulation of heart contraction 15.3846 6 yes
GO:0045823 positive regulation of heart contraction 15.3846 6 yes
GO:0045907 positive regulation of vasoconstriction 15.3846 5 yes
GO:0045933 positive regulation of muscle contraction 15.3846 5 yes
GO:0045987 positive regulation of smooth muscle contraction 15.3846 6 yes
GO:0045989 positive regulation of striated muscle contraction 15.3846 6 yes
GO:0050806 positive regulation of synaptic transmission 15.3846 5 yes
GO:0055117 regulation of cardiac muscle contraction 15.3846 7 yes
GO:0060191 regulation of lipase activity 15.3846 5 yes
GO:0060193 positive regulation of lipase activity 15.3846 6 yes
GO:0060402 calcium ion transport into cytosol 15.3846 4 yes
GO:0060452 positive regulation of cardiac muscle contraction 15.3846 7 yes
GO:0061049 cell growth involved in cardiac muscle cell development 15.3846 4 yes
GO:0070588 calcium ion transmembrane transport 15.3846 5 yes
GO:0071875 adrenergic receptor signaling pathway 15.3846 4 yes
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 15.3846 5 yes
GO:0090036 regulation of protein kinase C signaling 15.3846 6 yes
GO:0090037 positive regulation of protein kinase C signaling 15.3846 7 yes
GO:0090257 regulation of muscle system process 15.3846 5 yes
GO:0097195 pilomotor reflex 15.3846 4 yes
GO:0097553 calcium ion transmembrane import into cytosol 15.3846 6 yes
GO:0097746 blood vessel diameter maintenance 15.3846 5 yes
GO:0150099 neuron-glial cell signaling 15.3846 4 yes
GO:1900274 regulation of phospholipase C activity 15.3846 7 yes
GO:1903522 regulation of blood circulation 15.3846 5 yes
GO:1903523 negative regulation of blood circulation 15.3846 5 yes
GO:1903524 positive regulation of blood circulation 15.3846 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BMP1_HUMAN [view interactions] Low throughput no yes
ABR_HUMAN [view entry] [view interactions] Low throughput yes yes
FLNC_HUMAN [view entry] [view interactions] Low throughput yes no
CREL1_HUMAN [view interactions] Low throughput no yes
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ADA1A_HUMAN [view entry] [view interactions] Low throughput yes no
ADA1B_HUMAN [view interactions] Low throughput no no
CLH1_HUMAN [view entry] [view interactions] Low throughput yes yes
CLCA_HUMAN [view entry] [view interactions] Low throughput yes no
CLCB_HUMAN [view entry] [view interactions] Low throughput yes yes
ACKR3_HUMAN [view interactions] Low throughput no no
CXCR4_HUMAN [view interactions] Low throughput no no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
GDE1_HUMAN [view interactions] High throughput no no
AGRA3_HUMAN [view interactions] High throughput no yes
CD81_HUMAN [view interactions] High throughput no no
TM234_HUMAN [view interactions] High throughput no yes
FA50B_HUMAN [view interactions] High throughput no yes
F241B_HUMAN [view interactions] High throughput no yes
GPR37_HUMAN [view interactions] High throughput no no
HHATL_HUMAN [view interactions] High throughput no no
KLH22_HUMAN [view interactions] High throughput no no
K2013_HUMAN [view interactions] High throughput no yes
TPC2_HUMAN [view interactions] High throughput no no
SCN1B_HUMAN [view interactions] High throughput no no
TBC20_HUMAN [view interactions] High throughput no yes
ANO8_HUMAN [view interactions] High throughput no no
NTNG2_HUMAN [view entry] [view interactions] High throughput yes no
MBOA7_HUMAN [view interactions] High throughput no no
SGCB_HUMAN [view interactions] High throughput no no
UBR4_HUMAN [view entry] [view interactions] High throughput yes yes
CGT_HUMAN [view interactions] High throughput no no
RN123_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
RAB31_HUMAN [view interactions] High throughput no yes