Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NTNG2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
81 Cys Tyr Neurodevelopmentaldisorderwithbehavioralabnormalities,absentspeech,andhypotonia(NEDBASH) -
107 Trp Gly Neurodevelopmentaldisorderwithbehavioralabnormalities,absentspeech,andhypotonia(NEDBASH) -
149 Met Thr Neurodevelopmentaldisorderwithbehavioralabnormalities,absentspeech,andhypotonia(NEDBASH) -
200 Ser Leu Neurodevelopmentaldisorderwithbehavioralabnormalities,absentspeech,andhypotonia(NEDBASH) -
355 Cys Trp Neurodevelopmentaldisorderwithbehavioralabnormalities,absentspeech,andhypotonia(NEDBASH) -
359 Ser Cys Neurodevelopmentaldisorderwithbehavioralabnormalities,absentspeech,andhypotonia(NEDBASH) -
456 Cys Tyr Neurodevelopmentaldisorderwithbehavioralabnormalities,absentspeech,andhypotonia(NEDBASH) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

No data found.

Biological process

Term Name % Distance from top the of the tree Annotated in NTNG2_HUMAN
GO:0010646 regulation of cell communication 71.4286 4 yes
GO:0050804 modulation of chemical synaptic transmission 71.4286 5 yes
GO:0051128 regulation of cellular component organization 71.4286 4 yes
GO:0099177 regulation of trans-synaptic signaling 71.4286 4 yes
GO:0022607 cellular component assembly 57.1429 4 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 57.1429 4 yes
GO:0099560 synaptic membrane adhesion 57.1429 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 42.8571 4 yes
GO:0031344 regulation of cell projection organization 42.8571 5 yes
GO:0044087 regulation of cellular component biogenesis 42.8571 4 yes
GO:0031323 regulation of cellular metabolic process 42.8571 4 no
GO:0048522 positive regulation of cellular process 42.8571 4 no
GO:0048523 negative regulation of cellular process 42.8571 4 no
GO:0051171 regulation of nitrogen compound metabolic process 42.8571 4 no
GO:0060255 regulation of macromolecule metabolic process 42.8571 4 no
GO:0080090 regulation of primary metabolic process 42.8571 4 no
GO:0006996 organelle organization 28.5714 4 yes
GO:0010975 regulation of neuron projection development 28.5714 7 yes
GO:0022604 regulation of cell morphogenesis 28.5714 5 yes
GO:0030030 cell projection organization 28.5714 4 yes
GO:0032990 cell part morphogenesis 28.5714 4 yes
GO:0048812 neuron projection morphogenesis 28.5714 7 yes
GO:0048858 cell projection morphogenesis 28.5714 5 yes
GO:0050807 regulation of synapse organization 28.5714 5 yes
GO:0051963 regulation of synapse assembly 28.5714 6 yes
GO:0099174 regulation of presynapse organization 28.5714 6 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 28.5714 6 yes
GO:0150011 regulation of neuron projection arborization 28.5714 6 yes
GO:1901888 regulation of cell junction assembly 28.5714 5 yes
GO:1905606 regulation of presynapse assembly 28.5714 7 yes
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 no
GO:0008104 protein localization 28.5714 4 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0009966 regulation of signal transduction 28.5714 4 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0031401 positive regulation of protein modification process 28.5714 7 no
GO:0033674 positive regulation of kinase activity 28.5714 6 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0042327 positive regulation of phosphorylation 28.5714 8 no
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0043549 regulation of kinase activity 28.5714 5 no
GO:0044057 regulation of system process 28.5714 4 no
GO:0045859 regulation of protein kinase activity 28.5714 6 no
GO:0045860 positive regulation of protein kinase activity 28.5714 7 no
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 28.5714 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 28.5714 9 no
GO:0050806 positive regulation of synaptic transmission 28.5714 5 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0051129 negative regulation of cellular component organization 28.5714 5 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.5714 5 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:0051347 positive regulation of transferase activity 28.5714 5 no
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 no
GO:0061097 regulation of protein tyrosine kinase activity 28.5714 7 no
GO:0061098 positive regulation of protein tyrosine kinase activity 28.5714 8 no
GO:0072657 protein localization to membrane 28.5714 4 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 no
GO:1902115 regulation of organelle assembly 28.5714 5 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LRRC4_HUMAN [view entry] [view interactions] Low throughput yes no
LRC4C_HUMAN [view entry] [view interactions] Low throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
ADA1A_HUMAN [view entry] [view interactions] High throughput yes no
CCR2_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
MKRN2_HUMAN [view interactions] High throughput no yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
LRC4B_HUMAN [view entry] [view interactions] Computational yes no