Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NTNG2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
81 Cys Tyr Neurodevelopmentaldisorderwithbehavioralabnormalities,absentspeech,andhypotonia(NEDBASH) -
107 Trp Gly Neurodevelopmentaldisorderwithbehavioralabnormalities,absentspeech,andhypotonia(NEDBASH) -
149 Met Thr Neurodevelopmentaldisorderwithbehavioralabnormalities,absentspeech,andhypotonia(NEDBASH) -
200 Ser Leu Neurodevelopmentaldisorderwithbehavioralabnormalities,absentspeech,andhypotonia(NEDBASH) -
355 Cys Trp Neurodevelopmentaldisorderwithbehavioralabnormalities,absentspeech,andhypotonia(NEDBASH) -
359 Ser Cys Neurodevelopmentaldisorderwithbehavioralabnormalities,absentspeech,andhypotonia(NEDBASH) -
456 Cys Tyr Neurodevelopmentaldisorderwithbehavioralabnormalities,absentspeech,andhypotonia(NEDBASH) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

No data found.

Biological process

Term Name % Distance from top the of the tree Annotated in NTNG2_HUMAN
GO:0010646 regulation of cell communication 83.3333 4 yes
GO:0050804 modulation of chemical synaptic transmission 83.3333 5 yes
GO:0099177 regulation of trans-synaptic signaling 83.3333 4 yes
GO:0022607 cellular component assembly 66.6667 4 yes
GO:0051128 regulation of cellular component organization 66.6667 4 yes
GO:0006996 organelle organization 50.0000 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 50.0000 4 yes
GO:0031344 regulation of cell projection organization 50.0000 5 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 50.0000 4 yes
GO:0099560 synaptic membrane adhesion 50.0000 5 yes
GO:0008104 protein localization 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0010975 regulation of neuron projection development 33.3333 7 yes
GO:0022604 regulation of cell morphogenesis 33.3333 5 yes
GO:0030030 cell projection organization 33.3333 4 yes
GO:0044087 regulation of cellular component biogenesis 33.3333 4 yes
GO:0048812 neuron projection morphogenesis 33.3333 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 33.3333 4 yes
GO:0150011 regulation of neuron projection arborization 33.3333 6 yes
GO:0072657 protein localization to membrane 33.3333 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0033365 protein localization to organelle 33.3333 5 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0044057 regulation of system process 33.3333 4 no
GO:0048522 positive regulation of cellular process 33.3333 4 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0050806 positive regulation of synaptic transmission 33.3333 5 no
GO:0051129 negative regulation of cellular component organization 33.3333 5 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LRRC4_HUMAN [view entry] [view interactions] Low throughput yes no
LRC4C_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
ADA1A_HUMAN [view entry] [view interactions] High throughput yes no
CCR2_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
MKRN2_HUMAN [view interactions] High throughput no yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes