LRRC4_HUMAN
Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in LRRC4_HUMAN |
---|---|---|---|---|
GO:0035639 | purine ribonucleoside triphosphate binding | 37.5000 | 4 | no |
GO:0106310 | protein serine kinase activity | 37.5000 | 4 | no |
GO:0004674 | protein serine/threonine kinase activity | 37.5000 | 4 | no |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 37.5000 | 4 | no |
GO:0005524 | ATP binding | 37.5000 | 5 | no |
GO:0016301 | kinase activity | 37.5000 | 4 | no |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 37.5000 | 4 | no |
GO:0017076 | purine nucleotide binding | 37.5000 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 37.5000 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 37.5000 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 37.5000 | 5 | no |
GO:0045309 | protein phosphorylated amino acid binding | 25.0000 | 4 | no |
GO:0001784 | phosphotyrosine residue binding | 25.0000 | 5 | no |
GO:0004707 | MAP kinase activity | 25.0000 | 5 | no |
GO:0004708 | MAP kinase kinase activity | 25.0000 | 5 | no |
GO:0019902 | phosphatase binding | 25.0000 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in LRRC4_HUMAN |
---|---|---|---|---|
GO:0010646 | regulation of cell communication | 75.0000 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 75.0000 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 62.5000 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 62.5000 | 4 | yes |
GO:0022607 | cellular component assembly | 50.0000 | 4 | yes |
GO:0006996 | organelle organization | 50.0000 | 4 | no |
GO:0036211 | protein modification process | 37.5000 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 37.5000 | 4 | no |
GO:0042325 | regulation of phosphorylation | 37.5000 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 37.5000 | 8 | no |
GO:0043085 | positive regulation of catalytic activity | 37.5000 | 4 | no |
GO:0043408 | regulation of MAPK cascade | 37.5000 | 6 | no |
GO:0043412 | macromolecule modification | 37.5000 | 4 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 37.5000 | 7 | no |
GO:0048522 | positive regulation of cellular process | 37.5000 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 37.5000 | 4 | no |
GO:0051049 | regulation of transport | 37.5000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 37.5000 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 37.5000 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 37.5000 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 37.5000 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 37.5000 | 6 | no |
GO:0051338 | regulation of transferase activity | 37.5000 | 4 | no |
GO:0051347 | positive regulation of transferase activity | 37.5000 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 37.5000 | 4 | no |
GO:0060341 | regulation of cellular localization | 37.5000 | 4 | no |
GO:0071310 | cellular response to organic substance | 37.5000 | 4 | no |
GO:0071417 | cellular response to organonitrogen compound | 37.5000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 37.5000 | 4 | no |
GO:1901699 | cellular response to nitrogen compound | 37.5000 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 37.5000 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 37.5000 | 5 | no |
GO:0008104 | protein localization | 37.5000 | 4 | yes |
GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 37.5000 | 4 | yes |
GO:0099560 | synaptic membrane adhesion | 37.5000 | 5 | yes |
GO:0033043 | regulation of organelle organization | 37.5000 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 37.5000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 37.5000 | 4 | no |
GO:0051493 | regulation of cytoskeleton organization | 37.5000 | 6 | no |
GO:0030334 | regulation of cell migration | 37.5000 | 5 | no |
GO:2000145 | regulation of cell motility | 37.5000 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 37.5000 | 7 | no |
GO:0001934 | positive regulation of protein phosphorylation | 37.5000 | 8 | no |
GO:0002684 | positive regulation of immune system process | 37.5000 | 4 | no |
GO:0006468 | protein phosphorylation | 37.5000 | 5 | no |
GO:0006796 | phosphate-containing compound metabolic process | 37.5000 | 4 | no |
GO:0008284 | positive regulation of cell population proliferation | 37.5000 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 37.5000 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 37.5000 | 4 | no |
GO:0009966 | regulation of signal transduction | 37.5000 | 4 | no |
GO:0010243 | response to organonitrogen compound | 37.5000 | 4 | no |
GO:0010468 | regulation of gene expression | 37.5000 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 37.5000 | 5 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 37.5000 | 6 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 37.5000 | 5 | no |
GO:0010628 | positive regulation of gene expression | 37.5000 | 6 | no |
GO:0010647 | positive regulation of cell communication | 37.5000 | 5 | no |
GO:0016310 | phosphorylation | 37.5000 | 5 | no |
GO:0018193 | peptidyl-amino acid modification | 37.5000 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 37.5000 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 37.5000 | 6 | no |
GO:0023056 | positive regulation of signaling | 37.5000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 37.5000 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 37.5000 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 37.5000 | 5 | no |
GO:0031399 | regulation of protein modification process | 37.5000 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 37.5000 | 7 | no |
GO:0034599 | cellular response to oxidative stress | 25.0000 | 4 | no |
GO:0034612 | response to tumor necrosis factor | 25.0000 | 5 | no |
GO:0034614 | cellular response to reactive oxygen species | 25.0000 | 5 | no |
GO:0040017 | positive regulation of locomotion | 25.0000 | 4 | no |
GO:0042473 | outer ear morphogenesis | 25.0000 | 4 | no |
GO:0043330 | response to exogenous dsRNA | 25.0000 | 5 | no |
GO:0043331 | response to dsRNA | 25.0000 | 4 | no |
GO:0045595 | regulation of cell differentiation | 25.0000 | 4 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.0000 | 6 | no |
GO:0046686 | response to cadmium ion | 25.0000 | 5 | no |
GO:0048534 | hematopoietic or lymphoid organ development | 25.0000 | 4 | no |
GO:0048538 | thymus development | 25.0000 | 5 | no |
GO:0048708 | astrocyte differentiation | 25.0000 | 5 | no |
GO:0048732 | gland development | 25.0000 | 4 | no |
GO:0048864 | stem cell development | 25.0000 | 4 | no |
GO:0048878 | chemical homeostasis | 25.0000 | 4 | no |
GO:0050776 | regulation of immune response | 25.0000 | 4 | no |
GO:0050778 | positive regulation of immune response | 25.0000 | 5 | no |
GO:0050801 | ion homeostasis | 25.0000 | 5 | no |
GO:0050806 | positive regulation of synaptic transmission | 25.0000 | 5 | no |
GO:0050890 | cognition | 25.0000 | 4 | no |
GO:0050920 | regulation of chemotaxis | 25.0000 | 4 | no |
GO:0050921 | positive regulation of chemotaxis | 25.0000 | 5 | no |
GO:0051052 | regulation of DNA metabolic process | 25.0000 | 5 | no |
GO:0051054 | positive regulation of DNA metabolic process | 25.0000 | 6 | no |
GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
GO:0051403 | stress-activated MAPK cascade | 25.0000 | 5 | no |
GO:0051972 | regulation of telomerase activity | 25.0000 | 5 | no |
GO:0051973 | positive regulation of telomerase activity | 25.0000 | 6 | no |
GO:0055067 | monovalent inorganic cation homeostasis | 25.0000 | 7 | no |
GO:0055080 | cation homeostasis | 25.0000 | 6 | no |
GO:0060020 | Bergmann glial cell differentiation | 25.0000 | 6 | no |
GO:0060291 | long-term synaptic potentiation | 25.0000 | 4 | no |
GO:0060425 | lung morphogenesis | 25.0000 | 4 | no |
GO:0060440 | trachea formation | 25.0000 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 25.0000 | 4 | no |
GO:0061308 | cardiac neural crest cell development involved in heart development | 25.0000 | 6 | no |
GO:0062197 | cellular response to chemical stress | 25.0000 | 4 | no |
GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 25.0000 | 5 | no |
GO:0070371 | ERK1 and ERK2 cascade | 25.0000 | 5 | no |
GO:0070663 | regulation of leukocyte proliferation | 25.0000 | 5 | no |
GO:0070665 | positive regulation of leukocyte proliferation | 25.0000 | 6 | no |
GO:0070848 | response to growth factor | 25.0000 | 4 | no |
GO:0071241 | cellular response to inorganic substance | 25.0000 | 4 | no |
GO:0071248 | cellular response to metal ion | 25.0000 | 5 | no |
GO:0071276 | cellular response to cadmium ion | 25.0000 | 6 | no |
GO:0071345 | cellular response to cytokine stimulus | 25.0000 | 5 | no |
GO:0071356 | cellular response to tumor necrosis factor | 25.0000 | 6 | no |
GO:0071407 | cellular response to organic cyclic compound | 25.0000 | 5 | no |
GO:0071622 | regulation of granulocyte chemotaxis | 25.0000 | 6 | no |
GO:0071675 | regulation of mononuclear cell migration | 25.0000 | 5 | no |
GO:0071867 | response to monoamine | 25.0000 | 5 | no |
GO:0071868 | cellular response to monoamine stimulus | 25.0000 | 5 | no |
GO:0071869 | response to catecholamine | 25.0000 | 4 | no |
GO:0071870 | cellular response to catecholamine stimulus | 25.0000 | 5 | no |
GO:0072584 | caveolin-mediated endocytosis | 25.0000 | 6 | no |
GO:0080134 | regulation of response to stress | 25.0000 | 4 | no |
GO:0080135 | regulation of cellular response to stress | 25.0000 | 4 | no |
GO:0090170 | regulation of Golgi inheritance | 25.0000 | 7 | no |
GO:0098771 | inorganic ion homeostasis | 25.0000 | 6 | no |
GO:0120040 | regulation of macrophage proliferation | 25.0000 | 6 | no |
GO:0120041 | positive regulation of macrophage proliferation | 25.0000 | 7 | no |
GO:1903350 | response to dopamine | 25.0000 | 5 | no |
GO:1903351 | cellular response to dopamine | 25.0000 | 6 | no |
GO:1903358 | regulation of Golgi organization | 25.0000 | 6 | no |
GO:1903649 | regulation of cytoplasmic transport | 25.0000 | 6 | no |
GO:1904353 | regulation of telomere capping | 25.0000 | 7 | no |
GO:1904355 | positive regulation of telomere capping | 25.0000 | 8 | no |
GO:1904356 | regulation of telomere maintenance via telomere lengthening | 25.0000 | 7 | no |
GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | 25.0000 | 8 | no |
GO:1905521 | regulation of macrophage migration | 25.0000 | 5 | no |
GO:1905523 | positive regulation of macrophage migration | 25.0000 | 6 | no |
GO:1990928 | response to amino acid starvation | 25.0000 | 4 | no |
GO:2000147 | positive regulation of cell motility | 25.0000 | 5 | no |
GO:2000278 | regulation of DNA biosynthetic process | 25.0000 | 6 | no |
GO:2000573 | positive regulation of DNA biosynthetic process | 25.0000 | 7 | no |
GO:2000641 | regulation of early endosome to late endosome transport | 25.0000 | 5 | no |
GO:2001252 | positive regulation of chromosome organization | 25.0000 | 7 | no |
GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 6 | no |
GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
GO:0043410 | positive regulation of MAPK cascade | 25.0000 | 7 | no |
GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
GO:0070372 | regulation of ERK1 and ERK2 cascade | 25.0000 | 7 | no |
GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 25.0000 | 8 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 25.0000 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 25.0000 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
GO:0034329 | cell junction assembly | 25.0000 | 5 | yes |
GO:0034330 | cell junction organization | 25.0000 | 4 | yes |
GO:0072657 | protein localization to membrane | 25.0000 | 4 | yes |
GO:0000904 | cell morphogenesis involved in differentiation | 25.0000 | 4 | no |
GO:0007010 | cytoskeleton organization | 25.0000 | 5 | no |
GO:0010810 | regulation of cell-substrate adhesion | 25.0000 | 5 | no |
GO:0030155 | regulation of cell adhesion | 25.0000 | 4 | no |
GO:0031333 | negative regulation of protein-containing complex assembly | 25.0000 | 6 | no |
GO:0043254 | regulation of protein-containing complex assembly | 25.0000 | 5 | no |
GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | no |
GO:0070925 | organelle assembly | 25.0000 | 5 | no |
GO:0010975 | regulation of neuron projection development | 25.0000 | 7 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 25.0000 | 4 | no |
GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
GO:0000165 | MAPK cascade | 25.0000 | 4 | no |
GO:0000302 | response to reactive oxygen species | 25.0000 | 4 | no |
GO:0002685 | regulation of leukocyte migration | 25.0000 | 4 | no |
GO:0002687 | positive regulation of leukocyte migration | 25.0000 | 5 | no |
GO:0002688 | regulation of leukocyte chemotaxis | 25.0000 | 5 | no |
GO:0002690 | positive regulation of leukocyte chemotaxis | 25.0000 | 6 | no |
GO:0006873 | cellular ion homeostasis | 25.0000 | 4 | no |
GO:0006885 | regulation of pH | 25.0000 | 8 | no |
GO:0006897 | endocytosis | 25.0000 | 5 | no |
GO:0006915 | apoptotic process | 25.0000 | 4 | no |
GO:0006974 | cellular response to DNA damage stimulus | 25.0000 | 4 | no |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 25.0000 | 4 | no |
GO:0009267 | cellular response to starvation | 25.0000 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
GO:0010001 | glial cell differentiation | 25.0000 | 4 | no |
GO:0010038 | response to metal ion | 25.0000 | 4 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
GO:0010638 | positive regulation of organelle organization | 25.0000 | 6 | no |
GO:0010758 | regulation of macrophage chemotaxis | 25.0000 | 6 | no |
GO:0010759 | positive regulation of macrophage chemotaxis | 25.0000 | 6 | no |
GO:0014032 | neural crest cell development | 25.0000 | 5 | no |
GO:0014070 | response to organic cyclic compound | 25.0000 | 4 | no |
GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | no |
GO:0018105 | peptidyl-serine phosphorylation | 25.0000 | 6 | no |
GO:0018209 | peptidyl-serine modification | 25.0000 | 6 | no |
GO:0030003 | cellular cation homeostasis | 25.0000 | 5 | no |
GO:0030004 | cellular monovalent inorganic cation homeostasis | 25.0000 | 6 | no |
GO:0030278 | regulation of ossification | 25.0000 | 4 | no |
GO:0030335 | positive regulation of cell migration | 25.0000 | 6 | no |
GO:0030641 | regulation of cellular pH | 25.0000 | 7 | no |
GO:0030878 | thyroid gland development | 25.0000 | 5 | no |
GO:0031098 | stress-activated protein kinase signaling cascade | 25.0000 | 4 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
GO:0031663 | lipopolysaccharide-mediated signaling pathway | 25.0000 | 4 | no |
GO:0031667 | response to nutrient levels | 25.0000 | 4 | no |
GO:0031669 | cellular response to nutrient levels | 25.0000 | 4 | no |
GO:0032101 | regulation of response to external stimulus | 25.0000 | 4 | no |
GO:0032103 | positive regulation of response to external stimulus | 25.0000 | 5 | no |
GO:0032204 | regulation of telomere maintenance | 25.0000 | 6 | no |
GO:0032206 | positive regulation of telomere maintenance | 25.0000 | 7 | no |
GO:0032210 | regulation of telomere maintenance via telomerase | 25.0000 | 7 | no |
GO:0032212 | positive regulation of telomere maintenance via telomerase | 25.0000 | 8 | no |
GO:0032386 | regulation of intracellular transport | 25.0000 | 5 | no |
GO:0032872 | regulation of stress-activated MAPK cascade | 25.0000 | 6 | no |
GO:0033044 | regulation of chromosome organization | 25.0000 | 6 | no |
GO:0034097 | response to cytokine | 25.0000 | 4 | no |
GO:0034198 | cellular response to amino acid starvation | 25.0000 | 5 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NTNG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
NTNG1_HUMAN | [view interactions] | Low throughput | no | no |
PARD3_HUMAN | [view interactions] | Low throughput | no | yes |
PAR6A_HUMAN | [view interactions] | Low throughput | no | yes |
KPCZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AGO2_HUMAN | [view interactions] | High throughput | no | yes |
LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
POMT2_HUMAN | [view interactions] | High throughput | no | yes |
F1142_HUMAN | [view interactions] | High throughput | no | yes |
XPO4_HUMAN | [view interactions] | High throughput | no | no |
CIP2A_HUMAN | [view interactions] | High throughput | no | yes |
ITB5_HUMAN | [view interactions] | High throughput | no | yes |
TRI18_HUMAN | [view interactions] | High throughput | no | no |
OSTP_HUMAN | [view interactions] | High throughput | no | yes |
TBCD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DPP9_HUMAN | [view interactions] | High throughput | no | yes |
TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
DRC6_HUMAN | [view interactions] | High throughput | no | yes |
STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBM28_HUMAN | [view interactions] | Computational | no | yes |