Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LRRC4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LRRC4_HUMAN
GO:0000166 nucleotide binding 33.3333 4 no
GO:0004674 protein serine/threonine kinase activity 33.3333 4 no
GO:0005524 ATP binding 33.3333 5 no
GO:0016301 kinase activity 33.3333 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 33.3333 4 no
GO:0017076 purine nucleotide binding 33.3333 5 no
GO:0030554 adenyl nucleotide binding 33.3333 6 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0032559 adenyl ribonucleotide binding 33.3333 5 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0043168 anion binding 33.3333 4 no
GO:0106310 protein serine kinase activity 33.3333 4 no
GO:0043169 cation binding 22.2222 4 no
GO:0046872 metal ion binding 22.2222 5 no
GO:0001784 phosphotyrosine residue binding 22.2222 5 no
GO:0004707 MAP kinase activity 22.2222 5 no
GO:0019902 phosphatase binding 22.2222 4 no
GO:0045309 protein phosphorylated amino acid binding 22.2222 4 no
GO:0003677 DNA binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in LRRC4_HUMAN
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0050804 modulation of chemical synaptic transmission 66.6667 5 yes
GO:0099177 regulation of trans-synaptic signaling 66.6667 4 yes
GO:0051128 regulation of cellular component organization 66.6667 4 no
GO:0022607 cellular component assembly 55.5556 4 yes
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0009889 regulation of biosynthetic process 44.4444 4 no
GO:0009891 positive regulation of biosynthetic process 44.4444 5 no
GO:0009893 positive regulation of metabolic process 44.4444 4 no
GO:0010556 regulation of macromolecule biosynthetic process 44.4444 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 44.4444 6 no
GO:0010604 positive regulation of macromolecule metabolic process 44.4444 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 44.4444 5 no
GO:0030334 regulation of cell migration 44.4444 5 no
GO:0031323 regulation of cellular metabolic process 44.4444 4 no
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 no
GO:0031326 regulation of cellular biosynthetic process 44.4444 5 no
GO:0031328 positive regulation of cellular biosynthetic process 44.4444 6 no
GO:0048522 positive regulation of cellular process 44.4444 4 no
GO:0060255 regulation of macromolecule metabolic process 44.4444 4 no
GO:0080090 regulation of primary metabolic process 44.4444 4 no
GO:2000145 regulation of cell motility 44.4444 4 no
GO:0006996 organelle organization 44.4444 4 no
GO:0002684 positive regulation of immune system process 33.3333 4 no
GO:0006468 protein phosphorylation 33.3333 5 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 no
GO:0008284 positive regulation of cell population proliferation 33.3333 5 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0016310 phosphorylation 33.3333 5 no
GO:0018193 peptidyl-amino acid modification 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0036211 protein modification process 33.3333 4 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0043408 regulation of MAPK cascade 33.3333 6 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:1901701 cellular response to oxygen-containing compound 33.3333 4 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0008104 protein localization 33.3333 4 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 33.3333 4 yes
GO:0099560 synaptic membrane adhesion 33.3333 5 yes
GO:0006355 regulation of DNA-templated transcription 33.3333 7 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0030335 positive regulation of cell migration 33.3333 6 no
GO:0040017 positive regulation of locomotion 33.3333 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:2000147 positive regulation of cell motility 33.3333 5 no
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0051493 regulation of cytoskeleton organization 33.3333 6 no
GO:0010975 regulation of neuron projection development 22.2222 7 no
GO:0031344 regulation of cell projection organization 22.2222 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.2222 6 no
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0009967 positive regulation of signal transduction 22.2222 5 no
GO:0009968 negative regulation of signal transduction 22.2222 5 no
GO:0010648 negative regulation of cell communication 22.2222 5 no
GO:0018105 peptidyl-serine phosphorylation 22.2222 6 no
GO:0018209 peptidyl-serine modification 22.2222 6 no
GO:0019220 regulation of phosphate metabolic process 22.2222 6 no
GO:0023057 negative regulation of signaling 22.2222 4 no
GO:0031399 regulation of protein modification process 22.2222 6 no
GO:0042325 regulation of phosphorylation 22.2222 7 no
GO:0043410 positive regulation of MAPK cascade 22.2222 7 no
GO:0045595 regulation of cell differentiation 22.2222 4 no
GO:0048585 negative regulation of response to stimulus 22.2222 4 no
GO:0050776 regulation of immune response 22.2222 4 no
GO:0050778 positive regulation of immune response 22.2222 5 no
GO:0050806 positive regulation of synaptic transmission 22.2222 5 no
GO:0050890 cognition 22.2222 4 no
GO:0051174 regulation of phosphorus metabolic process 22.2222 5 no
GO:0060291 long-term synaptic potentiation 22.2222 4 no
GO:0070372 regulation of ERK1 and ERK2 cascade 22.2222 7 no
GO:0070374 positive regulation of ERK1 and ERK2 cascade 22.2222 8 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:0000165 MAPK cascade 22.2222 5 no
GO:0000302 response to reactive oxygen species 22.2222 4 no
GO:0002685 regulation of leukocyte migration 22.2222 4 no
GO:0002687 positive regulation of leukocyte migration 22.2222 5 no
GO:0002688 regulation of leukocyte chemotaxis 22.2222 5 no
GO:0002690 positive regulation of leukocyte chemotaxis 22.2222 6 no
GO:0006873 intracellular monoatomic ion homeostasis 22.2222 4 no
GO:0006915 apoptotic process 22.2222 4 no
GO:0006974 DNA damage response 22.2222 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 22.2222 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 22.2222 5 no
GO:0008286 insulin receptor signaling pathway 22.2222 6 no
GO:0009267 cellular response to starvation 22.2222 4 no
GO:0010001 glial cell differentiation 22.2222 4 no
GO:0010038 response to metal ion 22.2222 4 no
GO:0010638 positive regulation of organelle organization 22.2222 6 no
GO:0010758 regulation of macrophage chemotaxis 22.2222 6 no
GO:0010759 positive regulation of macrophage chemotaxis 22.2222 7 no
GO:0014032 neural crest cell development 22.2222 5 no
GO:0014044 Schwann cell development 22.2222 5 no
GO:0014070 response to organic cyclic compound 22.2222 4 no
GO:0021782 glial cell development 22.2222 4 no
GO:0030003 intracellular monoatomic cation homeostasis 22.2222 5 no
GO:0030278 regulation of ossification 22.2222 4 no
GO:0030878 thyroid gland development 22.2222 5 no
GO:0031098 stress-activated protein kinase signaling cascade 22.2222 4 no
GO:0031663 lipopolysaccharide-mediated signaling pathway 22.2222 4 no
GO:0032101 regulation of response to external stimulus 22.2222 4 no
GO:0032103 positive regulation of response to external stimulus 22.2222 5 no
GO:0032204 regulation of telomere maintenance 22.2222 6 no
GO:0032206 positive regulation of telomere maintenance 22.2222 7 no
GO:0032210 regulation of telomere maintenance via telomerase 22.2222 7 no
GO:0032212 positive regulation of telomere maintenance via telomerase 22.2222 8 no
GO:0032386 regulation of intracellular transport 22.2222 5 no
GO:0032872 regulation of stress-activated MAPK cascade 22.2222 6 no
GO:0033044 regulation of chromosome organization 22.2222 6 no
GO:0034097 response to cytokine 22.2222 4 no
GO:0034198 cellular response to amino acid starvation 22.2222 5 no
GO:0034599 cellular response to oxidative stress 22.2222 4 no
GO:0034612 response to tumor necrosis factor 22.2222 5 no
GO:0034614 cellular response to reactive oxygen species 22.2222 5 no
GO:0038127 ERBB signaling pathway 22.2222 6 no
GO:0038128 ERBB2 signaling pathway 22.2222 7 no
GO:0038129 ERBB3 signaling pathway 22.2222 7 no
GO:0038133 ERBB2-ERBB3 signaling pathway 22.2222 8 no
GO:0042473 outer ear morphogenesis 22.2222 4 no
GO:0042552 myelination 22.2222 4 no
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0043330 response to exogenous dsRNA 22.2222 5 no
GO:0043331 response to dsRNA 22.2222 4 no
GO:0046686 response to cadmium ion 22.2222 5 no
GO:0048009 insulin-like growth factor receptor signaling pathway 22.2222 6 no
GO:0048534 hematopoietic or lymphoid organ development 22.2222 4 no
GO:0048538 thymus development 22.2222 5 no
GO:0048708 astrocyte differentiation 22.2222 5 no
GO:0048732 gland development 22.2222 4 no
GO:0048864 stem cell development 22.2222 4 no
GO:0050920 regulation of chemotaxis 22.2222 4 no
GO:0050921 positive regulation of chemotaxis 22.2222 5 no
GO:0051052 regulation of DNA metabolic process 22.2222 5 no
GO:0051054 positive regulation of DNA metabolic process 22.2222 6 no
GO:0051130 positive regulation of cellular component organization 22.2222 5 no
GO:0051338 regulation of transferase activity 22.2222 4 no
GO:0051347 positive regulation of transferase activity 22.2222 5 no
GO:0051403 stress-activated MAPK cascade 22.2222 5 no
GO:0051972 regulation of telomerase activity 22.2222 5 no
GO:0051973 positive regulation of telomerase activity 22.2222 6 no
GO:0055080 monoatomic cation homeostasis 22.2222 4 no
GO:0060020 Bergmann glial cell differentiation 22.2222 6 no
GO:0060425 lung morphogenesis 22.2222 4 no
GO:0060440 trachea formation 22.2222 4 no
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 no
GO:0061308 cardiac neural crest cell development involved in heart development 22.2222 6 no
GO:0062197 cellular response to chemical stress 22.2222 4 no
GO:0070302 regulation of stress-activated protein kinase signaling cascade 22.2222 5 no
GO:0070371 ERK1 and ERK2 cascade 22.2222 6 no
GO:0070663 regulation of leukocyte proliferation 22.2222 5 no
GO:0070665 positive regulation of leukocyte proliferation 22.2222 6 no
GO:0070849 response to epidermal growth factor 22.2222 4 no
GO:0071241 cellular response to inorganic substance 22.2222 4 no
GO:0071248 cellular response to metal ion 22.2222 5 no
GO:0071276 cellular response to cadmium ion 22.2222 6 no
GO:0071345 cellular response to cytokine stimulus 22.2222 5 no
GO:0071356 cellular response to tumor necrosis factor 22.2222 6 no
GO:0071622 regulation of granulocyte chemotaxis 22.2222 6 no
GO:0071675 regulation of mononuclear cell migration 22.2222 5 no
GO:0071677 positive regulation of mononuclear cell migration 22.2222 6 no
GO:0072584 caveolin-mediated endocytosis 22.2222 4 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:0080135 regulation of cellular response to stress 22.2222 4 no
GO:0090170 regulation of Golgi inheritance 22.2222 7 no
GO:0098657 import into cell 22.2222 4 no
GO:0120040 regulation of macrophage proliferation 22.2222 6 no
GO:0120041 positive regulation of macrophage proliferation 22.2222 7 no
GO:0141124 intracellular signaling cassette 22.2222 4 no
GO:1903358 regulation of Golgi organization 22.2222 6 no
GO:1904353 regulation of telomere capping 22.2222 7 no
GO:1904355 positive regulation of telomere capping 22.2222 8 no
GO:1904356 regulation of telomere maintenance via telomere lengthening 22.2222 7 no
GO:1904358 positive regulation of telomere maintenance via telomere lengthening 22.2222 8 no
GO:1905521 regulation of macrophage migration 22.2222 6 no
GO:1905523 positive regulation of macrophage migration 22.2222 7 no
GO:1990928 response to amino acid starvation 22.2222 4 no
GO:2000278 regulation of DNA biosynthetic process 22.2222 6 no
GO:2000573 positive regulation of DNA biosynthetic process 22.2222 7 no
GO:2000641 regulation of early endosome to late endosome transport 22.2222 5 no
GO:2001252 positive regulation of chromosome organization 22.2222 7 no
GO:0034329 cell junction assembly 22.2222 5 yes
GO:0034330 cell junction organization 22.2222 4 yes
GO:0072657 protein localization to membrane 22.2222 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0009059 macromolecule biosynthetic process 22.2222 4 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0009896 positive regulation of catabolic process 22.2222 5 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0010628 positive regulation of gene expression 22.2222 7 no
GO:0016070 RNA metabolic process 22.2222 5 no
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 no
GO:0043933 protein-containing complex organization 22.2222 4 no
GO:0045893 positive regulation of DNA-templated transcription 22.2222 8 no
GO:0045944 positive regulation of transcription by RNA polymerase II 22.2222 9 no
GO:0051094 positive regulation of developmental process 22.2222 4 no
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0051248 negative regulation of protein metabolic process 22.2222 6 no
GO:0051254 positive regulation of RNA metabolic process 22.2222 6 no
GO:0065003 protein-containing complex assembly 22.2222 5 no
GO:0090304 nucleic acid metabolic process 22.2222 4 no
GO:1902680 positive regulation of RNA biosynthetic process 22.2222 7 no
GO:2000026 regulation of multicellular organismal development 22.2222 4 no
GO:0007010 cytoskeleton organization 22.2222 5 no
GO:0010810 regulation of cell-substrate adhesion 22.2222 5 no
GO:0030155 regulation of cell adhesion 22.2222 4 no
GO:0031333 negative regulation of protein-containing complex assembly 22.2222 6 no
GO:0043254 regulation of protein-containing complex assembly 22.2222 5 no
GO:0051129 negative regulation of cellular component organization 22.2222 5 no
GO:0070925 organelle assembly 22.2222 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NTNG2_HUMAN [view entry] [view interactions] Low throughput yes no
NTNG1_HUMAN [view interactions] Low throughput no no
PARD3_HUMAN [view interactions] Low throughput no yes
PAR6A_HUMAN [view interactions] Low throughput no yes
KPCZ_HUMAN [view entry] [view interactions] Low throughput yes yes
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
AGO2_HUMAN [view entry] [view interactions] High throughput yes yes
LRC4C_HUMAN [view entry] [view interactions] High throughput yes yes
TRI18_HUMAN [view interactions] High throughput no no
ITB5_HUMAN [view interactions] High throughput no yes
CIP2A_HUMAN [view interactions] High throughput no yes
XPO4_HUMAN [view interactions] High throughput no no
F1142_HUMAN [view interactions] High throughput no yes
POMT2_HUMAN [view interactions] High throughput no yes
LCOR_HUMAN [view interactions] High throughput no yes
OSTP_HUMAN [view interactions] High throughput no yes
TBCD_HUMAN [view entry] [view interactions] High throughput yes no
DPP9_HUMAN [view interactions] High throughput no yes
TNPO2_HUMAN [view interactions] High throughput no yes
FXL13_HUMAN [view interactions] High throughput no yes
STX12_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes