Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TBCD_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis (PubMed). Involved in neuron morphogenesis (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
229 Leu Arg Encephalopathy,progressive,early-onset,withbrainatrophyandthincorpuscallosum(PEBAT) -
374 Thr Met Encephalopathy,progressive,early-onset,withbrainatrophyandthincorpuscallosum(PEBAT) -
377 Arg Gln Encephalopathy,progressive,early-onset,withbrainatrophyandthincorpuscallosum(PEBAT) -
387 Met Arg Encephalopathy,progressive,early-onset,withbrainatrophyandthincorpuscallosum(PEBAT) -
475 Ala Thr Encephalopathy,progressive,early-onset,withbrainatrophyandthincorpuscallosum(PEBAT) -
586 Ala Val Encephalopathy,progressive,early-onset,withbrainatrophyandthincorpuscallosum(PEBAT) -
626 Ala Thr Encephalopathy,progressive,early-onset,withbrainatrophyandthincorpuscallosum(PEBAT) -
772 Arg Cys Encephalopathy,progressive,early-onset,withbrainatrophyandthincorpuscallosum(PEBAT) -
921 Ala Thr Encephalopathy,progressive,early-onset,withbrainatrophyandthincorpuscallosum(PEBAT) -
937 Pro Arg Encephalopathy,progressive,early-onset,withbrainatrophyandthincorpuscallosum(PEBAT) -
1122 Pro Leu Encephalopathy,progressive,early-onset,withbrainatrophyandthincorpuscallosum(PEBAT) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TBCD_HUMAN
GO:0017076 purine nucleotide binding 29.6296 4 no
GO:0032555 purine ribonucleotide binding 25.9259 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.9259 4 no
GO:0016462 pyrophosphatase activity 22.2222 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 22.2222 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 22.2222 6 no
GO:0015631 tubulin binding 7.4074 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TBCD_HUMAN
GO:0010646 regulation of cell communication 48.1481 4 no
GO:0048522 positive regulation of cellular process 48.1481 4 no
GO:0060255 regulation of macromolecule metabolic process 48.1481 4 no
GO:0048523 negative regulation of cellular process 44.4444 4 yes
GO:0009893 positive regulation of metabolic process 44.4444 4 no
GO:0010468 regulation of gene expression 44.4444 5 no
GO:0051171 regulation of nitrogen compound metabolic process 44.4444 4 no
GO:0080090 regulation of primary metabolic process 44.4444 4 no
GO:0009966 regulation of signal transduction 40.7407 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.7407 5 no
GO:0031323 regulation of cellular metabolic process 40.7407 4 no
GO:0006996 organelle organization 37.0370 4 yes
GO:0051128 regulation of cellular component organization 37.0370 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 37.0370 5 no
GO:0007010 cytoskeleton organization 33.3333 5 yes
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0022607 cellular component assembly 29.6296 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.6296 5 no
GO:0031399 regulation of protein modification process 29.6296 6 no
GO:0009967 positive regulation of signal transduction 29.6296 5 no
GO:0010647 positive regulation of cell communication 29.6296 5 no
GO:0023056 positive regulation of signaling 29.6296 4 no
GO:0048584 positive regulation of response to stimulus 29.6296 4 no
GO:0006355 regulation of DNA-templated transcription 25.9259 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.9259 5 no
GO:0019220 regulation of phosphate metabolic process 25.9259 6 no
GO:0031401 positive regulation of protein modification process 25.9259 7 no
GO:0045595 regulation of cell differentiation 25.9259 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.9259 5 no
GO:0051174 regulation of phosphorus metabolic process 25.9259 5 no
GO:0051252 regulation of RNA metabolic process 25.9259 5 no
GO:1903506 regulation of nucleic acid-templated transcription 25.9259 7 no
GO:2001141 regulation of RNA biosynthetic process 25.9259 6 no
GO:0030030 cell projection organization 25.9259 4 no
GO:0051094 positive regulation of developmental process 25.9259 4 no
GO:0051240 positive regulation of multicellular organismal process 25.9259 4 no
GO:0008104 protein localization 25.9259 4 no
GO:0009968 negative regulation of signal transduction 22.2222 5 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0010648 negative regulation of cell communication 22.2222 5 no
GO:0023057 negative regulation of signaling 22.2222 4 no
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 no
GO:0036211 protein modification process 22.2222 4 no
GO:0042325 regulation of phosphorylation 22.2222 7 no
GO:0043412 macromolecule modification 22.2222 4 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0048585 negative regulation of response to stimulus 22.2222 4 no
GO:0001817 regulation of cytokine production 22.2222 4 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0051130 positive regulation of cellular component organization 22.2222 5 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 7 no
GO:0010628 positive regulation of gene expression 22.2222 6 no
GO:0033043 regulation of organelle organization 18.5185 5 yes
GO:0043933 protein-containing complex organization 18.5185 4 yes
GO:0044087 regulation of cellular component biogenesis 18.5185 4 yes
GO:0034329 cell junction assembly 14.8148 5 yes
GO:0034330 cell junction organization 14.8148 4 yes
GO:0051129 negative regulation of cellular component organization 14.8148 5 yes
GO:0065003 protein-containing complex assembly 14.8148 5 yes
GO:0000904 cell morphogenesis involved in differentiation 11.1111 4 yes
GO:0010639 negative regulation of organelle organization 11.1111 6 yes
GO:0030155 regulation of cell adhesion 11.1111 4 yes
GO:0043254 regulation of protein-containing complex assembly 11.1111 5 yes
GO:1902903 regulation of supramolecular fiber organization 11.1111 5 yes
GO:0010810 regulation of cell-substrate adhesion 7.4074 5 yes
GO:0031110 regulation of microtubule polymerization or depolymerization 7.4074 6 yes
GO:0031113 regulation of microtubule polymerization 7.4074 6 yes
GO:0032271 regulation of protein polymerization 7.4074 6 yes
GO:0032886 regulation of microtubule-based process 7.4074 4 yes
GO:0051493 regulation of cytoskeleton organization 7.4074 6 yes
GO:0070507 regulation of microtubule cytoskeleton organization 7.4074 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in TBCD_HUMAN
DOID:612 primary immunodeficiency disease 7.4074 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PP2AA_HUMAN [view entry] [view interactions] Low throughput yes yes
COMD4_HUMAN [view interactions] Low throughput no no
ARL3_HUMAN [view interactions] Low throughput no yes
ARL2_HUMAN [view interactions] Low throughput no yes
ACD_HUMAN [view interactions] High throughput no no
RPB9_HUMAN [view interactions] High throughput no yes
XRCC6_HUMAN [view interactions] High throughput no yes
DEXI_HUMAN [view interactions] High throughput no yes
NEMO_HUMAN [view interactions] High throughput no yes
TBB5_HUMAN [view interactions] High throughput no yes
TBB4B_HUMAN [view interactions] High throughput no yes
TERF1_HUMAN [view interactions] High throughput no no
POTE1_HUMAN [view interactions] High throughput no no
IMP2L_HUMAN [view interactions] High throughput no yes
OZF_HUMAN [view interactions] High throughput no yes
ZN836_HUMAN [view interactions] High throughput no no
T11L1_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
ABCE1_HUMAN [view interactions] High throughput no yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
TBB2A_HUMAN [view entry] [view interactions] High throughput yes yes
TBB2B_HUMAN [view entry] [view interactions] High throughput yes yes
SCN2B_HUMAN [view interactions] High throughput no no
5HT6R_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
FAF2_HUMAN [view interactions] High throughput no yes
LRRC4_HUMAN [view entry] [view interactions] High throughput yes no
NR3L1_HUMAN [view interactions] High throughput no no
VSIG1_HUMAN [view interactions] High throughput no no
CRYL1_HUMAN [view interactions] High throughput no yes
IL1R2_HUMAN [view interactions] High throughput no no
I17RA_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
HIF1A_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
CTDP1_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
CLUA1_HUMAN [view interactions] High throughput no yes
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
RIN3_HUMAN [view interactions] High throughput no yes
TBB4A_HUMAN [view interactions] High throughput no yes
HCST_HUMAN [view interactions] High throughput no no
SCN3B_HUMAN [view interactions] High throughput no no
F234A_HUMAN [view interactions] High throughput no yes
GLPA_HUMAN [view interactions] High throughput no no
EFNA4_HUMAN [view interactions] High throughput no no
OSTM1_HUMAN [view interactions] High throughput no yes
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
TBB8_HUMAN [view interactions] High throughput no no
PDCD1_HUMAN [view interactions] High throughput no yes
TCPQM_HUMAN [view interactions] High throughput no no
LRC25_HUMAN [view interactions] High throughput no yes
GPR17_HUMAN [view interactions] High throughput no no
CDHR2_HUMAN [view interactions] High throughput no yes
S10A6_HUMAN [view interactions] High throughput no yes
ARMC5_HUMAN [view interactions] High throughput no yes
DUS16_HUMAN [view interactions] High throughput no yes
VCIP1_HUMAN [view entry] [view interactions] High throughput yes no
CTDS1_HUMAN [view interactions] High throughput no no
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
D2HDH_HUMAN [view interactions] High throughput no no
HUMMR_HUMAN [view interactions] High throughput no yes
MFD4A_HUMAN [view interactions] High throughput no yes
ST1C4_HUMAN [view interactions] High throughput no no
GP182_HUMAN [view interactions] High throughput no no
PPARD_HUMAN [view interactions] High throughput no yes
PKHG7_HUMAN [view interactions] High throughput no no
EPN4_HUMAN [view interactions] High throughput no yes
MAP4_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
RIT1_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
LYRIC_HUMAN [view entry] [view interactions] High throughput yes yes
ACPH_HUMAN [view interactions] High throughput no yes
H12_HUMAN [view interactions] High throughput no yes
NASP_HUMAN [view interactions] High throughput no yes
NMI_HUMAN [view interactions] High throughput no yes
SNX2_HUMAN [view entry] [view interactions] High throughput yes no
STAT3_HUMAN [view entry] [view interactions] High throughput yes yes
GCP60_HUMAN [view interactions] High throughput no yes
ATG7_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
GORS2_HUMAN [view interactions] High throughput no yes
TF2AA_HUMAN [view interactions] High throughput no yes
MAOX_HUMAN [view interactions] High throughput no yes
RUSD2_HUMAN [view interactions] High throughput no yes
SYSC_HUMAN [view interactions] High throughput no yes
SHLB2_HUMAN [view entry] [view interactions] High throughput yes no
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
VPS25_HUMAN [view interactions] High throughput no yes
TOM1_HUMAN [view interactions] High throughput no yes
TSN_HUMAN [view interactions] High throughput no yes
VPS29_HUMAN [view entry] [view interactions] High throughput yes yes
WDR12_HUMAN [view interactions] High throughput no yes
PSMD5_HUMAN [view interactions] High throughput no yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
TPM4_HUMAN [view entry] [view interactions] High throughput yes yes
TBCC_HUMAN [view interactions] High throughput no yes
TBCE_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
SMAD9_HUMAN [view interactions] High throughput no yes
MTR1B_HUMAN [view interactions] High throughput no yes
SH2D3_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
KPCB_HUMAN [view entry] [view interactions] High throughput yes yes
H4_HUMAN [view interactions] High throughput no yes
TBCEL_HUMAN [view interactions] Computational no yes
TBCA_HUMAN [view interactions] Computational no yes
TBA1A_HUMAN [view entry] [view interactions] Computational yes yes
AR13A_HUMAN [view interactions] Computational no no
MD2L1_HUMAN [view interactions] Computational no no
TBCB_HUMAN [view entry] [view interactions] Computational yes yes