TBCD_HUMAN
Evidence for PS localization
Functions
Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis (PubMed). Involved in neuron morphogenesis (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TBCD_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 35.0000 | 4 | no |
| GO:0046872 | metal ion binding | 35.0000 | 5 | no |
| GO:0000166 | nucleotide binding | 25.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 5 | no |
| GO:0003723 | RNA binding | 22.5000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 22.5000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.5000 | 4 | no |
| GO:0043168 | anion binding | 22.5000 | 4 | no |
| GO:0015631 | tubulin binding | 20.0000 | 4 | yes |
| GO:0048487 | beta-tubulin binding | 5.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TBCD_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 60.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 57.5000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 57.5000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 57.5000 | 4 | no |
| GO:0010468 | regulation of gene expression | 55.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 55.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 55.0000 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 55.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 52.5000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 45.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 45.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 42.5000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 42.5000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 40.0000 | 5 | no |
| GO:0006996 | organelle organization | 37.5000 | 4 | yes |
| GO:0022607 | cellular component assembly | 37.5000 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 37.5000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 37.5000 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 37.5000 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 35.0000 | 7 | no |
| GO:0009890 | negative regulation of biosynthetic process | 35.0000 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 35.0000 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 35.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 35.0000 | 4 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 35.0000 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.0000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 35.0000 | 6 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 35.0000 | 6 | no |
| GO:0008104 | protein localization | 32.5000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 32.5000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 32.5000 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 32.5000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 32.5000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 30.0000 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 30.0000 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.5000 | 5 | no |
| GO:0007010 | cytoskeleton organization | 27.5000 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 27.5000 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 27.5000 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 27.5000 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 27.5000 | 6 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 27.5000 | 5 | no |
| GO:0071702 | organic substance transport | 27.5000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 27.5000 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 25.0000 | 7 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0097435 | supramolecular fiber organization | 25.0000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 25.0000 | 8 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 25.0000 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 4 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0006915 | apoptotic process | 25.0000 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0030030 | cell projection organization | 22.5000 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 22.5000 | 7 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.5000 | 5 | yes |
| GO:0065003 | protein-containing complex assembly | 22.5000 | 5 | yes |
| GO:0001817 | regulation of cytokine production | 22.5000 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 22.5000 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.5000 | 6 | no |
| GO:0045892 | negative regulation of DNA-templated transcription | 22.5000 | 8 | no |
| GO:0071310 | cellular response to organic substance | 22.5000 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 22.5000 | 4 | no |
| GO:1902679 | negative regulation of RNA biosynthetic process | 22.5000 | 7 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 22.5000 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 22.5000 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 22.5000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.5000 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 22.5000 | 4 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 20.0000 | 5 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 20.0000 | 5 | yes |
| GO:0034330 | cell junction organization | 17.5000 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 17.5000 | 6 | yes |
| GO:0010639 | negative regulation of organelle organization | 15.0000 | 6 | yes |
| GO:0030155 | regulation of cell adhesion | 12.5000 | 4 | yes |
| GO:0032271 | regulation of protein polymerization | 12.5000 | 6 | yes |
| GO:0034329 | cell junction assembly | 12.5000 | 5 | yes |
| GO:0031110 | regulation of microtubule polymerization or depolymerization | 10.0000 | 6 | yes |
| GO:0031113 | regulation of microtubule polymerization | 10.0000 | 6 | yes |
| GO:0032886 | regulation of microtubule-based process | 10.0000 | 4 | yes |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 10.0000 | 5 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 10.0000 | 6 | yes |
| GO:0007162 | negative regulation of cell adhesion | 7.5000 | 5 | yes |
| GO:0010810 | regulation of cell-substrate adhesion | 7.5000 | 5 | yes |
| GO:0031333 | negative regulation of protein-containing complex assembly | 7.5000 | 6 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 7.5000 | 7 | yes |
| GO:0010812 | negative regulation of cell-substrate adhesion | 5.0000 | 6 | yes |
| GO:0031111 | negative regulation of microtubule polymerization or depolymerization | 5.0000 | 7 | yes |
| GO:0031115 | negative regulation of microtubule polymerization | 5.0000 | 7 | yes |
| GO:0032272 | negative regulation of protein polymerization | 5.0000 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARL2_HUMAN | [view interactions] | Low throughput | no | yes |
| ARL3_HUMAN | [view interactions] | Low throughput | no | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COMD4_HUMAN | [view interactions] | Low throughput | no | no |
| TOM1_HUMAN | [view interactions] | High throughput | no | yes |
| TSN_HUMAN | [view interactions] | High throughput | no | yes |
| VPS29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR12_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD5_HUMAN | [view interactions] | High throughput | no | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCC_HUMAN | [view interactions] | High throughput | no | yes |
| TBCE_HUMAN | [view interactions] | High throughput | no | no |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RINI_HUMAN | [view interactions] | High throughput | no | yes |
| CAN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFU1_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD9_HUMAN | [view interactions] | High throughput | no | yes |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIM26_HUMAN | [view interactions] | High throughput | no | no |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| ACD_HUMAN | [view interactions] | High throughput | no | no |
| RPB9_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| DEXI_HUMAN | [view interactions] | High throughput | no | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| CTDP1_HUMAN | [view interactions] | High throughput | no | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| OZF_HUMAN | [view interactions] | High throughput | no | yes |
| ZN836_HUMAN | [view interactions] | High throughput | no | no |
| T11L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCN2B_HUMAN | [view interactions] | High throughput | no | no |
| 5HT6R_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| LRRC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NR3L1_HUMAN | [view interactions] | High throughput | no | no |
| VSIG1_HUMAN | [view interactions] | High throughput | no | no |
| CRYL1_HUMAN | [view interactions] | High throughput | no | yes |
| IL1R2_HUMAN | [view interactions] | High throughput | no | no |
| I17RA_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| HIF1A_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| TBB4A_HUMAN | [view interactions] | High throughput | no | yes |
| HCST_HUMAN | [view interactions] | High throughput | no | no |
| SCN3B_HUMAN | [view interactions] | High throughput | no | no |
| F234A_HUMAN | [view interactions] | High throughput | no | yes |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| EFNA4_HUMAN | [view interactions] | High throughput | no | no |
| OSTM1_HUMAN | [view interactions] | High throughput | no | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB8_HUMAN | [view interactions] | High throughput | no | no |
| PDCD1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPQM_HUMAN | [view interactions] | High throughput | no | no |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| CDHR2_HUMAN | [view interactions] | High throughput | no | yes |
| S10A6_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC5_HUMAN | [view interactions] | High throughput | no | yes |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| VCIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTDS1_HUMAN | [view interactions] | High throughput | no | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| D2HDH_HUMAN | [view interactions] | High throughput | no | no |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| ST1C4_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| PPARD_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG7_HUMAN | [view interactions] | High throughput | no | no |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACPH_HUMAN | [view interactions] | High throughput | no | yes |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| NASP_HUMAN | [view interactions] | High throughput | no | yes |
| NMI_HUMAN | [view interactions] | High throughput | no | yes |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCP60_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| TF2AA_HUMAN | [view interactions] | High throughput | no | yes |
| MAOX_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD2_HUMAN | [view interactions] | High throughput | no | yes |
| SYSC_HUMAN | [view interactions] | High throughput | no | yes |
| SHLB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS25_HUMAN | [view interactions] | High throughput | no | yes |