1433T_HUMAN
Evidence for PS localization
Functions
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 82%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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1433T_HUMAN has binary interactions with 50 proteins
Isoforms
LOADING 80%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in 1433T_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 31.0448 | 4 | no |
| GO:0000166 | nucleotide binding | 30.7463 | 4 | no |
| GO:0017076 | purine nucleotide binding | 30.1493 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 28.6567 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.4627 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 27.1642 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.6716 | 5 | no |
| GO:0005524 | ATP binding | 24.4776 | 5 | no |
| GO:0043169 | cation binding | 23.2836 | 4 | no |
| GO:0046872 | metal ion binding | 22.6866 | 5 | no |
| GO:0003723 | RNA binding | 22.6866 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in 1433T_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 54.9254 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 47.7612 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 47.7612 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 46.8657 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 43.5821 | 4 | yes |
| GO:0010646 | regulation of cell communication | 43.2836 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 42.3881 | 4 | no |
| GO:0006996 | organelle organization | 41.1940 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.2985 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 38.5075 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 37.9104 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 37.6119 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 36.4179 | 4 | no |
| GO:0010468 | regulation of gene expression | 35.8209 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.3284 | 5 | no |
| GO:0022607 | cellular component assembly | 32.2388 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 31.6418 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.3433 | 5 | no |
| GO:0008104 | protein localization | 30.7463 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 29.8507 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.5522 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.1642 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 26.5672 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 25.9701 | 4 | no |
| GO:0007010 | cytoskeleton organization | 25.9701 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2A5E_HUMAN | [view interactions] | High throughput | no | yes |
| 3BP2_HUMAN | [view interactions] | Low throughput | no | yes |
| 3BP5L_HUMAN | [view interactions] | High throughput | no | yes |
| 3HIDH_HUMAN | [view interactions] | High throughput | no | yes |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A1AT_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AA3R_HUMAN | [view interactions] | High throughput | no | no |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| AASS_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |