ACACA_HUMAN
Evidence for PS localization
Functions
Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed, PubMed, PubMed). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed, PubMed, PubMed). [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 64%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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ACACA_HUMAN has binary interactions with 50 proteins
Isoforms
Interacting regions
Canonical [ACACA_HUMAN]
Isoform [Q13085-2] alignment
Isoform [Q13085-3] alignment
Isoform [Q13085-4] alignment
Isoform [Q59FY4] alignment
Isoform [A0A087X0W4] alignment
Isoform [A0A087X126] alignment
Isoform [A0A087X2F8] alignment
Isoform [A0A087WVR6] alignment
Isoform [A0A087WWN5] alignment
Isoform [A0A087WYK6] alignment
Isoform [A0A087WYS8] alignment
Isoform [A0A0C4DGT1] alignment
LOADING 26%
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001256 | LIG_BRCT_BRCA1_1 | LIG | 1262 | 1266 | - |
| ELMI001256 | LIG_BRCT_BRCA1_1 | LIG | 1262 | 1266 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACACA_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 45.0450 | 4 | yes |
| GO:0043168 | anion binding | 44.1441 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 42.3423 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 42.3423 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.5405 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 33.3333 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 33.3333 | 5 | yes |
| GO:0005524 | ATP binding | 31.5315 | 5 | yes |
| GO:0003723 | RNA binding | 29.7297 | 4 | no |
| GO:0043169 | cation binding | 22.5225 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 22.5225 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.5225 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.5225 | 6 | no |
| GO:0046872 | metal ion binding | 20.7207 | 5 | yes |
| GO:0016421 | CoA carboxylase activity | 4.5045 | 4 | yes |
| GO:0003989 | acetyl-CoA carboxylase activity | 1.8018 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACACA_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.7568 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 51.3514 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.4505 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 48.6486 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.8468 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 42.3423 | 4 | no |
| GO:0006996 | organelle organization | 41.4414 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.4414 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 41.4414 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 38.7387 | 4 | no |
| GO:0010468 | regulation of gene expression | 37.8378 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 36.9369 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 35.1351 | 5 | no |
| GO:0010646 | regulation of cell communication | 34.2342 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.2342 | 5 | no |
| GO:0009966 | regulation of signal transduction | 31.5315 | 4 | no |
| GO:0008104 | protein localization | 31.5315 | 4 | no |
| GO:0022607 | cellular component assembly | 30.6306 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 30.6306 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.7297 | 5 | no |
| GO:0009894 | regulation of catabolic process | 27.9279 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.9279 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.9279 | 5 | no |
| GO:0043933 | protein-containing complex organization | 26.1261 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 26.1261 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2A5D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKB1_HUMAN | [view interactions] | Low throughput | no | yes |
| AAKG1_HUMAN | [view interactions] | Low throughput | no | no |
| AAPK1_HUMAN | [view interactions] | Low throughput | no | no |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| ABCG1_HUMAN | [view interactions] | High throughput | no | yes |
| ACACA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACACB_HUMAN | [view interactions] | High throughput | no | no |
| ACATN_HUMAN | [view interactions] | High throughput | no | yes |
| ADIP_HUMAN | [view interactions] | High throughput | no | yes |
| ADRM1_HUMAN | [view interactions] | High throughput | no | yes |
| AEN_HUMAN | [view interactions] | High throughput | no | no |
| AF9_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| AICDA_HUMAN | [view interactions] | High throughput | no | no |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AK1BA_HUMAN | [view interactions] | Low throughput | no | no |
| ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |