ACACA_HUMAN
Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed, PubMed, PubMed). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed, PubMed, PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001256 | LIG_BRCT_BRCA1_1 | LIG | 1262 | 1266 | - |
| ELMI001256 | LIG_BRCT_BRCA1_1 | LIG | 1262 | 1266 | - |
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACACA_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 45.0450 | 4 | yes |
| GO:0043168 | anion binding | 44.1441 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 42.3423 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 42.3423 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.5405 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 33.3333 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 33.3333 | 5 | yes |
| GO:0005524 | ATP binding | 31.5315 | 5 | yes |
| GO:0003723 | RNA binding | 29.7297 | 4 | no |
| GO:0043169 | cation binding | 22.5225 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 22.5225 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.5225 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.5225 | 6 | no |
| GO:0046872 | metal ion binding | 20.7207 | 5 | yes |
| GO:0016421 | CoA carboxylase activity | 4.5045 | 4 | yes |
| GO:0003989 | acetyl-CoA carboxylase activity | 1.8018 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACACA_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.7568 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 51.3514 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.4505 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 48.6486 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.8468 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 42.3423 | 4 | no |
| GO:0006996 | organelle organization | 41.4414 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.4414 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 41.4414 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 38.7387 | 4 | no |
| GO:0010468 | regulation of gene expression | 37.8378 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 36.9369 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 35.1351 | 5 | no |
| GO:0010646 | regulation of cell communication | 34.2342 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.2342 | 5 | no |
| GO:0009966 | regulation of signal transduction | 31.5315 | 4 | no |
| GO:0008104 | protein localization | 31.5315 | 4 | no |
| GO:0022607 | cellular component assembly | 30.6306 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 30.6306 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.7297 | 5 | no |
| GO:0009894 | regulation of catabolic process | 27.9279 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.9279 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.9279 | 5 | no |
| GO:0043933 | protein-containing complex organization | 26.1261 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 26.1261 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.1261 | 5 | no |
| GO:0051049 | regulation of transport | 25.2252 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.2252 | 5 | no |
| GO:0036211 | protein modification process | 24.3243 | 4 | no |
| GO:0043412 | macromolecule modification | 24.3243 | 4 | no |
| GO:0032880 | regulation of protein localization | 24.3243 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.3243 | 6 | no |
| GO:0060341 | regulation of cellular localization | 24.3243 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 24.3243 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 24.3243 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.4234 | 5 | no |
| GO:0071702 | organic substance transport | 23.4234 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.5225 | 6 | no |
| GO:0071705 | nitrogen compound transport | 22.5225 | 4 | no |
| GO:0031399 | regulation of protein modification process | 21.6216 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 21.6216 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.6216 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 21.6216 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.6216 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.6216 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 20.7207 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.7207 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 18.9189 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 18.0180 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 16.2162 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 10.8108 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 9.9099 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 9.9099 | 4 | yes |
| GO:0072521 | purine-containing compound metabolic process | 9.9099 | 4 | yes |
| GO:0032870 | cellular response to hormone stimulus | 9.0090 | 4 | yes |
| GO:0033993 | response to lipid | 9.0090 | 4 | yes |
| GO:0006163 | purine nucleotide metabolic process | 8.1081 | 5 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 8.1081 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 8.1081 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 7.2072 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 7.2072 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 7.2072 | 4 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 7.2072 | 6 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 7.2072 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 7.2072 | 4 | yes |
| GO:0051259 | protein complex oligomerization | 6.3063 | 6 | yes |
| GO:0051260 | protein homooligomerization | 6.3063 | 7 | yes |
| GO:0071396 | cellular response to lipid | 6.3063 | 5 | yes |
| GO:0001894 | tissue homeostasis | 5.4054 | 4 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 5.4054 | 4 | yes |
| GO:0097305 | response to alcohol | 5.4054 | 4 | yes |
| GO:0008610 | lipid biosynthetic process | 4.5045 | 4 | yes |
| GO:0097306 | cellular response to alcohol | 4.5045 | 5 | yes |
| GO:0006631 | fatty acid metabolic process | 3.6036 | 4 | yes |
| GO:0016053 | organic acid biosynthetic process | 3.6036 | 4 | yes |
| GO:0046394 | carboxylic acid biosynthetic process | 3.6036 | 5 | yes |
| GO:0051262 | protein tetramerization | 3.6036 | 7 | yes |
| GO:0051289 | protein homotetramerization | 3.6036 | 8 | yes |
| GO:1901654 | response to ketone | 3.6036 | 4 | yes |
| GO:0006633 | fatty acid biosynthetic process | 2.7027 | 5 | yes |
| GO:0033865 | nucleoside bisphosphate metabolic process | 2.7027 | 5 | yes |
| GO:0033875 | ribonucleoside bisphosphate metabolic process | 2.7027 | 6 | yes |
| GO:0034032 | purine nucleoside bisphosphate metabolic process | 2.7027 | 5 | yes |
| GO:0072330 | monocarboxylic acid biosynthetic process | 2.7027 | 6 | yes |
| GO:0072522 | purine-containing compound biosynthetic process | 2.7027 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 2.7027 | 4 | yes |
| GO:1901655 | cellular response to ketone | 2.7027 | 5 | yes |
| GO:0006084 | acetyl-CoA metabolic process | 1.8018 | 4 | yes |
| GO:0006164 | purine nucleotide biosynthetic process | 1.8018 | 6 | yes |
| GO:0009152 | purine ribonucleotide biosynthetic process | 1.8018 | 7 | yes |
| GO:0009165 | nucleotide biosynthetic process | 1.8018 | 6 | yes |
| GO:0009260 | ribonucleotide biosynthetic process | 1.8018 | 6 | yes |
| GO:0033866 | nucleoside bisphosphate biosynthetic process | 1.8018 | 6 | yes |
| GO:0034030 | ribonucleoside bisphosphate biosynthetic process | 1.8018 | 7 | yes |
| GO:0034033 | purine nucleoside bisphosphate biosynthetic process | 1.8018 | 6 | yes |
| GO:0034694 | response to prostaglandin | 1.8018 | 4 | yes |
| GO:0034695 | response to prostaglandin E | 1.8018 | 5 | yes |
| GO:0035337 | fatty-acyl-CoA metabolic process | 1.8018 | 4 | yes |
| GO:0035384 | thioester biosynthetic process | 1.8018 | 4 | yes |
| GO:0044272 | sulfur compound biosynthetic process | 1.8018 | 4 | yes |
| GO:0046390 | ribose phosphate biosynthetic process | 1.8018 | 5 | yes |
| GO:0046949 | fatty-acyl-CoA biosynthetic process | 1.8018 | 5 | yes |
| GO:0071379 | cellular response to prostaglandin stimulus | 1.8018 | 5 | yes |
| GO:0071380 | cellular response to prostaglandin E stimulus | 1.8018 | 6 | yes |
| GO:0071616 | acyl-CoA biosynthetic process | 1.8018 | 4 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 1.8018 | 4 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 1.8018 | 5 | yes |
| GO:1901568 | fatty acid derivative metabolic process | 1.8018 | 4 | yes |
| GO:1901570 | fatty acid derivative biosynthetic process | 1.8018 | 5 | yes |
| GO:2001293 | malonyl-CoA metabolic process | 1.8018 | 4 | yes |
| GO:2001295 | malonyl-CoA biosynthetic process | 1.8018 | 5 | yes |
Disease
No data found.
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TRIB1_HUMAN | [view interactions] | Low throughput | no | no |
| TRIB2_HUMAN | [view interactions] | Low throughput | no | yes |
| TRIB3_HUMAN | [view interactions] | Low throughput | no | yes |
| MELK_HUMAN | [view interactions] | Low throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | Low throughput | no | yes |
| AAKG1_HUMAN | [view interactions] | Low throughput | no | no |
| PP2AA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 2A5D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SIR1_HUMAN | [view interactions] | Low throughput | no | yes |
| M1IP1_HUMAN | [view interactions] | Low throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| AK1BA_HUMAN | [view interactions] | Low throughput | no | no |
| ACACA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AAPK1_HUMAN | [view interactions] | Low throughput | no | no |
| UBE2N_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FND11_HUMAN | [view interactions] | High throughput | no | no |
| TBCE_HUMAN | [view interactions] | High throughput | no | no |
| PSG1_HUMAN | [view interactions] | High throughput | no | no |
| NU214_HUMAN | [view interactions] | High throughput | no | no |
| RHG25_HUMAN | [view interactions] | High throughput | no | no |
| KCMF1_HUMAN | [view interactions] | High throughput | no | yes |
| LIPH_HUMAN | [view interactions] | High throughput | no | no |
| MEIS3_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CE046_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CENPN_HUMAN | [view interactions] | High throughput | no | no |
| ABCG1_HUMAN | [view interactions] | High throughput | no | yes |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| CCHL_HUMAN | [view interactions] | High throughput | no | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| OAS2_HUMAN | [view interactions] | High throughput | no | yes |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| ODAPH_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| TGFB1_HUMAN | [view interactions] | High throughput | no | no |
| NEIL3_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| ERC6L_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF6_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| NUP50_HUMAN | [view interactions] | High throughput | no | yes |
| KDM6B_HUMAN | [view interactions] | High throughput | no | yes |
| PSB7_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| P4R3A_HUMAN | [view interactions] | High throughput | no | yes |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYIC_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP2_HUMAN | [view interactions] | High throughput | no | yes |
| PSB2_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| PRS10_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| SNUT1_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| SMC2_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| RINI_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| GNS_HUMAN | [view interactions] | High throughput | no | yes |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| PYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| PCCB_HUMAN | [view interactions] | High throughput | no | yes |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| MCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| MCCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| H2B1J_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTR9_HUMAN | [view interactions] | High throughput | no | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| PRS7_HUMAN | [view interactions] | High throughput | no | yes |
| CX7A2_HUMAN | [view interactions] | High throughput | no | no |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDF1_HUMAN | [view interactions] | High throughput | no | yes |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| IF4G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACACB_HUMAN | [view interactions] | High throughput | no | no |
| UBE3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD71_HUMAN | [view interactions] | High throughput | no | no |
| KLC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THRSP_HUMAN | [view interactions] | High throughput | no | no |
| GOGA4_HUMAN | [view interactions] | High throughput | no | yes |
| PIGF_HUMAN | [view interactions] | High throughput | no | no |
| MCM6_HUMAN | [view interactions] | High throughput | no | yes |
| NPTXR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAPD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CKAP2_HUMAN | [view interactions] | High throughput | no | yes |
| CND2_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| CND1_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| ADRM1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| KDM3B_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| KATL2_HUMAN | [view interactions] | High throughput | no | yes |
| PIGR_HUMAN | [view interactions] | High throughput | no | no |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CND3_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NADAP_HUMAN | [view interactions] | High throughput | no | yes |
| REN3B_HUMAN | [view interactions] | High throughput | no | yes |
| GCP60_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP53_HUMAN | [view interactions] | High throughput | no | yes |
| VTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| SMC4_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHMP5_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRBP_HUMAN | [view interactions] | High throughput | no | yes |
| TBX5_HUMAN | [view interactions] | High throughput | no | no |
| PSD13_HUMAN | [view interactions] | High throughput | no | yes |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| BIG1_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| R113A_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| OTUL_HUMAN | [view interactions] | High throughput | no | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| GRB7_HUMAN | [view interactions] | High throughput | no | no |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOB3C_HUMAN | [view interactions] | High throughput | no | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFNA3_HUMAN | [view interactions] | High throughput | no | yes |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| PUR4_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| PGAP2_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| MOGS_HUMAN | [view interactions] | High throughput | no | yes |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| MBTD1_HUMAN | [view interactions] | High throughput | no | yes |
| PER2_HUMAN | [view interactions] | High throughput | no | yes |
| MYO10_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| BRD2_HUMAN | [view interactions] | High throughput | no | yes |
| DTX2_HUMAN | [view interactions] | High throughput | no | yes |
| IMA4_HUMAN | [view interactions] | High throughput | no | yes |
| ARF4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPHLN_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC3_HUMAN | [view interactions] | High throughput | no | yes |
| ARL4D_HUMAN | [view interactions] | High throughput | no | no |
| RBNS5_HUMAN | [view interactions] | High throughput | no | yes |
| ARL5A_HUMAN | [view interactions] | High throughput | no | yes |
| RLGPB_HUMAN | [view interactions] | High throughput | no | yes |
| ARL5B_HUMAN | [view interactions] | High throughput | no | yes |
| M4K4_HUMAN | [view interactions] | High throughput | no | yes |
| ARL10_HUMAN | [view interactions] | High throughput | no | yes |
| SPB6_HUMAN | [view interactions] | High throughput | no | yes |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| ZDBF2_HUMAN | [view interactions] | High throughput | no | yes |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| TIPRL_HUMAN | [view interactions] | High throughput | no | yes |
| RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKAP_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| RNF12_HUMAN | [view interactions] | High throughput | no | yes |
| PF21A_HUMAN | [view interactions] | High throughput | no | yes |
| ACATN_HUMAN | [view interactions] | High throughput | no | yes |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| GUAA_HUMAN | [view interactions] | High throughput | no | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF4_HUMAN | [view interactions] | High throughput | no | yes |
| CLCC1_HUMAN | [view interactions] | High throughput | no | yes |
| DCA10_HUMAN | [view interactions] | High throughput | no | no |
| S35B2_HUMAN | [view interactions] | High throughput | no | no |
| DCA12_HUMAN | [view interactions] | High throughput | no | yes |
| RM35_HUMAN | [view interactions] | High throughput | no | no |
| DDA1_HUMAN | [view interactions] | High throughput | no | yes |
| HACD3_HUMAN | [view interactions] | High throughput | no | yes |
| DET1_HUMAN | [view interactions] | High throughput | no | no |
| RGMC_HUMAN | [view interactions] | High throughput | no | no |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT21_HUMAN | [view interactions] | High throughput | no | no |
| NUP43_HUMAN | [view interactions] | High throughput | no | yes |
| OXSM_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
| WEE1_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP7_HUMAN | [view interactions] | High throughput | no | yes |
| RBGPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COP1_HUMAN | [view interactions] | High throughput | no | no |
| SRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| SNR40_HUMAN | [view interactions] | High throughput | no | yes |
| SDHF4_HUMAN | [view interactions] | High throughput | no | yes |
| TOIP2_HUMAN | [view interactions] | High throughput | no | no |
| PYRD_HUMAN | [view interactions] | High throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| UNKL_HUMAN | [view interactions] | High throughput | no | no |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| DDX46_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| SP16H_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MSTO1_HUMAN | [view interactions] | High throughput | no | yes |
| PIGC_HUMAN | [view interactions] | High throughput | no | no |
| EIF3M_HUMAN | [view interactions] | High throughput | no | yes |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIK2A_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| COR2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SO4A1_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CC140_HUMAN | [view interactions] | High throughput | no | no |
| NOP58_HUMAN | [view interactions] | High throughput | no | yes |
| F186B_HUMAN | [view interactions] | High throughput | no | no |
| FOLC_HUMAN | [view interactions] | High throughput | no | no |
| SEPT5_HUMAN | [view interactions] | High throughput | no | no |
| VMA21_HUMAN | [view interactions] | High throughput | no | no |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPAG7_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| KAT7_HUMAN | [view interactions] | High throughput | no | yes |
| NOL4L_HUMAN | [view interactions] | High throughput | no | yes |
| UB2G2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| GANAB_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM25_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| I5P1_HUMAN | [view interactions] | High throughput | no | yes |
| H2AZ_HUMAN | [view interactions] | High throughput | no | yes |
| GBRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFIT1_HUMAN | [view interactions] | High throughput | no | no |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| YRDC_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| IR3IP_HUMAN | [view interactions] | High throughput | no | yes |
| SHOC2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADIP_HUMAN | [view interactions] | High throughput | no | yes |
| INT1_HUMAN | [view interactions] | High throughput | no | yes |
| SPHK1_HUMAN | [view interactions] | High throughput | no | yes |
| QRIC1_HUMAN | [view interactions] | High throughput | no | yes |
| CLSPN_HUMAN | [view interactions] | High throughput | no | no |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAD51_HUMAN | [view interactions] | High throughput | no | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| OGA_HUMAN | [view interactions] | High throughput | no | yes |
| CHC10_HUMAN | [view interactions] | High throughput | no | yes |
| ELOF1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SREK1_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
| RT09_HUMAN | [view interactions] | High throughput | no | yes |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CENPM_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT12_HUMAN | [view interactions] | High throughput | no | yes |
| SIM43_HUMAN | [view interactions] | High throughput | no | no |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYMC_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AICDA_HUMAN | [view interactions] | High throughput | no | no |
| RL18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAXI1_HUMAN | [view interactions] | High throughput | no | no |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| DAPK3_HUMAN | [view interactions] | High throughput | no | yes |
| CDK6_HUMAN | [view interactions] | High throughput | no | yes |
| OXSR1_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| CDK17_HUMAN | [view interactions] | High throughput | no | yes |
| C56D2_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESF1_HUMAN | [view interactions] | High throughput | no | yes |
| PXK_HUMAN | [view interactions] | High throughput | no | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| KS6B2_HUMAN | [view interactions] | High throughput | no | yes |
| ARI2_HUMAN | [view interactions] | High throughput | no | no |
| KC1G3_HUMAN | [view interactions] | High throughput | no | yes |
| PRP16_HUMAN | [view interactions] | High throughput | no | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| EPOP_HUMAN | [view interactions] | High throughput | no | no |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| CRACD_HUMAN | [view interactions] | High throughput | no | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| AEN_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| IL25_HUMAN | [view interactions] | High throughput | no | no |
| CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
| ELMD3_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSS_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC125_HUMAN | [view interactions] | High throughput | no | yes |
| OSMR_HUMAN | [view interactions] | High throughput | no | yes |
| REC8_HUMAN | [view interactions] | High throughput | no | yes |
| LN28A_HUMAN | [view interactions] | High throughput | no | no |
| NU205_HUMAN | [view interactions] | High throughput | no | no |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| REEP4_HUMAN | [view interactions] | High throughput | no | no |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| SCG1_HUMAN | [view interactions] | High throughput | no | no |
| CENPX_HUMAN | [view interactions] | High throughput | no | no |
| EF2K_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MFRN2_HUMAN | [view interactions] | High throughput | no | no |
| STK25_HUMAN | [view interactions] | High throughput | no | no |
| PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
| PHKG2_HUMAN | [view interactions] | High throughput | no | no |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| PATL1_HUMAN | [view interactions] | High throughput | no | yes |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SBDS_HUMAN | [view interactions] | High throughput | no | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| STK3_HUMAN | [view interactions] | High throughput | no | yes |
| MBD3_HUMAN | [view interactions] | High throughput | no | yes |
| RIOK2_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF5_HUMAN | [view interactions] | High throughput | no | yes |
| STK4_HUMAN | [view interactions] | High throughput | no | yes |
| EPCR_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| S12A4_HUMAN | [view interactions] | High throughput | no | yes |
| PAF1_HUMAN | [view interactions] | High throughput | no | yes |
| BCL2_HUMAN | [view interactions] | High throughput | no | no |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| RBM34_HUMAN | [view interactions] | High throughput | no | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| TRM2A_HUMAN | [view interactions] | High throughput | no | yes |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| S12A9_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| RM21_HUMAN | [view interactions] | High throughput | no | no |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCD17_HUMAN | [view interactions] | High throughput | no | yes |
| FGF14_HUMAN | [view interactions] | High throughput | no | no |
| INT6_HUMAN | [view interactions] | High throughput | no | yes |
| APOC1_HUMAN | [view interactions] | High throughput | no | no |
| KTNA1_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| COL10_HUMAN | [view interactions] | High throughput | no | no |
| AF9_HUMAN | [view interactions] | High throughput | no | yes |
| SEN2_HUMAN | [view interactions] | High throughput | no | yes |
| ENL_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD1_HUMAN | [view interactions] | High throughput | no | no |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SART3_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| PPIL2_HUMAN | [view interactions] | High throughput | no | yes |
| KLF9_HUMAN | [view interactions] | High throughput | no | no |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC5_HUMAN | [view interactions] | High throughput | no | yes |
| UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
| AURKC_HUMAN | [view interactions] | High throughput | no | no |
| P85B_HUMAN | [view interactions] | High throughput | no | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MACD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BFAR_HUMAN | [view interactions] | High throughput | no | no |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELP1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAH9_HUMAN | [view interactions] | High throughput | no | no |
| KERA_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUND1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CI114_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIP30_HUMAN | [view interactions] | High throughput | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAFF_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| SIAH3_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| APC1_HUMAN | [view interactions] | High throughput | no | no |
| MDM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RANB3_HUMAN | [view interactions] | High throughput | no | yes |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| NFRKB_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI16_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOCS6_HUMAN | [view interactions] | High throughput | no | yes |
| PRLD1_HUMAN | [view interactions] | High throughput | no | yes |
| SGCZ_HUMAN | [view interactions] | High throughput | no | no |
| ELL_HUMAN | [view interactions] | High throughput | no | no |