GAPD1_HUMAN
Evidence for PS localization
Functions
Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GAPD1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 33.3333 | 4 | no |
| GO:0003723 | RNA binding | 33.3333 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.7692 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.7692 | 4 | no |
| GO:0045296 | cadherin binding | 23.0769 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 23.0769 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.0769 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.0769 | 6 | no |
| GO:0030695 | GTPase regulator activity | 20.5128 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 7.6923 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GAPD1_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 56.4103 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 56.4103 | 4 | no |
| GO:0010646 | regulation of cell communication | 51.2821 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 51.2821 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 48.7179 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 48.7179 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 48.7179 | 4 | no |
| GO:0015031 | protein transport | 46.1538 | 4 | no |
| GO:0071702 | organic substance transport | 46.1538 | 4 | no |
| GO:0071705 | nitrogen compound transport | 46.1538 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.1538 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 43.5897 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 41.0256 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 41.0256 | 5 | no |
| GO:0009966 | regulation of signal transduction | 38.4615 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 38.4615 | 4 | no |
| GO:0051049 | regulation of transport | 35.8974 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.8974 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 30.7692 | 4 | no |
| GO:0006886 | intracellular protein transport | 28.2051 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.2051 | 5 | no |
| GO:0031399 | regulation of protein modification process | 28.2051 | 6 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.6410 | 5 | no |
| GO:0071310 | cellular response to organic substance | 25.6410 | 4 | no |
| GO:0006996 | organelle organization | 25.6410 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.6410 | 6 | no |
| GO:0009894 | regulation of catabolic process | 25.6410 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.6410 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.6410 | 5 | no |
| GO:0032880 | regulation of protein localization | 23.0769 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 23.0769 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 23.0769 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 23.0769 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.0769 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.0769 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.0769 | 4 | no |
| GO:0006897 | endocytosis | 20.5128 | 5 | yes |
| GO:0033365 | protein localization to organelle | 20.5128 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 20.5128 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.5128 | 5 | no |
| GO:0022607 | cellular component assembly | 20.5128 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.5128 | 5 | no |
| GO:0042176 | regulation of protein catabolic process | 20.5128 | 5 | no |
| GO:0031329 | regulation of cellular catabolic process | 20.5128 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.5128 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 20.5128 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 20.5128 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 15.3846 | 4 | yes |
| GO:0043087 | regulation of GTPase activity | 12.8205 | 5 | yes |
| GO:0051223 | regulation of protein transport | 12.8205 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 12.8205 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| VAV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXB1_HUMAN | [view interactions] | High throughput | no | no |
| FOXL1_HUMAN | [view interactions] | High throughput | no | no |
| FOXF1_HUMAN | [view interactions] | High throughput | no | no |
| RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EEA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| HSF1_HUMAN | [view interactions] | High throughput | no | yes |
| TF3C4_HUMAN | [view interactions] | High throughput | no | no |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM6_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MCM4_HUMAN | [view interactions] | High throughput | no | yes |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| KCAB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSSK1_HUMAN | [view interactions] | High throughput | no | no |
| SPT46_HUMAN | [view interactions] | High throughput | no | no |
| MICU2_HUMAN | [view interactions] | High throughput | no | yes |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| AXIN1_HUMAN | [view interactions] | High throughput | no | yes |
| TBE_HUMAN | [view interactions] | High throughput | no | yes |
| ZN618_HUMAN | [view interactions] | High throughput | no | no |
| SNX24_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| AGO2_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS19_HUMAN | [view interactions] | High throughput | no | yes |
| DUS22_HUMAN | [view interactions] | High throughput | no | yes |
| MGDP1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPC1_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KC1AL_HUMAN | [view interactions] | High throughput | no | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F110D_HUMAN | [view interactions] | High throughput | no | no |
| PER2_HUMAN | [view interactions] | High throughput | no | yes |
| FBX11_HUMAN | [view interactions] | High throughput | no | no |
| THRSP_HUMAN | [view interactions] | High throughput | no | no |
| MED17_HUMAN | [view interactions] | High throughput | no | no |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| UBP32_HUMAN | [view interactions] | High throughput | no | yes |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| CSN2_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC6_HUMAN | [view interactions] | High throughput | no | yes |
| FOXK1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPR_HUMAN | [view interactions] | High throughput | no | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRC47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF3A1_HUMAN | [view interactions] | High throughput | no | yes |
| RASA2_HUMAN | [view interactions] | High throughput | no | yes |
| RASA3_HUMAN | [view interactions] | High throughput | no | yes |
| RASL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| GOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| RAE1_HUMAN | [view interactions] | Computational | no | yes |
| RAB5B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RHOQ_HUMAN | [view interactions] | Computational | no | no |
| RAB31_HUMAN | [view interactions] | Computational | no | yes |
| RABE1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GDIB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ALS2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CIP4_HUMAN | [view interactions] | Computational | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAE2_HUMAN | [view interactions] | Computational | no | yes |
| GDIA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |