Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GAPD1_HUMAN

Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. [View more on UniProt]

02004006008001,0001,2001,400
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

02004006008001,0001,2001,400
GAPD1_HUMAN
LOADING 67%
Download full PS network for entry.
02004006008001,0001,2001,400
Interacting regions
Canonical [GAPD1_HUMAN]
Isoform [C9IZ08] alignment
Isoform [C9IZX9] alignment
Isoform [B0QZ65] alignment
Isoform [Q14C86-2] alignment
Isoform [Q14C86-3] alignment
Isoform [Q14C86-4] alignment
Isoform [Q14C86-5] alignment
Isoform [Q14C86-6] alignment
Isoform [F8W9S7] alignment
Isoform [H0Y7I9] alignment
Isoform [H0Y4E7] alignment
Isoform [B4DGD8] alignment
LOADING 97%

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Biological process

Disease

No data found.

[GDPR]

By using PSINDB you accept the Privacy Notice in compliance with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. Read the

Privacy notes
Understood