Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FLII_HUMAN

May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development . May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in FLII_HUMAN
GO:0017076 purine nucleotide binding 36.5079 4 no
GO:0003779 actin binding 34.9206 4 yes
GO:0032555 purine ribonucleotide binding 34.9206 4 no
GO:0035639 purine ribonucleoside triphosphate binding 34.9206 4 no
GO:0030554 adenyl nucleotide binding 33.3333 5 no
GO:0005524 ATP binding 31.7460 5 no
GO:0032559 adenyl ribonucleotide binding 31.7460 5 no
GO:0003723 RNA binding 30.1587 4 no
GO:0019900 kinase binding 20.6349 4 no
GO:0019901 protein kinase binding 20.6349 5 no
GO:0045296 cadherin binding 20.6349 4 no
GO:0035091 phosphatidylinositol binding 6.3492 4 yes
GO:1901981 phosphatidylinositol phosphate binding 6.3492 5 yes
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 3.1746 4 yes
GO:1902936 phosphatidylinositol bisphosphate binding 3.1746 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in FLII_HUMAN
GO:0048522 positive regulation of cellular process 65.0794 4 no
GO:0060255 regulation of macromolecule metabolic process 55.5556 4 no
GO:0051128 regulation of cellular component organization 52.3810 4 yes
GO:0031323 regulation of cellular metabolic process 50.7937 4 no
GO:0080090 regulation of primary metabolic process 50.7937 4 no
GO:0048523 negative regulation of cellular process 47.6190 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 47.6190 4 no
GO:0006996 organelle organization 46.0317 4 yes
GO:0010468 regulation of gene expression 46.0317 5 no
GO:0010646 regulation of cell communication 39.6825 4 no
GO:0009893 positive regulation of metabolic process 38.0952 4 no
GO:0022607 cellular component assembly 34.9206 4 yes
GO:0009889 regulation of biosynthetic process 34.9206 4 no
GO:0010556 regulation of macromolecule biosynthetic process 34.9206 5 no
GO:0010604 positive regulation of macromolecule metabolic process 34.9206 5 no
GO:0031326 regulation of cellular biosynthetic process 34.9206 5 no
GO:0051246 regulation of protein metabolic process 34.9206 5 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 yes
GO:0007010 cytoskeleton organization 31.7460 5 yes
GO:0009966 regulation of signal transduction 31.7460 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.7460 5 no
GO:0008104 protein localization 30.1587 4 no
GO:0033043 regulation of organelle organization 28.5714 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 28.5714 5 no
GO:0051252 regulation of RNA metabolic process 28.5714 5 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0036211 protein modification process 26.9841 4 no
GO:0043412 macromolecule modification 26.9841 4 no
GO:0051049 regulation of transport 26.9841 4 no
GO:0009892 negative regulation of metabolic process 26.9841 4 no
GO:0031325 positive regulation of cellular metabolic process 26.9841 5 no
GO:0051130 positive regulation of cellular component organization 26.9841 5 no
GO:0010647 positive regulation of cell communication 26.9841 5 no
GO:0023056 positive regulation of signaling 26.9841 4 no
GO:0051493 regulation of cytoskeleton organization 25.3968 6 yes
GO:0006355 regulation of DNA-templated transcription 25.3968 6 no
GO:1903506 regulation of nucleic acid-templated transcription 25.3968 7 no
GO:2001141 regulation of RNA biosynthetic process 25.3968 6 no
GO:0031324 negative regulation of cellular metabolic process 23.8095 5 no
GO:0071310 cellular response to organic substance 23.8095 4 no
GO:1902531 regulation of intracellular signal transduction 23.8095 5 no
GO:0009967 positive regulation of signal transduction 23.8095 5 no
GO:0032970 regulation of actin filament-based process 22.2222 4 yes
GO:0097435 supramolecular fiber organization 22.2222 4 yes
GO:1902903 regulation of supramolecular fiber organization 22.2222 5 yes
GO:0006796 phosphate-containing compound metabolic process 22.2222 4 no
GO:0045595 regulation of cell differentiation 22.2222 4 no
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0032956 regulation of actin cytoskeleton organization 20.6349 5 yes
GO:0051129 negative regulation of cellular component organization 20.6349 5 yes
GO:0051094 positive regulation of developmental process 20.6349 4 no
GO:0010628 positive regulation of gene expression 20.6349 6 no
GO:0010941 regulation of cell death 20.6349 4 no
GO:0031399 regulation of protein modification process 20.6349 6 no
GO:0016192 vesicle-mediated transport 20.6349 4 no
GO:0007015 actin filament organization 19.0476 5 yes
GO:0110053 regulation of actin filament organization 19.0476 6 yes
GO:0043254 regulation of protein-containing complex assembly 17.4603 5 yes
GO:0010639 negative regulation of organelle organization 15.8730 6 yes
GO:0032271 regulation of protein polymerization 14.2857 6 yes
GO:0032535 regulation of cellular component size 14.2857 4 yes
GO:0008064 regulation of actin polymerization or depolymerization 12.6984 6 yes
GO:0030832 regulation of actin filament length 12.6984 5 yes
GO:0051494 negative regulation of cytoskeleton organization 12.6984 7 yes
GO:0070925 organelle assembly 12.6984 5 yes
GO:1902904 negative regulation of supramolecular fiber organization 12.6984 6 yes
GO:0030833 regulation of actin filament polymerization 11.1111 7 yes
GO:0031032 actomyosin structure organization 11.1111 4 yes
GO:0031333 negative regulation of protein-containing complex assembly 9.5238 6 yes
GO:0032272 negative regulation of protein polymerization 9.5238 7 yes
GO:0030834 regulation of actin filament depolymerization 7.9365 7 yes
GO:0030835 negative regulation of actin filament depolymerization 7.9365 7 yes
GO:0030837 negative regulation of actin filament polymerization 7.9365 7 yes
GO:0043242 negative regulation of protein-containing complex disassembly 7.9365 6 yes
GO:0043244 regulation of protein-containing complex disassembly 7.9365 5 yes
GO:1901879 regulation of protein depolymerization 7.9365 6 yes
GO:1901880 negative regulation of protein depolymerization 7.9365 7 yes
GO:0051693 actin filament capping 6.3492 8 yes
GO:0140694 non-membrane-bounded organelle assembly 6.3492 6 yes
GO:0051016 barbed-end actin filament capping 4.7619 9 yes
GO:0008154 actin polymerization or depolymerization 3.1746 6 yes
GO:0030239 myofibril assembly 3.1746 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in FLII_HUMAN
DOID:0111962 combined immunodeficiency 3.1746 4 no
DOID:612 primary immunodeficiency disease 3.1746 3 no
DOID:627 severe combined immunodeficiency 3.1746 5 no
DOID:0050686 organ system cancer 3.1746 3 no
DOID:114 heart disease 3.1746 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LRRF1_HUMAN [view interactions] Low throughput no yes
LRRF2_HUMAN [view interactions] Low throughput no yes
KCC2D_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2B_HUMAN [view entry] [view interactions] Low throughput yes yes
TRAIP_HUMAN [view interactions] Low throughput no yes
CARM1_HUMAN [view interactions] Low throughput no yes
ACL6A_HUMAN [view interactions] Low throughput no yes
MYD88_HUMAN [view entry] [view interactions] Low throughput yes yes
ANM1_HUMAN [view interactions] Low throughput no yes
ESR1_HUMAN [view interactions] Low throughput no no
EP300_HUMAN [view interactions] Low throughput no yes
TRIM8_HUMAN [view interactions] Low throughput no yes
SPOP_HUMAN [view interactions] Low throughput no no
OTUD3_HUMAN [view interactions] Low throughput no yes
OTUD4_HUMAN [view interactions] Low throughput no yes
OTU6B_HUMAN [view interactions] Low throughput no yes
OTU7A_HUMAN [view interactions] Low throughput no no
GRIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
NCOA2_HUMAN [view interactions] Low throughput no no
NCOA3_HUMAN [view interactions] Low throughput no yes
NMT1_HUMAN [view interactions] High throughput no yes
PDCD6_HUMAN [view interactions] High throughput no no
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
RFC2_HUMAN [view interactions] High throughput no yes
RFC4_HUMAN [view interactions] High throughput no yes
RL27_HUMAN [view entry] [view interactions] High throughput yes yes
TRI14_HUMAN [view interactions] High throughput no yes
IF4A3_HUMAN [view entry] [view interactions] High throughput yes yes
LZTS2_HUMAN [view interactions] High throughput no no
PAIP2_HUMAN [view interactions] High throughput no yes
TDRD3_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ANC2_HUMAN [view interactions] High throughput no no
DYR2_HUMAN [view interactions] High throughput no yes
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
IF6_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
RPB3_HUMAN [view interactions] High throughput no yes
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
RIPK4_HUMAN [view interactions] High throughput no no
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
ANLN_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
SRSF5_HUMAN [view interactions] High throughput no yes
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
CALL3_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
MYO5C_HUMAN [view entry] [view interactions] High throughput yes yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
NEST_HUMAN [view interactions] High throughput no no
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
CFA97_HUMAN [view interactions] High throughput no yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
WRP73_HUMAN [view interactions] High throughput no no
ZNRD2_HUMAN [view interactions] High throughput no yes
TMOD4_HUMAN [view interactions] High throughput no no
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
SAP_HUMAN [view interactions] High throughput no yes
SH3L1_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
DCAF7_HUMAN [view interactions] High throughput no yes
JAZF1_HUMAN [view interactions] High throughput no yes
MATR3_HUMAN [view interactions] High throughput no yes
AKAP8_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
PPP5_HUMAN [view entry] [view interactions] High throughput yes yes
MED4_HUMAN [view interactions] High throughput no yes
MED20_HUMAN [view interactions] High throughput no no
PRKX_HUMAN [view interactions] High throughput no yes
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
MK07_HUMAN [view interactions] High throughput no yes
PTBP3_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
ITF2_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
HERC2_HUMAN [view interactions] High throughput no yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
CEP89_HUMAN [view interactions] High throughput no no
NPHP1_HUMAN [view interactions] High throughput no yes
HOOK2_HUMAN [view interactions] High throughput no yes
RBTN2_HUMAN [view interactions] High throughput no yes
FBX25_HUMAN [view interactions] High throughput no no
BRCA1_HUMAN [view interactions] High throughput no yes
FMNL1_HUMAN [view entry] [view interactions] High throughput yes no
PAN2_HUMAN [view interactions] High throughput no no
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
CCDC8_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
FBW1B_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
KAT5_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
CDK2_HUMAN [view interactions] High throughput no yes
RCC1_HUMAN [view interactions] High throughput no yes
NAT9_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
CCND2_HUMAN [view interactions] High throughput no yes
TEDC2_HUMAN [view interactions] High throughput no no
DX39B_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CRYL1_HUMAN [view interactions] High throughput no yes
KC1A_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
SYLC_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
HIF1A_HUMAN [view interactions] High throughput no no
TNFA_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
DCPS_HUMAN [view interactions] High throughput no yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
CCND1_HUMAN [view interactions] High throughput no yes
TF3B_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
SOX2_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
LRC31_HUMAN [view interactions] High throughput no no
AURKB_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CIC_HUMAN [view interactions] High throughput no yes
F16P1_HUMAN [view interactions] High throughput no no
ASXL1_HUMAN [view interactions] High throughput no no
ANDR_HUMAN [view interactions] High throughput no no
ISG15_HUMAN [view interactions] High throughput no no
TULP3_HUMAN [view interactions] High throughput no yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
WDR5_HUMAN [view interactions] High throughput no no
CTU2_HUMAN [view interactions] High throughput no yes
ABRA_HUMAN [view interactions] High throughput no no
CENPQ_HUMAN [view interactions] High throughput no yes
STRN_HUMAN [view entry] [view interactions] High throughput yes yes
PDZ11_HUMAN [view interactions] High throughput no yes
CTU1_HUMAN [view interactions] High throughput no no
TEBP_HUMAN [view interactions] High throughput no yes
WAPL_HUMAN [view interactions] High throughput no yes
SRP68_HUMAN [view interactions] High throughput no yes
KIF7_HUMAN [view interactions] High throughput no yes
MYCPP_HUMAN [view interactions] High throughput no no
CC174_HUMAN [view interactions] High throughput no yes
HERC1_HUMAN [view interactions] High throughput no no
TTC9C_HUMAN [view interactions] High throughput no yes
FBX30_HUMAN [view interactions] High throughput no yes
SGT1_HUMAN [view interactions] High throughput no no
CRGD_HUMAN [view interactions] High throughput no no
HERC4_HUMAN [view interactions] High throughput no no
UBP54_HUMAN [view interactions] High throughput no yes
FBX40_HUMAN [view interactions] High throughput no no
KLH34_HUMAN [view interactions] High throughput no no
FRIL_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
SLN11_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
FGD5_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
BRDT_HUMAN [view interactions] High throughput no no
PLK4_HUMAN [view interactions] High throughput no yes
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
CALD1_HUMAN [view entry] [view interactions] High throughput yes no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP5_HUMAN [view interactions] High throughput no yes
ML12A_HUMAN [view interactions] High throughput no no
PI3R4_HUMAN [view interactions] High throughput no yes
PSB10_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
IF1AX_HUMAN [view interactions] High throughput no yes
DGCR8_HUMAN [view entry] [view interactions] High throughput yes yes
RTRAF_HUMAN [view interactions] High throughput no yes
RTCB_HUMAN [view interactions] High throughput no yes
DDX1_HUMAN [view entry] [view interactions] High throughput yes yes
DHX9_HUMAN [view interactions] High throughput no yes
EI2BG_HUMAN [view interactions] High throughput no yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
IF2B3_HUMAN [view interactions] High throughput no no
K1C18_HUMAN [view interactions] High throughput no no
MRE11_HUMAN [view interactions] High throughput no yes
FKRP_HUMAN [view interactions] Computational no yes
EWS_HUMAN [view interactions] Computational no yes