Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DGCR8_HUMAN

Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed, PubMed). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed). Involved in the silencing of embryonic stem cell self-renewal . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in DGCR8_HUMAN
GO:0003723 RNA binding 69.7674 4 yes
GO:0003677 DNA binding 27.9070 4 no
GO:0005524 ATP binding 25.5814 5 no
GO:0017076 purine nucleotide binding 25.5814 4 no
GO:0030554 adenyl nucleotide binding 25.5814 5 no
GO:0032555 purine ribonucleotide binding 25.5814 4 no
GO:0032559 adenyl ribonucleotide binding 25.5814 5 no
GO:0035639 purine ribonucleoside triphosphate binding 25.5814 4 no
GO:0046872 metal ion binding 25.5814 4 yes
GO:0003725 double-stranded RNA binding 18.6047 5 yes
GO:0042803 protein homodimerization activity 11.6279 4 yes
GO:0070878 primary miRNA binding 9.3023 5 yes
GO:0020037 heme binding 4.6512 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DGCR8_HUMAN
GO:0090304 nucleic acid metabolic process 58.1395 4 yes
GO:0016070 RNA metabolic process 53.4884 5 yes
GO:0010468 regulation of gene expression 53.4884 5 no
GO:0031323 regulation of cellular metabolic process 53.4884 4 no
GO:0051171 regulation of nitrogen compound metabolic process 53.4884 4 no
GO:0060255 regulation of macromolecule metabolic process 53.4884 4 no
GO:0080090 regulation of primary metabolic process 53.4884 4 no
GO:0006396 RNA processing 46.5116 6 yes
GO:0048523 negative regulation of cellular process 46.5116 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 46.5116 5 no
GO:0048522 positive regulation of cellular process 46.5116 4 no
GO:0051252 regulation of RNA metabolic process 44.1860 5 no
GO:0009889 regulation of biosynthetic process 39.5349 4 no
GO:0010556 regulation of macromolecule biosynthetic process 39.5349 5 no
GO:0031326 regulation of cellular biosynthetic process 39.5349 5 no
GO:0009892 negative regulation of metabolic process 37.2093 4 no
GO:0010605 negative regulation of macromolecule metabolic process 37.2093 5 no
GO:0009893 positive regulation of metabolic process 37.2093 4 no
GO:0010604 positive regulation of macromolecule metabolic process 37.2093 5 no
GO:0022607 cellular component assembly 37.2093 4 no
GO:0031324 negative regulation of cellular metabolic process 34.8837 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 34.8837 5 no
GO:0034660 ncRNA metabolic process 32.5581 6 yes
GO:0043933 protein-containing complex organization 32.5581 4 no
GO:0034470 ncRNA processing 30.2326 7 yes
GO:0009059 macromolecule biosynthetic process 30.2326 4 no
GO:0044271 cellular nitrogen compound biosynthetic process 30.2326 4 no
GO:0065003 protein-containing complex assembly 30.2326 5 no
GO:0006355 regulation of DNA-templated transcription 30.2326 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 30.2326 5 no
GO:1903506 regulation of nucleic acid-templated transcription 30.2326 7 no
GO:2001141 regulation of RNA biosynthetic process 30.2326 6 no
GO:0051128 regulation of cellular component organization 27.9070 4 no
GO:0010646 regulation of cell communication 27.9070 4 no
GO:0006357 regulation of transcription by RNA polymerase II 27.9070 7 no
GO:0031325 positive regulation of cellular metabolic process 27.9070 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 27.9070 6 no
GO:0034645 cellular macromolecule biosynthetic process 25.5814 4 no
GO:0006996 organelle organization 25.5814 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 25.5814 6 no
GO:0006412 translation 23.2558 4 no
GO:0006518 peptide metabolic process 23.2558 4 no
GO:0043043 peptide biosynthetic process 23.2558 5 no
GO:0043603 cellular amide metabolic process 23.2558 4 no
GO:0043604 amide biosynthetic process 23.2558 5 no
GO:1901566 organonitrogen compound biosynthetic process 23.2558 4 no
GO:0009890 negative regulation of biosynthetic process 23.2558 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.2558 6 no
GO:0031327 negative regulation of cellular biosynthetic process 23.2558 6 no
GO:0010628 positive regulation of gene expression 23.2558 6 no
GO:0080134 regulation of response to stress 23.2558 4 no
GO:0009966 regulation of signal transduction 23.2558 4 no
GO:0048584 positive regulation of response to stimulus 23.2558 4 no
GO:0016071 mRNA metabolic process 23.2558 6 no
GO:0051253 negative regulation of RNA metabolic process 23.2558 6 no
GO:0002181 cytoplasmic translation 20.9302 5 no
GO:0051246 regulation of protein metabolic process 20.9302 5 no
GO:0071310 cellular response to organic substance 20.9302 4 no
GO:0033043 regulation of organelle organization 20.9302 5 no
GO:0051254 positive regulation of RNA metabolic process 20.9302 6 no
GO:0035196 miRNA processing 16.2791 9 yes
GO:0070918 small regulatory ncRNA processing 16.2791 8 yes
GO:0031053 primary miRNA processing 9.3023 10 yes

Disease

Term Name % Distance from top the of the tree Annotated in DGCR8_HUMAN
DOID:331 central nervous system disease 4.6512 3 no
DOID:480 movement disease 4.6512 5 no
DOID:936 brain disease 4.6512 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RN168_HUMAN [view interactions] Low throughput no no
UBP51_HUMAN [view interactions] Low throughput no yes
RNC_HUMAN [view entry] [view interactions] Low throughput yes no
DGCR8_HUMAN [view entry] [view interactions] Low throughput yes yes
DDX17_HUMAN [view entry] [view interactions] Low throughput yes yes
HIF1A_HUMAN [view interactions] Low throughput no no
FUBP2_HUMAN [view interactions] Low throughput no yes
ERH_HUMAN [view interactions] Low throughput no yes
NR2E1_HUMAN [view interactions] Low throughput no yes
GZF1_HUMAN [view interactions] High throughput no yes
ABC3F_HUMAN [view interactions] High throughput no no
PRD15_HUMAN [view interactions] High throughput no no
ZN770_HUMAN [view interactions] High throughput no yes
FBLN5_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
CX001_HUMAN [view interactions] High throughput no no
ZN624_HUMAN [view interactions] High throughput no yes
RL13A_HUMAN [view entry] [view interactions] High throughput yes yes
ZC3HA_HUMAN [view interactions] High throughput no yes
TAP26_HUMAN [view interactions] High throughput no yes
ZN512_HUMAN [view interactions] High throughput no yes
DDX50_HUMAN [view interactions] High throughput no yes
RBM19_HUMAN [view interactions] High throughput no yes
PURA_HUMAN [view entry] [view interactions] High throughput yes no
CG050_HUMAN [view interactions] High throughput no yes
NIP7_HUMAN [view interactions] High throughput no yes
KCTD5_HUMAN [view interactions] High throughput no no
RRP15_HUMAN [view interactions] High throughput no yes
TRI56_HUMAN [view interactions] High throughput no yes
RL7L_HUMAN [view interactions] High throughput no no
SREK1_HUMAN [view interactions] High throughput no yes
ABT1_HUMAN [view interactions] High throughput no no
RS4Y2_HUMAN [view interactions] High throughput no no
RL23A_HUMAN [view entry] [view interactions] High throughput yes yes
RRS1_HUMAN [view interactions] High throughput no yes
SSF1_HUMAN [view interactions] High throughput no yes
MBB1A_HUMAN [view interactions] High throughput no yes
AATF_HUMAN [view interactions] High throughput no yes
NKRF_HUMAN [view interactions] High throughput no no
RRP1B_HUMAN [view interactions] High throughput no yes
NOP56_HUMAN [view interactions] High throughput no yes
TUT7_HUMAN [view interactions] High throughput no yes
RL3_HUMAN [view entry] [view interactions] High throughput yes yes
RLP24_HUMAN [view interactions] High throughput no yes
FGFP1_HUMAN [view interactions] High throughput no no
OASL_HUMAN [view interactions] High throughput no no
SAS10_HUMAN [view interactions] High throughput no yes
NGDN_HUMAN [view entry] [view interactions] High throughput yes yes
RBM34_HUMAN [view interactions] High throughput no yes
E41LB_HUMAN [view interactions] High throughput no yes
RBMX2_HUMAN [view interactions] High throughput no yes
NOC2L_HUMAN [view interactions] High throughput no yes
E41L5_HUMAN [view interactions] High throughput no no
WDR74_HUMAN [view interactions] High throughput no no
IMP4_HUMAN [view interactions] High throughput no no
RRP1_HUMAN [view interactions] High throughput no yes
RPF1_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
CDK12_HUMAN [view interactions] High throughput no yes
BMS1_HUMAN [view interactions] High throughput no yes
NOP53_HUMAN [view interactions] High throughput no yes
LUC7L_HUMAN [view interactions] High throughput no yes
RL36L_HUMAN [view interactions] High throughput no no
NALP7_HUMAN [view interactions] High throughput no no
RNF8_HUMAN [view interactions] High throughput no yes
UBP36_HUMAN [view interactions] High throughput no yes
XRCC6_HUMAN [view interactions] High throughput no yes
XRCC5_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
PRP19_HUMAN [view interactions] High throughput no yes
FEN1_HUMAN [view interactions] High throughput no yes
PCNA_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
MSH2_HUMAN [view interactions] High throughput no yes
MSH6_HUMAN [view interactions] High throughput no yes
DDB1_HUMAN [view interactions] High throughput no yes
CHK1_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
PRP4_HUMAN [view interactions] High throughput no yes
MARE2_HUMAN [view entry] [view interactions] High throughput yes yes
NAT10_HUMAN [view interactions] High throughput no yes
PLEK2_HUMAN [view interactions] High throughput no no
RPRD2_HUMAN [view interactions] High throughput no yes
FLII_HUMAN [view entry] [view interactions] High throughput yes yes
CDT1_HUMAN [view interactions] High throughput no yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
TRI36_HUMAN [view interactions] High throughput no no
YAP1_HUMAN [view interactions] High throughput no yes
EWS_HUMAN [view interactions] High throughput no yes
DHX40_HUMAN [view interactions] High throughput no yes
TE2IP_HUMAN [view interactions] High throughput no yes
SRPK1_HUMAN [view interactions] High throughput no yes
TLN2_HUMAN [view entry] [view interactions] High throughput yes yes
KIF15_HUMAN [view interactions] High throughput no no
MEOX2_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
EF1D_HUMAN [view entry] [view interactions] High throughput yes yes
TP53B_HUMAN [view entry] [view interactions] High throughput yes yes
MDC1_HUMAN [view interactions] High throughput no yes
NUCL_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPR_HUMAN [view interactions] High throughput no yes
DDX5_HUMAN [view entry] [view interactions] High throughput yes yes
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
DHX9_HUMAN [view interactions] High throughput no yes
HNRPU_HUMAN [view interactions] High throughput no yes
ILF3_HUMAN [view interactions] High throughput no yes
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
ANM1_HUMAN [view interactions] High throughput no yes
P5CR3_HUMAN [view interactions] High throughput no no
RAE1L_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
HNRL1_HUMAN [view interactions] High throughput no yes
KIF11_HUMAN [view interactions] High throughput no yes
SYN1_HUMAN [view entry] [view interactions] High throughput yes no
CTR9_HUMAN [view interactions] High throughput no yes
TFG_HUMAN [view interactions] High throughput no yes
ZWINT_HUMAN [view entry] [view interactions] High throughput yes no
KLF8_HUMAN [view interactions] High throughput no no
FANCI_HUMAN [view interactions] High throughput no yes
TET5A_HUMAN [view interactions] High throughput no yes
SMC6_HUMAN [view interactions] High throughput no no
HSF1_HUMAN [view interactions] High throughput no yes
MCM3_HUMAN [view interactions] High throughput no no
NFYA_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
TMEDA_HUMAN [view interactions] High throughput no yes
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
LNX1_HUMAN [view interactions] High throughput no yes
RRP8_HUMAN [view interactions] High throughput no yes
ZNF7_HUMAN [view interactions] High throughput no yes
CENPI_HUMAN [view interactions] High throughput no no
CENPR_HUMAN [view interactions] High throughput no yes
CENPO_HUMAN [view interactions] High throughput no no
SHQ1_HUMAN [view interactions] High throughput no no
CENPC_HUMAN [view interactions] High throughput no no
CENPN_HUMAN [view interactions] High throughput no no
CENPU_HUMAN [view interactions] High throughput no no
ZN189_HUMAN [view interactions] High throughput no yes
PAPD5_HUMAN [view interactions] High throughput no no
ZNF70_HUMAN [view interactions] High throughput no no
CENPQ_HUMAN [view interactions] High throughput no yes
ZN483_HUMAN [view interactions] High throughput no no
ZN800_HUMAN [view interactions] High throughput no yes
NSA2_HUMAN [view interactions] High throughput no yes
NSD2_HUMAN [view interactions] High throughput no yes
NOG2_HUMAN [view interactions] High throughput no yes
RENT1_HUMAN [view entry] [view interactions] High throughput yes yes
BEND7_HUMAN [view interactions] High throughput no no
NMNA1_HUMAN [view interactions] High throughput no yes
RL26L_HUMAN [view interactions] High throughput no yes
DKC1_HUMAN [view interactions] High throughput no yes
TTF1_HUMAN [view interactions] High throughput no yes
DDX31_HUMAN [view interactions] High throughput no no
KNOP1_HUMAN [view interactions] High throughput no yes
BRX1_HUMAN [view interactions] High throughput no no
RALY_HUMAN [view interactions] High throughput no yes
GTPB4_HUMAN [view interactions] High throughput no yes
MPP10_HUMAN [view interactions] High throughput no yes
Z324B_HUMAN [view interactions] High throughput no no
DDX24_HUMAN [view interactions] High throughput no yes
CC137_HUMAN [view interactions] High throughput no no
ZN689_HUMAN [view interactions] High throughput no yes
NOP2_HUMAN [view interactions] High throughput no yes
GLYR1_HUMAN [view interactions] High throughput no yes
ZFP62_HUMAN [view interactions] High throughput no no
DDX27_HUMAN [view interactions] High throughput no no
REXO4_HUMAN [view interactions] High throughput no yes
DDX10_HUMAN [view interactions] High throughput no yes
MECP2_HUMAN [view interactions] High throughput no yes
UTP23_HUMAN [view interactions] High throughput no no
ZCHC7_HUMAN [view interactions] High throughput no yes
RPF2_HUMAN [view interactions] High throughput no yes
TZAP_HUMAN [view interactions] High throughput no no
SPB1_HUMAN [view interactions] High throughput no yes
LARP1_HUMAN [view interactions] High throughput no yes
ZNF22_HUMAN [view interactions] High throughput no yes
RL17_HUMAN [view entry] [view interactions] High throughput yes yes
MAK16_HUMAN [view interactions] High throughput no yes
STAU2_HUMAN [view interactions] High throughput no yes
LAR1B_HUMAN [view interactions] High throughput no no
RBM28_HUMAN [view interactions] High throughput no yes
TDIF2_HUMAN [view interactions] High throughput no yes
ZN771_HUMAN [view interactions] High throughput no no
NVL_HUMAN [view interactions] High throughput no no
ZCCHV_HUMAN [view interactions] High throughput no yes
MOV10_HUMAN [view interactions] High throughput no no
DDX18_HUMAN [view interactions] High throughput no yes
PUM3_HUMAN [view interactions] High throughput no yes
SURF6_HUMAN [view interactions] High throughput no yes
FCF1_HUMAN [view interactions] High throughput no yes
PINX1_HUMAN [view interactions] High throughput no yes
SPT2_HUMAN [view interactions] High throughput no yes
ZN646_HUMAN [view interactions] High throughput no yes
PK1IP_HUMAN [view interactions] High throughput no yes
RLA2_HUMAN [view entry] [view interactions] High throughput yes yes
CENPH_HUMAN [view interactions] High throughput no yes
ZN777_HUMAN [view interactions] High throughput no yes
CTCF_HUMAN [view interactions] High throughput no yes
DHX30_HUMAN [view entry] [view interactions] High throughput yes yes
NOL10_HUMAN [view interactions] High throughput no yes
RS13_HUMAN [view entry] [view interactions] High throughput yes yes
REPI1_HUMAN [view interactions] High throughput no yes
PRKRA_HUMAN [view entry] [view interactions] High throughput yes yes
RL7A_HUMAN [view entry] [view interactions] High throughput yes no
H2A2B_HUMAN [view interactions] High throughput no yes
RL10A_HUMAN [view entry] [view interactions] High throughput yes yes
WDR12_HUMAN [view interactions] High throughput no yes
ZN668_HUMAN [view interactions] High throughput no yes
DDX56_HUMAN [view interactions] High throughput no yes
MK67I_HUMAN [view interactions] High throughput no yes
DDX54_HUMAN [view interactions] High throughput no yes
POP1_HUMAN [view interactions] High throughput no no
RS8_HUMAN [view entry] [view interactions] High throughput yes no
HERC5_HUMAN [view interactions] High throughput no yes
NOC3L_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
RU17_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
CCD86_HUMAN [view interactions] High throughput no yes
NOP16_HUMAN [view interactions] High throughput no yes
SRSF6_HUMAN [view interactions] High throughput no yes
MAGB2_HUMAN [view interactions] High throughput no no
HP1B3_HUMAN [view interactions] High throughput no yes
RL4_HUMAN [view entry] [view interactions] High throughput yes yes
AGO1_HUMAN [view interactions] Computational no no
AGO3_HUMAN [view interactions] Computational no yes
MET14_HUMAN [view interactions] Computational no yes
DICER_HUMAN [view entry] [view interactions] Computational yes yes
XPO5_HUMAN [view interactions] Computational no yes
ROA2_HUMAN [view entry] [view interactions] Computational yes yes
TRBP2_HUMAN [view interactions] Computational no yes
AGO2_HUMAN [view interactions] Computational no yes
AGO4_HUMAN [view interactions] Computational no no
DSRAD_HUMAN [view entry] [view interactions] Computational yes yes