Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SAM50_HUMAN

Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes (PubMed, PubMed). Required for the assembly of TOMM40 into the TOM complex (PubMed). [View more on UniProt]

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No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SAM50_HUMAN
GO:0017076 purine nucleotide binding 30.1075 4 no
GO:0032555 purine ribonucleotide binding 29.0323 4 no
GO:0035639 purine ribonucleoside triphosphate binding 27.9570 4 no
GO:0003723 RNA binding 26.8817 4 no
GO:0030554 adenyl nucleotide binding 22.5806 5 no
GO:0016462 pyrophosphatase activity 22.5806 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 22.5806 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 22.5806 6 no
GO:0032559 adenyl ribonucleotide binding 21.5054 5 no
GO:0005524 ATP binding 20.4301 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in SAM50_HUMAN
GO:0006996 organelle organization 44.0860 4 yes
GO:0048522 positive regulation of cellular process 43.0108 4 no
GO:0051128 regulation of cellular component organization 40.8602 4 no
GO:0060255 regulation of macromolecule metabolic process 37.6344 4 no
GO:0048523 negative regulation of cellular process 36.5591 4 no
GO:0031323 regulation of cellular metabolic process 36.5591 4 no
GO:0051171 regulation of nitrogen compound metabolic process 35.4839 4 no
GO:0080090 regulation of primary metabolic process 35.4839 4 no
GO:0022607 cellular component assembly 34.4086 4 yes
GO:0071702 organic substance transport 33.3333 4 yes
GO:0071705 nitrogen compound transport 31.1828 4 yes
GO:0033043 regulation of organelle organization 31.1828 5 no
GO:0009893 positive regulation of metabolic process 30.1075 4 no
GO:0008104 protein localization 29.0323 4 yes
GO:0043933 protein-containing complex organization 26.8817 4 yes
GO:0061024 membrane organization 26.8817 4 yes
GO:0015031 protein transport 25.8065 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.8065 5 no
GO:0010941 regulation of cell death 25.8065 4 no
GO:0007005 mitochondrion organization 24.7312 5 yes
GO:0065003 protein-containing complex assembly 24.7312 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 24.7312 5 no
GO:0042981 regulation of apoptotic process 24.7312 6 no
GO:0043067 regulation of programmed cell death 24.7312 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 23.6559 5 no
GO:0009889 regulation of biosynthetic process 22.5806 4 no
GO:0006886 intracellular protein transport 21.5054 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 21.5054 5 no
GO:0010468 regulation of gene expression 21.5054 5 no
GO:0010646 regulation of cell communication 21.5054 4 no
GO:0031326 regulation of cellular biosynthetic process 20.4301 5 no
GO:0051130 positive regulation of cellular component organization 20.4301 5 no
GO:0007006 mitochondrial membrane organization 17.2043 5 yes
GO:0033365 protein localization to organelle 17.2043 5 yes
GO:0072594 establishment of protein localization to organelle 13.9785 4 yes
GO:0007007 inner mitochondrial membrane organization 12.9032 6 yes
GO:0006839 mitochondrial transport 10.7527 4 yes
GO:0070585 protein localization to mitochondrion 10.7527 6 yes
GO:0042407 cristae formation 8.6022 7 yes
GO:0072655 establishment of protein localization to mitochondrion 8.6022 5 yes
GO:0072657 protein localization to membrane 7.5269 4 yes
GO:0090150 establishment of protein localization to membrane 6.4516 4 yes
GO:0033108 mitochondrial respiratory chain complex assembly 4.3011 6 yes
GO:0051205 protein insertion into membrane 2.1505 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in SAM50_HUMAN
DOID:574 peripheral nervous system disease 5.3763 3 no
DOID:870 neuropathy 5.3763 4 no
DOID:10595 Charcot-Marie-Tooth disease 3.2258 6 no
DOID:440 neuromuscular disease 3.2258 5 no
DOID:0050539 Charcot-Marie-Tooth disease type 2 2.1505 7 no
DOID:1891 optic nerve disease 2.1505 6 no
DOID:5656 cranial nerve disease 2.1505 5 no
DOID:5723 optic atrophy 2.1505 7 no
DOID:700 mitochondrial metabolism disease 2.1505 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MFN2_HUMAN [view entry] [view interactions] Low throughput yes yes
DNM1L_HUMAN [view entry] [view interactions] Low throughput yes yes
MIC60_HUMAN [view entry] [view interactions] Low throughput yes yes
MTX1_HUMAN [view entry] [view interactions] Low throughput yes yes
SQSTM_HUMAN [view interactions] Low throughput no yes
PINK1_HUMAN [view interactions] Low throughput no yes
MFN1_HUMAN [view interactions] Low throughput no yes
MFF_HUMAN [view entry] [view interactions] Low throughput yes yes
TOM40_HUMAN [view interactions] Low throughput no yes
GBRL1_HUMAN [view interactions] Low throughput no yes
TFB2M_HUMAN [view interactions] High throughput no no
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
RPP38_HUMAN [view interactions] High throughput no yes
TCPE_HUMAN [view entry] [view interactions] High throughput yes yes
TAF6_HUMAN [view interactions] High throughput no no
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
TAF2_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
ARP5L_HUMAN [view entry] [view interactions] High throughput yes yes
CLK3_HUMAN [view interactions] High throughput no yes
EBP_HUMAN [view interactions] High throughput no no
CYTSA_HUMAN [view interactions] High throughput no yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
OSBL5_HUMAN [view interactions] High throughput no yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
KLH12_HUMAN [view interactions] High throughput no no
FXRD2_HUMAN [view interactions] High throughput no yes
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
LRRF2_HUMAN [view interactions] High throughput no yes
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
MED17_HUMAN [view interactions] High throughput no no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
MIC27_HUMAN [view entry] [view interactions] High throughput yes yes
NMES1_HUMAN [view interactions] High throughput no no
F136A_HUMAN [view interactions] High throughput no yes
OCAD1_HUMAN [view interactions] High throughput no yes
MIC13_HUMAN [view interactions] High throughput no yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
OPA3_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
SNF5_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
ATG2A_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
SCRB2_HUMAN [view interactions] High throughput no yes
VMP1_HUMAN [view interactions] High throughput no yes
HSPB2_HUMAN [view interactions] High throughput no yes
KCNQ1_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
CAV3_HUMAN [view interactions] High throughput no no
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
BMI1_HUMAN [view interactions] High throughput no yes
MIC25_HUMAN [view entry] [view interactions] High throughput yes yes
MEOX2_HUMAN [view interactions] High throughput no no
ERH_HUMAN [view interactions] High throughput no yes
RAB8A_HUMAN [view entry] [view interactions] High throughput yes no
CI072_HUMAN [view interactions] High throughput no no
COX14_HUMAN [view interactions] High throughput no yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
PLRKT_HUMAN [view interactions] High throughput no yes
SCO1_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
TOM22_HUMAN [view interactions] High throughput no yes
IMP2L_HUMAN [view interactions] High throughput no yes
HTRA2_HUMAN [view interactions] High throughput no yes
IMP1L_HUMAN [view interactions] High throughput no yes
LACTB_HUMAN [view interactions] High throughput no yes
OMA1_HUMAN [view interactions] High throughput no no
PARL_HUMAN [view interactions] High throughput no yes
YMEL1_HUMAN [view interactions] High throughput no yes
FHI2B_HUMAN [view interactions] High throughput no yes
MIC10_HUMAN [view interactions] High throughput no yes
CLN3_HUMAN [view interactions] High throughput no no
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
SUZ12_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
AT5F1_HUMAN [view interactions] High throughput no yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
GELS_HUMAN [view entry] [view interactions] High throughput yes no
MYO1B_HUMAN [view entry] [view interactions] High throughput yes no
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
TPM2_HUMAN [view entry] [view interactions] High throughput yes yes
AKA12_HUMAN [view entry] [view interactions] High throughput yes no
PRDX5_HUMAN [view entry] [view interactions] High throughput yes yes
RT17_HUMAN [view interactions] High throughput no yes
DGCR8_HUMAN [view entry] [view interactions] High throughput yes yes
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes
KLHL7_HUMAN [view interactions] High throughput no yes
DCAKD_HUMAN [view entry] [view interactions] High throughput yes no
CCNQ_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
OXDA_HUMAN [view interactions] High throughput no no
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
DUS22_HUMAN [view interactions] High throughput no yes
MTM1_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
ZN598_HUMAN [view interactions] High throughput no no
EGLN3_HUMAN [view interactions] High throughput no no
LAP2A_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
TM41B_HUMAN [view interactions] High throughput no yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
TIA1_HUMAN [view interactions] High throughput no no
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
RNF26_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
EDEM1_HUMAN [view interactions] High throughput no yes
S22A8_HUMAN [view interactions] High throughput no no
TRAK1_HUMAN [view interactions] High throughput no yes
PCNP_HUMAN [view interactions] High throughput no yes
FAXC_HUMAN [view interactions] High throughput no no
CLC5A_HUMAN [view interactions] High throughput no no
EXOC6_HUMAN [view entry] [view interactions] High throughput yes yes
RETR3_HUMAN [view interactions] High throughput no yes
SPSB4_HUMAN [view interactions] High throughput no no
GTR8_HUMAN [view interactions] High throughput no yes
DOXA2_HUMAN [view interactions] High throughput no no
T150A_HUMAN [view interactions] High throughput no yes
NAAA_HUMAN [view interactions] High throughput no yes
FFAR1_HUMAN [view interactions] High throughput no no
TMM72_HUMAN [view interactions] High throughput no no
GPR3_HUMAN [view interactions] High throughput no no
GPR45_HUMAN [view interactions] High throughput no no
LRN4L_HUMAN [view interactions] High throughput no yes
CD244_HUMAN [view interactions] High throughput no no
GTR1_HUMAN [view entry] [view interactions] High throughput yes no
CCG7_HUMAN [view entry] [view interactions] High throughput yes no
AQP3_HUMAN [view interactions] High throughput no no
HM13_HUMAN [view interactions] High throughput no yes
HUMMR_HUMAN [view interactions] High throughput no yes
MFD4A_HUMAN [view interactions] High throughput no yes
S1PR4_HUMAN [view interactions] High throughput no no
TRAK2_HUMAN [view interactions] High throughput no yes
SLAF8_HUMAN [view interactions] High throughput no no
P2RY8_HUMAN [view interactions] High throughput no no
SPRTN_HUMAN [view interactions] High throughput no yes
PDE2A_HUMAN [view entry] [view interactions] High throughput yes yes
NIPS1_HUMAN [view entry] [view interactions] High throughput yes yes
NIPS2_HUMAN [view interactions] High throughput no yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
MP3B2_HUMAN [view interactions] High throughput no yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
A1BG_HUMAN [view interactions] High throughput no no
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
MLP3C_HUMAN [view interactions] High throughput no no
GBRAP_HUMAN [view interactions] High throughput no no
NDUS8_HUMAN [view interactions] High throughput no yes
RM11_HUMAN [view interactions] High throughput no yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
SDHA_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
RT11_HUMAN [view interactions] High throughput no yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
SURF1_HUMAN [view interactions] High throughput no yes
RS23_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB8_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
SQOR_HUMAN [view interactions] High throughput no yes
SERC1_HUMAN [view interactions] High throughput no yes
HNRL1_HUMAN [view interactions] High throughput no yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
PM34_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
CC90B_HUMAN [view interactions] High throughput no yes
CLPB_HUMAN [view interactions] High throughput no yes
COX15_HUMAN [view interactions] High throughput no yes
DBLOH_HUMAN [view interactions] High throughput no no
FIS1_HUMAN [view entry] [view interactions] High throughput yes yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
MIC26_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
OPA1_HUMAN [view entry] [view interactions] High throughput yes yes
RMND1_HUMAN [view interactions] High throughput no yes
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
CYBP_HUMAN [view entry] [view interactions] High throughput yes yes
CC138_HUMAN [view interactions] High throughput no yes
CDC20_HUMAN [view interactions] High throughput no no
CDC37_HUMAN [view interactions] High throughput no yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC7_HUMAN [view interactions] High throughput no yes
DTL_HUMAN [view interactions] High throughput no no
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
GBB1_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC3_HUMAN [view interactions] High throughput no yes
LRC49_HUMAN [view interactions] High throughput no no
MAVS_HUMAN [view interactions] High throughput no yes
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NFL_HUMAN [view entry] [view interactions] High throughput yes yes
NUDC3_HUMAN [view interactions] High throughput no yes
PCNT_HUMAN [view interactions] High throughput no yes
PDCD5_HUMAN [view interactions] High throughput no yes
PHLP_HUMAN [view interactions] High throughput no yes
PDCL3_HUMAN [view interactions] High throughput no yes
PFD1_HUMAN [view interactions] High throughput no yes
PFD4_HUMAN [view interactions] High throughput no yes
PFD5_HUMAN [view interactions] High throughput no yes
RPAP3_HUMAN [view interactions] High throughput no yes
TRABD_HUMAN [view interactions] High throughput no yes
TXND9_HUMAN [view interactions] High throughput no yes
TXNL1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP33_HUMAN [view interactions] High throughput no yes
PFD3_HUMAN [view interactions] High throughput no yes
WDR6_HUMAN [view entry] [view interactions] High throughput yes yes
DAA10_HUMAN [view interactions] High throughput no yes
TCAB1_HUMAN [view interactions] High throughput no yes
CMC1_HUMAN [view entry] [view interactions] High throughput yes yes
S2551_HUMAN [view interactions] High throughput no no
TIM29_HUMAN [view interactions] High throughput no no
DJC30_HUMAN [view interactions] High throughput no no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
HMGB2_HUMAN [view interactions] High throughput no yes
TIDC1_HUMAN [view interactions] High throughput no yes
MTX2_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
S10A4_HUMAN [view entry] [view interactions] High throughput yes no
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX3_HUMAN [view interactions] High throughput no yes
XPOT_HUMAN [view interactions] High throughput no no
TM40L_HUMAN [view entry] [view interactions] Computational yes yes
TOM20_HUMAN [view entry] [view interactions] Computational yes yes
TIM8A_HUMAN [view interactions] Computational no yes
LYPL1_HUMAN [view interactions] Computational no yes
TIM13_HUMAN [view interactions] Computational no yes
MIA40_HUMAN [view interactions] Computational no yes
GRP75_HUMAN [view entry] [view interactions] Computational yes yes
TOM70_HUMAN [view interactions] Computational no yes
TIM21_HUMAN [view interactions] Computational no yes
TOM7_HUMAN [view interactions] Computational no no
MTX3_HUMAN [view interactions] Computational no yes
TIM50_HUMAN [view entry] [view interactions] Computational yes yes