Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SAM50_HUMAN

Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes (PubMed, PubMed). Required for the assembly of TOMM40 into the TOM complex (PubMed). [View more on UniProt]

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No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SAM50_HUMAN
GO:0043168 anion binding 30.4348 4 no
GO:0000166 nucleotide binding 29.3478 4 no
GO:0017076 purine nucleotide binding 28.2609 5 no
GO:0032555 purine ribonucleotide binding 28.2609 4 no
GO:0035639 purine ribonucleoside triphosphate binding 27.1739 4 no
GO:0003723 RNA binding 25.0000 4 no
GO:0016462 pyrophosphatase activity 21.7391 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.7391 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.7391 6 no
GO:0030554 adenyl nucleotide binding 20.6522 6 no
GO:0032559 adenyl ribonucleotide binding 20.6522 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in SAM50_HUMAN
GO:0006996 organelle organization 46.7391 4 yes
GO:0048522 positive regulation of cellular process 45.6522 4 no
GO:0051128 regulation of cellular component organization 43.4783 4 no
GO:0031323 regulation of cellular metabolic process 41.3043 4 no
GO:0060255 regulation of macromolecule metabolic process 41.3043 4 no
GO:0080090 regulation of primary metabolic process 38.0435 4 no
GO:0048523 negative regulation of cellular process 36.9565 4 no
GO:0022607 cellular component assembly 34.7826 4 yes
GO:0009893 positive regulation of metabolic process 32.6087 4 no
GO:0033043 regulation of organelle organization 32.6087 5 no
GO:0009889 regulation of biosynthetic process 31.5217 4 no
GO:0010556 regulation of macromolecule biosynthetic process 31.5217 5 no
GO:0031326 regulation of cellular biosynthetic process 31.5217 5 no
GO:0010646 regulation of cell communication 29.3478 4 no
GO:0043933 protein-containing complex organization 28.2609 4 yes
GO:0008104 protein localization 27.1739 4 yes
GO:0061024 membrane organization 27.1739 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 27.1739 5 no
GO:0007005 mitochondrion organization 25.0000 5 yes
GO:0065003 protein-containing complex assembly 25.0000 5 yes
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0042981 regulation of apoptotic process 23.9130 5 no
GO:0043067 regulation of programmed cell death 23.9130 4 no
GO:0071702 organic substance transport 23.9130 4 yes
GO:0031325 positive regulation of cellular metabolic process 22.8261 5 no
GO:0009891 positive regulation of biosynthetic process 22.8261 5 no
GO:0010468 regulation of gene expression 21.7391 6 no
GO:0071705 nitrogen compound transport 21.7391 4 yes
GO:0051130 positive regulation of cellular component organization 21.7391 5 no
GO:0009892 negative regulation of metabolic process 20.6522 4 no
GO:0032880 regulation of protein localization 20.6522 5 no
GO:0060341 regulation of cellular localization 20.6522 4 no
GO:0031328 positive regulation of cellular biosynthetic process 20.6522 6 no
GO:0033365 protein localization to organelle 18.4783 5 yes
GO:0007006 mitochondrial membrane organization 17.3913 5 yes
GO:0015031 protein transport 15.2174 4 yes
GO:0072594 establishment of protein localization to organelle 14.1304 4 yes
GO:0006886 intracellular protein transport 13.0435 4 yes
GO:0007007 inner mitochondrial membrane organization 13.0435 6 yes
GO:0070585 protein localization to mitochondrion 11.9565 6 yes
GO:0006839 mitochondrial transport 10.8696 4 yes
GO:0072657 protein localization to membrane 10.8696 4 yes
GO:0042407 cristae formation 9.7826 7 yes
GO:0090150 establishment of protein localization to membrane 9.7826 4 yes
GO:0072655 establishment of protein localization to mitochondrion 8.6957 5 yes
GO:0007008 outer mitochondrial membrane organization 4.3478 6 yes
GO:0033108 mitochondrial respiratory chain complex assembly 4.3478 6 yes
GO:0045040 protein insertion into mitochondrial outer membrane 4.3478 5 yes
GO:0090151 establishment of protein localization to mitochondrial membrane 4.3478 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MFN2_HUMAN [view entry] [view interactions] Low throughput yes yes
DNM1L_HUMAN [view entry] [view interactions] Low throughput yes yes
MIC60_HUMAN [view entry] [view interactions] Low throughput yes yes
MTX1_HUMAN [view entry] [view interactions] Low throughput yes yes
SQSTM_HUMAN [view interactions] Low throughput no yes
PINK1_HUMAN [view interactions] Low throughput no yes
MFN1_HUMAN [view interactions] Low throughput no yes
MFF_HUMAN [view entry] [view interactions] Low throughput yes yes
TOM40_HUMAN [view interactions] Low throughput no yes
GBRL1_HUMAN [view interactions] Low throughput no yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
TAF6_HUMAN [view interactions] High throughput no no
TCPE_HUMAN [view entry] [view interactions] High throughput yes yes
RPP38_HUMAN [view interactions] High throughput no yes
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
TFB2M_HUMAN [view interactions] High throughput no no
XPOT_HUMAN [view interactions] High throughput no no
PRDX3_HUMAN [view interactions] High throughput no yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
S10A4_HUMAN [view entry] [view interactions] High throughput yes no
MIC27_HUMAN [view entry] [view interactions] High throughput yes yes
NMES1_HUMAN [view interactions] High throughput no no
F136A_HUMAN [view interactions] High throughput no yes
OCAD1_HUMAN [view interactions] High throughput no yes
MIC13_HUMAN [view interactions] High throughput no yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
OPA3_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
SNF5_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
SIM26_HUMAN [view interactions] High throughput no no
ATG2A_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
SCRB2_HUMAN [view interactions] High throughput no yes
VMP1_HUMAN [view interactions] High throughput no yes
HSPB2_HUMAN [view interactions] High throughput no yes
KCNQ1_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
CAV3_HUMAN [view interactions] High throughput no no
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
BMI1_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
MIC25_HUMAN [view entry] [view interactions] High throughput yes yes
MEOX2_HUMAN [view interactions] High throughput no no
ERH_HUMAN [view interactions] High throughput no yes
RAB8A_HUMAN [view entry] [view interactions] High throughput yes no
CI072_HUMAN [view entry] [view interactions] High throughput yes no
SOX4_HUMAN [view interactions] High throughput no yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
COX14_HUMAN [view interactions] High throughput no yes
PLRKT_HUMAN [view interactions] High throughput no yes
SCO1_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
TOM22_HUMAN [view interactions] High throughput no yes
IMP2L_HUMAN [view interactions] High throughput no yes
HTRA2_HUMAN [view interactions] High throughput no yes
IMP1L_HUMAN [view interactions] High throughput no yes
LACTB_HUMAN [view interactions] High throughput no yes
OMA1_HUMAN [view interactions] High throughput no no
PARL_HUMAN [view interactions] High throughput no yes
YMEL1_HUMAN [view interactions] High throughput no yes
FHI2B_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
MIC10_HUMAN [view interactions] High throughput no yes
CLN3_HUMAN [view interactions] High throughput no no
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
SUZ12_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
AT5F1_HUMAN [view interactions] High throughput no yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
GELS_HUMAN [view entry] [view interactions] High throughput yes no
MYO1B_HUMAN [view entry] [view interactions] High throughput yes no
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
TPM2_HUMAN [view entry] [view interactions] High throughput yes yes
AKA12_HUMAN [view entry] [view interactions] High throughput yes no
PRDX5_HUMAN [view entry] [view interactions] High throughput yes yes
RT17_HUMAN [view interactions] High throughput no yes
DGCR8_HUMAN [view entry] [view interactions] High throughput yes yes
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes
KLHL7_HUMAN [view interactions] High throughput no yes
DCAKD_HUMAN [view entry] [view interactions] High throughput yes no
CCNQ_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
OXDA_HUMAN [view interactions] High throughput no no
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
DUS22_HUMAN [view interactions] High throughput no yes
MTM1_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
ZN598_HUMAN [view interactions] High throughput no no
EGLN3_HUMAN [view interactions] High throughput no no
LAP2A_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
TM41B_HUMAN [view interactions] High throughput no yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
TIA1_HUMAN [view interactions] High throughput no no
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
RNF26_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
EDEM1_HUMAN [view interactions] High throughput no yes
S22A8_HUMAN [view interactions] High throughput no no
TRAK1_HUMAN [view interactions] High throughput no yes
PCNP_HUMAN [view interactions] High throughput no yes
FAXC_HUMAN [view interactions] High throughput no no
CLC5A_HUMAN [view interactions] High throughput no no
EXOC6_HUMAN [view entry] [view interactions] High throughput yes yes
RETR3_HUMAN [view interactions] High throughput no yes
SPSB4_HUMAN [view interactions] High throughput no no
SL2A8_HUMAN [view interactions] High throughput no yes
DOXA2_HUMAN [view interactions] High throughput no no
T150A_HUMAN [view interactions] High throughput no yes
NAAA_HUMAN [view interactions] High throughput no yes
FFAR1_HUMAN [view interactions] High throughput no no
TMM72_HUMAN [view interactions] High throughput no no
GPR3_HUMAN [view interactions] High throughput no no
GPR45_HUMAN [view interactions] High throughput no no
LRN4L_HUMAN [view interactions] High throughput no yes
CD244_HUMAN [view interactions] High throughput no no
GTR1_HUMAN [view entry] [view interactions] High throughput yes no
CCG7_HUMAN [view entry] [view interactions] High throughput yes no
AQP3_HUMAN [view interactions] High throughput no no
HM13_HUMAN [view interactions] High throughput no yes
HUMMR_HUMAN [view interactions] High throughput no yes
MFD4A_HUMAN [view interactions] High throughput no yes
S1PR4_HUMAN [view interactions] High throughput no no
TRAK2_HUMAN [view interactions] High throughput no yes
SLAF8_HUMAN [view interactions] High throughput no no
P2RY8_HUMAN [view interactions] High throughput no no
SPRTN_HUMAN [view interactions] High throughput no yes
PDE2A_HUMAN [view entry] [view interactions] High throughput yes yes
NIPS1_HUMAN [view entry] [view interactions] High throughput yes yes
NIPS2_HUMAN [view interactions] High throughput no yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
MP3B2_HUMAN [view interactions] High throughput no yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
A1BG_HUMAN [view interactions] High throughput no no
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
CL16A_HUMAN [view interactions] High throughput no yes
MIDN_HUMAN [view interactions] High throughput no no
B3GN2_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
MLP3C_HUMAN [view interactions] High throughput no no
GBRAP_HUMAN [view entry] [view interactions] High throughput yes no
NDUS8_HUMAN [view interactions] High throughput no yes
RM11_HUMAN [view interactions] High throughput no yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
SDHA_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
RT11_HUMAN [view interactions] High throughput no yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
SURF1_HUMAN [view interactions] High throughput no yes
RS23_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB8_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
SQOR_HUMAN [view interactions] High throughput no yes
SERC1_HUMAN [view interactions] High throughput no yes
HNRL1_HUMAN [view interactions] High throughput no yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
PM34_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
CC90B_HUMAN [view interactions] High throughput no yes
CLPB_HUMAN [view interactions] High throughput no yes
COX15_HUMAN [view interactions] High throughput no yes
DBLOH_HUMAN [view interactions] High throughput no no
FIS1_HUMAN [view entry] [view interactions] High throughput yes yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
MIC26_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
OPA1_HUMAN [view entry] [view interactions] High throughput yes yes
RMND1_HUMAN [view interactions] High throughput no yes
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
CYBP_HUMAN [view entry] [view interactions] High throughput yes yes
CC138_HUMAN [view interactions] High throughput no yes
CDC20_HUMAN [view interactions] High throughput no no
CDC37_HUMAN [view interactions] High throughput no yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC7_HUMAN [view interactions] High throughput no yes
DTL_HUMAN [view interactions] High throughput no no
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
GBB1_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC3_HUMAN [view interactions] High throughput no yes
LRC49_HUMAN [view interactions] High throughput no no
MAVS_HUMAN [view interactions] High throughput no yes
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NFL_HUMAN [view entry] [view interactions] High throughput yes yes
NUDC3_HUMAN [view interactions] High throughput no yes
PCNT_HUMAN [view interactions] High throughput no yes
PDCD5_HUMAN [view interactions] High throughput no yes
PHLP_HUMAN [view interactions] High throughput no yes
PDCL3_HUMAN [view interactions] High throughput no yes
PFD1_HUMAN [view interactions] High throughput no yes
PFD4_HUMAN [view interactions] High throughput no yes
PFD5_HUMAN [view interactions] High throughput no yes
RPAP3_HUMAN [view interactions] High throughput no yes
TRABD_HUMAN [view interactions] High throughput no yes
TXND9_HUMAN [view interactions] High throughput no yes
TXNL1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP33_HUMAN [view interactions] High throughput no yes
PFD3_HUMAN [view interactions] High throughput no yes
WDR6_HUMAN [view entry] [view interactions] High throughput yes yes
DAA10_HUMAN [view interactions] High throughput no yes
TCAB1_HUMAN [view interactions] High throughput no yes
S2512_HUMAN [view entry] [view interactions] High throughput yes yes
S2551_HUMAN [view interactions] High throughput no no
TIM29_HUMAN [view interactions] High throughput no no
HMGB2_HUMAN [view interactions] High throughput no yes
DJC30_HUMAN [view interactions] High throughput no no
TIDC1_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
MTX2_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
RFA2_HUMAN [view interactions] High throughput no yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
RFA3_HUMAN [view interactions] High throughput no yes
MED17_HUMAN [view interactions] High throughput no no
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
LRRF2_HUMAN [view interactions] High throughput no yes
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
FXRD2_HUMAN [view interactions] High throughput no yes
KLH12_HUMAN [view interactions] High throughput no no
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
OSBL5_HUMAN [view interactions] High throughput no yes
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
CYTSA_HUMAN [view interactions] High throughput no yes
EBP_HUMAN [view interactions] High throughput no no
CLK3_HUMAN [view interactions] High throughput no yes
ARP5L_HUMAN [view entry] [view interactions] High throughput yes yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
TAF2_HUMAN [view interactions] High throughput no no