ARP5L_HUMAN
Evidence for PS localization
Functions
May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
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Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
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Network
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ARP5L_HUMAN has binary interactions with 50 proteins
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
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Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ARP5L_HUMAN |
---|---|---|---|---|
GO:0003779 | actin binding | 54.5455 | 4 | yes |
GO:0000166 | nucleotide binding | 32.7273 | 4 | no |
GO:0017076 | purine nucleotide binding | 32.7273 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 32.7273 | 6 | no |
GO:0043168 | anion binding | 32.7273 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 30.9091 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 30.9091 | 5 | no |
GO:0005524 | ATP binding | 29.0909 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 29.0909 | 4 | no |
GO:0043169 | cation binding | 21.8182 | 4 | no |
GO:0046872 | metal ion binding | 21.8182 | 5 | no |
GO:0045296 | cadherin binding | 21.8182 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ARP5L_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 61.8182 | 4 | no |
GO:0051128 | regulation of cellular component organization | 54.5455 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 54.5455 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 52.7273 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 52.7273 | 4 | no |
GO:0006996 | organelle organization | 49.0909 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 49.0909 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 38.1818 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 36.3636 | 4 | yes |
GO:0097435 | supramolecular fiber organization | 36.3636 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 36.3636 | 5 | no |
GO:0009966 | regulation of signal transduction | 36.3636 | 4 | no |
GO:0007015 | actin filament organization | 34.5455 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 34.5455 | 4 | no |
GO:0010468 | regulation of gene expression | 34.5455 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 34.5455 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 34.5455 | 5 | no |
GO:0007010 | cytoskeleton organization | 34.5455 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 34.5455 | 5 | no |
GO:0033043 | regulation of organelle organization | 32.7273 | 5 | yes |
GO:0008104 | protein localization | 32.7273 | 4 | no |
GO:0051493 | regulation of cytoskeleton organization | 29.0909 | 6 | yes |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
ARC1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARC1B_HUMAN | [view interactions] | Low throughput | no | no |
ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
ARP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARPC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARPC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARPC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ARPC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CALL3_HUMAN | [view interactions] | High throughput | no | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALU_HUMAN | [view interactions] | High throughput | no | yes |