ARP5L_HUMAN
Evidence for PS localization
Functions
May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARP5L_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 54.5455 | 4 | yes |
| GO:0000166 | nucleotide binding | 32.7273 | 4 | no |
| GO:0017076 | purine nucleotide binding | 32.7273 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 32.7273 | 6 | no |
| GO:0043168 | anion binding | 32.7273 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.9091 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 30.9091 | 5 | no |
| GO:0005524 | ATP binding | 29.0909 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.0909 | 4 | no |
| GO:0043169 | cation binding | 21.8182 | 4 | no |
| GO:0046872 | metal ion binding | 21.8182 | 5 | no |
| GO:0045296 | cadherin binding | 21.8182 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARP5L_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.8182 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 54.5455 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 54.5455 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.7273 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 52.7273 | 4 | no |
| GO:0006996 | organelle organization | 49.0909 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 49.0909 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.1818 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 36.3636 | 4 | yes |
| GO:0097435 | supramolecular fiber organization | 36.3636 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 36.3636 | 5 | no |
| GO:0009966 | regulation of signal transduction | 36.3636 | 4 | no |
| GO:0007015 | actin filament organization | 34.5455 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 34.5455 | 4 | no |
| GO:0010468 | regulation of gene expression | 34.5455 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.5455 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 34.5455 | 5 | no |
| GO:0007010 | cytoskeleton organization | 34.5455 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 34.5455 | 5 | no |
| GO:0033043 | regulation of organelle organization | 32.7273 | 5 | yes |
| GO:0008104 | protein localization | 32.7273 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 29.0909 | 6 | yes |
| GO:0051049 | regulation of transport | 29.0909 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 27.2727 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 27.2727 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.2727 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 27.2727 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.2727 | 5 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 25.4545 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 25.4545 | 6 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 25.4545 | 5 | yes |
| GO:0030030 | cell projection organization | 25.4545 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.4545 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.4545 | 4 | no |
| GO:0043933 | protein-containing complex organization | 25.4545 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.4545 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.6364 | 5 | no |
| GO:0031399 | regulation of protein modification process | 23.6364 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.6364 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.8182 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.8182 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.8182 | 5 | no |
| GO:0071310 | cellular response to organic substance | 21.8182 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.8182 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.8182 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.8182 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.8182 | 6 | no |
| GO:0051050 | positive regulation of transport | 21.8182 | 4 | no |
| GO:0032535 | regulation of cellular component size | 16.3636 | 4 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 16.3636 | 5 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 14.5455 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 14.5455 | 5 | yes |
| GO:0032271 | regulation of protein polymerization | 14.5455 | 6 | yes |
| GO:0034314 | Arp2/3 complex-mediated actin nucleation | 14.5455 | 7 | yes |
| GO:0045010 | actin nucleation | 14.5455 | 6 | yes |
| GO:0030833 | regulation of actin filament polymerization | 12.7273 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARC1B_HUMAN | [view interactions] | Low throughput | no | no |
| ARPC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARC1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GA45G_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEO1_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| ITA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STRN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIM43_HUMAN | [view interactions] | High throughput | no | no |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB27A_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARPC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHUR_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| UBP22_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| RNF38_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| CALU_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM10A_HUMAN | [view interactions] | High throughput | no | no |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UFD1_HUMAN | [view interactions] | High throughput | no | no |