ARP5L_HUMAN
Evidence for PS localization
Functions
May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARP5L_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 60.3774 | 4 | yes |
| GO:0005524 | ATP binding | 28.3019 | 5 | no |
| GO:0017076 | purine nucleotide binding | 28.3019 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 28.3019 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 28.3019 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 28.3019 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.3019 | 4 | no |
| GO:0045296 | cadherin binding | 22.6415 | 4 | no |
| GO:0046872 | metal ion binding | 20.7547 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARP5L_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.0377 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 62.2642 | 4 | yes |
| GO:0006996 | organelle organization | 54.7170 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 52.8302 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 52.8302 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.9434 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 49.0566 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 49.0566 | 4 | no |
| GO:0033043 | regulation of organelle organization | 45.2830 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 45.2830 | 4 | yes |
| GO:0022607 | cellular component assembly | 45.2830 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 41.5094 | 6 | yes |
| GO:0032970 | regulation of actin filament-based process | 39.6226 | 4 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 37.7358 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 37.7358 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 37.7358 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 37.7358 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 37.7358 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.7358 | 5 | no |
| GO:0110053 | regulation of actin filament organization | 35.8491 | 6 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 35.8491 | 5 | yes |
| GO:0010646 | regulation of cell communication | 35.8491 | 4 | no |
| GO:0051049 | regulation of transport | 35.8491 | 4 | no |
| GO:0007015 | actin filament organization | 35.8491 | 5 | yes |
| GO:0010468 | regulation of gene expression | 33.9623 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.9623 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 32.0755 | 5 | no |
| GO:0009966 | regulation of signal transduction | 32.0755 | 4 | no |
| GO:0008104 | protein localization | 30.1887 | 4 | no |
| GO:0030030 | cell projection organization | 30.1887 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 28.3019 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 28.3019 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.3019 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 26.4151 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.4151 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 26.4151 | 4 | no |
| GO:0031399 | regulation of protein modification process | 26.4151 | 6 | no |
| GO:0051050 | positive regulation of transport | 26.4151 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 24.5283 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.5283 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.5283 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.5283 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.5283 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 24.5283 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.5283 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.5283 | 6 | no |
| GO:0032535 | regulation of cellular component size | 22.6415 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.6415 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.6415 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 22.6415 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.6415 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.6415 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.6415 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 22.6415 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.6415 | 5 | no |
| GO:0043933 | protein-containing complex organization | 22.6415 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.6415 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.6415 | 5 | no |
| GO:0030832 | regulation of actin filament length | 20.7547 | 5 | yes |
| GO:0032271 | regulation of protein polymerization | 20.7547 | 6 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 20.7547 | 5 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 20.7547 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.7547 | 6 | no |
| GO:0022604 | regulation of cell morphogenesis | 20.7547 | 5 | no |
| GO:0030334 | regulation of cell migration | 20.7547 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 20.7547 | 4 | no |
| GO:2000145 | regulation of cell motility | 20.7547 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 20.7547 | 7 | no |
| GO:0043269 | regulation of ion transport | 20.7547 | 5 | no |
| GO:0051726 | regulation of cell cycle | 20.7547 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.7547 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 20.7547 | 5 | no |
| GO:0008064 | regulation of actin polymerization or depolymerization | 20.7547 | 6 | yes |
| GO:0030833 | regulation of actin filament polymerization | 18.8679 | 7 | yes |
| GO:0034314 | Arp2/3 complex-mediated actin nucleation | 13.2075 | 7 | yes |
| GO:0045010 | actin nucleation | 13.2075 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ARP5L_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 7.5472 | 3 | no |
| DOID:0050700 | cardiomyopathy | 5.6604 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 5.6604 | 5 | no |
| DOID:2843 | long QT syndrome | 3.7736 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARC1B_HUMAN | [view interactions] | Low throughput | no | no |
| ARC1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARPC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GA45G_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEO1_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| ITA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STRN3_HUMAN | [view interactions] | High throughput | no | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB27A_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARPC5_HUMAN | [view interactions] | High throughput | no | yes |
| CHUR_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| UBP22_HUMAN | [view interactions] | High throughput | no | yes |
| CALU_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM10A_HUMAN | [view interactions] | High throughput | no | no |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UFD1_HUMAN | [view interactions] | High throughput | no | no |
| HCLS1_HUMAN | [view interactions] | Computational | no | no |
| WASL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARP3C_HUMAN | [view interactions] | Computational | no | no |
| WASP_HUMAN | [view interactions] | Computational | no | yes |
| WASF2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |