ARC1A_HUMAN
Evidence for PS localization
Functions
Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARC1A_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 47.7273 | 4 | yes |
| GO:0019900 | kinase binding | 27.2727 | 4 | no |
| GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
| GO:0045296 | cadherin binding | 22.7273 | 4 | no |
| GO:0017076 | purine nucleotide binding | 22.7273 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 20.4545 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 20.4545 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.4545 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARC1A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.6364 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 61.3636 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 54.5455 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 54.5455 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 52.2727 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 52.2727 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.2727 | 4 | no |
| GO:0006996 | organelle organization | 45.4545 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.9091 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 38.6364 | 4 | yes |
| GO:0010646 | regulation of cell communication | 38.6364 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.6364 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 38.6364 | 5 | no |
| GO:0022607 | cellular component assembly | 38.6364 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.3636 | 5 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 34.0909 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 34.0909 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 34.0909 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 34.0909 | 6 | yes |
| GO:0110053 | regulation of actin filament organization | 34.0909 | 6 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 34.0909 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.0909 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 31.8182 | 4 | yes |
| GO:0008104 | protein localization | 31.8182 | 4 | no |
| GO:0009966 | regulation of signal transduction | 31.8182 | 4 | no |
| GO:0051049 | regulation of transport | 31.8182 | 4 | no |
| GO:0007010 | cytoskeleton organization | 31.8182 | 5 | yes |
| GO:0007015 | actin filament organization | 31.8182 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 29.5455 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 29.5455 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.5455 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 29.5455 | 5 | no |
| GO:0010468 | regulation of gene expression | 27.2727 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.2727 | 5 | no |
| GO:0031399 | regulation of protein modification process | 27.2727 | 6 | no |
| GO:0008064 | regulation of actin polymerization or depolymerization | 25.0000 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 25.0000 | 5 | yes |
| GO:0030833 | regulation of actin filament polymerization | 25.0000 | 7 | yes |
| GO:0032271 | regulation of protein polymerization | 25.0000 | 6 | yes |
| GO:0032535 | regulation of cellular component size | 25.0000 | 4 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 25.0000 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0030030 | cell projection organization | 25.0000 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
| GO:0015031 | protein transport | 22.7273 | 4 | no |
| GO:0071702 | organic substance transport | 22.7273 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.7273 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.7273 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 22.7273 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.7273 | 6 | no |
| GO:0043933 | protein-containing complex organization | 22.7273 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.7273 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.7273 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 20.4545 | 4 | no |
| GO:0051050 | positive regulation of transport | 20.4545 | 4 | no |
| GO:0051726 | regulation of cell cycle | 20.4545 | 4 | no |
| GO:0071310 | cellular response to organic substance | 20.4545 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.4545 | 5 | no |
| GO:0009894 | regulation of catabolic process | 20.4545 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 20.4545 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.4545 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 20.4545 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.4545 | 5 | no |
| GO:0034314 | Arp2/3 complex-mediated actin nucleation | 15.9091 | 7 | yes |
| GO:0045010 | actin nucleation | 15.9091 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ARC1A_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 6.8182 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 6.8182 | 5 | no |
| DOID:114 | heart disease | 6.8182 | 3 | no |
| DOID:2843 | long QT syndrome | 4.5455 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARP5L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC5_HUMAN | [view interactions] | Low throughput | no | yes |
| EXOC7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PKHO1_HUMAN | [view interactions] | High throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CND3_HUMAN | [view interactions] | High throughput | no | yes |
| CND1_HUMAN | [view interactions] | High throughput | no | yes |
| CND2_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HACD3_HUMAN | [view interactions] | High throughput | no | yes |
| ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| RET1_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| ARC1B_HUMAN | [view interactions] | High throughput | no | no |
| CHUR_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| PLK4_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL14E_HUMAN | [view interactions] | High throughput | no | yes |
| ARL3_HUMAN | [view interactions] | High throughput | no | yes |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| AR6P6_HUMAN | [view interactions] | High throughput | no | yes |
| ARL8A_HUMAN | [view interactions] | High throughput | no | no |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MIS12_HUMAN | [view interactions] | High throughput | no | yes |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| UBP22_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERCC6_HUMAN | [view interactions] | High throughput | no | no |
| CNDP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AASD1_HUMAN | [view interactions] | High throughput | no | yes |
| AGFG1_HUMAN | [view interactions] | High throughput | no | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| GON7_HUMAN | [view interactions] | High throughput | no | yes |
| CALR_HUMAN | [view interactions] | High throughput | no | yes |
| CALU_HUMAN | [view interactions] | High throughput | no | yes |
| METH_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAB_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM10A_HUMAN | [view interactions] | High throughput | no | no |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THG1_HUMAN | [view interactions] | High throughput | no | yes |
| TPD54_HUMAN | [view interactions] | High throughput | no | yes |
| TPRKB_HUMAN | [view interactions] | High throughput | no | yes |
| MARK4_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WASF2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| WASP_HUMAN | [view interactions] | Computational | no | yes |
| FCG2A_HUMAN | [view interactions] | Computational | no | no |
| PROF2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FCGR1_HUMAN | [view interactions] | Computational | no | no |
| PSA7_HUMAN | [view interactions] | Computational | no | yes |
| CD3Z_HUMAN | [view interactions] | Computational | no | no |
| WASF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARP3C_HUMAN | [view interactions] | Computational | no | no |
| IGLL5_HUMAN | [view interactions] | Computational | no | no |
| WASL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HCLS1_HUMAN | [view interactions] | Computational | no | no |