ARC1A_HUMAN
Evidence for PS localization
Functions
Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 64%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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ARC1A_HUMAN has binary interactions with 45 proteins
Isoforms
Interacting regions
Canonical [ARC1A_HUMAN]
Isoform [Q92747-2] alignment
Isoform [E9PF58] alignment
LOADING 86%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARC1A_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 39.1304 | 4 | yes |
| GO:0019900 | kinase binding | 30.4348 | 4 | no |
| GO:0019901 | protein kinase binding | 28.2609 | 5 | no |
| GO:0000166 | nucleotide binding | 26.0870 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.0870 | 5 | no |
| GO:0043168 | anion binding | 26.0870 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 23.9130 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 21.7391 | 6 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.7391 | 4 | no |
| GO:0043169 | cation binding | 21.7391 | 4 | no |
| GO:0046872 | metal ion binding | 21.7391 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARC1A_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 56.5217 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 56.5217 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 52.1739 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.8261 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.6522 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 43.4783 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 43.4783 | 5 | no |
| GO:0006996 | organelle organization | 41.3043 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.9565 | 5 | no |
| GO:0022607 | cellular component assembly | 36.9565 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.9565 | 5 | no |
| GO:0010646 | regulation of cell communication | 36.9565 | 4 | no |
| GO:0008104 | protein localization | 34.7826 | 4 | no |
| GO:0009966 | regulation of signal transduction | 32.6087 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 30.4348 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 30.4348 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.4348 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.4348 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.4348 | 5 | no |
| GO:0007010 | cytoskeleton organization | 28.2609 | 5 | yes |
| GO:0007015 | actin filament organization | 28.2609 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 28.2609 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 28.2609 | 4 | no |
| GO:0051049 | regulation of transport | 28.2609 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAB_HUMAN | [view interactions] | High throughput | no | yes |
| AASD1_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGFG1_HUMAN | [view interactions] | High throughput | no | yes |
| AL14E_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| AR6P6_HUMAN | [view interactions] | High throughput | no | yes |
| ARC1B_HUMAN | [view interactions] | High throughput | no | no |
| ARL3_HUMAN | [view interactions] | High throughput | no | yes |
| ARL8A_HUMAN | [view interactions] | High throughput | no | no |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| ARP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP5L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARPC5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |