ARP2_HUMAN
Evidence for PS localization
Functions
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed). Seems to contact the pointed end of the daughter actin filament (PubMed). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed, PubMed). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARP2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 32.8467 | 4 | yes |
| GO:0003779 | actin binding | 32.1168 | 4 | yes |
| GO:0000166 | nucleotide binding | 31.3869 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 31.3869 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 29.9270 | 6 | yes |
| GO:0032555 | purine ribonucleotide binding | 28.4672 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.7372 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 27.0073 | 5 | yes |
| GO:0005524 | ATP binding | 26.2774 | 5 | yes |
| GO:0003723 | RNA binding | 26.2774 | 4 | no |
| GO:0043169 | cation binding | 20.4380 | 4 | no |
| GO:0046872 | metal ion binding | 20.4380 | 5 | no |
| GO:0045296 | cadherin binding | 20.4380 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARP2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.3139 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 55.4745 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 55.4745 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 54.7445 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 54.7445 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 51.0949 | 4 | yes |
| GO:0006996 | organelle organization | 43.0657 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 41.6058 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.8759 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.8759 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 40.8759 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.1460 | 5 | yes |
| GO:0010646 | regulation of cell communication | 38.6861 | 4 | no |
| GO:0022607 | cellular component assembly | 37.2263 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 37.2263 | 5 | yes |
| GO:0010468 | regulation of gene expression | 35.0365 | 6 | yes |
| GO:0009966 | regulation of signal transduction | 34.3066 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 32.8467 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 32.8467 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 32.1168 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.6569 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 29.9270 | 4 | yes |
| GO:0008104 | protein localization | 27.7372 | 4 | no |
| GO:0043933 | protein-containing complex organization | 27.7372 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 27.7372 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 27.0073 | 4 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 27.0073 | 6 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.2774 | 6 | yes |
| GO:0048584 | positive regulation of response to stimulus | 25.5474 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 25.5474 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.5474 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 25.5474 | 4 | no |
| GO:0071310 | cellular response to organic substance | 24.8175 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 24.8175 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.8175 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.0876 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.3577 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 23.3577 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.3577 | 4 | no |
| GO:0051049 | regulation of transport | 23.3577 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.6277 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.6277 | 5 | no |
| GO:0060341 | regulation of cellular localization | 22.6277 | 4 | no |
| GO:0007015 | actin filament organization | 22.6277 | 5 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 21.8978 | 6 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 21.8978 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.8978 | 4 | no |
| GO:0032880 | regulation of protein localization | 21.8978 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.8978 | 7 | yes |
| GO:0042981 | regulation of apoptotic process | 21.1679 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.1679 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 21.1679 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.4380 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 20.4380 | 5 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 20.4380 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 19.7080 | 6 | yes |
| GO:0030030 | cell projection organization | 19.7080 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 19.7080 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 16.7883 | 5 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 16.7883 | 8 | yes |
| GO:0080134 | regulation of response to stress | 16.0584 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 15.3285 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 13.1387 | 6 | yes |
| GO:0034097 | response to cytokine | 13.1387 | 4 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 12.4088 | 6 | yes |
| GO:0071345 | cellular response to cytokine stimulus | 12.4088 | 5 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 12.4088 | 7 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 12.4088 | 8 | yes |
| GO:0051052 | regulation of DNA metabolic process | 10.9489 | 5 | yes |
| GO:0051054 | positive regulation of DNA metabolic process | 10.9489 | 6 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 10.2190 | 9 | yes |
| GO:0070925 | organelle assembly | 9.4891 | 5 | yes |
| GO:0080135 | regulation of cellular response to stress | 8.7591 | 4 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 8.0292 | 6 | yes |
| GO:0030031 | cell projection assembly | 8.0292 | 5 | yes |
| GO:0034341 | response to type II interferon | 8.0292 | 5 | yes |
| GO:0060491 | regulation of cell projection assembly | 7.2993 | 5 | yes |
| GO:0071346 | cellular response to type II interferon | 7.2993 | 6 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 7.2993 | 6 | yes |
| GO:1902743 | regulation of lamellipodium organization | 7.2993 | 7 | yes |
| GO:0034314 | Arp2/3 complex-mediated actin nucleation | 6.5693 | 7 | yes |
| GO:0045010 | actin nucleation | 6.5693 | 6 | yes |
| GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 5.1095 | 6 | yes |
| GO:1902745 | positive regulation of lamellipodium organization | 5.1095 | 7 | yes |
| GO:0010591 | regulation of lamellipodium assembly | 5.1095 | 7 | yes |
| GO:0060271 | cilium assembly | 4.3796 | 6 | yes |
| GO:0061640 | cytoskeleton-dependent cytokinesis | 4.3796 | 4 | yes |
| GO:0044782 | cilium organization | 4.3796 | 5 | yes |
| GO:2000779 | regulation of double-strand break repair | 3.6496 | 6 | yes |
| GO:2000781 | positive regulation of double-strand break repair | 3.6496 | 6 | yes |
| GO:0006282 | regulation of DNA repair | 3.6496 | 5 | yes |
| GO:0010592 | positive regulation of lamellipodium assembly | 3.6496 | 7 | yes |
| GO:0045739 | positive regulation of DNA repair | 3.6496 | 5 | yes |
| GO:1905168 | positive regulation of double-strand break repair via homologous recombination | 2.9197 | 7 | yes |
| GO:0000018 | regulation of DNA recombination | 2.9197 | 6 | yes |
| GO:0010569 | regulation of double-strand break repair via homologous recombination | 2.9197 | 7 | yes |
| GO:0045911 | positive regulation of DNA recombination | 2.9197 | 7 | yes |
| GO:0016482 | cytosolic transport | 1.4599 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PLK4_HUMAN | [view interactions] | Low throughput | no | yes |
| BMP2_HUMAN | [view interactions] | Low throughput | no | no |
| POTEF_HUMAN | [view interactions] | Low throughput | no | no |
| ARP5L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARC1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SRC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARC1B_HUMAN | [view interactions] | Low throughput | no | no |
| ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTS_HUMAN | [view interactions] | Low throughput | no | no |
| WASP_HUMAN | [view interactions] | Low throughput | no | yes |
| CD44_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SPAG6_HUMAN | [view interactions] | Low throughput | no | no |
| SHRPN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRI59_HUMAN | [view interactions] | Low throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYDE2_HUMAN | [view interactions] | High throughput | no | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| CE85L_HUMAN | [view interactions] | High throughput | no | yes |
| CRTC2_HUMAN | [view interactions] | High throughput | no | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EI2BA_HUMAN | [view interactions] | High throughput | no | yes |
| ANGP1_HUMAN | [view interactions] | High throughput | no | no |
| SPN90_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RENT2_HUMAN | [view interactions] | High throughput | no | no |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPPC8_HUMAN | [view interactions] | High throughput | no | yes |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN32A_HUMAN | [view interactions] | High throughput | no | yes |
| CLAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCD4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL1_HUMAN | [view interactions] | High throughput | no | yes |
| RANG_HUMAN | [view interactions] | High throughput | no | no |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESTD_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1TC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MNDA_HUMAN | [view interactions] | High throughput | no | no |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL14E_HUMAN | [view interactions] | High throughput | no | yes |
| ARL3_HUMAN | [view interactions] | High throughput | no | yes |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| AR6P6_HUMAN | [view interactions] | High throughput | no | yes |
| BPNT1_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| PSB10_HUMAN | [view interactions] | High throughput | no | no |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| UBP22_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PLD6_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ASXL2_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| MYO10_HUMAN | [view interactions] | High throughput | no | no |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| CYTN_HUMAN | [view interactions] | High throughput | no | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| ERCC6_HUMAN | [view interactions] | High throughput | no | no |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| AN32B_HUMAN | [view interactions] | High throughput | no | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHYS_HUMAN | [view interactions] | High throughput | no | no |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF2K_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFL1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P3H1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTL12_HUMAN | [view interactions] | High throughput | no | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| HEM2_HUMAN | [view interactions] | High throughput | no | no |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALU_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CRTAP_HUMAN | [view interactions] | High throughput | no | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| HPBP1_HUMAN | [view interactions] | High throughput | no | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KBP_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRMB_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PANK4_HUMAN | [view interactions] | High throughput | no | no |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| ITA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KAPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPR1A_HUMAN | [view interactions] | High throughput | no | yes |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| COBL_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| CYBR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRP09_HUMAN | [view interactions] | High throughput | no | no |
| PDCL3_HUMAN | [view interactions] | High throughput | no | yes |
| SURF2_HUMAN | [view interactions] | High throughput | no | yes |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM1L1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM27_HUMAN | [view interactions] | High throughput | no | yes |
| PRPK_HUMAN | [view interactions] | High throughput | no | yes |
| TPD54_HUMAN | [view interactions] | High throughput | no | yes |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| TPRKB_HUMAN | [view interactions] | High throughput | no | yes |
| UFM1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR4_HUMAN | [view interactions] | High throughput | no | no |
| ZPR1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LUZP1_HUMAN | [view interactions] | High throughput | no | yes |
| COR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTA70_HUMAN | [view interactions] | High throughput | no | no |
| EFHD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD7_HUMAN | [view interactions] | High throughput | no | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITPR3_HUMAN | [view interactions] | High throughput | no | yes |
| FA98B_HUMAN | [view interactions] | High throughput | no | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| DSG2_HUMAN | [view interactions] | High throughput | no | no |
| P5CR2_HUMAN | [view interactions] | High throughput | no | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHUR_HUMAN | [view interactions] | High throughput | no | yes |
| BIEA_HUMAN | [view interactions] | High throughput | no | yes |
| RAI3_HUMAN | [view interactions] | High throughput | no | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| TCPW_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| SAP_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FKBP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC3_HUMAN | [view interactions] | High throughput | no | yes |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| PFD2_HUMAN | [view interactions] | High throughput | no | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTCB_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SIR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| VMP1_HUMAN | [view interactions] | High throughput | no | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| BAK_HUMAN | [view interactions] | High throughput | no | no |
| ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| WIPF1_HUMAN | [view interactions] | High throughput | no | no |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| ANGI_HUMAN | [view interactions] | High throughput | no | no |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ELF5_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| STIL_HUMAN | [view interactions] | High throughput | no | no |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| LBN_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYTSB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| B2CL1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| HIF1A_HUMAN | [view interactions] | High throughput | no | no |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANO7_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |