ARP2_HUMAN
Evidence for PS localization
Functions
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed). Seems to contact the pointed end of the daughter actin filament (PubMed). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed, PubMed). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARP2_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 37.0629 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 29.3706 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.6713 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 28.6713 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 26.5734 | 5 | yes |
| GO:0005524 | ATP binding | 25.8741 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 25.8741 | 5 | yes |
| GO:0003723 | RNA binding | 24.4755 | 4 | no |
| GO:0045296 | cadherin binding | 20.2797 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARP2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.9371 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 57.3427 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 53.8462 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 50.3497 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.3497 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 49.6503 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 48.9510 | 4 | yes |
| GO:0006996 | organelle organization | 41.9580 | 4 | yes |
| GO:0022607 | cellular component assembly | 41.2587 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 41.2587 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 39.8601 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.4615 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 36.3636 | 5 | yes |
| GO:0010646 | regulation of cell communication | 35.6643 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.2657 | 5 | yes |
| GO:0010468 | regulation of gene expression | 33.5664 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 33.5664 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 32.1678 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 32.1678 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 32.1678 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 31.4685 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 31.4685 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 31.4685 | 5 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 30.7692 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.0699 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 30.0699 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.3706 | 5 | yes |
| GO:0007010 | cytoskeleton organization | 29.3706 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 28.6713 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 27.9720 | 5 | no |
| GO:0007015 | actin filament organization | 27.2727 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 27.2727 | 6 | no |
| GO:0051049 | regulation of transport | 26.5734 | 4 | no |
| GO:0030030 | cell projection organization | 25.8741 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 25.8741 | 4 | no |
| GO:0071310 | cellular response to organic substance | 25.1748 | 4 | yes |
| GO:0008104 | protein localization | 25.1748 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 24.4755 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 23.0769 | 4 | no |
| GO:0031399 | regulation of protein modification process | 23.0769 | 6 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 23.0769 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.3776 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 22.3776 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 22.3776 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.3776 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.6783 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 21.6783 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 21.6783 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 20.9790 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 20.9790 | 6 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 20.9790 | 6 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.9790 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.9790 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.9790 | 5 | no |
| GO:0043412 | macromolecule modification | 20.9790 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.9790 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.2797 | 6 | yes |
| GO:0031344 | regulation of cell projection organization | 20.2797 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.2797 | 6 | yes |
| GO:0010647 | positive regulation of cell communication | 20.2797 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.2797 | 4 | no |
| GO:0036211 | protein modification process | 20.2797 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 18.8811 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 18.8811 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 18.1818 | 5 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 18.1818 | 6 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 17.4825 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 17.4825 | 6 | yes |
| GO:0051094 | positive regulation of developmental process | 17.4825 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 16.0839 | 6 | yes |
| GO:0022604 | regulation of cell morphogenesis | 16.0839 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 15.3846 | 6 | yes |
| GO:2000026 | regulation of multicellular organismal development | 14.6853 | 4 | yes |
| GO:0030031 | cell projection assembly | 13.2867 | 5 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 12.5874 | 7 | yes |
| GO:0010243 | response to organonitrogen compound | 12.5874 | 4 | yes |
| GO:0010975 | regulation of neuron projection development | 12.5874 | 7 | yes |
| GO:0045597 | positive regulation of cell differentiation | 12.5874 | 5 | yes |
| GO:0060284 | regulation of cell development | 12.5874 | 5 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 12.5874 | 4 | yes |
| GO:0080134 | regulation of response to stress | 11.8881 | 4 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 11.8881 | 6 | yes |
| GO:0034097 | response to cytokine | 11.1888 | 4 | yes |
| GO:1901699 | cellular response to nitrogen compound | 11.1888 | 4 | yes |
| GO:0010720 | positive regulation of cell development | 10.4895 | 6 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 10.4895 | 6 | yes |
| GO:0071345 | cellular response to cytokine stimulus | 10.4895 | 5 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 10.4895 | 4 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 9.7902 | 7 | yes |
| GO:0050807 | regulation of synapse organization | 9.7902 | 5 | yes |
| GO:0051052 | regulation of DNA metabolic process | 9.7902 | 5 | yes |
| GO:0051054 | positive regulation of DNA metabolic process | 9.7902 | 6 | yes |
| GO:0060491 | regulation of cell projection assembly | 9.7902 | 5 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 9.7902 | 6 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 9.7902 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 9.7902 | 8 | yes |
| GO:0014070 | response to organic cyclic compound | 9.0909 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 9.0909 | 5 | yes |
| GO:1902743 | regulation of lamellipodium organization | 9.0909 | 7 | yes |
| GO:0010769 | regulation of cell morphogenesis involved in differentiation | 8.3916 | 6 | yes |
| GO:0050767 | regulation of neurogenesis | 8.3916 | 6 | yes |
| GO:0070925 | organelle assembly | 8.3916 | 5 | yes |
| GO:0010591 | regulation of lamellipodium assembly | 7.6923 | 7 | yes |
| GO:0010976 | positive regulation of neuron projection development | 7.6923 | 7 | yes |
| GO:0034341 | response to interferon-gamma | 7.6923 | 5 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 7.6923 | 8 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 7.6923 | 5 | yes |
| GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 7.6923 | 6 | yes |
| GO:1902745 | positive regulation of lamellipodium organization | 7.6923 | 7 | yes |
| GO:0010770 | positive regulation of cell morphogenesis involved in differentiation | 6.9930 | 7 | yes |
| GO:0050769 | positive regulation of neurogenesis | 6.9930 | 6 | yes |
| GO:0050890 | cognition | 6.9930 | 4 | yes |
| GO:0051962 | positive regulation of nervous system development | 6.9930 | 5 | yes |
| GO:0071346 | cellular response to interferon-gamma | 6.9930 | 6 | yes |
| GO:0080135 | regulation of cellular response to stress | 6.9930 | 4 | yes |
| GO:0099175 | regulation of postsynapse organization | 6.9930 | 6 | yes |
| GO:0010592 | positive regulation of lamellipodium assembly | 6.2937 | 7 | yes |
| GO:0045010 | actin nucleation | 6.2937 | 6 | yes |
| GO:0050773 | regulation of dendrite development | 6.2937 | 4 | yes |
| GO:0061001 | regulation of dendritic spine morphogenesis | 6.2937 | 5 | yes |
| GO:0034314 | Arp2/3 complex-mediated actin nucleation | 5.5944 | 7 | yes |
| GO:0048814 | regulation of dendrite morphogenesis | 5.5944 | 5 | yes |
| GO:0060998 | regulation of dendritic spine development | 4.8951 | 4 | yes |
| GO:0060999 | positive regulation of dendritic spine development | 4.8951 | 5 | yes |
| GO:0007612 | learning | 4.1958 | 4 | yes |
| GO:0044782 | cilium organization | 4.1958 | 5 | yes |
| GO:0050775 | positive regulation of dendrite morphogenesis | 4.1958 | 6 | yes |
| GO:0060271 | cilium assembly | 4.1958 | 6 | yes |
| GO:0061003 | positive regulation of dendritic spine morphogenesis | 4.1958 | 6 | yes |
| GO:0061640 | cytoskeleton-dependent cytokinesis | 3.4965 | 4 | yes |
| GO:0097305 | response to alcohol | 3.4965 | 4 | yes |
| GO:2001020 | regulation of response to DNA damage stimulus | 3.4965 | 5 | yes |
| GO:0006282 | regulation of DNA repair | 2.7972 | 6 | yes |
| GO:0008306 | associative learning | 2.7972 | 5 | yes |
| GO:0016482 | cytosolic transport | 2.7972 | 4 | yes |
| GO:0045739 | positive regulation of DNA repair | 2.7972 | 6 | yes |
| GO:2000779 | regulation of double-strand break repair | 2.7972 | 7 | yes |
| GO:2000781 | positive regulation of double-strand break repair | 2.7972 | 7 | yes |
| GO:2001022 | positive regulation of response to DNA damage stimulus | 2.7972 | 5 | yes |
| GO:0000018 | regulation of DNA recombination | 2.0979 | 6 | yes |
| GO:0010569 | regulation of double-strand break repair via homologous recombination | 2.0979 | 7 | yes |
| GO:0045911 | positive regulation of DNA recombination | 2.0979 | 7 | yes |
| GO:1905168 | positive regulation of double-strand break repair via homologous recombination | 2.0979 | 8 | yes |
| GO:0035983 | response to trichostatin A | 1.3986 | 4 | yes |
| GO:0035984 | cellular response to trichostatin A | 1.3986 | 5 | yes |
| GO:0045471 | response to ethanol | 1.3986 | 5 | yes |
| GO:0071236 | cellular response to antibiotic | 1.3986 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ARP2_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 2.7972 | 3 | no |
| DOID:0050851 | glomerulosclerosis | 2.0979 | 6 | no |
| DOID:10952 | nephritis | 2.0979 | 4 | no |
| DOID:1312 | focal segmental glomerulosclerosis | 2.0979 | 7 | no |
| DOID:2921 | glomerulonephritis | 2.0979 | 5 | no |
| DOID:557 | kidney disease | 2.0979 | 3 | no |
| DOID:0050700 | cardiomyopathy | 2.0979 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 2.0979 | 5 | no |
| DOID:2843 | long QT syndrome | 1.3986 | 6 | no |
| DOID:0050155 | sensory system disease | 1.3986 | 3 | no |
| DOID:0050563 | nonsyndromic deafness | 1.3986 | 5 | no |
| DOID:0050564 | autosomal dominant nonsyndromic deafness | 1.3986 | 6 | no |
| DOID:2742 | auditory system disease | 1.3986 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARC1B_HUMAN | [view interactions] | Low throughput | no | no |
| ARPC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC5_HUMAN | [view interactions] | Low throughput | no | yes |
| SRC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARC1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTS_HUMAN | [view interactions] | Low throughput | no | no |
| ARP5L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WASP_HUMAN | [view interactions] | Low throughput | no | yes |
| CD44_HUMAN | [view interactions] | Low throughput | no | yes |
| SHRPN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRI59_HUMAN | [view interactions] | Low throughput | no | no |
| PLK4_HUMAN | [view interactions] | Low throughput | no | yes |
| BMP2_HUMAN | [view interactions] | Low throughput | no | no |
| POTEF_HUMAN | [view interactions] | Low throughput | no | no |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| HPBP1_HUMAN | [view interactions] | High throughput | no | yes |
| KBP_HUMAN | [view interactions] | High throughput | no | yes |
| TRMB_HUMAN | [view interactions] | High throughput | no | yes |
| NIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PANK4_HUMAN | [view interactions] | High throughput | no | no |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPR1A_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRP09_HUMAN | [view interactions] | High throughput | no | no |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| SURF2_HUMAN | [view interactions] | High throughput | no | yes |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM1L1_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRPK_HUMAN | [view interactions] | High throughput | no | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPD54_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPRKB_HUMAN | [view interactions] | High throughput | no | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UFM1_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| WDR4_HUMAN | [view interactions] | High throughput | no | no |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZPR1_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EFHD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSMD7_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FA98B_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P5CR2_HUMAN | [view interactions] | High throughput | no | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYBR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAI3_HUMAN | [view interactions] | High throughput | no | yes |
| CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHUR_HUMAN | [view interactions] | High throughput | no | yes |
| TCPW_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| DSG2_HUMAN | [view interactions] | High throughput | no | no |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITPR3_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC3_HUMAN | [view interactions] | High throughput | no | yes |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| MTA70_HUMAN | [view interactions] | High throughput | no | no |
| PFD2_HUMAN | [view interactions] | High throughput | no | yes |
| LUZP1_HUMAN | [view interactions] | High throughput | no | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
| RTCB_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| SIR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM27_HUMAN | [view interactions] | High throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| PDCL3_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| COBL_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| SAP_HUMAN | [view interactions] | High throughput | no | yes |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| VMP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| BAK_HUMAN | [view interactions] | High throughput | no | no |
| ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| WIPF1_HUMAN | [view interactions] | High throughput | no | no |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| ANGI_HUMAN | [view interactions] | High throughput | no | no |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| ELF5_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| STIL_HUMAN | [view interactions] | High throughput | no | no |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| LBN_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYTSB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| B2CL1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| HIF1A_HUMAN | [view interactions] | High throughput | no | no |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANO7_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYDE2_HUMAN | [view interactions] | High throughput | no | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| CE85L_HUMAN | [view interactions] | High throughput | no | yes |
| CRTC2_HUMAN | [view interactions] | High throughput | no | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EI2BA_HUMAN | [view interactions] | High throughput | no | yes |
| ANGP1_HUMAN | [view interactions] | High throughput | no | no |
| SPN90_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RENT2_HUMAN | [view interactions] | High throughput | no | no |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPPC8_HUMAN | [view interactions] | High throughput | no | yes |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN32A_HUMAN | [view interactions] | High throughput | no | yes |
| CLAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCD4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL1_HUMAN | [view interactions] | High throughput | no | yes |
| RANG_HUMAN | [view interactions] | High throughput | no | no |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESTD_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1TC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MNDA_HUMAN | [view interactions] | High throughput | no | no |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL14E_HUMAN | [view interactions] | High throughput | no | yes |
| ARL3_HUMAN | [view interactions] | High throughput | no | yes |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| AR6P6_HUMAN | [view interactions] | High throughput | no | yes |
| BPNT1_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| PSB10_HUMAN | [view interactions] | High throughput | no | no |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| UBP22_HUMAN | [view interactions] | High throughput | no | yes |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| ERCC6_HUMAN | [view interactions] | High throughput | no | no |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN32B_HUMAN | [view interactions] | High throughput | no | yes |
| CALR_HUMAN | [view interactions] | High throughput | no | yes |
| DHYS_HUMAN | [view interactions] | High throughput | no | no |
| EF2K_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EFL1_HUMAN | [view interactions] | High throughput | no | yes |
| P3H1_HUMAN | [view interactions] | High throughput | no | yes |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| TTL12_HUMAN | [view interactions] | High throughput | no | yes |
| HEM2_HUMAN | [view interactions] | High throughput | no | no |
| CALU_HUMAN | [view interactions] | High throughput | no | yes |
| CRTAP_HUMAN | [view interactions] | High throughput | no | yes |
| FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| WASF2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FCG2A_HUMAN | [view interactions] | Computational | no | no |
| FCGR1_HUMAN | [view interactions] | Computational | no | no |
| BRK1_HUMAN | [view interactions] | Computational | no | no |
| RHOC_HUMAN | [view interactions] | Computational | no | no |
| GMFG_HUMAN | [view interactions] | Computational | no | yes |
| WASF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HIP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IGLL5_HUMAN | [view interactions] | Computational | no | no |
| WHAMM_HUMAN | [view interactions] | Computational | no | yes |
| NCKPL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HCLS1_HUMAN | [view interactions] | Computational | no | no |
| MYO5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RHG10_HUMAN | [view interactions] | Computational | no | no |
| GAB1_HUMAN | [view interactions] | Computational | no | yes |
| WIPF2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| WDR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FMN1_HUMAN | [view interactions] | Computational | no | no |
| NCK1_HUMAN | [view interactions] | Computational | no | yes |
| PSA7_HUMAN | [view interactions] | Computational | no | yes |
| CD3Z_HUMAN | [view interactions] | Computational | no | no |
| MYO1E_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARP3C_HUMAN | [view interactions] | Computational | no | no |
| NCK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ABI1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PGFRB_HUMAN | [view interactions] | Computational | no | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| WASF3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PDGFB_HUMAN | [view interactions] | Computational | no | yes |
| COTL1_HUMAN | [view interactions] | Computational | no | yes |
| WIPF3_HUMAN | [view interactions] | Computational | no | yes |